• Bulletin of the Korean Chemical Society
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• v.33 no.9
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• pp.2991-2998
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• 2012

A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.4
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• pp.351-356
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• 2006

This study developed an artificial neural network (ANN) to estimate the growth of microorganisms during a fermentation process. The ANN relies solely on the cumulative consumption of alkali and the buffer capacity, which were measured on-line from the on/off control signal and pH values through automatic pH control. The two input variables were monitored on-line from a series of different batch cultivations and used to train the ANN to estimate biomass. The ANN was refined by optimizing the network structure and by adopting various algorithms for its training. The software estimator successfully generated growth profiles that showed good agreement with the measured biomass of separate batch cultures carried out between at 25 and $35^{\circ}C$.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.50 no.8
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• pp.394-400
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• 2001

This paper describes an application of the on line partial discharge measurement method in operating transformer. In the operating transformer, the partial discharge signal may be superimposed by radio intereference voltage(RIV) and pulse shaped noise signals generated by external corona. The partial discharge quantity showed about 3,800pC due to very high sinusoidal interferences at the measuring impedance terminal of the transformer bushing tap. In order to reject these noises, this paper applied RIV filter, band-pass filters and noise gating method. The resulting measuring sensitivity was improved from 3,800pC to 160pC.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.05c
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• pp.38-42
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• 2001

This paper describes an application of the on line partial discharge measurement method in operating transformer. In the operating transformer, the partial discharge signal may be superimposed by radio intereference voltage(RIV) and pulse shaped noise signals generated by external corona. The partial discharge quantity showed about 3,800pC due to very high sinusoidal interferences at the measuring impedance terminal of the transformer bushing tap. In order to reject these noises, this paper applied RIV filter, band-pass filters and noise gating method. The resulting measuring sensitivity was improved from 3,800pC to 160pC.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.16 no.4
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• pp.322-329
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• 2003

We have studied how surface pretilt angle affects generation of disclination line in liquid-crystal-on silicon cells for 45$^{\circ}$-twisted nematic (TN) and vertical alignment (VA) modes with pixel size of 15$\mu\textrm{m}$. Our studies show that when the pretilt angle is increased from 0$^{\circ}$to 3$^{\circ}$ in the 45$^{\circ}$-TN cell, the disclination line at left side of on-pixel becomes weak and is well suppressed with $\theta$$\_$p/=3$^{\circ}$ although the pixel size Is decreased. In the VA cell, when the pretilt angle is decreased from 89$^{\circ}$ to 86$^{\circ}$, the disclination line at right side of the on-pixel is suppressed well and even for a smaller pixel size, it does not exist when $\theta$$\_$p/=86$^{\circ}$. The results inform that the pretilt angle strongly affects the image quality of microdisplays.

• Korean Journal of Poultry Science
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• v.42 no.2
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• pp.101-108
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• 2015

This study investigated the initial pH measured at 15 min post-mortem, ultimate pH, water holding capacity (WHC), and color of meats obtained from five lines of Korean native chicken (KNC) for the development of breed for high-quality meat. In addition, the effect of sex was examined. In total, 595 $F_1$ progeny (Black [B], Grey-Brown [G], Red-Brown [R], White [W] and Yellow-Brown [Y]) from 70 full-sib families were used. Chickens were slaughtered at 20 wk of age and the measurement traits of all breast and thigh meats from 595 chickens were analyzed. The initial pH at 15 min post-slaughter of the breast and thigh meats was affected by the line and sex of Korean native chicken (P<0.05). However, there was no line and sex effect on ultimate pH and WHC of the breast and thigh meat except that the ultimate pH of thigh meat had line effect. Except for the $L^*$ value of breast meat, the meat color was significantly affected by line and sex (P<0.05). The ultimate pH showed consistently negative correlation with the $L^*$ value and positive correlation with the $a^*$ value in breast and thigh meats. Based on the results, we concluded that the line W in male chickens and the line G and W in female chickens may be good candidates for the selection to develop breed for high-quality meat because these lines showed property of high initial pH or/and ultimate pH.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.4
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• pp.304-308
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• 2005

The response of IPTG induction was investigated through the monitoring of the alkali consumption rate and buffer capacity during the cultivation of recombinant E. coli BL21 (DE3) harboring the plasmid pRSET-LacZ under the control of lac promoter. The rate of alkali consumption increased along with cell growth, but declined suddenly after approximately 0.2 h of IPTG induction. The buffer capacity also declined after 0.9 h of IPTG induction. The profile of buffer capacity seems to correlate with the level of acetate production. The IPTG response was monitored only when introduced into the mid-exponential phase of bacterial cell growth. The minimum concentration of IPTG for induction, which was found out to be 0.1 mM, can also be monitored on-line and in-situ. Therefore, the on-line monitoring of alkali consumption rate and buffer capacity can be an indicator of the metabolic shift initiated by IPTG supplement, as well as for the physiological state of cell growth.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.12 no.2
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• pp.55-68
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• 2008

One of well known and much studied nonlinear matrix equations is the matrix polynomial which has the form $P(X)=A_0X^m+A_1X^{m-1}+{\cdots}+A_m$, where $A_0$, $A_1$, ${\cdots}$, $A_m$ and X are $n{\times}n$ complex matrices. Newton's method was introduced a useful tool for solving the equation P(X)=0. Here, we suggest an improved approach to solve each Newton step and consider how to incorporate line searches into Newton's method for solving the matrix polynomial. Finally, we give some numerical experiment to show that line searches reduce the number of iterations for convergence.

• Proceedings of the KIEE Conference
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• 1989.07a
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• pp.707-711
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• 1989

This system exchange half-duplex serial data at 1200 baud by FSK modulating a carrier frequency at 200KHz over the 110V A.C. power line. Transmitter output voltage to A.C. line is 4V p-p and line sensitivity is selected 2.54mV because CISPR Noise limitation is $66dB{\mu}V$ at 150 ${\sim}$ 500KHz. The designed and realized system has abtained system margin of 58 dB and probability of error, Pe = $1.78{\times}10^{-7}$ was obtained

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.80-80
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• 1993

(목적) 본 연구에서 사용된 바이러스는 HIV-1 nef유전자가 일부 삭제되고 대신 Chloramphenicol acetyltransferase(CAT)가 pSVCAT recombinant 바이러스다. 이러한 recombinant 바이러스를 사용하는 이유는 첫째, CAT activity가 매우 민감하므로 바이러스의 복제억제 정도를 정확하게 측정 할 수 있고 둘째, simian immunodeficiency virus(SIV)의 경우 nef 유전가 in vivo에서는 바이러스의 복제에 필수적이므로 HIV가 SIV와 유사한 것으로 미루어 본 연구에서 사용되는 recombinant SVCAT 바이러스가 안전한 것으로 고려되기 때문이다. (방법) 특히 화합물이 HIV-1의 복제에 얼마나 영향이 있는가는 1) 어느정 도의 virus inoculm을 넣었는지 2) 사용하는 cell line 3) 사용한 cell line의 infection kinetics 4) 실험의 지속기간 5) 테스트하는 assay의 sensitivity에 의존한다. 따라서 $10^{5}$ cell의 H9과 sup T1을 24 well plate에 넣고 sup T1 cell line의 경우 3일 후 항 화합물에 의한 syncytia 형성 및 CAT activity의 억제정도를 현재 AIDS drug으로 쓰이고 있는 Zidovudine을 control로 비교 관찰하였다. H9 cell line의 경우 3일 간격으로 media의 3/4을 fresh media로 바꾸어 주고 9일 후 CAT assay를 하였다. 이러한 assay에서 activity를 보이는 화합물을 reverse transcriptase와 P24 ELISA assay를 재확인하였다.다.