• Title/Summary/Keyword: P/A ratio

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Effect of pH on Swelling Property of Hyaluronic Acid Hydrogels for Smart Drug Delivery Systems

  • Kim, Jin-Tae;Lee, Deuk-Yong;Kim, Young-Hun;Lee, In-Kyu;Song, Yo-Seung
    • Journal of Sensor Science and Technology
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    • v.21 no.4
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    • pp.256-262
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    • 2012
  • Hyaluronic acid(HA) hydrogels were synthesized by immersing HA microbeads in phosphate buffered saline solutions having different pH levels to assess the effect of pH on the swelling ratio of HA hydrogels for smart drug delivery systems. No beads were formed when the HA solution(below pH 9) was crosslinked with divinyl sulfone(DVS) because DVS is a basic solution. The variation regarding the size of the microbead was not significant, suggesting that the bead size is not a function of pH(10 ~ 14). However, the pore size of the microbeads decreased with increasing pH from 10 to 14, leading to the surface smoothness and dense network as a result of higher crosslinking. The swelling ratio of hydrogels increased when the pH rose from 2(acidic) to 6(neutral). Afterwards, it decreased with further increasing pH(basic). The lower swelling ratio may be due to the lack of ionization of the carboxyl groups. On the other hand, a higher swelling ratio is likely due to the increased electrostatic repulsions between negatively charged carboxyl groups on different chains. Experimental results suggested that pH-responsive HA hydrogels can be applicable to the controlled drug delivery systems.

Nutrients and Phytoplankton Blooms in the Southern Coastal Waters of Korea: I. The Elemental Composition of C, N, and P in Particulate Matter in the Coastal Bay Systems

  • Kang, Chang-Keun;Kim, Pyoung-Joong;Lee, Won-Chan;Lee, Pil-Yong
    • Journal of the korean society of oceanography
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    • v.34 no.2
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    • pp.86-94
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    • 1999
  • An investigation was conducted to determine limiting nutrients in the bay systems of the southern coastal area of Korea. The elemental composition of C, N, and P in suspended particulate matter was monitored nearly monthly in Chinhae and Koje Bays and seasonally in Deukryang Bay for 2 years. Atomic C:N ratio in particulate matter ranges from 4.3 to 9.6, typical of marine phytoplankton. C:P and N:P ratios vary from the Redfield ratio to 229 (C:P) and 37 (N:P). A constant C:N ratio of 6.87 from regression of particulate C and N concentrations demonstrates that the particulate matter in the systems originates from primary production. C:P and N:P ratios from regression of C on P and N on P are well associated with changes in salinity. The low N:P ratio of 13.1 implies N limitation in the environments of the systems. This seems to result from the low N:P ratio of nutrients released across sediment-water interface. Phytoplankton response, expressed here as the increase of chlorophyll a, to N addition also verifies N limitation for phytoplankton communities. In heavy rainfall season (from June to September), the addition of excessive N via streams into the stratified coastal water proliferates phytoplankton greatly. During the phytoplankton blooms, C:P and N:P ratios are much higher than the Redfield ratio, implying P limitation. This results from the high N:P ratio in nutrients supplied from stream waters. Strong stratification during the blooms also interrupts the supply of nutrients, particularly p, from bottom waters. Dependent upon precipitation, this tendency shows great inter-annual variation.

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Effect of different concentrations and ratios of ammonium, nitrate, and phosphate on growth of the blue-green alga (cyanobacterium) Microcystis aeruginosa isolated from the Nakdong River, Korea

  • Kim, Hocheol;Jo, Bok Yeon;Kim, Han Soon
    • ALGAE
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    • v.32 no.4
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    • pp.275-284
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    • 2017
  • Microcystis aeruginosa causes harmful algal blooms in the Nakdong River of Korea. We studied the effect of different concentrations and ratios of ammonium ($NH_4{^+}$), nitrate ($NO_3{^-}$), and phosphate ($PO{_4}^{3-}$) on growth of this species in BG-11 medium: each nutrient alone, $NO_3{^-}:NH_4{^+}$ ratio, the N : P ratio with fixed total N (TN), and the N : P ratio with fixed total P (TP). The single nutrient experiments indicated that M. aeruginosa had the highest growth rate at $NH_4{^+}$ and $NO_3{^-}$ concentrations of $500{\mu}M$, and at a $PO{_4}^{3-}$ concentration of $5{\mu}M$. The $NO_3{^-}:NH_4{^+}$ ratio experiments showed that M. aeruginosa had the highest growth rate at a ratio of 1 : 1 when TN was $100{\mu}M$ and $250{\mu}M$, and the lowest growth rate at a ratio of 1 : 1 when the TN was $500{\mu}M$. The N : P ratio with fixed TN experiments indicated that M. aeruginosa had the highest growth rates at 50 : 1, 20 : 1, and 100 : 1 ratios when the TN was 100, 250, and $500{\mu}M$, respectively. In contrast, the N : P ratio with fixed TP experiments showed that M. aeruginosa had the highest growth rates at 200 : 1 ratio at all tested TP concentrations. In conclusion, our results imply that the $NO_3{^-}:NH_4{^+}$ ratio and the $PO{_4}^{3-}$ concentration affect the early stage of growth of M. aeruginosa. In particular, our results suggest that the maximum growth of M. aeruginosa is not simply affected by the $NO_3{^-}:NH_4{^+}$ ratio and the N : P ratio, but is determined by the TN concentration if a certain minimum $PO{_4}^{3-}$ concentration is present.

THE EFFECT OF INVESTMENT'S W/P RATIO ON THE FIN OF PARTIAL DENTURE METAL CASTINGS (매몰재의 혼수비가 국부의치 금속구조물의 Fin에 미치는 영향에 관한 실험적 연구)

  • Choi, Sub-Ho
    • The Journal of Korean Academy of Prosthodontics
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    • v.16 no.1
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    • pp.45-47
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    • 1978
  • We use investment to retain the mould of the wax pattern in making dental metal castings. A fin on the metal casting is occasionally formed due to several factors. The factors making the fin are improper burn out time and temperature, improper W/P ratio of investment and lining of asbestos in casting ring. The purpose of this study is to investigate the effect of W/P ratio of investment on the fin formation. Except the W/P ratio of investment which used to invest the wax pattern, the study was done under same condition; burn out time and temperature, W/P ratio of refractory cast(W/P=0.12) and asbestos lining in casting ring. The obtained result is that the fin is more likely to be formed on the casting which invested with higher W/P ratio of investment to that of refractory cast.

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Comparision of Family Environment, Health Behavior and Health State of Elementary Students in Urban and Rural Areas (도시.농촌 지역 초등학생의 가족환경, 건강행위 및 건강상태에 관한 비교)

  • Bae, Yeon-Suk;Park, Kyung-Min
    • Research in Community and Public Health Nursing
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    • v.9 no.2
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    • pp.502-517
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    • 1998
  • This research intends to survey family environment, health behavior and health status of the students in urban-rural elementary schools and analyze those factors comparatively, and use the result as basic material for school health teacher to teach health education in connection with family and regional areas. It also intends to improve a pupil's self-abilitiy in health care. The subjects involve 2,774 students of urban elementary schools and 583 student in rural ones, who were selected by means of a multi -stage probability sampling. Using the questionnaire and school documents, we collected data on family environment, health behavior and health status for 19 days. Feb. 2nd 1998 through Feb. 20th 1998. The R -form of Family Environment Scale (Moos, 1974) was used in the analysis of family environment(Cronbach's Alpha =0.80). Questionnaires of Health Behavior in School-aged children used by the WHO in Europe(Aaro et al., 1986) and the ones developed by the Health Promotion Committee of the Western Pacific(WHO, 1995)(adapted by long Young-suk and Moon Young-hee(1996)) were used in the analysis of health behavior, as well documents on absences due to sickness, school health room-visits, levels of physical strength, height, weight and degree of obesity were used to determine health status. In next step, We used them with an $X^2$-test, t-test, Odds Ratio, and a 95% Confidence Interval. 1. In two dimensions of three, family-relationship (t=3.41, p=0.001) and system -maintenances(t= 2.41, p=0.0l6) the mean score of urban children were significantly higher than those of rural ones. In the personal development dimension however, there was little significant difference. Assorting family environment into 10 sub-fields and analyzing them, we recognized that urban children were superior to rural children in the sub-fields of expressiveness (t =3.47, p=0.001), conflict (t=0.48, p=0.001), active-recreational orientation (t = 1.97, p=0.049) and organization (t=4.33, p=0.000). 2. Referring to the Odds Ratios of urban-rural children's health behaviors, urban children set up more desirable behavior than rural children wear ing safety belts (Odds Ratio =0.32, p=0.000), washing hands after meals(Odds Ratio = 0.43, p= 0.000), washing hands after excreting (Odds Ratio = 0.39, p=O.OOO), washing hands after coming - home ( Odds Ratio = 0.75, p = 0.003), brushing teeth before sleeping(Odds Ratio =0.45, p=0.000), brushing teeth more than once a day (Odds Ratio =0.73, p=0.0l2), drinking boiled water (Odds Ratio = 0.49, p=0.000), collecting garbage at home(Odds Ratio=0.31, p=0.000) and in the school(Odds Ratio =0. 67, p=0.000). All these led to significant differences. As to taking milk(Odds Ratio = 1.50, p=0.000), taking care of eyesight(Odds Ratio=1.41, p=0.001) and getting physical exercise in(Odds Ratio = 1.33, p=0.0l9) and outside the school(Odds Ratio = 1.32, p=0.005), rural children had more desirable behavior which also revealed a significant difference. There was little significant difference in smoking, but the smoking rate of rural children(5.5%) was larger than that of urban children(3.9%). 3. Health status was analyzed in terms of absences, school health room-visits, levels of physical strength, and the degree of obesity, height and weight. Considering Odds Ratios of the health status of urban-rural children, the health status of rural children was significantly better than that of the urban ones in the level of physical strength(t=1.51, p=0.000) and the degree of obesity(t=1.84, p=0.000). The mean height of urban children ($150.4{\pm}7.5cm$) is taller than that of their counterparts($149.5{\pm}7.9$), which revealed a significant difference (t =2.47, p=0.0l4). The mean weight of urban children($42.9{\pm}8.6kg$) is larger than that of their counterparts($41.8{\pm}9.0kg$), which was also a significant difference(t=2.81, p=0.005). Considering the results above, we can recognize that there are significant differences in family environment, health behavior, and health status in urban-rural children. These results also suggestion ideas for health education. What we would suggest for the health program of elementary schools is that school health teachers should play an active role in promoting the need and importance of health education, develop the appropriate programs which correspond to the regional characteristics, and incorporate them into schools to improve children's ability to manage their own health management.

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The Study of Distance and Near AC/A Ratio by Stimulus (조절자극 방식에 따른 원거리와 근거리 AC/A비에 관한 연구)

  • Jo, Tae-Sik;Kim, In-Suk;Jang, Jung-Un
    • Journal of Korean Ophthalmic Optics Society
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    • v.16 no.4
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    • pp.417-423
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    • 2011
  • Purpose: This study was to investigate that near gradient AC/A ratio could be used to prescribe a patient with distance exophoria, we compared the difference between distance gradient AC/A ratio and near gradient AC/A ratio. Also, this thesis was to understand the relationship between calculated AC/A ratio and gradient AC/A ratio. Methods: Objective and subjective refractive error were corrected and we used Howell (3 m) chart for distance phoria tests and Howell-Kim (40 cm) chart for near phoria tests. The near gradient AC/A ratio and calculated AC/A ratio were used by Howell-Kim (40 cm) combined with +1.00 D, -1.00 D, +2.00 D and -2.00 D. Results: The average value of distance exophoria was 1.17${\pm}$1.17 $\Delta$, and the average value of near exophoria was 3.71${\pm}$2.80 $\Delta$ (t-test. p<0.001). The correlation of distance phoria with near phoria was little higher (r = 0.59, p < 0.001). Gradient AC/A ratios depending on measuring distance and stimulus were higher (r = 0.11~0.53. P < 0.001), when distance was shorter and stimulus to accommodation was more. Also, stimulus to accommodation by plus lens was higher than stimulus to accommodation by minus lens (paired t-test. p < 0.001). There was negative correlation between calculated AC/A ratio and gradient AC/A ratio. As the calculated AC/A ratio was higher, gradient AC/A ratio was lesser. Near gradient AC/A ratio was slightly higher than distance gradient AC/A ratio. Distance and near gradient AC/A ratio taken through the subjective -1.00 D were 1.30 $\Delta$/D and 1.68 $\Delta$/D(t-test. t=1.67, p < 0.001). Conclusions: There is negative correlation between calculated AC/A ratio and gradient AC/A ratio. Also, there is subtle difference between near gradient AC/A ratio and distance gradient AC/A ratio. Therefore, we need to measure distance gradient AC/A ratio when a practitioner prescribe glasses for a patient with distance exophoria.

An Experimental Study on the Variable Sonic Ejector System (가변형 음속 이젝터 시스템에 관한 실험적 연구)

  • Lee, Jun-Hee;Jung, Sung-Jae;Kim, Heuy-Dong;Koo, Byoung-Soo
    • Proceedings of the KSME Conference
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    • 2004.04a
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    • pp.2035-2040
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    • 2004
  • A cone cylinder is used to obtain variable operation conditions for the sonic ejector-diffuser system. The cone cylinder is designed to move upstream and downstream to change the ejector throat area ratio, thus obtaining variable mass flow rates. The present study investigates the effects of ejector throat area ratio and operating pressure ratio on the entrainment of secondary stream for the variable sonic ejector system. In experiment, the ejector throat area is varied in the range from ${\psi}=11.88$ to 66.69, and the operating pressure ratio from $p_{0p}/p_a=1.25$ to 9.0. The results show that the variable sonic ejector system is suitable for a required entrainment ratio of secondary stream by altering the ejector throat area ratio and operating pressure ratio.

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Stability of Bulk Heterojunction Organic Solar Cells with Different Blend Ratios of P3HT:PCBM

  • Kwon, Moo-Hyun
    • Transactions on Electrical and Electronic Materials
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    • v.13 no.2
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    • pp.98-101
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    • 2012
  • I studied the stability of organic photovoltaic cells in terms of P3HT:PCBM-71 blend ratio as a function of storage time. I obtained the best cell performance by optimizing the blend ratio of electron donor and electron acceptor within the active layer. In this study, I found that the more the P3HT:PCBM ratio increases within the active layer, the more the cell efficiency decreases as the storage time increases. As a result, the best optimized blend ratio was the 1:0.6 ratio of P3HT:PCBM-71, and cell efficiency of the device with the 1:0.6 blend ratio was 4.49%. The device with the best cell efficiency showed good stability.

Echocardiographic evaluation of heart failure in dogs with myxomatous mitral valve disease: a retrospective study

  • Han, Donghyun;Lee, Dong-Guk;Jung, Dong-In
    • Journal of Biomedical and Translational Research
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    • v.19 no.4
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    • pp.79-85
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    • 2018
  • Echocardiography is one of the most useful diagnostic techniques for differentiating heart disease as well as mitral valve lesion. Forty client-owned small breed dogs (weight, 2.3-13.2 kg) aged between 8-17 years with myxomatous mitral valve degeneration (MMVD) were included in the present study. The diagnosis of MMVD in dogs was made based on the clinical signs, chest radiography data, and echocardiographic findings. Echocardiographic examinations were conducted in accordance with recommended standards for dogs. M-mode, Doppler, and 2D echocardiography were performed in left and right lateral recumbency. 2D echocardiography was used to measure LA and Ao diameter from 2D short axis at the level of the aortic valve. In the comparison of conventional echocardiography indices in dogs with different stages of heart failure with MMVD, significant differences were observed in E/A ratio (p=0.005), EDV (p<0.001), EDVI (p<0.001), E-peak velocity (p= 0.001), ESV (p=0.028), ESVI (p=0.004), LA (p<0.001), LA/Ao Ratio (p<0.001), LVIDd (p<0.001), LVIDd/Ao Ratio (p<0.001), LVIDs (p=0.036), LVIDs/Ao Ratio (p=0.002), and MR Velocity (p=0.026). In addition, distinct correlations were found in EDV (r=0.712), LA/Ao ration (r=0.830), LVIDd (r=0.724), and LVIDd/Ao ratio (r=0.759). This study found that known conventional echocardiographic indices, including EDV, LA/Ao ratio, LVIDd dimension, and LVIDd/Ao ratio correlated with the severity of MMVD in point of significant differences and distinct correlations.

Effects of Combining Feed Grade Urea and a Slow-release Urea Product on Characteristics of Digestion, Microbial Protein Synthesis and Digestible Energy in Steers Fed Diets with Different Starch:ADF Ratios

  • Lopez-Soto, M.A.;Rivera-Mendez, C.R.;Aguilar-Hernandez, J.A.;Barreras, A.;Calderon-Cortes, J.F.;Plascencia, A.;Davila-Ramos, H.;Estrada-Angulo, A.;Valdes-Garcia, Y.S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.27 no.2
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    • pp.187-193
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    • 2014
  • As a result of the cost of grains, the replacement of grains by co-products (i.e. DDGS) in feedlot diets is a common practice. This change produces diets that contain a lower amount of starch and greater amount of fibre. Hypothetically, combining feed grade urea (U) with slow release urea (Optigen) in this type of diet should elicit a better synchrony between starch (high-rate of digestion) and fibre (low-rate of digestion) promoting a better microbial protein synthesis and ruminal digestion with increasing the digestible energy of the diet. Four cannulated Holstein steers ($213{\pm}4$ kg) were used in a $4{\times}4$ Latin square design to examine the combination of Optigen and U in a finishing diet containing different starch:acid detergent fibre ratios (S:F) on the characteristics of digestive function. Three S:F ratios (3.0, 4.5, and 6.0) were tested using a combination of U (0.80%) and Optigen (1.0%). Additionally, a treatment of 4.5 S:F ratio with urea (0.80% in ration) as the sole source of non-protein nitrogen was used to compare the effect of urea combination at same S:F ratio. The S:F ratio of the diet was manipulated by replacing the corn grain by dried distillers grain with solubles and roughage. Urea combination did not affect ruminal pH. The S:F ratio did not affect ruminal pH at 0 and 2 h post-feeding but, at 4 and 6 h, the ruminal pH decreased as the S:F ratio increased (linear, p<0.05). Ruminal digestion of OM, starch and feed N were not affected by urea combination or S:F ratio. The urea combination did not affect ADF ruminal digestion. ADF ruminal digestion decreased linearly (p = 0.02) as the S:F ratio increased. Compared to the urea treatment (p<0.05) and within the urea combination treatment (quadratic, p<0.01), the flow of microbial nitrogen (MN) to the small intestine and ruminal microbial efficiency were greater for the urea combination at a S:F ratio of 4.5. Irrespective of the S:F ratio, the urea combination improved (2.8%, p = 0.02) postruminal N digestion. As S:F ratio increased, OM digestion increased, but ADF total tract digestion decreased. The combination of urea at 4.5 S:F improved (2%, p = 0.04) the digestible energy (DE) more than expected. Combining urea and Optigen resulted in positive effects on the MN flow and DE of the diet, but apparently these advantages are observed only when there is a certain proportion of starch:ADF in the diet.