• Clinical and Experimental Pediatrics
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• v.62 no.3
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• pp.95-101
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• 2019

Purpose: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure overload, cardiac apoptosis appears to result from an exaggerated local production of angiotensin in adult SHRs. Altered expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor (CCR)-2, monocyte chemoattractant protein (MCP)-1, transforming growth factor $(TGF)-{\beta}1$, phosphorylated extracellular signal-regulated kinases (PERK), and connexin 43 proteins, and kallikrein mRNA were investigated to explore the effects of losartan on the SHR model. Methods: Twelve-week-old male rats were grouped as follows: control (C), SHR (hypertension: H), and losartan (L; SHRs were treated with losartan [10 mg/kg/day] for 5 weeks). Western blot and reverse transcription polymerase chain reaction assays were performed. Results: Expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, PERK, and connexin 43 proteins, and kallikrein mRNA was significantly increased in the H group compared to that in the C group at weeks 3 and 5. Expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, and connexin 43 proteins and kallikrein mRNA was significantly decreased after losartan treatment at week 5. PERK protein expression was significantly decreased after losartan treatment at weeks 3 and 5. Bcl-2 protein expression was significantly decreased in the H group compared to that in the C group at weeks 3 and 5. Conclusion: Losartan treatment reduced expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, PERK, and connexin 43 proteins, and kallikrein mRNA in SHRs, along with decreased inflammation and apoptosis.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.13 no.6
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• pp.173-186
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• 2003

Distributed Denial-of-Service(DDoS) attack prevent users from accessing services on the target network by spoofing its origin source address with a large volume of traffic. The objective of IP Traceback is to determine the real attack sources, as well as the full path taken by the attack packets. Existing IP Traceback methods can be categorized as proactive or reactive dating. Proactive tracing(such as packet marking and messaging) prepares information for tracing when packets are in transit. Reactive tracing starts tracing after an attack is detected. In this paper, we propose a 'advanced ICW Traceback' mechanism, which is based on the modified pushback system with secure router mechanism. Proposed mechanism can detect and control DDoS traffic on router and can generate ICMP Traceback message for reconstructing origin attack source, by which we can diminish network overload and enhance Traceback performance.

• Journal of the Korean Recycled Construction Resources Institute
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• v.8 no.4
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• pp.444-449
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• 2020

In this study, On-Board Truck Scale was installed on the construction waste collection / transportation vehicles to monitor the weight of the waste at all stages from generation to final treatment. It was performed as a case study of a construction waste control technology that can efficiently manage the total generating and recycling amount using real-time weight/location information obtained by the On-Board Truck Scale device. As a result of the study, it was confirmed that the total amount of construction waste can be monitored in real time, and a plan for efficient logistics transportation can be derived through the analysis of operation patterns by managing the real-time transport volume, transport distance, and transport time of the construction waste collection / transportation vehicles. It was confirmed that overloading can be prevented in advance by controlling the loading also.

• The Korea Journal of Herbology
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• v.38 no.6
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• pp.29-44
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• 2023

Objectives : This study was planned to evaluate the therapeutic effectiveness and possible underlying mechanism of TPE (Tetrapanax papyrifer stem(inner part of the stem Extract) and AQE (Akebiae quinata stem Extract) on osteoarthritis. Methods : Osteoarthritis models were induced through intra-articular injection of MIA (monosodium iodoacetate) 50 μL with 80 mg/ml in rats. Excluding the normal group, Osteoarthritis-induced rats were divided into 4 groups (Control, INDO, TPE, AQE). The drug concentrations were indomethacin 5 mg/kg, TPE 200 mg/kg, and AQE 200 mg/kg, and were orally administered once a day for a couple of weeks. After drug supplementation, the effects of TPE and AQE were measured with serum diagnosis, western blotting, and histopathological staining. Results : It was found that the DPPH and ABTS free radical erasure ability of AQE was better than that of TPE. AQE administration improved rear limb overload and it led to relieving pain. Both PTE and AQE significantly reduced the expression of inflammatory mediators COX-2, iNOS, and inflammatory cytokine IL-1β and IL-6 by inhibiting the phosphorylation of IκBα and deactivating the pathway of NF-κBp65. On the other hand, TNF-α was significantly reduced only by administration of AQE. In addition, histopathological analysis showed that the administration of AQE compared to PTE suppressed cartilage degeneration and effectively suppressed damage to proteoglycan, a component of ECM. Conclusion : Reviewing these experimental results, TPE and AQE possessed the effect of delaying the progress of osteoarthritis and protecting cartilage. In addition, the results of this study show that AQE has a better cartilage protection effect than TPE.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.263-272
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• 2023

In recent times, short videos have become highly popular among college students, serving as a vibrant platform for information sharing and self-expression, while fostering a unique culture. However, their excessive consumption can lead to negative effects like reduced concentration and information overload, necessitating a balanced approach and self-control. Our study examined the impact of different characteristics of short video media on college students' organizational commitment and mental health. The findings highlighted that attributes such as accessibility and immediacy positively influence different levels of engagement, and that organizational commitment significantly affects students' mental well-being. The research underscores the importance of judicious use of short video media to positively affect college students' mental health.

• The Journal of the Korea institute of electronic communication sciences
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• v.18 no.6
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• pp.1081-1086
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• 2023

The rapid growth and increasing complexity of modern networks have highlighted the limitations of traditional network architectures. The emergence of SDN (Software-Defined Network) in response to these challenges has changed the existing network environment. The SDN separates the control unit and the data unit, and adjusts the network operation using a centralized controller. However, this structure has also recently caused a huge amount of traffic due to the rapid spread of numerous Internet of Things (IoT) devices, which has not only slowed the transmission speed of the network but also made it difficult to ensure quality of service (QoS). Therefore, this paper proposes a method of load distribution by switching the IP and any server (processor) from the existing data processing scheduling technique, RR (Round-Robin), to mapping when a large amount of data flows in from a specific IP, that is, server overload and data loss.

• Smart Structures and Systems
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• v.33 no.1
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• pp.1-16
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• 2024

The investigation on vehicle-bridge coupling system (VBCS) is crucial in bridge design, bridge condition evaluation, and vehicle overload control. A real-time hybrid testing (RTHT) method for VBCS (RTHT-VBCS) is proposed in this paper for accurately and economically disclosing the dynamic performance of VBCSs. In the proposed method, one of the carriages is chosen as the experimental substructure loaded by servo-hydraulic actuator loading system in the laboratory, and the remaining carriages as well as the bridge structure are chosen as the numerical substructure numerically simulated in one computer. The numerical substructure and the experimental substructure are synchronized at their coupling points in terms of force equilibrium and deformation compatibility. Compared to the traditional iteration experimental method and the numerical simulation method, the proposed RTHT-VBCS method could not only obtain the dynamic response of VBCS, but also economically analyze various working conditions. Firstly, the theory of RTHT-VBCS is proposed. Secondly, numerical models of VBCS for RTHT method are presented. Finally, the feasibility and accuracy of the RTHT-VBCS are preliminarily validated by real-time hybrid simulations (RTHSs). It is shown that, the proposed RTHT-VBCS is feasible and shows great advantages over the traditional methods, and the proposed models can effectively represent the VBCS for RTHT method in terms of the force equilibrium and deformation compatibility at the coupling point. It is shown that the results of the single-degree-of-freedom model and the train vehicle model are match well with the referenced results. The RTHS results preliminarily prove the effectiveness and accuracy of the proposed RTHT-VBCS.

• Journal of Periodontal and Implant Science
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• v.34 no.1
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• pp.71-81
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• 2004

Peri-implantitis could be the result of biomechanical and occlusal overload as well as microbiologic invasion. The dental implant may be more susceptible to dental plaque than the natural tooth, as the predictability of a stable soft tissue attachment complex has not yet been confirmed. With the development of peri-implantitis, the implant surface would be exposed to the oral environment and becomes coated with bacteria. The objective of therapy for this condition is to regain integration of the implant with bone. Since fibroblast adherence to surfaces is impeded by endotoxin, it would seem that decontamination would be desirable to obtain maximum osseointegration. The purpose of this study was to determine whether various chemotherapeutic and mechanical treatments(distilled water, air-powder abrasive, hypersaturated citric acid, tetracycline) can detoxify contaminated titanium implant surface by means of kinetic LAL test. Experimental rough surface titanium disks were fabricated. All of them were divided into two groups(A.a group and P.g group) and each contaminated by A. actinomycetemcomitans and P. gingivalis suspension. Contaminated disks were treated with distilled water, air-powder abrasive, citric acid and tetracycline, and then all disks were placed into LPS-free water for elution. The results were as follows : 1. In A.a group, LPS elute level of all test groups were significantly lower than control group(p<0.05). 2. In A.a group, LPS elute level of test 2, test 3 and test4 groups were significantly lower than that of control group(p<0.05). But, among the test 2, test 3, test4 groups, the significant differences were not detected. 3. In P.g group, LPS elute level of test 2, test 3 and test 4 groups were lower than that of control group(p<0.05). But, among the test groups, the significant differences were not detected. From the result of this study, it would be concluded that air-powder abrasive, hypersaturated citric acid and tetracycline treatments may be effective at reducing endotoxin level on rough titanium implant surfaces, and can be clinically used. But the treatments in peri-implantitis differentially impact osseointegration making one method clinically superior. To gain this knowledges, further molecular biologic and histopathologic studies should be developed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.4
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• pp.768-779
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• 2017

Recently, the great number of mobile devices causes excessive data/control traffic problems in the centralized LTE/EPC network and such dramatically increased traffic is emerging as a critical issue. In the Centralized Mobility Management (CMM) based LTE/EPC network, the Packet Data Network Gateway (P-GW) plays the centralized mobility anchor role and it accommodates most of data traffic. To solve this problem, the IETF has proposed the Distributed Mobility Management (DMM) scheme, but it has only focused on the data traffic load balancing and could not solve the control traffic overload problem. In this paper, therefore, we propose a new SDN based hybrid CMM/DMM Mobility Management (C-DMM) architecture based on Packet Network Edge Gateway (P-EGW), and introduce a selection scheme between CMM and DMM according to a device's mobility and the number of PDN connections. In order to prove the efficiency of the proposed architecture and scheme, we compare the data traffic processing load and the control traffic processing load over each scheme by emulating them in the ONOS controller and the Mininet environment.

• Journal of the Institute of Convergence Signal Processing
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• v.16 no.2
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• pp.74-82
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• 2015

In this study, a BMW plant process control system model which produces BMW is suggested and the BMW plant process controller with the following functions is developed. The first function is to operate the electronic overload relays to stop the blower for a certain period of time and to re-operate it again when the blower is overloaded. The second function is to close the motor operated valve automatically in case of power failure to prevent the circulation from the guided tank to the compost throwing tank and to block leak from the compost throwing tank due to the failure of ball valve. The third function is to transfer produced BMW from the concentration tank to 4 storage tanks for automatic managing of the BMW output. A device to measure the signal of the BMW plant process controller and a test equipment are developed. The designed BMW plant process controller is checked to see if it operates correctly according to the design specifications. The sequence control method based on BMW plant process controller is developed at a low cost in this study, so it is expected to bring improvements in the stability and the efficiency of system and to cause reductions in the operation and the management costs in the future.