• 대한세포병리학회지
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• 제7권2호
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• pp.144-150
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• 1996

Although bladder cancers are very common, little is known about their molecular pathogenesis. It is known that p53 alteration is found in about 60% of muscle-invasive bladder cancer, necessiating aggressive therapy and poor outcome. We examined the nuclear expression of p53 protein, using D07 monoclonal antibody in the urine samples from 31 patients with transitional cell carcinoma of the bladder to investigate the correlation of p53 overexpression with histologic grades and depth of invasion. The positive rate of p53 protein was 27% in superficial bladder tumor, but increased up to 71% in the invasive bladder carcinomas. The overexpression of p53 protein increased according to Mostofi grading system from 18% in grade I, 45% in grade II, and up to 100% in grade III. The p53 expression tended to be higher in the invasive and high grade bladder cancers than in the superficial and low grade ones(p<0.05). These results suggest that immunohistochemical analysis of the urine specimen in the bladder cancer patients could be a useful method of screening for the presence of p53 mutant protein. The mutant p53 protein expression may be an indicator of bladder cancer with more proliferative potential and/or aggressive biologic behavior.

• 대한핵의학회지
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• 제25권2호
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• pp.177-185
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• 1991

Dipyridamole thallium imaging is one of the most widely accepted means of evaluating patients with suspected or known coronay artery disease. The results of thallium imaging help diagnose coronary artery disesse (CAD), determine the hemodynamic significance of coronary stenosis, evaluate viability of myocardium, assess the outcome of therapeutic interventions and stratify patients according to their risk for luther cardiac events. An increased lung thallium uptake and transient LV dilation has been reported as poor prognostic indicator and associated with extensive and severe coronary artery disease. We quantitated lung/heart uptake ratio (l/HUR) and transient left ventricular dilation ratio in 44 patients and 17 controls undertaking dipyridamole thallium-201 scintigraphy. The results are as follows: 1) The lung/heart uptake ratio was high in patients with CAD and which became higher according to increasing number of diseased vessel. The L/HUR of patients with low LVEF (<35%) was lower than those with normal LVEF. 2) Transient left ventricular dilation ratio of CAD patients had no close relation between numbers of diseased vessels and was not higher than normals. But transient left ventricular dilation ratio of patients with myocardial infartion was higher than normals. We concluded that lung/heart uptake ratio seems to be sensitive marker for severity of CAD and myocardial function, but transient left ventricular dilation ratio alone is not sufficient to be a marker for severe and extensive CAD.

• 정보관리학회지
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• 제34권3호
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• pp.209-228
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• 2017

이 연구에서는 기존의 h-지수와 g-지수에 대해 달리 해석해보고 새로운 Hirsch 유형 복합 지표인 전치 g-지수를 제안하고자 한다. 새로운 해석에 따라서 h-지수 및 g-지수 산출 그래프의 가로축이 인용빈도 기준값에 해당하고 세로축이 논문 수가 되도록 축을 전치하고, 이로부터 새로운 전치 g-지수를 제안하였다. 한국학술지인용색인 KCI의 문헌정보학 분야 연구자들을 대상으로 적용해본 결과, 제안된 새 지수는 h-지수 및 g-지수에 비해서 변별력이 높으며 연구의 질보다 연구의 양 차이에 더 민감한 것으로 나타났다. 연구를 지속하는 꾸준한 연구자를 그렇지 못한 연구자와 변별해주는 차별화된 특성을 가지고 있으므로 전치 g-지수는 다면적인 연구 성과 평가에 도움이 될 것으로 기대된다.

• Journal of the Optical Society of Korea
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• 제15권3호
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• pp.252-263
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• 2011

In this work, for the first time, the quality of restoration in wide-field microscopy images after deconvolution was analyzed as a function of different Point Spread Functions using one deconvolution method, on a specimen of known size and on a biological specimen. The empirical Point Spread Function determination can significantly depend on the numerical aperture, refractive index of the embedding medium, refractive index of the immersion oil and cover slip thickness. The influence of all of these factors is shown in the same article and using the same microscope. We have found that the best deconvolution results are obtained when the empirical PSF utilized is obtained under the same conditions as the specimen. We also demonstrated that it is very important to quantitatively check the process' outcome using several quality indicators: Full-Width at Half-Maximum, Contrast-to-Noise Ratio, Signal-to-Noise Ratio and a Tenengrad-based function. We detected a significant improvement when using an indicator to measure the focus of the whole stack. Therefore, to qualitatively determinate the best deconvolved image between different conditions, one approach that we are pursuing is to use Tenengrad-based function indicators in images obtained using a wide-field microscope.

• 한국지리정보학회지
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• 제9권2호
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• pp.206-216
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• 2006

본 연구의 주된 목적은 환경지리정보체계(이하 EGIS)의 성과분석을 위한 분석모형 중 IT BSC의 적합성을 검토하고, 이를 실제로 적용해 봄으로써 나타나는 분석결과를 바탕으로 EGIS의 체계적 성과관리를 위한 바람직한 방향을 제시하는 것이다. 이러한 목적을 달성하기 위해 본 연구는 기존의 BSC를 이용한 정보시스템 성과측정 모형을 EGIS에 맞게 재정립하였다. 정립된 분석모형을 이용하여 지난 5년간 EGIS가 낸 성과를 도출하고 각각의 근본원인을 규명하여 향후 개선방향의 기반자료로 활용하였다. 최종적 성과를 종합하기 위하여 핵심성과지표 별 측정치와 AHP를 통하여 산출된 가중치를 곱하여 환산한 결과 환경지리정보체계의 종합성과는 총 105.3점으로 산출되어, '성과목표 달성'의 기준이 되는 100점을 넘어서 5.3점 만큼의 성과를 더 낸 것으로 나타났다. 성과분석결과 기존의 재무적 관점 이외의 다양한 관점으로 환경지리정보체계의 균형적 성과를 살펴 본 것이 본 연구의 장점이며, 이와 같은 성과가 환경분야에 어떠한 영향을 미치는가에 대한 향후 연구가 필요하다.

• 컴퓨터교육학회논문지
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• 제10권3호
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• pp.19-29
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• 2007

국가 경제성장에만 집중되어 추진된 정보화 정책은 기술과 사회문화 간의 불균형을 초래하고 심각한 연기능 현상을 나타냈으며, 이러한 문제들은 사이버 공간에서 개인의 정체성을 위협하고 있다. 본 연구에서는 국가 수준의 정보통신윤리 수준을 진단할 수 있는 정보통신윤리지수 모델을 개발하였다. 이를 위해 다양한 선행 연구물을 근거로 연구진의 브레인스토밍을 통해 정보통신윤리지표의 영역을 추출하였으며, 전문가와의 협의를 통해 지표로서의 타당성과 대표성을 높이고 계층분석법에 의해 가중치를 부여하였다. 또한 정보이용자와 정보사업자를 대상으로 설문조사를 통하여 수집된 설문결과를 단순평균방식으로 지수 구성요소들의 가중치 산정에 반영하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2355-2362
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• 2012

The SH2B1 adaptor protein is recruited to multiple ligand-activated receptor tyrosine kinases that play important role in the physiologic and pathologic features of many cancers. The purpose of this study was to assess SH2B1 expression and to explore its contribution to the non-small cell lung cancer (NSCLC). Methods: SH2B1 expression in 114 primary NSCLC tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patients' outcome. Additionally, 15 paired NSCLC background tissues, 5 NSCLC cell lines and a normal HBE cell line were evaluated for SH2B1 expression by RT-PCR and immunoblotting, immunofluorescence being applied for the cell lines. Results: SH2B1 was found to be overexpressed in NSCLC tissues and NSCLC cell lines. More importantly, high SH2B1 expression was significantly associated with tumor grade, tumor size, clinical stage, lymph node metastasis, and recurrence respectively. Survival analysis demonstrated that patients with high SH2B1 expression had both poorer disease-free survival and overall survival than other patients. Multivariate Cox regression analysis revealed that SH2B1 overexpression was an independent prognostic factor for patients with NSCLC. Conclusions: Our findings suggest that the SH2B1 protein may contribute to the malignant progression of NSCLC and could offer a novel prognostic indicator for patients with NSCLC.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5889-5893
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• 2014

Over-expression of epidermal growth factor receptor (EGFR) has been identified as a common feature associated with clinical outcome in many types of cancer, including squamous cell carcinoma of the oesophagus (SCCO). However, the clinical importance of EGFR over-expression in SCCO remains unsettled as conflicting results exist. Therefore we carried out the present meta-analysis of published studies for clarification. A total of 13 studies including 1, 150 patients were enrolled. EGFR over-expression was positive in 722 of these cases. With EGFR over-expression, patients had higher depth of invasion, vascular invasion, and poor prognosis. However, expression had no relation with degree of differentiation, histological grade, lymph node metastasis, clinical stage or lymphatic invasion. EGFR over-expression is probably a valuable predictor for the T stage, vascular invasion and OS, and it could be used as a poor prognosis indicator for the esophageal SCC patients. Targeting therapy to EFGR should be considered to the combined treatment in SCCO.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5055-5060
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• 2013

Objective: Twist, a basic helix-loop-helix transcription factor, plays a key role in the metastatic progression of human cancer. Matrix metalloproteinase (MMP)-9 is an endopeptidase that digests basement membrane type IV collagen, therefore being possibly related to tumor progression. It has been reported that Twist and matrix metalloproteinase-9 (MMP-9) are expressed in gastric cancers. However, the exact roles of Twist and MMP-9 in tumor metastasis and prognosis remain unclear. The aim of this study was to casts light on this question. Methods:Twist and MMP-9 expression in tissue sections of 37 gastric carcinomas was evaluated with immunohistochemistry. The staining results were compared with clinicopatholgic features and to patients' outcome. Results: Twist positive expression was significantly increased in gastric cancer cases with lymph node metastasis (P=0.023). But no correlations were found between MMP-9 overexpression and clinicopathologic features, such as recurrence, TNM stage, and lymph node metastasis. Overall survival (OS) was significantly correlated with recurrence, serosa invasion, TNM stages, distant metastasis, and MMP-9 (P=0.027, 0.021, 0.000, 0.024 and 0.036, respectively). Disease-free survival (DFS) was prominently related to recurrence location, serosa invasion and TNM stages (P=0.000, 0.038 and 0.003, respectively). In the Cox regression multivariate analysis, TNM stage, distant metastasis and MMP-9 were significantly associated with prognosis of gastric cancer (P=0.002, 0.019, and 0.032, respectively). Conclusions: This study showed Twist positive expression to be significantly correlated with lymph node metastasis in gastric cancer. MMP-9 overexpression is associated with OS, suggesting that MMP-9 is a prognostic indicator for survival in patients with gastric cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5293-5299
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• 2013

Purpose: High levels of bone morphogenetic protein (BMPs) have been reported in patients with lung cancer. This study was conducted to assess correlations between serum BMP-2 levels and prognostic outcome in patients with non-small-cell lung cancer (NSCLC). Methods: Blood samples from 84 patients with advanced NSCLC and 42 healthy controls were analyzed and quantitated for serum BMP-2 levels before and after two cycles of chemotherapy using a commercially available ELISA kit. Results: The median level of BMP-2 was 146.9 pg/ml in patients with NSCLC vs. 87.7 pg/ml in healthy controls (P<0.01). A significant correlation was observed between pretreatment serum BMP-2 level and ECOG PS, disease stage and number of organs with metastases (P<0.05). Serum BMP-2 level decreased significantly in patients who achieved objective response after two cycles of chemotherapy. Multivariate analysis showed that increased BMP-2 level and advanced clinical stage were significantly correlated with poor prognosis. Conclusion: Thes erum BMP-2 level is positively correlated with clinical stage, ECOG PS and metastatic burden and may serve as an independent negative predictor for prognosis. Decreased BMP-2 after chemotherapy could be a reliable marker for efficacy of treatment.