• 치과방사선
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• 제25권1호
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• pp.141-150
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• 1995

종양유발성 골연화증은 종양에 의하여 생성된 활동성 펩티드호르몬과 유사한 물질이 골이나 위장관에 작용하여 칼슘대사와 인대사의 변화를 일으키거나, 정상적인 비타민 D대사에 장애를 일으킴으로써 2차적으로 발생되는 대사성 질환으로 알려져 있다. 이의 발생빈도는 매우 낮으며, 임상적으로는 체중과 신장의 감소, 전신적인 골격의 동통 및 근무력증과 병적 골절이 동반되어 나타난다. 방사선사진에서는 골소주의 전반적인 소실, 피질골의 비박, 위골절, 치조백선의 소실 등을 보이고, 실험실 소견에서는 혈청인의 농도와 신세뇨관에서 인의 재흡수율의 감소 및 혈청 알칼리성 인산화효소 농도의 상승이 관찰된다. 본질환은 종양이 제거되면 별도의 부가적인 치료 없이도 임상적, 방사선학적 소견 및 실험실 소견의 뚜렷한 개선을 보이므로 이의 치료에 있어서 정확한 진단이 매우 중요하다. 저자들은 전신적인 동통과 근무력증을 주소로 내원한 환자들에게서 발생된 종양유발성 골연화증 3예를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다.

• 한국조리학회지
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• 제23권6호
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• pp.173-183
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• 2017

Conditions related to body composition and aging, such as osteopenic obesity, sarcopenia/ sarcopenic obesity, and the newly termed osteosarcopenic obesity(triad of bone, muscle and adipose tissue impairment), are beginning to gain recognition. Currently, it has begun to attract the attention of scholars from all over the world, however, for this disease, it still needs a more clear understanding and perception. Therefore, this article considered the osteoporosis, muscle depression, and obesity, these diseases as a gate to study the relationship among muscle, bone, and fat. In addition, in the aging process, the formation of IGF-cortisol, testosterone, and estrogen is sensitive. These hormones can not only absorb muscle protein metabolism, but also affect alienation. The decrease in IGF-cortisol in the elderly resulted in increased visceral fat, decreased muscle mass and bone mineral density, and then affected decreased skeletal muscle atrophy and decreased quality. The reduction of skeletal muscle quality and strength and increase body fat affected the adipose tissue to produce inflammatory cytokines, thereby reduced skeletal muscle, promoted cardiovascular disease, metabolic syndrome and insulin resistance in chronic diseases. Almost all chronic inflammatory diseases were associated with bone, muscle and fat. These mechanisms were complex and interrelated. Inflammation reduces bone formation, increases fat and reduces muscle mass. And thus not only had a significant impact on the motor system, but also made the incidence increase of fracture, osteoporosis, fragile syndrome, fall, osteomalacia and other bone disease. This article aimed to start from the interaction between the muscles and bones of the elderly, extended to obesity, muscle deficiency, osteoporosis and other diseases, finally, from a nutritional point of view, to discuss how to treat osteoporosis obesity.

• 한국의류학회지
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• 제21권5호
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• pp.903-910
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• 1997

Vit. D3 was measured which was produced by UVB irradiation to provit. D3, 7-d ehyd rock o 1 cst or of (7-DH Cl Measuring the amount of vie. D3 when it was irradiated to the fabrics which had different UV8 transmittance, production of vile. Ds by UVB(Ultraviolet B) and inhibition from formation of vile. D3 by fabrics were absorbed and followings are the results. As the amount of irradiated compared UVB increased, the amount of the production of vile. D3 produced by UVB irradiation from 7-DHC was increased. After treatment of 7-DHC by UVB irradiation and incubated respectively for 24hr, 48hr and 72hr at 36.5$^{\circ}C$ The amount of lit. D3 was increased as incubating time passed. When irradiated UVB on 7-DHC, intermediate of vile. D3, lumisterol, tachysterol and previt. D were showed and those materials were seemed to be changed to vile. D3 as incubation time passed. The amount of vile. D3 which was produced by irradiation 7-DHC showed close relation with UVB transmittance rate of summer fabrics (r= 0.987). Clothes, hats, and sun screen cream reduce the amount of vile. D3 Produced naturally in human skin and it result the decrease of calcium in blood which is absorbed through vit. D. Those all can cause or worsen osteomalacia especially to women and the aged people. Therefore, it is necessary to research and to develop function oriented clothing which can transmit UV which produce vile. D3 at the same time which can protect toxical UVB.

• Journal of Nutrition and Health
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• 제49권1호
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• pp.1-7
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• 2016

Purpose: The aim of this review is to comprehensively summarize the definition of vitamin D as a nutrient as well as a hormone-like molecule and its new function in prevention of various chronic diseases. Methods: The review was written by the method for systematic reivew writing. Literatures from the various sources, including research articles, book chapters, proceedings and electronic materials as appropriate, were screened first and then reviewed and analyzed for the review. Results: Vitamin D was originally considered as the essential nutrient as a vital carbon compound and was first discovered among children with osteomalacia, also known as ricket disease, characterized by poorly calcified bones which were easily bent rather than broken. Since that time, vitamin D has been known as the key nutrient to improve bone health. However, recently emerging study findings have shown that vitamin D acts as the hormone-like nutrient since it is synthesized like a hormone when our body needs and this particular vitamin also acts like a cell signaling ligand which regulates gene expression of various proteins. So far positive effects of vitamin D have been suggested for the action of anticancer, anti-immune function, and anti-cardiovascular disease, as well as antidiabetic function, etc. In this review, the definition for vitamin D as a nutrient vitamin as well as a hormone-like molecule, cell signaling mechanism of vitamin D, and finally the potential role for the prevention of chronic diseases are discussed. Conclusion: Vitamin D is now being considered as a vital nutrient as a vitamin and as a potential substance for prevention of several chronic diseases.

• 대한의생명과학회지
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• 제19권4호
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• pp.338-343
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• 2013

Serum levels of alkaline phosphatase (ALP) are widely used in the clinical diagnosis of hepatic diseases and the assessment of liver status. They also have epidemiological significance to be prospective risk factors for bone diseases, such as osteitis deformans, rickets, osteomalacia, hyperparathyroidism, healing fractures, and osteoblastic bone tumors. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum levels of liver enzyme in American population. We aimed to confirm whether the genetic variation of RETNLB (resistin like beta) gene also influence the serum levels of liver enzyme in Korean population. We genotyped variants in or near RETNLB in a population-based sample including 994 Korean adults. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in RETNLB gene with serum levels of liver enzyme. By examining genotype data of a total of 944 subjects in 5 hospital health promotion centers, we discovered the RETNLB gene polymorphisms are associated with serum levels of ALP. The common and highest significant polymorphism was rs736327 (${\beta}$=8.66, P=2.37E-05), rs7639070 (${\beta}$=8.56, P=3.24E-05) with ALP in all groups. Furthermore, the ALP was consistently associated with rs736327 (${\beta}$=10.40, P=5.23E-05), rs7639070 (${\beta}$=10.32, P=6.74E-05) in the male population. Consequently, we found statistically significant SNPs in RETNLB gene that are associated with serum levels of ALP. In addition, these results suggest that the individuals with the minor alleles of the SNP in the RETNLB gene may have elevated serum levels of ALP in the Korean population.

• 핵의학기술
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• 제14권1호
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• pp.133-137
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• 2010

Vitamin D의 주된 작용은 칼슘과 인의 흡수증가로 인한 골의 무기질화이며 vitamin D 결핍 시 에는 소아에서는 연골에 석회 침착이 안되어 구루병을 일으키고 성인에서는 골연화증 또는 골다공증이 생긴다. 또한 최근 이슈가 되고 있는 모든 암세포의 성장을 억제하고 심장병 등도 예방한다는 역학 연구 결과들이 발표되어 혈중 최적의 vitamin D농도에 관한 연구가 지속되고 있지만 일반적으로는 20~32 ng/mL의 농도가 최적의 농도라고 여겨지고 있다. 이에 우리 한국인들의 25-Hydroxy vitamin $D_3$농도를 측정하여 어느 정도의 농도를 유지하고 있는지 분석해 보고자 하였다. 2008년 2월20일부터 2009년 4월21일까지 14개월간 (재)네오딘의학연구소에 의뢰된 의료기관 종합검진 수진자 들의 혈청 25-Hydroxy vitamin $D_3$ 검사한 2,800검체를 수집하였다. 이 검체는 모두 25-Hydroxy vitamin $D_3$ ($^{125}I$ Kit: Diasorin, USA)로 검사한 후 성별, 연령별, 계절별, 지역별로 분석하여 보았다. 총 2800 검체 중 25-Hydroxy vitamin $D_3$ 평균농도는 남 20ng/mL 여 17.22 ng/mL 연령별로는 남자 10~20세 18 ng/mL, 21~30세 17 ng/mL, 31~40세 19 ng/mL, 41~50세 21 ng/mL, 51~60세는 22 ng/mL, 61~70세는 22 ng/mL, 71~80세 22 ng/mL, 81~90세는 19.9 ng/mL 여자 10~20세는 16 ng/mL, 21~30세는 15.26 ng/mL, 31~40세는 16 ng/mL, 41~50세는 17ng/mL, 51~60세는 19 ng/mL, 61~70세는 19 ng/mL, 71~80세는 19 ng/mL, 81~90세는 17 ng/mL이었다. 계절별로는 12월~5월이 15.97 ng/mL 6월~11월이 21.60 ng/mL이었다. 지역별로는 1월~4월까지의 남성을 비교해 본 결과 서울 경기 15.52ng/mL 강원도 15.33 ng/mL 충청도 18.03 ng/mL 전라도 18.68 ng/mL 경상도 18.76 ng/mL 제주도 21.23 ng/mL의 농도를 보였다. 한국인 일반인(칼슘 보충제나 종합비타민제의 복용상태는 모름)을 대상으로 25-Hydroxy vitamin $D_3$검사를 하였을때 최소치 1.98 ng/mL, 최대치 58.66 ng/mL의 분포를 보여 메뉴얼에서 제시한 Deficiency (0~5 ng/mL)에 0.3%의 상태가 있었고, Insufficiency (5~20 ng/mL) 63.3% Hypovitaminosis(20~40 ng/mL)는 36.0%인 것으로 나타났으며 Sufficiency(40~100 ng/mL)는 0.4%로 나타났다. 또한 Toxicity (>100ng/mL)상태의 대상자는 없었다. 분석결과는 실외활동을 많이 하는 남성이 여성보다 25-Hydroxy vitamin $D_3$가 높았으며 연령별로는 남 여 모두 51~80세가 가장 높았다. 또한 계절별로는 6~11월이 높았다. 지역별로는 지방이 도시보다 높았다. 최근 vitamin D의 적정농도가 골다공증과 암 예방을 할 수 있다는 연구결과가 이슈가 되고 있는 시점에 한국인의 vitamin D농도가 다른 논문에서 언급한 20~32 ng/mL에는 미치지 못한 것으로 나타났다. 물론 한국인의 참고치가 미 설정된 상태이기에 더 많은 연구와 노력이 필요하리라 생각된다. Vitamin D의 급원인 자외선이 중요한 만큼 모든 사람들이 실외활동 시간을 많이 늘려야 할 것으로 사료된다. 또한 RIA 방법이 많이 줄고 있는 이 시점에 방법이 불편하긴 하지만 vitamin D의 유용성을 높이 평가해 종합검진이나 R&D용 등으로 검사가 널리 되었으면 하는 바램이다.

• 대한유전성대사질환학회지
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• 제16권3호
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• pp.141-147
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• 2016

저인산증은 드문 선천성 대사 이상 질환으로, 조직-비특이 알칼리 포스파테이스(TNSALP)의 결핍으로 인해 발생한다. 상염색체 우성 혹은 열성 유전이 모두 가능하며, 발생시기에 따라서 주산기, 영아기, 아동기, 성인기로 나뉘고, 증상이 일찍 발현할수록 예후가 나쁜 것으로 알려져 있다. 혈청 알칼리 포스파테이스가 감소해 있으면서 구루병 혹은 골연화증을 보이는 환자에서 ALPL 유전자 변이를 규명하는 것이 저인산증을 진단하는 가장 확실한 방법이다. 본 증례 보고는 산전 초음파에서 장골의 이상과 출생 후 저포스파테이스증이 확인되어 ALPL 유전자 검사를 통해 양성 주산기 저인산증으로 진단된 환자 보고이다. 환자는 출생 당시 호흡곤란이나 고칼슘혈증, 피리독신 의존성 발작 등의 합병증 없이 경과가 양호하였다. 생후 12개월 이후 성장 지연이 확인되었지만, 생후 53개월까지 골격의 무기질화가 호전된 양성 경과를 가지게 되었다. 현재 재조합 TNSALP인 asfotase alfa가 개발되어 주산기 및 영아기 저인산증 환아에서 조속한 진단과 치료가 더욱 중요해진 바, 좀더 많은 환자들의 진단이 이루어져야 하겠다.

• 대한한방내과학회지
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• 제15권2호
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• pp.318-346
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• 1994

A Bibliographical study was done about lumbago in oriental internal Medicine. The results are as follows. 1. Shenxu,sexual active, senile, Feng, Han, Shi, shiji, Tanyin and Qi lumbago are applicable to internal medical lumbago in oriental medicine, and Shenxu is essential pathogenesis. 2. Shenxu lumbago is characterized by continous pain, improved after chiropsia, deep pulse in Chi pulse, and used QingeWan, LiuweiDihuangWan and AnshenWan in herb-medicine. and Cortex Eucommiae, Radix Rehmanniae Praeparata and Fructus Psoraleae in drugs for the purpose of ZishenYijing, and related to lumbago caused by chronic prostatitis, calculus or tumor in kidney and diabetes mellitus. 3. Sexual active lumbago is dim-aching and weak pain in or after sexual life at low back and knee joint, and classified to Shenyang Buzu, ShenjingKuisun. GanshenYinxu and XinshenBujiao ; Liuwei Dihuang Wan, ZuoguiWan In herb-medicine. Cornu Cervi Pantotrichum, Fructus Lycii and Fructus Corni in drug were used for treatment. 4. Senile Lumbago is a kind of consumptive disease due to exhaused essential energy and caused by lack of Shenjing, Yangqi ; and described as repeated mild dim pain and ErzhiWan, QingeWan and MoyaoGao were used frequently, supposed to connected with osteoporosis, osteomalacia and osteoarthropathy deformons caused by aging. 5. Feng lumbago is attacked by Liuyin, and characterized by chilling and fever. stabbing pain from thoracic and lumbar vertebrae to pedes, and used WujiXan, XiaoxumingTang for treatment. Han lumbago is caused by cold's attacking Shenjing, distinguished for chilling,icing sense improved by heat on low back, and used WujiXan, JiangfuTang. Shi lumbago is caused by damp's inflowing Shenjing, described as stone-like lumbago which was subsided low back pain growing worse by gloomy rain, and used ShenshiTang. ShenzhuTang for the purpose of ZaoshiXingqi. And it is supposed that lumbago occured in the initial of urinary track infection was belong to those of Feng,Han and Sill's. 6. Sillji lumbago is caused by pathogen being in the spleen and the stomach, and used ChenxiangJiangqiTang, PingweiSan for treatment. And it is supposed that it belong to lumbago caused by gastrointerstinal disease such as peptic ulcer. gastroduodenal tumor and colonic inflammatory disease. 7. Tanyin lumbago is caused by Tanyin's flowing meridian, characterized by thoracolumbar verterber's heaviness, covered sense with something on low back and painless massage. Kuaiqi-drug are added to ErchenTang, DaotanTang for treatment, and it supposed that Tanyin lumbago's belong to that accompanied with metabolic disease such as obesity and gout. 8. Qi lumbago is caused by excessive stress such as melancholy and fury, described as multiple stabbing pain, an unexpected on and improvement, ranging back pain until flank and abdomine. Tiaoqi-drugs were added to RenshenShunqiSan, WuyaoShunqiSan for treatment, and it supposed to connecting with emotional lumbago such as hysteria, feigned illness and anxiety psychosis.

• 한국보건간호학회지
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• 제14권2호
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• pp.431-445
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• 2000

In general the prevalence of old people is high and frequently have multiple diseases and symtoms requiring treatment. The nature of illness in the elderly has to be faced, and drugs do have an important part in the treatment of that illness. The purpose of this study were to describe health status and medication, and to provide some basic data for elderly's health education, especially for the right medication. Body mass index, self perceived health status, activities of daily living, disease and experience of past operation were surveyed to recognize the 249 elderly's actual health status. The degree of the elderly's understanding the way of medication, experience of side effects, experience of drug combination and incidence of drug adverse reaction along with drug combination were examined for medication. The aged $women(BMI; 10.7\pm13.3\%)$ overweighed the aged $men(BMI; 4.0\pm10.4\%)$. $69.0\%$ of them recognized their health good. Their activities of daily living were diminished following by the age group(p=0.0068) and relationship with self perceived health status were very significant(p=0.0005). They(192 elderly) suffered from multiple disease such as $osteoarthritis(49.5\%)$, $hypertension(32.0\%)$, gastric $disorder(16.1%)$, $diabetes(14.6\%)$, $osteomalacia(10.9\%)$, cardiovascular $disease(9.9\%)$, senile $cataract(5.7\%)$, skin $rash(5.2\%)$, liver $disease(4.2\%)$, kidney $disease(3.6\%)$, spinal cord $problem(3.6\%)$, respiratory $disease(2.1\%)$ $tuberculosis(1.0\%)\;etc(1.0\%).$ $28.3\%$ of them replied that they had an operation for appendictis senile cataract, peptic ulcer, spinal cord problem, pleurisy, hemorrhoid and the rest. Most of $them(87.4\%)$ knew the way very well how to use drugs, and $21.6\%$ of the replied 171 elderly experienced adverse drug reaction. Drug compliance rate were $high(83.6\%)$. In our study 56.9% of the 167 elderly took several medicine together. And $18.9\%$ of the 95 elderly who did drug combination had an experience of drug interaction. One person kept average 5.5 kinds of drugs at home among 243 elderly. They kept $digestives(79.4\%)$, $ointments(68.7\%)$, $vitamins(59.7\%)$, $analgesics(59.7\%)$, cold $medicines(45.3\%)$ antiarthritic $drugs(33.3\%)$, health $foods(27.7\%)$, antihypertensive $drugs(25.1\%)$, anti peptic ulcer $drugs(24.7\%)$, $laxatives(19.8\%)$, $antacids(16.5\%),\;antibiotics(l6.5\%)$, hypoglycemic $agents(10.3\%)$, cardiac $stimulants(7.0\%)$, $diuretics(4.5\%)$, antiarrhythmic $drugs(4.9\%)$, anti anginal $drugs(4.1\%)$, $hypnotics(3.3\%)$, $etc(38.3\%)$. With this result, we ascertain that polypharmacy in the elderly caused by multiple disease is common, which lead to drug interaction. So our task is to educate elderly how to use drugs in order to maximize their efficiency and to minimize their adverse effects.

• 생명과학회지
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• 제30권11호
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• pp.983-989
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• 2020

파골세포에 의한 뼈의 재흡수와 조골세포에 의한 뼈 형성의 균형은 뼈 건강에 매우 중요한 요소이다. 따라서 이들의 불균형은 골다공증, 골연화증 및 골석화증과 같은 다양한 골 질환을 유발할 수 있다. 특히 파골세포의 기능이 비정상적으로 항진된 경우 골 파괴가 증가되어 골다공증이 야기되며 이런 현상은 류마티스 관절염 같은 염증성 질환의 골 소실과 밀접한 연관이 있다. 그러나 현재 사용중인 골 흡수 억제제는 장기간 사용시 부작용이 보고되고 있어 천연물 소재를 기반으로한 새로운 골 흡수 억제제 개발이 요구되고 있다. 따라서 본 연구에서는 갈색거저리 유충 에탄올 추출물이 RANKL에 의해 유도되는 파골세포 분화에 미치는 영향을 확인하고 그 작용기작을 구명하고자 하였다. 갈색거저리 유충 에탄올 추출물이 파골세포 분화에 미치는 영향을 조사하기 위하여 RAW264.7 세포에 RANKL을 단독 처리 및 추출물과 함께 5일간 처리한 후 TRAP 활성을 비교하였다. 그 결과 RANKL에 의해 증가한 파골세포 분화는 갈색거저리 유충 추출물 2 mg/ml 농도까지 세포독성 없이 농도 의존적으로 감소하는 것을 확인할 수 있었다. 또한 갈색거저리 추출물이 TRAP, NFATc1 및 CtsK와 같은 파골세포 분화마커 유전자 및 단백질 발현량에 미치는 변화를 확인한 결과, RANKL 처리에 의해 현저히 증가한 이들 유전자가 갈색거저리 추출물에 의해 현저하게 감소하는 것을 확인하였다. 또한 갈색거저리 추출물의 파골세포 분화 억제작용기작을 확인한 결과 mitogen activated protein kinases (MAPKs)중 p38의 신호 전달 억제 기작을 통하여 파골세포 분화가 억제됨을 확인 할 수 있었다. 이러한 결과로 보아 갈색거저리 유충 에탄올 추출물 및 그 생리활성 물질들은 골다공증과 같은 골 질환 치료 및 예방을 위한 잠재적 기능성 소재로 사용될 수 있음을 확인하였다.