• 동의생리병리학회지
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• 제22권6호
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• pp.1454-1461
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• 2008

In oriental medicine, it is known that Eucommiae Cortex (EC) has strengthening and rehabilitative effects on the bone-muscle dysfunction. This study aimed to evaluate the effect of EC on the skeletal muscle atrophy. The muscle atrophy was induced by unilateral transection of the sciatic nerve in Sprague-Dawley rats. EC (water-extract, 170mg/100 g body weight) was treated once a day for 12 days. In this study, the effect of EC examined the muscle weight of hind limb, cross section areas of muscle fibers, fiber type compositions, apoptosis related factors (Bax and Bcl-2). EC reduced muscle atrophy in soleus (SOL), medial gastrocnemius (MGT), extensor digitorum longus, and tibialis posterior significantly in the damaged hind limb. EC increased type-I muscle fibers and decreased type-II muscle fibers significantly in SOL of the damaged hind limb. EC enlarged cross section areas of type-I and type-II muscle fibers significantly in SOL. EC enlarged cross section areas of type-I and type-II muscle fibers significantly in. EC reduced apoptotic nuclei and atrophic muscle fibers in SOL and MGT. EC reduced Bax positive muscle nuclei in SOL and MGT. EC up-regulated Bcl-2 positive muscle fibers in SOL and MGT. These results suggest that EC has an anti-atrophic effect and anti-apoptotic effect against myonuclear apoptosis induced by the peripheral nerve damage.

• 대한한방소아과학회지
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• 제21권2호
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• pp.35-50
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• 2007

Objectives The purpose of this study was to revitalize pediatric emergency care in oriental medical hospital. Methods The study was composed of 281 pediatric patients who visited emergency room of the ${\bigcirc}{\bigcirc}$ university oriental hospital, from March 2006 to February 2007. Results The age distribution showed that 1 to 3 year's patients(40.6%) are the most New pediatric patients(59.1%) were more than who received medical treatment in this place. The seasonal distribution of between month's section and the 24 solar terms's section made no differences and pediatric patients who visited in emergency room was most in spring, least in autumn. Moreover the changes of season's patients were more than others. Pediatric patients who visited during the weekends and holidays(50.9%) were more than during the weekdays(49.1%). Systemic division of the major problems were the digestive symptoms(44.5%) and nervous symptoms(30.6%), respiratory symptoms(12.5%), musculoskeletal symptoms(5.3%), dermatological symptoms(1.8%), cardiovascular symptoms(0.7%) and others(4.6%) followed. The time interval between arrival and onset : within 6 hours were the most(54.5%). Pediatric patients who had digestive, nervous, musculoskeletal diseases within 6 hours were the most, but in the case of patients who had respiratory diseases, most of them were visited within 48 hours. Acting and herb-med treatment(77.9%) were the most in medical treatments. Pediatric patients(69.0%) who didn't revisit in this hospital after treatment in emergency room were more than who revisited(29.9%). Conclusions Pediatric patients who visited in emergency room of oriental medical hospital were most not acute form of a serious diseases, patients most visited in disease prefer to oriental medicine; such as dyspepsia, convulsions, crying, ankle sprain. Further studies will be needed for the actual circumstance's reflecion from this hospital and other oriental hospitals nearby or other western emergency rooms for the accurate studies.

• 대한한방소아과학회지
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• 제27권3호
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• pp.12-19
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• 2013

Objectives Children's unique taste bud often gives them difficult time to take oriental medicines. To overcome, survey was conducted focusing on useful and practical tips on how to take them. Methods The survey was carried out by posting mail questionnaire. Target clinics for the survey were selected by the internet search engine, Google, Daum, and Naver, and typing in "oriental treatment + pediatrics", "pediatrics + oriental medicine", "pediatric oriental clinic". 24 clinics were searched, but they were further narrowed down to the specialized pediatric oriental clinics. Also, total of 38 inquiry leaflets were distributed to 14 University Oriental Hospitals. Results If children refuse to take the medicine, mixture with sweeteners can be prescribed for them. Among them, oligosaccharide is the most recommended followed by sugar and honey. To avoid rejection to medication, use of different formulation, such as distillation medicine, soft X-Section, granulated medicine, and character printing can be used. Conclusions The most effective method is to investigate the mixture first, and then the alternative formulations.

• 한국의사학회지
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• 제16권1호
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• pp.3-16
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• 2003

In researches done previously, the characteristics of the Hyangyak medicine in the early period of Chosun shown in "HyangyakBoncho(鄕藥本草)" in Vol. 76-85 of "Hyangyakjipseongbang(鄕藥集成方)" and "Sanghan section(傷寒門)" in Vol. 5-8 of "Hyangyakjipseongbang(鄕藥集成方)" was investigated. "Cough section(咳嗽門)" in "Various Diseases volume" of "Dongeuibogam(東醫寶鑑 雜病篇)" Vol. 5 and "Various Coughs section(諸咳門)" of "Hyangyakjipseongbang(鄕藥集成方)" Vol 24-25 which is a paragraph related to "Sanghan section(傷寒門)" was compared. The variety of the Hyangyak, processing methods and forms of the Hyangyak were shown by comparing each oriental medical botany(本草) used for treating cough(咳嗽) in "Dongeuibogam(東醫寶鑑)". Subsequently, the difference between each structure and medical theory was speculated. The facts revealed in this research is as follows. First, [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)" uses only the Hyangyak, and no foreign medicines were used for treating cough(咳嗽) in "Dongeuibogam(東醫寶鑑)". Second, in [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)", medicines related to diet and medicines taken raw were widely used, and various forms of medicine such as extracts, plasters, and gruels were used. Third, like other medical books in earlier periods, [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)" describes the medical theory with conciseness, and keeps the structure of symptom classification focused on treatment and prescription. Fourth, as [Hyangyakboncho(鄕藥本草)] extensively uses the knowledge of oriental medical botany(本草) from two of Four Masters of GeumWon(金 元); JangWonSo(張元素) and LeeDongWon(李東垣), "Various Coughs section(諸咳門)" of "Hyangyakjipseongbang(鄕藥集成方)" quotes the books of JuDanGae but does not adopt the theory and prescriptions of 'replenishing yin and downbearing fire (滋陰降火)'. To find a more descriptive picture of the Hyangyak medicine for the treatment of 'cough(咳嗽)', a comparatitive study between the books written in the same period -"Euibangyuchui(醫方類聚)" and books compilated in China should be done, and there should be more profound researches done on individual medicines and prescriptions.

• 대한한의진단학회지
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• 제9권2호
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• pp.123-144
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• 2005

Objectives: Pulse-Respiration Ratio has been used for estimating subject's Han-Yeol [寒熱] status since it mentioned in suwen [素問]. In practicing Pulse-Respiration Ratio over 5 means the status of Yeol [熱], Pulse-Respiration Ratio below 3 means the status of Han [寒]. We performed this study to examine the Optimum Standard for Measuring Pulse-Respiration Ratio on the Basis of Repeatability and Reproducibility. Methods: After subject's 5 minutes rest we measured subject's ECG, respiration pattern, EEG, EMG simultaneously. In this research examiner's number is two, subject's number is four, and the number of repeat is two. We calculated Pulse-Respiration Ratio through dividing Respiration cycle average by Pulse cycle average according to each standard including time section, $EEG(relative-{\alpha}$ density, $relative-{\beta}$ density, ${\alpha}/{\beta}$ and EMG. We analyzed these data through Gage R&R study using MINITAB 13.20 program and considered the results of below 30 %R&R and over 4 Number of Distinct Categories to have a significance. Results: 1. In the applying of time standard, Pulse-Respiration Ratio from section 3, 4, 6, 8 had a significant meaning in the aspect of Repeatability and Reproducibility. 2. In the applying of $EEG({\alpha}$ I , ${\beta}$ I , ${\alpha}/{\beta})$, EMG(E I) standard, there was no significant results. 3. In the applying of time standard(section 5, 6, 7), $EEG({\alpha}$ I , ${\beta}$ I , ${\alpha}/{\beta})$ and EMG(E I) standard simultaneously, Pulse-Respiration Ratio from ${\alpha}/{\beta}$ in section 6, ${\beta}$ I in section 8 had a significant meaning in the aspect of Repeatability and Reproducibility. Conclusions: We can suggest the Optimum Standard for Measuring Pulse-Respiration Ratio on the basis of Repeatability and Reproducibility as followings; 1. Pulse-Respiration Ratio Measuring time should be at least 15 minutes. 2. Applying of time(section 6, 8) and $EEG({\beta}$ I, ${\alpha}/{\beta})$ standard simultaneously is recommended considering reliability and validity but more study is needed. 3. EMG(E I) may be helpful to detect the segment of physical rest and exclude artifacts but more study is needed.

• 대한한의학회지
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• 제30권1호
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• pp.95-108
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• 2009

Objectives: Uwhangchungsim-won (DC) has been used in various medical fields such as stroke, hypertension, atherosclerosis, autonomic imbalance and mental instability, etc. The aim of this study was to evaluate the effect of UC on cerebral hemodynamics and estimate the appropriate dose of UC. Methods: We studied changes of hyperventilation-induced cerebrovascular reactivity and mean blood flow velocity of middle cerebral arteries (MCA) using transcranial Doppler. We observed the changes of mean blood pressure, pulse rate and expiratory CO2 using S/5 Compact Anesthesia Monitor from 10 healthy young volunteers who were administered UC twice a day in the 1 st section and then once a day in the 2nd section. Results: Mean blood pressure tended to decrease at 1 hour and pulse rate tended to decrease at 2 hours after second administration. After 2 hours, mean blood pressure rose to state before administration, but pulse rate maintained from 2 hours to 4 hours. The changes were not statistically significant. Cerebral blood flow velocity in middle cerebral artery was not statistically significant after second administration. Cerebrovascular reactivity increased from 2 hours to 4 hours after second administration. Conclusions: This study provides that administration of UC twice a day is more effective on hyperventilation-induced cerebrovascular reactivity than administration of UC once a day.

• 대한예방한의학회지
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• 제18권2호
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• pp.147-154
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• 2014

Objective : The purpose of this study is to analyze for the patent application tendency in Korean Oriental Pediatric Medicine. Recently, many studies are published in Korean Oriental Pediatric Medicine. However, in the patent area, the research results are few. Method : For patent analysis, we searched the database kipris (http://www.kipris.or.kr) which managed in the Korean Intellectual Property Office by keywords about Korean Oriental Pediatrics. They are technically analysed by year and IPC, patent's contents, main applicant and organization. Results : 1. Patents by year have been on the rise 2 in 1997 to 32 in 2011. 2. Our findings are Section A61;182, A23;46 in IPC analysis 3. In classification of content, 'application-food' is 67 cases, 'application-functional cosmetic' is 18 cases, 'application-clothes' is 5 cases. 4. Korea Institute of Oriental Medicine have 14 patent cases, that is the most patent agency in possession. Main applicants are person > company > university > laboratory > state or local government. Conclusion : This study shows that it has high frequency of daily necessity in patent cases about oriental pediatrics. The results are more distributed 'applied' field than 'treatment' field. The patent information should be connected research achievement results in Korean Oriental Medicine.

• 동의생리병리학회지
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• 제19권5호
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• pp.1356-1362
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• 2005

The purpose of this study os to investigative the effect of Carrageenan-Induced Pain on lower limb muscle and ligament of rat. To evaluate pain mechanism in muscle and ligament, pain was induced by the injection of 2% $0.1m{\ell}$ carrageenan into the left lower limb muscle of rats after rats were anesthesized with 3% enflurane. Rats were killed on 72 hours after pain induction under the anesthesia. anterior rectus femoris muscle and its ligament were removed from rat hind limb. Morphological changes of them were peformed by the observation of light and electron microscopes. In the light microscopic findings, the muscle cells were polyheadral and situated with each other without small gap in control group. nucleus of cell was seen along the cell margin, and muscle cell groups were divided by regular narrow gap in cross section. In the pain-induced group, muscle cell groups were divided each other by the irregular gap, and some of groups formed larger than other cell groups by the fusion. Intercellular gap of most cell groups were increased compared with control groups. And also, perimysium of muscle cell groups was swollen in cross section. In control group, muscle cells contacted each other closely and each cell was divided by perimysium. The intracellular gaps were not seen between myofibrills, and also striations were well defined between muscle cells in longitudinal section. In pain-induced group, muscle cells were divided by the small intracellular gaps. And also, muscle cell showed many a short cross or longitudinal intercellular gaps in longitudinal section. In light microscopic findings of control group, tendon was composed with many tendon fibers contacted each other closely without gap. The free margin of tendon was fused, and apso the tendon fibers did not invaded between muscles. In pain-induced group, tendon was divided small groups by intertendinous gap, and also the margin of tendon divided by small groups. In the free margin, tendon invaded into muscle cells, and also fibroblasts between tendon fibers were long and lance-shaped. From these results, it is suggested that pain induction by carrageenan injured rat skeletal muscle and ligament by the morphological changes.

• 대한한의학원전학회지
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• 제11권1호
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• pp.396-413
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• 1998

The HyeolRacRon(血絡論) of the YoungChu(靈樞) is one of the section associate with the study of bloodletting(depletion of blood) by acupunture. The bloodletting therapy, one of the treatment of Oriental Medicine, has been advanced in civilization. By studying of this section, I could find some conculution as follows: 1. It is the superficial venules(血絡) that has been included blood stasis which has been interrupted by pathogenic factor(邪氣), and still could not enter into the meridian's line. 2. When bloodletting therapy, we should carefully study of patient's health condition, because doctor's missed acupuncure leads to very serious side effects. 3. External shape of HyeolRac(血絡) is like acu-niddle or muscle, so its thickness and location were not fixed position, its color is redish, and its quality is hard. 4. It is reason of heating that fixation of acu-niddle and muscle fiber.

• 대한한방내과학회지
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• 제39권6호
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• pp.1168-1180
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• 2018

Objective: As the number of sarcopenic patients worldwide is increasing, the need for the treatment of sarcopenia is increasing. Ginseng has been reported to be a major herbal supplement. We tested whether red ginseng would be effective for sarcopenia using red ginseng preparation which can be easily obtained locally in Korea. Methods: 30 rats were randomly divided into three groups: the control group (n=10) (Group C), the group with Dexamethasone -induced sarcopenia (n=10) (Group D), and the group to which red ginseng was administered group after induced sarcopenia with Dexamethasone (n=10) (Group DH). Dexamethasone was intraperitoneally administered to group D and group DH for 7 days to make sarcopenic model. After that, the red ginseng tablets prepared by Korea Ginseng Corporation were diluted in distilled water and administered orally to the DH group for 2 weeks. Body weight and grip strength were measured 8 times during the experiment. At the end of the experiment, blood was collected by cardiac puncture. In addition, the tibialis muscle was extracted, a myofibril cross section was measured by immunohistochemical staining and MyHC (myosin heavy chain) was quantified by Western blotting. Results: The ratio of the area on myofibril cross-section showed significant differences after administration of the red ginseng tablet. Conclusions: Red ginseng has a significant effect on the recovery of myofibril cross-section on sarcopenia. This experiment will be helpful for future clinical studies on drug effects in sarcopennia.