• 제목/요약/키워드: Oriental Medicine Prescription

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호두인 에탄올 추출물의 사고화탄소 유도 간섬유화 억제 효과 (Inhibitory effects of the Juglans sinensis Walnut Ethanol Extract on Carbon Tetrachloride-induced hepatic fibrosis in Rats)

  • 장선일;임창경;유진덕;김희수;윤용갑
    • 동의생리병리학회지
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    • 제17권5호
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    • pp.1264-1269
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    • 2003
  • The inhibitory effects of the Juglans sinensis walnut ethanol extract (JSWE) on carbon tetrachloide (CCl₄)-induced fibrosis, serum transaminases (GOT and GTP), hepatic glutathione (GSH), serum pro-inflammatory cytokines (IL-1β and IL-6) were investigated in rats. JSWE significantly inhibited on CCl₄-induced fibrosis in dose-dependent manner. Moreover, JSWE significantly inhibited on the serum levels of GOT, GTP, IL-1β, and IL-6 in dose-dependent manner in CCl₄-induced fibrosis rat. However, JSWE markedly increased the production of hepatic GSH in a dose-dependent manner. These results show that JSWE may explain some known biological activities of Juglans sinensis walnut including their anti-fibrotic and anti-inflammatory effects, and is of considerable benefit in the treatment for live diseases.

한방병원 산후조리센터 내 신생아의 한방적 처치에 대한 임상적 고찰 (Clinical Study of Oriental Medical Treatments for Neonates in Oriental Medicine Hospital Postpartum Care Center)

  • 양미라;김선미
    • 대한한방소아과학회지
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    • 제18권2호
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    • pp.93-106
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    • 2004
  • Objective : The aim of this study is to investigate the effects of oriental medical treatments for neonates in the Postpartum care center. Methods : This clinical study was carried out with the 186 neonates who admitted to the Postpartum Care Center of Conmaul Oriental Medicine Hospital, from November, 2003 to May, 2004. The data of sex, delivery method, gestation age, birthweight, symptoms, herbal prescription, improved condition and other treatments was collected via the medical charts. Results : Among 186 newborn babies, 48 cases had diarrhea. We used Gwakhyangjeonggi-san for 31 cases, Bulwhangumjeongnggi-san for 5 cases, compound prescription of the two for 8 cases. The effect of treatment was excellent for 25 cases, good for 11 cases, not good for 8 cases. In fever, there were 39 cases. We used Gwakhyangjeonggi-san and venesection of blood for 17 cases, only venesection of blood for 20 cases, and only Gwakhyangjeongg-isan for 3 cases. The effect of treatment was excellent for 37 cases, good for 3 cases. In cold, there were 4 cases. We used Samsoum for 1 case, Socheongryong-tang for 3 cases. The effect of treatment was excellent for 2 cases, good for 1 case, not good for 1 case. Conclusions : This study shows oriental medical treatments like acupucture, herbal medicine, and venesection of blood for neonates have significant effects. we will need further prospective studies about effects of these oriental medical treatments.

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상한론(傷寒論)의 학술연원(學術淵源)을 통(通)한 상한방(傷寒方)의 평형관 고찰 (Study on the viewpoint of the balance(平衡觀) on the 'Sanghan prescription(傷寒方) throughout the academic sources of 'Sang Han Lon')

  • 김지형;박선동
    • 동국한의학연구소논문집
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    • 제4권
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    • pp.25-52
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    • 1995
  • 'Sang Han Lon' became the sources for treatment and prescription in the Oriental medicine. After that, for some 1800 years the various writings for studying in many ways more than 1000 books which many old sages really intended to inquire into and study the value of books. It is considered that it is the result which the old sages tried to grope for many-sided directions in order to understand 'Sang Han Lon'. In this study, I tried to inquire into prescription and its relevant medicinal substances, that is to say, the crystalization of the physiology, pathology and treating method on the basis of the academic sources of his thoughts. The method to approach is "from what basis of thought system was 'Sang Han Lon' derived first of all?" Secondly, how was the thought system, which became the basis of 'Sang Han Lon', applied to concretely? I studied on the basis of the above important two problems. It is well known to everybody that 'Sang Han Lon' succeeded to the tradition of Naekyung(內經) as well as Cwuyek(周易, Chinese classic on divination). Besides, I inquired into and arrived at conclusion as follows that how the viewpoint on the balance(平衡觀), which was one of the common point between. Cwuyek(周易) and medical science in case of the 'Sanghan prescription'(傷寒方), was applied to concretely. 1. In naming, it is considered that from the same interconnection which the common point with Cwuyek(周易) was the same as obtaining the imigination(取象), the imagination was obtained and was named. 2. In case of being concerned in the gastro-intestinal track, namely, the core of the balance and harmony with the balance and harmony being emphasized, '理中'(It implies 'taking care of gasstro-intestinal track')" and '建中'(It implies 'establishing of gastro-intestinal track'), that is to say, '中'(It implies 'taking care of' & 'establishing of gastro-intestinal track') was emphasized much more. 3. In case of treatment taking advantage of three kinds of medicine in draught, powder and pills in the prescription, while treating during adjusting the slowness and fastness, I maintained the harmony not to damage the righteousness(正氣). 4. In case of the prescription, when exhaling(發散), astringing(收斂), loosing bowels, protecting the gastro-intestinal track and vomitting, he used the medicinal sustances in order to protect the gastro-intestinal track and treated not to damage the righteousness. 5. Especially, in case of the prescription in order to adjust the negative and positive principle of inside-outside(素囊陰陽), he composed of medicinal substances relevant to hot, cold, spicy and sour(寒熱辛酸) in conformity with the prescription and I paid much more attention to the one-sided treatment. Considering the various prescriptions, it is regarded that the adjusting prescription is kept its balance. 6. In the way of processing the medicinal substances in order to change effect of medicine in conformity with the reenactment, he tried to plan the balance of '一升一降' with the decrease of RHEI RADIX ET RHIZOMA(大黃) and increase of wine. 7. In boiling the medicine, he boiled the composed medicine in the time sequence for the purpose of adjusting the slowness and fastness and adapted to harmony of the negative and positive principle(陰陽調和) on the essence function(體峻用純). 8. In taking medicine, he tried to reduce the time of taking the medicine in case of being boiled slowly and tried to increase the dosage and eventually he planned the balance of one time slowness and one time fastness. As I inquired into the above result, a few steps for protecting method to boil the relevant medicinal substances, how to take the medicine and how to process the composed medicinal substances in order to change the effect of medicine can make the human body, which the disease penetrate into, go forward to the righteousness(正氣) and what is much beter, it is considered that this protecting method can be a carefully considerable one in order to protect the righteousness and can subdue the disease, not to damage the gastro-intestinal track and there can exist the viewpoint of balance(平衡觀) on its core.

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Mucin 분비에 미치는 대청룡탕(大靑龍湯) 및 <석실비록(石室秘錄)> 급치법방(急治法方)에 대한 연구 (The Effect of Daecheongryong-tang and prescription A on airway mucin secretion)

  • 박완열;서운교
    • 대한한방내과학회지
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    • 제27권1호
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    • pp.92-101
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    • 2006
  • Objectives : This study was done with intend to investigate whether two oriental medical prescriptions, daecheongryong-tang (DCRT) and prescription A (P-A) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Methods : Confluent HTSE cells were metabolically radiolabeled with $^3H$-glucosamine for 24 hrs and chased for 30 min in the presence of DCRT or P-A to assess the effect of each agent on $^3H$-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of DCRT and P-A on contractility of isolated tracheal smooth muscle were investigated. Results were as follows : 1. DCRT significantly inhibited mucin release from cultured HTSE cells, with significant cytotoxicity. 2. P-A significantly increased mucin release from cultured HTSE cells, with significant cytotoxicity. 3. DCRT inhibited Ach-induced contraction of isolated tracheal smooth muscle. 4. P-A also inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusion: Results suggest that DCRT and P-A have regulating effects on mucin secretion from goblet cells. Further investigation is needed, because of the value in finding novel agents to this purpose, and these oriental medical prescriptions have potential for this role.

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소청룡탕가석고(小靑龍湯加石膏) 및 ${\ll}$석실비록${\gg}$소치법방(小治法方)이 호흡기 점액의 분비에 미치는 영향 (Effects of Socheongryongtang-ga-seoggo and Prescription D on Airway Mucin Secretion)

  • 김호;서운교
    • 대한한방내과학회지
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    • 제27권4호
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    • pp.895-904
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    • 2006
  • Objectives : In the present study, the author intended to investigate whether two oriental medical prescriptions named Socheongryongtang-ga-seoggo (SCTS) and Prescription D (P-D) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Materials and Methods : Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of SCTS or P-D to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of SCTS and P-D on contractility of isolated tracheal smooth muscle were investigated. Results : SCTS did not affect mucin release from cultured HTSE cells, without cytotoxicity. However, P-D significantly increased mucin release from cultured HTSE cells. with significant cytotoxicity. SCTS inhibited Ach-induced contraction of isolated tracheal smooth muscle. P-D also inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusions : The author suggests that the effects of SCTS and P-D with their components should be further investigated and it is valuable to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.

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아토피 피부염 치료제 개발에 활용할 수 있는 마우스 모델에 대한 고찰 (Mouse Models of Atopic Dermatitis for Drug Discovery from Medicinal Plants)

  • 윤용갑;황주민;김형률;장선일
    • 대한한의학방제학회지
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    • 제15권1호
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    • pp.145-161
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    • 2007
  • Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers. The clinical phenotype that characterizes AD is the product of interactions between susceptible genes, the environmental factors, defective skin barrier function, and immunologic responses. This review summarizes recent progress in our understanding of the immunopathophysiology of AD and the implications for mouse models of AD in drug discovery from medicinal plants.

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동의보감(東醫寶鑑) 허노문(虛勞門) 처방(處方)의 방제(方劑) 분석(分析)에 대한 고찰(考察) (A Study on Analysis all Prescriptions of Consumptive part in DonguiBogam)

  • 이주희;윤현자;윤용갑
    • 대한한의학방제학회지
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    • 제20권1호
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    • pp.101-121
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    • 2012
  • Objectives : As the understand about historical consumptive part through studying prescriptions in DonguiBogam, we would like to study some modern geriatric and chronic diseases. Methods : We analyzed application frequency of basic prescriptions, symptoms of prescriptions and the pathology analysis against historical comsumptive in DonguiBogam. Results : Through investigation into application frequency of basic prescriptions, symptoms of prescriptions, and two way analysis of Qi blood(yin yang) pathologies and viscera and bowels pathologies, we were able to found mostly used basic prescription, common symptoms, and separate some characteristics pathologies. Conclusions : We expected that this study will can help to give rationale for future study of consumptive caring.

우귀음가미방(右歸飮加味方) 투여로 호전된 레이노 병 환자 1례 (Case Report of Raynaud's Disease Treated with Prescription of Modified Woogyu-yeum)

  • 하예진;조문영;장원석;은선혜;신용진;신선호
    • 동의생리병리학회지
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    • 제25권5호
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    • pp.908-913
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    • 2011
  • Major symptoms of Raynaud's Disease are pain, edema, cyanosis, and redness of hands, feet, nose, and etc. The purpose of this report is to show the curative effect of herbal medicine for Raynaud's Disease. We provided Prescription of Modified Woogyu-yeum(Yougui-yinjiaweifang ) to patient who was diagnosed with Raynaud's Disease three times a day for 22 days. We observed changes of symptoms through Digital Infrared Thermographic Imaging, taking photos of both hands, and collecting the survey answered by the patient. Modified Woogyu-yeum reduced pain, edema, and redness of both hands. The frequency of cyanosis decreased after the treatment. Digital Infrared Thermographic Imaging proved a rise in temperature of fingertips after the treatment. In conclusion, Modified Woogyu-yeum showed the possibility of effect on Raynaud's Disease.

동의보감(東醫寶鑑) 중(中) 지모(知母)가 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察) (A study on Applications of prescriptions including Rhizoma Anemarrhenae as a main component in Dongeuibogam)

  • 신동근;이치웅;전경혜;성시열;윤용갑
    • 대한한의학방제학회지
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    • 제16권1호
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    • pp.39-53
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    • 2008
  • This report describes 68 studies related to the use of Rhizoma Anemarrhenae main blended prescription from Dongeuibogam. The following conclusion were reached through investigations on the prescriptions that use Rhizoma Anemarrhenae as a key ingredient. Prescriptions that Rhizoma Anemarrhenae was taken as a monarch drug are utilized for 21 therapeutic purposes, for example, cough, malaria, Sang Han syndromes and eye disease. In particular, 22.1% of prescriptions appear in the chapter of cough, and 13.2% of those appear in the chapter of malaria. Prescriptions that utilize Rhizoma Anemarrhenae as the main ingredient are used in the treatment of cough, asthma and malaria. Rhizoma Anemarrhenae is used in pathogenic factors such as fire, and used in pathology related to kidny system. The dosage of Rhizoma Anemarrhenae is 3bun(about 1.12 gram) to 3jeon(about 11.25 gram), however 1jeon(about 3.75 gram) has been taken the most for clinical application. Gamlihuan is the most useful base prescription which use the Rhizoma Anemarrhenae as the main ingredient.

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아토피피부염에 대한 고삼가미방(苦參加味方)과 청기해독산(淸肌解毒散)의 겸용 투여 효과 (Study on Combination of External Gosamgamibang and Internal Chenggihaedok-san for the Treatment of Atopic Dermatitis)

  • 고홍윤;김동희
    • 동의생리병리학회지
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    • 제23권6호
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    • pp.1282-1291
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    • 2009
  • A combined prescription of GGB and CHS (G&C prescription group) was used to investigate its effects on immune related factors and histological changes in atopic dermatitis(AD) induced mice. Significant decrease of atopic dermatitis clinical index in G&C prescription group. In DLN, G&C prescription group significantly modulated the immune cells. G&C prescription group also showed significant effect on the immune cells of the dorsal skin as well as DLN. The group indicated significant decrease of the biosynthesis of IL-4, IL-5, IL-13, GM-CSF, cytokines in serum. On the other hand, the biosynthesis of TNF-$\alpha$ was decreased. G&C prescription group significantly decreased the immunoglobulin IgE levels in serum. The results suggest that G&C prescription significantly improves atopic dermatitis through regulation of immune cells and cytokines. Comparative studies with Protopic ointment also showed that G&C prescription showed significant effect in AD patients, and active application of the prescription in clinicals is anticipated. However, the reason for the results that oppose to those of previous studies should be investigated. Also, therapeutic effects of both internal and external applications should be studied individually as well as for any synergistic effects. Safety, toxicity, as well as stability studies should follow to develop G&C prescription into long-term external clinical product.