• Title/Summary/Keyword: Oriental Medicine Prescription

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Effects of Jakyakgamchotang extract on the Analgesic effect in Mice (작약감초탕(芍藥甘草湯) 및 구성약물(構成藥物)이 진통(鎭痛)에 미치는 영향(影響))

  • Lee Ki-Ok;Kuk Yun-Beum;Yun Young-Gab
    • Herbal Formula Science
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    • v.11 no.1
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    • pp.161-170
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    • 2003
  • This study was designed to elucidate the analgesic effects of Jakyakgamchotang and Radix paeinia, Radix Glycyrrhiziae which are the component of Jakyakgamchotang in mice. The analgesic effects were measured by the Whittle's method and hot plate method. The results were as follows ; After the administration of Jakyakgamchotang extrace, the frequency of writhing syndrome was significantly inhibited. After the administration of Radix paeinia extract, the frequency of writhing syndrome was significantly inhibited. After the administration of Radix Glycyrrhiziae extract, the frequency of writhing syndrome was significantly inhibited. After the administration of Jakyakgamchotang extrace, paw licking time and escape time were significantly prolonged. After the administration of Radix paeinia extract, paw licking time was significantly prolonged. After the administration of Radix Glycyrrhiziae extract, paw licking time was significantly prolonged. It is concluded that the analgesic effects of Jakyakgamchotang were found to be more effective than Radix paeinia and Radix Glycyrrhiziae.

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The Origin, Changes and Compositive Principles of Hyangsayangyi-tang (향사양위탕(香砂養胃湯)의 기원(基源), 변천과정(變遷過程) 및 구성원리(構成原理))

  • Kang, Mi-Jeong;Lee, Jun-Hee;Koh, Byung-Hee;Lee, Eui-Ju
    • Journal of Sasang Constitutional Medicine
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    • v.22 no.3
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    • pp.43-50
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    • 2010
  • 1. Objectives: The purpose of this study is to understand the origin, changes and the constructive principles of Hyangsayangyitang (XiangShaYangWeiTang). 2. Methods: Hyangsayangyi-tang and other related prescriptions were analyzed in terms of pathology, based on "Donguibogam(東醫寶鑑)", "Donguisusebowon Chobongwon(東醫壽世保元 草本卷)", "Donguisusebowon Gabobon(東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon(東醫壽世保元 辛丑本)". 3. Results and Conclusions: (1) The origin of Hyangsayangyi-tang is Hyangsayukgunja-tang from "Gongshin Uigamseo(龔信 醫鑑書"). Hyangsayangyi-tang inherited some of the principles from"Euihangangmok(醫學綱目)" Jeonssiyigong-san's (全氏異功散) application. (2) "Gabobon(甲午本)"'s prescription emphasizes the effect of lossen up by using Pogostemonis Herba(藿香). "Sinchukbon(辛丑本)"'s prescription emphasizes the effect of warm up stomach by using Zingiberis Rhizoma(乾薑). (3) Ginseng Radix(人蔘), Atractlodis Rhizoma White(白朮), Glycyrrhizae Radix(甘草), Paeoniae Radix Alba(白芍藥) support Soeumin's spleen root (脾元), and Zingiberis Rhizoma(乾薑), Myristicae Semen(肉豆蔲) warm up stomach, and Pinelliae Rhizoma(半夏), Citri Pericarpium(陳皮) circulate Qi, Crataegi Fructus(山楂), Amomi Fructus(砂仁), Cyperi Rhizoma(香附子) encourage digestion to maintain descending Yin.

Subacute Toxicity Study on Palmultang(Bawu-Tang) in SD Rats (SD 랫트를 이용하여 팔물탕(八物湯)의 4주 반복투여 독성에 관한 연구)

  • Ma, Jin-Yeul;Yu, Young-Beob;Ha, Hye-Kyung;Huang, Dae-Sun;Shin, Hyun-Kyoo
    • The Korea Journal of Herbology
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    • v.22 no.4
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    • pp.59-64
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    • 2007
  • Objectives : Palmultang(Bawu-tang) has been traditionally prescribed as a restorative, The present study was undertaken to determine the possible toxic effects of Palmultang on SD rats. Methods : In this study, we investigated the subacute toxicity of water-extracted Palmultang(Bawu-tang) on SD rats. Twenty rats were orally adiministered Palmultang for 28 days at a dose of 0 mg/kg(control group) or 1500 mg/kg(treated group), respectively. Results : All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Conclusions : Compared with the control group, we could not find any subacute toxic alteration in treated group (1500 mg/kg) for 28 days. This result suggests that Palmultang, a herbal medicine prescription, is a safe prescription to body.

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Study on the Confidential Document of A Distinguished Medical Family (기문비록(岐門秘錄)에 대한 고찰)

  • Kim, Dong-Min;Choi, Kyung-Suk;Shin, Seung-Yuel;Ahn, Jun-Mo;Keum, Kyung-Soo;Lee, Si-Hyeong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.5
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    • pp.1078-1105
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    • 2008
  • An empirical formula that has been empirically shown to be effective for a particular condition can be said to add medicinal materials to an existing formula or to make a new prescription by the Korean medical doctors' empirical clinic. This dissertation aims to study the prescriptions according to A Confidential Document of A Distinguished Medical Family written by the writer's ancestor and to contribute to the development of Korean medicine. A Confidential Document of A Distinguished Medical Family is a medicinal recipe that is an heirloom of the Gyeongju Kim family for the eighth generation. And the date and the writer of the book are unknown. The contents of the book consist of 18 parts and are made up of about 300 medical recipes. Of these, 158 formulas and indications of cold damage, wind, urination, stool, jaundice, and internal injury are found in the book. From among these, 61 formulas was directly quoted out of The Precious Mirror of Oriental Medicine, 97 formulas are adjusted in proportion or combined. By the parity of reasoning of the above, I think that this book was published after The Precious Mirror of Oriental Medicine. I will continue to study other formulas except the formulas above mentioned.

Compilation of 104 Experimental Theses on the Antitumor and Immuno-activating therapies of Oriental Medicine (한의학의 항종양 면역치료에 관한 연구 -1990년 이후 발표된 실험논문을 중심으로-)

  • Kang Yeon Yee;Kim Tai Im;Park Jong Ho;Kim Sung Hoon;Park Jong Dai;Kim Dong Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.1
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    • pp.1-24
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    • 2003
  • This study was done to compile 104 experimental theses which are related to the antitumor and immuno-activating therapies between February 1990 through February 2002. Master's and doctoral theses were dassified by schools, degrees, materials, effects, experimental methods of antitumor and immunoactivity, and results. The following results were obtained from this study : 1. Classifying the theses by the school, 34.6% were presented by Daejeon University, 29.8% by Kyung-hee University and 11.5% by Won-kwang University. Of all theses, 51.0% were aimed for the doctoral degree and 43.3% were for the master's degree. All of three universities have their own cancer centers. 2. Classifying the theses by herb materials, complex prescription accounted for 60.3%, single herb accounted for 24.8% and herbal acupuncture accounted for 14.2%. Considering the key principles of the traditional medicine, complex prescription was much more thoroughly studied than single herb prescription. The results showed that the complex prescription had both antitumor activity and immuno-activating activity, which might reflects on multi-activation mechanisms by complex components. 3. Classifying the theses by the efficacy of herbs examined, in single herb, invigorating spleen and supplementing was 35.5%, expelling toxin and cooling was 29.0%, activating blood flow and removing blood stasis was 12.9%. In herbal acupuncture, invigorating spleen and supplementing was 52.9%, expelling toxin and cooling was 29.4%. In complex prescription, pathogen-free status was 41.9%, strengthening healthy qi to eliminate pathogen was 35.5%, strengthening healthy qi was 22.6%. It is presumed that the antitumor and immunoactivating therapy based on syndrome differentiation is the best way to develop oriental oncology. 4. Classifying the theses by antitumor experiments, cytotoxic effect was 48.1 %, survival time was 48.1 % and change of tumor size was 42.3%. Survival rate was not necessarily correlated with cytotoxicity. These data reflect the characteristic, wholistic nature of the oriental medicine which is based on BRM (biological response modifier). 5. Classifying the theses by immunoactivating experiments, hemolysin titer was 51.0%, hemagglutinin titer was 46.2% and NK cell's activity was 44.2%. In the future studies, an effort to elucidate specific molecular and cellular mechanisms of cytokine production in the body would be crucial. 6. Classifying the theses according to the data in terms of antitumor activity, 50% was evaluated good, 24.0% was excellent, and 15.5% have no effect. In an evaluation of immuno-activating activity, 35.9% was excellent and 18.0% showed a little effect. The index point, as described here, may helps to use experimental data for clinical trials. Changes in index points by varying dosage implicate the importance of oriental medical theory for prescription. 7. In 167 materials, IIP (immunoactivating index point, mean : 3.12±0.07) was significantly higher than AIP(antitumor index point, mean : 2.83±0.07). These data demonstrate that the effect of herb medicine on tumor activity depends more on immunoactivating activity than antitumor activity. This further implies that the development of herbal antitumor drugs must be preceded by the mechanistic understanding of immunoactivating effect. 8. After medline-searching tumor and herb-related articles from NCBI web site, we conclude that most of the studies are primarily focused on biomolecular mechanisms and/or pathways. Henceforth, we need to define the biomolecular mechanisms and/or pathways affected by herbs or complicated prescriptions. 9. Therefore, the most important point of oriental medical oncology is to conned between experimental results and clinical trials. For the public application of herbal therapy to cancer, it is critical to present the data to mass media. 10. To develop the relationship of experimental results and clinical trials, university's cancer clinic must have a long-range plan related to the university laboratories and, at the same time, a regular consortium for this relationship is imperative. 11. After all these efforts, a new type herbal medicine for cancer therapy which is to take care of the long-term administering and safety problem must be developed. Then, it would be expected that anti-tumor herbal acupuncture can improve clinical symptoms and quality of life (QOL) for cancer patients. 12. Finally, oriental medical cancer center must be constructed in NCC (National Cancer Center) or government agency for the development of oriental medical oncology which has international competitive power.

Free Radical Scavenging and Hepatoprotective Effects of Osumokkya-tang (오수목과탕(吳茱木瓜湯)의 자유(自由)라디칼 소거활성(演去活性) 및 肝(간) 세포(細胞) 보호효과(保護效果))

  • Jeong, Ok-Sam;Yun, Young-Gab;Kim, Youn-Chul
    • Herbal Formula Science
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    • v.13 no.2
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    • pp.93-100
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    • 2005
  • In order to find the new hepatoprotective agents preliminary screening of twelve prescriptions which have been used for the treatment of hepatic disease in Oriental traditional medicine has been carried out. Both DPPH free radical scavenging and hepatoprotective effect on tacrine-induced cytotoxicity in Hep G2 cells are performed. Osumokkya-tang which is one of the prescription belongs to interior-warming properties showed the DPPH free radical scavenging effect as well as hepatoprotective activity significantly. It is also suggested that its hepatoprotective effect is derived from Chaenomelis Fructus.

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Considerations of Jungpung(中風) in Chungumbang(千金方) at Tang(唐)‘s dynasty (당(唐), 천금방(千金方)에 기재(記載)된 중풍(中風)에 관한 고찰(考察))

  • Choi, Eun-Jeong;Jeong, Sung-Hyun;Shin, Gil-Cho;Lee, Won-Chul
    • The Journal of Korean Medicine
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    • v.17 no.2 s.32
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    • pp.117-132
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    • 1996
  • The study of Jungpung(中風)'s section in Chungumyobang (千金要方, 諸風門) by Sonsamak(孫思邈) showed the following results. 1. The cause of Jungpung(中風) in Jungpung(中風)'s section in Chungumyobang (千金要方, 諸風門) was quotated from the theory of Naekyung(內經) -Pung(風) evil from the external environment invade on Hu(虛) of human body(外來風邪, 內虛邪中). 2. At Jungpung(中風)'s section in Chungumyobang (千金要方, 諸風門), he devided into the four classes of Jungpung(中風)'s symptom-Pyungo, Pungbi, Pungyi, Pungbi(偏枯, 風?, 風懿, 風痺)-, and this classification had a great influence on the next generations. 3. At Jungpung(中風)'s section in Chungumyobang (千金要方, 諸風門), he understanded that changes of Jungpung(中風)'s pathology depended on the Eum-Yang-Han-Yul-Hu-Shil(陰陽寒熱虛實) of the patients. 4. At Jungpung(中風)'s section in Chungumyobang (千金要方, 諸風門), he gathered and rearranged various prescription which accumulated the clinical experiences during the period from Naekyung(內經), Sanghan(傷寒) times, to Tang(唐)'s dynasty. There were major Jungpung(中風)'s prescription -Sosokmyungtang(小續命湯), Daesokmyungtang(大續命湯), Jukryuktang(竹瀝湯), Jihwangjun(地黃煎), Dokhwalgisaengtang(獨活寄生湯) etc. And the principle of treatment was the remedy method of removing evil through sweating(發汗祛邪法). 5. Chungumyobang(千金要方) showed the development of quality, quantity in their prescription comparing the fomer ages. And the method of classification of Jungpung(中風)'s symptom had a great influence on the next generation in clinical aspect. But the basic theory in Chungumyobang(千金要方) coudn't get out of the limits of Naekyung(內經), Gumgueyoryak(金?要略).

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The Literature Study on Correlation between Wushijiuyu(五十九兪) and Fangfengtongshengsan(防風通聖散) for the Treatment of Fever Disease ($\ll$황제내경(黃帝內經)$\gg$의 열병(熱病) 치료혈(治療穴)과 방풍통성산(防風通聖散)의 이론적 상관성에 관한 연구)

  • Jung, Mi-Kyung;Yun, Jong-Hwa;Park, Hyun-Guk;Kim, Gi-Wook;Jang, Min-Gee;Lee, Seung-Deok;Kim, Kap-Sung
    • Journal of Acupuncture Research
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    • v.25 no.5
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    • pp.1-16
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    • 2008
  • Backgrounds : There have not been so many studies about the correlation of logical background between acupuncture and herbal medicine. Objectives : This study was aimed to find out the logical relationship between acupuncture points of Wushijiuyu(五十九兪) and Fangfengtongshengsan(防風通聖散) for the treatment of fever disease. Methods : I investigated the background of rationale of Wushijiuyu(五十九兪) and Fangfengtongshengsan(防風通聖散) through survey of classical text include Yellow Emperor's Classic of Medicine(.帝.經內經, Hwang Di Nei Jing), Liujing(類經), Zhenjiujiayijing(鍼灸甲乙經) and Huangdisuwenxuanmingfanglun(黃帝素問宣明方論). Results & Conclusions : The words "Wushijiuyu(五十九兪) and Wushijiuci(五十九刺)" are founded in the Yellow Emperor's Classic of Medicine(黃帝內經) are either prescription of the acupuncture points for the treatment of fever disease. However, acupuncture points of two methods are not same. According to Liujing(類經), Wushijiuyu(五十九兪) have used acupuncture points located in head, upper and lower extremities, trunk, and back. However Wushijiuci(五十九刺) just select acupuncture points of head and extremities without those of trunk and back. Acupuncture points located in yang meridian(45points) and Dumai(督脈, 5points) are significantly used more than those of yin meridian(8 points) and Renmai(任脈, 2points) in Wushijiuyu(五十九兪) and Wushijiuci(五十九刺). The distribution of acupuncture points used Wushijiuyu(五十九兪) have closer correlation with Fangfengtongshengsan(防風通聖散) than Wushijiuci(五十九刺) in the prescription.

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A Study on Application of Radix Saposhnikoviae Main Blended Prescription From Dongeubogam (동의보감(東醫寶鑑) 중(中) 방풍(防風)이 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察))

  • Kim, Gyu-Min;Lee, Jang-Cheon;Oh, Hwang;Kim, Chang-Min;Yun, Young-Gab
    • Herbal Formula Science
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    • v.14 no.1
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    • pp.11-29
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    • 2006
  • This report describes 71 studies related to the use of Radix Saposhnikoviae main blended prescription from Donguibogam. The following conclusion were reached through investigations on the prescriptions that use Radix Saposhnikoviae as a main ingredient. Prescriptions that Radix Saposhnikoviae was taken as a monarch drug are utilized for 20 therapeutic purposes, for example, eye disease, wind disease, head disease and Sang Han syndromes. In particular, 28.1% of prescriptions appear in the chapter of eye, and 25.3% of those appear in the chapter of head. Prescriptions that utilize Radix Saposhnikoviae as the main ingredient are used in the treatment of eye disease. paralysis and tetanus. Radix Saposhnikoviae is used in pathogenic factors such as wind. wind with cold. and used in pathology related to liver system. The dosage of Radix Saposhnikoviae in prescriptions is 7 li(about 0.26 gram) to 2.5 jeon(about 9.38 gram), however 1 jeon(about 3.75 gram) has been taken the most for clinical application. Bangpungtang is the most useful base prescription which use the Radix Saposhnikoviae as the main ingredient.

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Literature research on the use of succium and pumpkin in postpartum edema (산후부종(産後浮腫)의 호박(琥珀)과 남과(南瓜)의 오용에 대한 문헌고찰)

  • Ahn, Sang-Young;Han, Chang-Hyun;Kwon, Oh-Min;Park, Sang-Young;Ahn, Sang-Woo
    • Herbal Formula Science
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    • v.17 no.2
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    • pp.39-51
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    • 2009
  • Objectives : In Korea the practice of folk remedies is widely spread. One of the main uses is the utilization of pumpkin in postpartum edema. While this practice is widely propagated no one could exactly define the evidence of its uses. Therefore we aimed to provide literature evidence of correct prescription in postpartum edema. Methods : As the use of pumpkin in postpartum edema is particular to korea, we revised all the medical book published from the 17th century, the time supposed to have been introduced pumpkin in Korean peninsula. We also researched the prescription mainly used in postpartum edema, and the common main herbal component, succium. As pumpkin and succium is homophony to 'Ho bak' in korean it had the possibility of being misinterpreted. Results : On our literature research we found the precautions of pumpkin to provoke gi-stagnatio and dampness obstruction and that it was restricted while the recovery of all kind of diseases as well as in puerperium. The main reason of postpartum edema is caused by blood stasis which when the blood gains its normal circulation, edema is dispersed by itself. For this propose main prescription was Jogyeongsan調經散 type with its main component succium which medical properties are cited in all medical classics consistently. From the literature of "Juchonsinbang" and "Uibanghapbu" we found three different prescriptions, Hobakgo琥珀膏, Hobakgo胡朴膏, and Namgwago南瓜膏 which contents and their medical proposes were equal. Conclusions : By these finding we could refer that the use of pumpkin in postpartum edema was caused by homophonic reasonal misinterpretation of succinum in korean. This research provides the literature evidence to correct pumpkin's misuse and also the necessity of restriction of the use of even most common products for medical proposes and/or at least the importance of being guided by the experts.

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