• 제목/요약/키워드: Organization Resistance

검색결과 169건 처리시간 0.022초

Phenotypic and Genotypic Differences of the Vancomycin-Resistant Enterococcus faecium Isolates from Humans and Poultry in Korea

  • Oh, Jae-Young;An, Seung-Hun;Jin, Jong-Sook;Lee, Yoo-Chul;Cho, Dong-Teak;Lee, Je-Chul
    • Journal of Microbiology
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    • 제45권5호
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    • pp.466-472
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    • 2007
  • A total of 98 vancomycin-resistant Enterococcus faecium (VREF) isolates (58 isolates from patients and 40 isolates from poultry) were compared based on their antimicrobial susceptibility, Tn1546 element organization, and pulsed-field gel electrophoresis (PFGE) patterns. This comparison aided in determining the relationships between the groups of isolates. All the VREF isolates harbored the vanA gene; however, 29 (29.6%) of the isolates exhibited the VanB phenotype-vanA genotype. Furthermore, the VREF isolates from humans and poultry exhibited distinct antimicrobial resistance patterns. The PCR mapping of the Tn1546 elements exhibited 12 different transposon types (A to L). The VREF isolates of poultry were classified into types A to D, whereas the human isolates were classified into types E to L. A PFGE analysis demonstrated a high degree of clonal heterogeneity in both groups of isolates; however, the distinct VREF clones appeared in each group of isolates. The deletion of the vanX-vanY genes or insertion of IS1216V in the intergenic region from the vanX-vanY genes is directly associated with the incongruence of the VanB phenotype-vanA genotype in human VREF isolates. These data suggest that the VREF isolates exhibit distinct phenotypic and genotypic traits according to their origins, which suggests that no evidence exists to substantiate the clonal spread or transfer of vancomycin resistance determinants between humans and poultry.

제주 해녀의 맥파전도속도 분석 (The Analysis of Pulse Wave Velocity of Jeju female divers)

  • 이한영
    • 디지털융복합연구
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    • 제13권9호
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    • pp.515-521
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    • 2015
  • 본 연구에서는 우리는 평균 연령이 높은 제주 해녀의 경-대퇴 맥파 전도 속도와 발목-상완지표를 측정하여 찬물에서 산소의 보조 없이 채취활동을 하는 제주 해녀의 동맥 혈관의 경직도를 측정하였으며, 결과는 다음과 같다. 첫째, 경-대퇴 맥파 전도 속도는 동연령대의 일반여성보다 유의하게 낮게 나타났다. 둘째, 발목-상완지표(ABI)는 해녀와 일반여성 모두 정상범위 안에 포함되어 있었으며, 일반여성보다 해녀집단이 높은 경향을 보였다. 이러한 결과는 고령의 나이임에도 불구하고 장기간 침수활동을 통해 신체의 적응이 이미 완료된 상태로써 저온 및 높은 수압환경에 대한 적응이 완료된 신체상태이며, 아울러 높은 신체활동 수준으로 인하여 말초혈관저항이 고연령임에도 불구하고 감소되지 않았으며, 오히려 동연령 여성들보다 양호한 수준임을 확인할 수 있었다. 하지만 해녀들의 고령화는 여전히 진행되고 있는 중요한 현상이기에 동맥혈관경직도에 대한 관심과 향후의 지속적인 연구는 반드시 더 필요할 것으로 보인다.

A60급 구획 적용 격벽 관통용 관의 열전달 특성 I: 관의 설계에 따른 과도 열해석 (Heat Transfer Characteristics of Bulkhead Penetration Piece for A60 Class Compartment I: Transient Thermal)

  • 박우창;송창용;나옥균
    • 한국해양공학회지
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    • 제32권5호
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    • pp.310-323
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    • 2018
  • In order to protect lives and prevent large-scale injuries in the event of a fire on a ship or an offshore plant, most classification societies are strengthening their fire resistance designs of relevant cargo holds and accommodation compartments to keep flames from being transferred from a fire point to other compartments. Particularly in critical compartments, where flames should not propagate for a certain period of time, such as the A60 class division, both the airtightness and fire-resistant design of a piece passing through a bulkhead are subject to the Safety of Life at Sea Convention (SOLAS) issued by the International Maritime Organization (IMO). In order to verify the suitability of a fire-resistant design for such a penetrating piece, the fire test procedure prescribed by the Maritime Safety Committee (MSC) must be carried out. However, a numerical simulation should first be conducted to minimize the time and cost of the fire resistance test. In this study, transient thermal analyses based on the finite element method were applied to investigate the heat transfer characteristics of a bulkhead penetration piece for the A60 class compartment. In order to determine a rational bulkhead penetration piece design, the transient heat transfer characteristics according to the variation of design parameters such as the diameter, length, and material were reviewed. The verification of the design specification based on a numerical analysis of the transient heat transfer performed in this study will be discussed in the following research paper for the actual fire protection test of the A60 class bulkhead penetration piece.

Association Analysis of Charcoal Rot Disease Resistance in Soybean

  • Ghorbanipour, Ali;Rabiei, Babak;Rahmanpour, Siamak;Khodaparast, Seyed Akbar
    • The Plant Pathology Journal
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    • 제35권3호
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    • pp.189-199
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    • 2019
  • In this research, the relationships among the 31 microsatellite markers with charcoal rot disease resistance related indices in 130 different soybean cultivars and lines were evaluated using association analysis based on the general linear model (GLM) and the mixed linear model (MLM) by the Structure and Tassel software. The results of microsatellite markers showed that the genetic structure of the studied population has three subpopulations (K=3) which the results of bar plat also confirmed it. In association analysis based on GLM and MLM models, 31 and 35 loci showed significant relationships with the evaluated traits, respectively, and confirmed considerable variation of the studied traits. The identified markers related to some of the studied traits were the same which can probably be due to pleiotropic effects or tight linkage among the genomic regions controlling these traits. Some of these relationships were including, the relationship between Sat_252 marker with amount of charcoal rot disease, Satt359, Satt190 and Sat_169 markers with number of microsclerota in stem, amount of charcoal rot disease and severity of charcoal rot disease, Sat_416 marker with number of microsclerota in stem and amount of charcoal rot disease and the Satt460 marker with number of microsclerota in stem and severity of charcoal rot disease. The results of this research and the linked microsatellite markers with the charcoal rot disease-related characteristics can be used to identify the suitable parents and to improve the soybean population in future breeding programs.

Multi-epitope vaccine against drug-resistant strains of Mycobacterium tuberculosis: a proteome-wide subtraction and immunoinformatics approach

  • Md Tahsin Khan;Araf Mahmud;Md. Muzahidul Islam;Mst. Sayedatun Nessa Sumaia;Zeaur Rahim;Kamrul Islam;Asif Iqbal
    • Genomics & Informatics
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    • 제21권3호
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    • pp.42.1-42.23
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    • 2023
  • Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, one of the most deadly infections in humans. The emergence of multidrug-resistant and extensively drug-resistant Mtb strains presents a global challenge. Mtb has shown resistance to many frontline antibiotics, including rifampicin, kanamycin, isoniazid, and capreomycin. The only licensed vaccine, Bacille Calmette-Guerin, does not efficiently protect against adult pulmonary tuberculosis. Therefore, it is urgently necessary to develop new vaccines to prevent infections caused by these strains. We used a subtractive proteomics approach on 23 virulent Mtb strains and identified a conserved membrane protein (MmpL4, NP_214964.1) as both a potential drug target and vaccine candidate. MmpL4 is a non-homologous essential protein in the host and is involved in the pathogen-specific pathway. Furthermore, MmpL4 shows no homology with anti-targets and has limited homology to human gut microflora, potentially reducing the likelihood of adverse effects and cross-reactivity if therapeutics specific to this protein are developed. Subsequently, we constructed a highly soluble, safe, antigenic, and stable multi-subunit vaccine from the MmpL4 protein using immunoinformatics. Molecular dynamics simulations revealed the stability of the vaccine-bound Tolllike receptor-4 complex on a nanosecond scale, and immune simulations indicated strong primary and secondary immune responses in the host. Therefore, our study identifies a new target that could expedite the design of effective therapeutics, and the designed vaccine should be validated. Future directions include an extensive molecular interaction analysis, in silico cloning, wet-lab experiments, and evaluation and comparison of the designed candidate as both a DNA vaccine and protein vaccine.

Growth and yield responses of rice varieties to various soil water deficit conditions under different soil types

  • Kikuta, Mayumi;Samejima, Hiroaki;Magoti, Rahab;Kimani, John M.;Yamauchi, Akira;Makihara, Daigo
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.322-322
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    • 2017
  • To avoid drought stress under rainfed upland conditions, it is important for rice to efficiently utilize water at shallow soil layers supplied by rainfall, and access to water retained in deer soil layers. The root developmental characteristics of rice, which play important role in the adaptability to drought conditions, vary depending on the variety. Moreover, water availability for plant differs depending on the soil types that have different physical properties such as water holding capacity, permeability, capillary force, penetration resistance, etc. In this study, we evaluated growth and yield responses of rice varieties to various soil water deficit conditions under three different soil types. The experiment was conducted in a plastic greenhouse at the Kenya Agricultural and Livestock Research Organization-Mwea from October 2016 to January 2017. Two upland varieties (NERICA 1 and 4) and one lowland variety (Komboka) were grown in handmade PVC pots (15.2 cm diameter and 85.0 cm height) filled with three different types of soil collected from major rice-growing areas of the country, namely black cotton (BC), red clay (RC), and sandy clay (SC). Three watering methods, 1) supplying water only from the soil surface (W1), 2) supplying water only from the bottom of the pots (W2), and 3) supplying water both from the soil surface and the bottom of pots (W3), were imposed from 40 days after sowing to maturity. Soil water content (SWC) at 20, 40, and 60 cm depths was measured regularly. At the harvesting stage, aboveground and root samples were collected to determine total dry weight (TDW), grain yield, and root length at 0-20, 20-40, 40-60, and 60-80 cm soil layers. Irrespective of the watering methods, the greatest root development was obtained in RC, while that in BC was less than other two soils. In BC, the degree of yield reduction under W1 was less than that in RC and SC, which could be attributed to the higher water holding capacity of BC. In RC, the growth and yield reduction observed in all varieties under W1 was attributed to the severe drought stress. On the other hand, under W2, SWC at the shallow soil depth in RC was maintained because of its higher capillary force compared with BC and SC. As the result, growths and yields in RC were not suppressed under W2. In SC, deep root development was not promoted by W2 irrespective of the varieties, which resulted in significant yield losses. Under W1, the rice growth and yield in SC was decreased although shallow root development was enhanced, and the stomatal conductance was maintained higher than RC. It was suspected that W1 caused nutrients leaching in SC because of its higher permeability. Under rainfed conditions, growth and yield of rice can be strongly affected by soil types because dynamics of soil water conditions change according to soil physical properties.

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국제화에 따른 한국내 자생테러 발생 가능성과 대응전략 (A Study on the Possibility of Homegrown Terrorism in Korea Depending on Internalization and Strategy to Cope with the Terrorism)

  • 유형창
    • 시큐리티연구
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    • 제31호
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    • pp.125-155
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    • 2012
  • 테러 조직은 비밀스럽고 점조직으로 전환하는 양상을 보이고 있으며, 테러의 불예측성으로 테러대응은 점점 어려워지고 있다. 자생테러는 자연적으로 생성된 테러리즘으로 테러의 준비, 시행, 효과 등 국내에 국한된 테러리즘이다. 한편 최근들어 세계적인 경제침체와 자유화의 열기로 인하여 중동, 아프리카의 정치혁명, 유럽의 반사회적 저항, 미국의 월가점령 등 폭력과 과격시위가 가열, 확산추세를 보이고 있다. 미국은 물론 영국, 스페인 등 다수의 국가에서 자생적 테러가 발생하고 있으며, 한국에서도 자생적 테러의 가능성에 대한 경고가 전문가들에 의해서 제기되고 있다. 본 연구에서는 국내에서의 국제화의 진전에 따른 다양한 형태의 외국인 국내 유입으로 급속하게 다문화 사회로 전환되어 가는 상황에서 발생할 수 있는 자생테러 가능성을 전망하고, 이에 대한 대응방안을 제시하였다. 그리고 한국이 처해 있는 자생테러 환경과 위협을 분석하였다. 자생테러에 대한 대응방안은 다음과 같다. 첫째, 인터넷을 통한 자생테러 급진주의 전파 차단. 둘째, 테러조직과 잠재 자생테러주의자의 연계 차단. 셋째, 정부와 시민, 종교단체간의 자생 테러 예방 협력. 넷째, 다문화 사회에 대한 열린 접근. 다섯째, 새로운 갈등원인에 대한 체계적 관리 마지막으로 자생테러에 대한 장기적 접근이다. 우리가 이러한 노력을 게을리 한다면 국내의 테러 환경은 새로운 국면을 맞이할 수 있으며, 이에 대한 국가적, 사회적 비용도 커질 수밖에 없을 것이다.

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필리핀 지방정치의 역동성: 북부 수리가오 주의 토착 기독교 종교단체 (PBMA) 사례 연구 (The Dynamics of Local Politics in the Philippines: A Case Study on the PBMA in Surigao del Norte Province)

  • 류석춘;왕혜숙
    • 동남아시아연구
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    • 제19권2호
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    • pp.1-56
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    • 2009
  • It is generally acknowledged that Philippines politics has achieved a basic soil for democracy at the macro-level by the two incidents of 'People Power' (1986 & 2001). However, in spite of such an achievement, Philippine politics at the micro-level, does not enjoy the same reputation. Institutionalized 'Bossism' or 'patron/clientelism' political culture has been attributed to make such a gap. This paper aims to bridge the gap by a longitudinal observation on local politics of a particular province in the Philippines. Surigao del Norte is the province picked up for the study. The reason why this particular province attracts special concerns is that there appears to come a very dynamic local politics, led by an indigenous Christian organization, the PBMA (Philippines Benevolent Missionary Association), which was founded in the mid 1960s. With the coming of the organization in the province, the political power of the traditional families has been narrowed. On the other hand, new families, not only the leader family of the PBMA but also the family allied with the PBMA, has expanded political influence. Following steps are adopted to understand the meaning of such a change. First, institutional frame of Philippine politics and elections will be reviewed. Second, demographic changes will be investigated on Surigao del Norte province to find out how popular the PBMA organization is among the people. Third, local election outcomes will be examined to describe the changing nature of political landscape of the province. This will reveal how the relationship between the old and new families has been developed in the province. Lastly, based on the facts discovered by a longitudinal observation, an attempt to evaluate theories on Philippines politics will be made Conclusions are as follows. To understand the dynamics of Philippine politics, 'expectations from the below,' or, 'passions of the people,' suggested by Ileto, needs more attention. Furthermore, 'mutual accommodation' between domination and resistance, coined by Abinales, also demands more appreciation. The case of local politics in the Surigao del Norte, with the coming of the PBMA, is sure to show a concrete example of changing politics in the 'changeless land.'

Design and analysis of low velocity impact on thermoplastic hat section with curvilinear profile

  • Gaur, Kumresh K;Dwivedi, Mayank;Bhatnagar, Naresh
    • Advances in materials Research
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    • 제6권1호
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    • pp.65-78
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    • 2017
  • A hat section was designed and developed for maximum impact energy absorption and/or transmission under low velocity impact. Towards this, different hat sections, having material properties of thermoplastic, were modeled and investigated numerically using finite element analysis (FEA) in the range of 20-50 J impact energy. In the study it was experienced that the design configuration of hat section with curvilinear profile (HSCP) was excellent in energy attenuation capacity and for even distribution of maximum impact force around and along the hat section under low velocity impact loading. To validate the numerical findings, polypropylene copolymer (Co-PP) HSCP and low density polyethylene (LDPE) HSCP were developed and evaluated experimentally in the said impact energy range. A correlation was established between FEA and experimental test results, thereby, validating a numerical model to predict results for other thermoplastic materials under given range of impact energy. The LDPE HSCP exhibited better performance as compared to Co-PP HSCP in the said range of impact energy. The findings of this study will enable the engineers and technologists to design and develop low velocity impact resistance devices for various applications including devices to protect bone joints.

조직 내 상사의 비인격적 감독이 부하의 조직시민행동에 미치는 영향에 관한 연구 (A Study on the Abusive Supervision and its impact on Subordinates' Organizational Citizenship Behavior)

  • 김정진
    • 지식경영연구
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    • 제12권4호
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    • pp.1-15
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    • 2011
  • The purpose of this study is to determine abusive supervision and its effect on the resistance to such behavior by workers, and also to determine the moderating roles of subordinate's personalities that can strengthen or weaken the relationship between the abusive supervision and employee behaviors. Because the key factors underlying the choice of individual OCB(Organizational Citizenship Behavior) or organizational OCB have to do with subordinates' concern for the task and relational consequences of their behavior, the analysis focused on Neuroticism, the Big Five domains that represent one's orientations toward task and relational matters, respectively(Costa & McCrae, 1992). For empirical study, survey was performed for the analysis, and a total of 233 was used. The following is a summary of the verification results. First, in the relationships between the use of abusive supervision and employee's OCB, the relationship is negatively correlated to the abusive supervision. Second, moderating effects of subordinates' personalities(neuroticism) between abusive supervision and subordinates' were not verified. Finally, future research will explore the effects of situational variables that affect the extent to which supervisors engage in abusive behavior and how subordinates respond to abusive supervision.

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