• Natural Product Sciences
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• v.9 no.3
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• pp.161-166
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• 2003

In the course of our studies for new anticancer medicinal plants, we evaluated the effects of an alcohol-water (1:1, V/V) extract of Dendrostellera lesserii (Thymelaeaceae) leaves on the growth rates of breast tumors of rats. The breast tumors were induced in a group of rats by Dimethylbenz[a]anthracene (DMBA) injection. Our data showed that daily oral feeding of the crude extract to the rats, for 20 consecutive weeks, significantly repressed the growth rates of the breast tumors. In addition, the probable effect of D. lessertii crude extract or one of its purified active components on metastasis was evaluated using wehi-164 cells. Treatment of the cells with a single nontoxic dose of the purified active component for 48 hours inhibited the adhesion of the cells to the immobilized fibronectin molecules by almost 80% compared to the untreated control cells.

• Journal of the Korean Home Economics Association
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• v.11 no.2
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• pp.139-146
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• 1973

The level of serum cholesterol was successively determined for 4 weeks after the basic diet feeding for 8 weeks in the rabbits. It was observed that the individual serum cholesterol levels were highly elevated by the oral administration of cholesterol for 18 days, and then the rabbit were fed by sesame and rape seed oils for 11 weeks to survey the effect of the oils which was playing a role of decreasing factor for serum cholesterol values. The results were obtained as follows ; 1. The rabbit's serum cholesterol level was 128±29.0mg/dl in average, it was higher in female (162±50.6) than male(95±17.6). 2. It can be possible elevating experimentally the level of serum cholesterol by the cholesterol administration per os. 3. There were significant effect of the vegetable oils to decrease the experimental hypercholesteremia in the rabbits.

• Korean Journal of Bronchoesophagology
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• v.3 no.2
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• pp.307-312
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• 1997

Reconstruction of the pharyngoesophagus is one of the most difficult challenges in head and neck surgery. The goals of pharyngoesophageal reconstruction include restoration of a person's ability to swallow and to speak with minimal morbidity, but no current reconstruction modality is clearly best. Following its first introduction as fasciocutaneous flap by Yang in 1981, the forearm flap based on radial artery has become recognized as a very reliable and relatively easy one to use. The forearm flap has thin, pliable and predominantly hairless skin and scant subcutaneous layer In addition, its vascular pedicle is long and of large caliber, which greatly increases the chance of successful revascularization. The forearm flap shows the potentiality for better functional rehabilitation in swallowing and speech as well as the possibility of three dimensional reconstruction. We experienced a case of radial forearm free flap for the reconstruction in a patient with the hypopharyngeal stricture. The early return of oral feeding was possible and successfully enough to return to the normal daily activity.

• Journal of Chest Surgery
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• v.53 no.4
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• pp.211-216
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• 2020

Esophageal fistulas may occur in an advanced stage or as a potentially life-threatening complication of treatment. They can be divided into esophageal-respiratory and esophageal-aorta fistulas. The diagnosis is confirmed with fluoroscopy using dilute barium oral contrast, followed by thin-section computed tomography, which defines the precise location and extent of the fistula. Flexible esophagoscopy and bronchoscopy are required for confirmation and anatomic assessment of the suspected fistula and provide additional information for treatment planning. Contamination is traditionally controlled by surgical exclusion, along with a jejunal feeding tube. Currently, fully covered self-expanding metal stents are the primary treatment option.

• Journal of dental hygiene science
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• v.11 no.3
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• pp.205-211
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• 2011

The present study seeks to find the effect of oral health status that parents recognized, oral health habit and food intake on existence of decalcified teeth and decayed teeth. Participants were 293 infants aged 18-24 months who visited C dental clinic in Kyungki province between January and December 2010. Questionnaires and oral exam results were used and statistically analyzed by the SPSS program. Fisher's Exact and chi-square test were used to analyze the data. The 18-20 month-old age group had the highest rate of decalcified teeth with 36.4% while the 23-24 month-old age group had the highest rate of decayed teeth with 37.0%. Bottle feeding showed correlation with decalcified teeth, and decayed teeth. Parents were able to recognize decayed teeth and decalcified teeth. Group 2 food(soda/soft drinks/sugared fruit juice) was related to decalcified teeth and decayed teeth(p<.001). Group 4 food (cake/cookies/doughnut/dried fruit/banana) and group 5food(caramel/candy/chocolate bar) were both related to decalcified teeth(p<.001). As the result of dental examination, dental treatment was highly needed for the 21-22 month-old age group(89.3%), and preventive treatment and plaque control were highly needed for the 18-20 month-old age group(94.5%). The results concluded that 18-24 months was the critical period for children's oral health, therefore organized oral health education for parents is necessary.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.9 no.2
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• pp.153-161
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• 2006

Purpose: This study was designed to investigate rotavirus infection by comparing the clinical characteristics in neonates and infants. Methods: We enrolled 104 neonates and 250 infants wiht gastroenteritis and a rotazyme test positive reaction at the Soonchunhyang University Bucheon Hospital from February 2001 to January 2003. Results: The seasonal peaks of infection in infants occurred from February to June. However, in neonates, it occurred from October to December due to nursery outbreaks. Diarrhea, vomiting, fever and convulsions were significant symptoms in infants; however, metabolic acidosis with dehydration, jaundice, irritability, apnea, bloody stool, gastric residual, grunting, poor oral intake, lethargy as well as fever and diarrhea were more common in the neonates. Upper respiratory infection, pneumonia and bronchitis were present in the infants; however, necrotizing enterocolitis was more commonly observed in the in neonates. Among the patients with rotaviral infection, formula feeding was more popular than breast milk feeding in both the neonates and infants; however, this finding was not statistically significant. Conclusion: Rotavirus can be a significant pathogen in neonates as well as infants. Neonates suffering from fever, poor oral intake, lethargy and apnea should be investigated for rotaviral infection. A new vaccine, rotaviral specific immunoglobulin and treatment guidelines are needed for eradicating rotavirus infection. Further studies on isolation, infection pathway, immune response and treatment of rotavirus are needed.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.1
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• pp.92-98
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• 2001

The dumping syndrome has been a known complication of gastric surgery in adults, but it is recognized as a very rare disease in the pediatric population, especially in Korea. We report a case of dumping syndrome in a 10-month-old infant, who underwent Nissen fundoplication for the treatment of gastroesophageal reflux(GER). He was admitted because of aspiration pneumonia, and diagnosed as GER by 24-hour ambulatory esophageal pH monitoring test. For the treatment of GER, Nissen fundoplication was performed. After the operation, symptoms occurred within 30 minutes of meals, such as diaphoresis, palpitation, weakness, abdominal fullness, nausea, and diarrhea. The gastric emptying scan showed very rapid gastric emptying. His oral glucose tolerance tests revealed early-onset hyperglycema followed by delayed-onset hypoglycemia, which was the characteristic finding of the dumping syndrome. We introduced uncooked cornstarch to resolve symptoms and maintain the serum glucose level. After the feeding of uncooked cornstarch, his symptoms subsided and normal oral glucose test was restored. After the six months of treatment, his weight and height were increased dramatically from below 3 percentiles up to the normal range. The dumping syndrome should be considered when an infant suffers from the feeding difficulties after the gastric surgery like Nissen fundoplication, and the diet therapy including uncooked cornstarch could be applied as an effective measure.

• Journal of Animal Science and Technology
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• v.51 no.4
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• pp.321-328
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• 2009

A total of fourteen, 1-wk-old male Holstein calves were allotted into two groups consisted of control (CON) and IGY which was orally administrated with immunoglobulin yolk (IgY) for 1wk. Calves in both groups were provided with milk replacer according to feeding program and had ad libitum access to timothy hay for the entire experimental period (7wks). At 0, 7 and 49 day of experiment, blood samples were collected from the jugular vein of calves to investigate blood biochemical profiles and the differential count (%) of white blood cell (WBC). We also monitored growth performance and colony forming unit (CFU) of fecal microbial population in calves. The adminstration of IgY in calves did not affect body weight and weight gain during 49 days feeding trial compared with control group. The CFU of E. coli and Lactobacilli in the feces of calves were not significantly affected by IgY treatment, whereas the score of the calf scours during day 43 to 49 in IgY group showed a significant (P<0.05) solid type. There were no differences in plasma biochemical components including total protein, albumin, immunoglobulin and the other indicators. As for WBC differential count (%), there was no statistical difference in the percentages of neutrophil, lymphocyte, monocyte, eosinophil and basophil at 0, 7 and 49 days after the oral supplementation of IgY. In conclusion, the oral supplementation of IgY as an immunostimulant did not affect growth performance, fecal microbial population, blood biochemical profile and WBC differential count in Holstein calves.

• Journal of Nutrition and Health
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• v.47 no.3
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• pp.157-166
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• 2014

Purpose: Rice bran is a byproduct of the hulling of rice and contains a variety of bioactive components. Various studies have reported on the antioxidative, anticancer, immune-enhancing, and hypocholesterolemic effects of rice bran. However, few studies about the physiological activity of stabilized rice bran supplement on dietary intake of sugars is limited. The aim of this study was to investigate the effect of stabilized rice bran supplement on blood glucose in C57BL/6 mice fed a high sucrose diet. Methods: Animals were randomly divided into three groups respectively, and were fed a normal diet (ND group), a high sucrose diet (HSD group) or a high sucrose diet containing 20% stabilized rice bran (HSD-SRB group) for 12 weeks. Results: In the oral glucose tolerance test (OGTT), after seven weeks of feeding on the experimental diets, a significantly lower result was observed for HSD-SRB than for HSD at 30 and 60 minutes after oral administration in glucose solution (2 g/kg body weight). The incremental area under the curve (IAUC) of HSD-SRB was significantly lower than that of HSD. After 12 weeks, fasting blood glucose level of HSD-SRB was significantly lower than that of HSD. No significant difference in the serum insulin level was observed between HSD and HSD-SRB. However, HOMA-IR was significantly decreased in HSD-SRB compared to HSD. In addition, HOMA ${\beta}$-cell was significantly increased in HSD-SRB compared to HSD. Triglyceride in liver of HSD-SRB was significantly lower than that of HSD. Conclusion: Feeding diets containing 20% rice bran improved insulin resistance and insulin secretion by decreasing triglyceride in liver. Thus, rice bran has a positive effect on glycemic control. In addition, the results are expected to be utilized as a basis for human study and development of food products with added rice bran.

• Journal of the Korean Society of Food Science and Nutrition
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• v.22 no.4
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• pp.398-404
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• 1993

In order to examine the anticarcinogenic effects of garlic juice on the hamster buccal pouch carcinogenesis induced by 9, 10-dimethyl-1, 2-benzanthracene (DMBA) totally 135 hamster.0.5% DMBA in mineral oil were painted onto the hamster buccal pouch three times a week on 50th, 70th and 90th day, while normal saline, 1% and 3% garlic juice were forced to oral tube feeding. Tumor cell induction could be seen on 50th experimental day, presumed to early carcinogenic inductive stage. And the tumor cells proliferated rapidly thereafter, so 70th and 90th experimental day were chosen for the comparison of anticarcinogenic effect of garlic juice. The every specimens were fixed in 10% buffered formalin for routine histopathological observation and also fixed in Carnoy's solution for the BrdU immunohistochemital detection of S-stage tumor cell distribution during the carcinogenesis. There showed more or less increased anticarcinogenic effect of garlic juice against DMBA induced hamster buccal pouch carcinoma, increased comparing to the control group showing invasive tumor growth after all histopathologically, BrdU immunoreactivity on normal pouch mucosa epithelium, representing the mitotic status, more decreased in the garlic juice feeding group than the control group. Meanwhile the neoplastic epithelium of all experimental groups showed much increased BrdU immunostaining irregularly.