• Journal of the Korean Data and Information Science Society
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• 제22권4호
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• pp.619-630
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• 2011

본 연구에서는 두 분포함수의 혼합된 자료에서 적절한 분류점을 추정하고 평가하기 위하여 많이 사용하는 아홉 종류의 분류정확도 측도인 MVD, Youden지수, (0,1)까지최단기준, 수정된 (0,1)까지 최단기준, SSS, 대칭점, 정확도면적, TA, TR을 다섯 개의 조건범주로 군집시킨다. 신용평가분석에서 정상과 부도상태의 스코어 확률변수가 정규분포를 따르며 전체부도율로 혼합되었다고 가정한다. 다양한 정규혼합분포의 상황에서 군집된 측도들의 최적분류점을 발견하고, 그 분류점에 대응하는 제I종 오류율과 제II종 오류율 그리고 두 종류의 오류율 합을 구하여 각각의 오류율이 최소인 경우를 탐색적으로 살펴본다. 현실자료에 적합한 정규혼합분포를 추정하여 본 연구 결과를 적용하면 최소 오류율이 보장되는 분류정확도를 선택할 수 있으며, 이를 사용하여 모형의 판별력을 향상시킬 수 있다.

• 한국전산구조공학회논문집
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• 제27권5호
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• pp.345-352
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• 2014

본 논문에서는 아이소-지오메트릭 형상 최적설계 기법에서 얻은 CAD 정보를 직접 활용하여, 3D 프린터를 활용한 실험적 검증을 위한 시편을 제작하였다. 유한요소법에서는 요소망에 내재하는 기하학적인 근사가 응답과 설계민감도 해석에서 정밀도 문제를 발생시킨다. 더욱이 유한요소 기반 형상 최적화 과정에서는 CAD와의 정보교환이 필수적이나 그 과정에서 최적설계 정보의 손실이 발생할 수 있다. 아이소-지오메트릭 기법은 CAD에서 사용된 동일한 NURBS 기저함수와 조정점을 사용하므로 법선벡터와 곡률과 같은 엄밀한 기하학적 정보를 응답해석과 설계민감도 해석에 사용할 수 있다. 또한 최적설계 과정에서 CAD와 정보교환 없이 복잡한 형상을 손쉽게 변경할 수 있다. 그러므로 최적의 설계의 재료량을 실험적 검증을 위한 시편제작에 엄밀하게 반영할 수 있다. 굽힘 하중을 받는 단순지지 구조물에 대한 최적설계 및 실험적 검증을 통해 최적형상이 초기 형상에 비해 더 큰 강성을 가지며 실험결과와 수치 해석결과가 매우 잘 일치함을 보였다. 또한 인장력을 받는 유공판에 대한 형상 최적설계를 수행하였으며, 비접촉식 3차원 변형 측정 장치를 이용하여 초기설계에 비해 최적설계에서 구멍주변에서의 응력집중 현상이 완화됨을 확인하였다. 따라서 수치적인 방법을 활용한 최적설계가 실제 구조물에 대한 실험에서도 유효함을 입증하였다고 할 수 있다. 또한, 아이소-지오메트릭 최적설계 방법론이 기존의 유한요소법에 비해서 최적설계 결과를 제작하여 활용하는데 있어서도 훨씬 효율적이고 엄밀한 방법임을 보였다.

• The Korean Journal of Physiology and Pharmacology
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• 제24권1호
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• pp.89-99
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• 2020

Although microscopic analysis of tissue slides has been the basis for disease diagnosis for decades, intra- and inter-observer variabilities remain issues to be resolved. The recent introduction of digital scanners has allowed for using deep learning in the analysis of tissue images because many whole slide images (WSIs) are accessible to researchers. In the present study, we investigated the possibility of a deep learning-based, fully automated, computer-aided diagnosis system with WSIs from a stomach adenocarcinoma dataset. Three different convolutional neural network architectures were tested to determine the better architecture for tissue classifier. Each network was trained to classify small tissue patches into normal or tumor. Based on the patch-level classification, tumor probability heatmaps can be overlaid on tissue images. We observed three different tissue patterns, including clear normal, clear tumor and ambiguous cases. We suggest that longer inspection time can be assigned to ambiguous cases compared to clear normal cases, increasing the accuracy and efficiency of histopathologic diagnosis by pre-evaluating the status of the WSIs. When the classifier was tested with completely different WSI dataset, the performance was not optimal because of the different tissue preparation quality. By including a small amount of data from the new dataset for training, the performance for the new dataset was much enhanced. These results indicated that WSI dataset should include tissues prepared from many different preparation conditions to construct a generalized tissue classifier. Thus, multi-national/multi-center dataset should be built for the application of deep learning in the real world medical practice.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권4호
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• pp.310-317
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• 2002

We have examined 20 tongue-tie patients who had been operated the lingual frenectomy in Dept. of Oral & Maxillofacial surgery, Pusan National University for the effect of the lingual frenectomy on the tongue motion and speech, and divided patients into groups by age. Each group was separated as follows ; the age of 5-6, 7-9, 10-12, 13-15, and 16-18. We measured the frenal lengh, the range of tongue motion and evaluated the speech pre- and postoperatively. The preoperative patient groups have larger tongue tips and smaller lingual frenums than normal ones. In the preoperative patient group, there was significant obstacle of the protrusive and superior movement of the tongue. The exception was the laterotrusive movement on both sides. There was the lower value of the Picture Consonant Articulation Test(PCAT) in the preoperative 5 to 6 year-old group compared with normal group. In other age groups, there was no significant difference. The range of postoperative PCAT in all age groups has become as similiar as that of normal group. The 5 to 6 year-old group which had significant difference in PCAT was improved in PCAT. In conclusion, we propose that the PCAT as well as anatomical tongue size and functional tongue movement is the basis of the indication of lingual frenectomy and the 5-6 year-old is the optimal time of the lingual frenectomy for improvement of the tongue movement and the speech.

• Journal of Preventive Medicine and Public Health
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• 제38권2호
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• pp.203-207
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• 2005

Objectives: Recently, the American Diabetes Association (ADA) redefined the criteria of prediabetes, which has lowered the diagnostic level of fasting plasma glucose (FPG) from 110 to 125 mg/dl, down to levels between 100 to 125mg/dl. The purpose of this study was to determine the predictive cutoff level of FPG as a risk for the development of diabetes mellitus in Korean men. Methods: A retrospective cohort study was conducted on 11,423 (64.5%) out of 17,696 males $\leq$30 years of age, and who met the FPG of $\leq$125 mg/dl and hemoglobin A1c of $\leq$ 6.4% criteria, without a history of diabetes, and who were enrolled at the screening center of a certain university hospital between January and December 1999. The subjects were followed from January 1999 to December 2002 (mean follow-up duration; 2.3(${\pm}0.7$) years). They were classified as normal (FPG <100mg/dl), high glucose (FPG $\geq$100mg/dl and <110mg/dl) and impaired fasting glucose (FPG $\geq$110mg/dl and $\leq$125mg/dl) on the basis of their fasting plasma glucose level measured in 1999. We compared the incidence of diabetes between the 3 groups by performing Cox proportional hazards model and used receiver operating characteristic analyses of the FPG level, in order to estimate the optimal cut-off values as predictors of incident diabetes. Results: At the baseline, most of the study subjects were in age in their 30s to 40s (mean age, 41.8(${\pm}7.1$) year). The incidence of diabetes mellitus in this study was 1.19 per 1,000 person-years (95% CI=0.68-1.79), which was much lower than the results of a community-based study that was 5.01 per 1,000 person-years. The relative risks of incident diabetes in the high glucose and impaired fasting glucose groups, compared with the normal glucose group, were 10.3 (95% CI=2.58-41.2) and 95.2 (95% CI= 29.3-309.1), respectively. After adjustment for age, body mass index, and log triglyceride, a FPG greater than 100mg/dl remained significant predictors of incident diabetes. Using the receiver operating characteristic (ROC) curve, the optimal cutoff level of FPG as a predictor of incident diabetes was 97.5 mg/dl, with a sensitivity and a specificity of 81.0% and 86.0%, respectively. Conclusion: These results suggest that lowering the criteria of impaired fasting glucose is needed in Korean male adults. Future studies on community-based populations, including women, will be required to determine the optimal cutoff level of FPG as a predictor of incident diabetes.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 춘계학술대회 논문집
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• pp.49-55
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• 2003

When a body with slant angle after its shoulder is moving at high speed, the turbulent motion around the afterbody is generally associated with the flaw separation and determines the normal component of the drag. By changing the slant angle of afterbody, there exists a critical angle at which the drag coefficients change drastically. Understanding and control of the turbulent separated flows are of significant importance for the design of optimal configuration of the moving bodies. In the present paper, a new Large Eddy Simulation technique has been developed to investigate turbulent vortical motions around the afterbodies with slant angle. By basis of understanding the structure of turbulent flaw around the body, the new configuration of afterbodies are designed to reduce the drag of body and the nonlinear effects due to the interaction between the body configuration and the turbulent separated flows are investigated by use of the developed LES technique.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권4호
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• pp.2094-2112
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• 2019

Focusing on the issue that the conventional Kernel Correlation Filter (KCF) algorithm has poor performance in handling scale change and obscured objects, this paper proposes an anti-occlusion and scale adaptive tracking algorithm in the basis of KCF. The average Peak-to Correlation Energy and the peak value of correlation filtering response are used as the confidence indexes to determine whether the target is obscured. In the case of non-occlusion, we modify the searching scheme of the KCF. Instead of searching for a target with a fixed sample size, we search for the target area with multiple scales and then resize it into the sample size to compare with the learnt model. The scale factor with the maximum filter response is the best target scaling and is updated as the optimal scale for the following tracking. Once occlusion is detected, the model updating and scale updating are stopped. Experiments have been conducted on the OTB benchmark video sequences for compassion with other state-of-the-art tracking methods. The results demonstrate the proposed method can effectively improve the tracking success rate and the accuracy in the cases of scale change and occlusion, and meanwhile ensure a real-time performance.

• Journal of Veterinary Science
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• 제24권6호
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• pp.79.1-79.16
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• 2023

Background: The need for a storage method capable of preserving the intrinsic properties of bones without using toxic substances has always been raised. Supercooling is a relatively recently introduced preservation method that meets this need. Supercooling refers to the phenomenon of liquid in which the temperature drops below its freezing point without solidifying or crystallizing. Objectives: The purpose of this study was to identify the preservation efficiency and applicability of the supercooling technique as a cortical bone allograft storage modality. Methods: The biomechanical effects of various storage methods, including deep freezing, cryopreservation, lyophilization, glycerol preservation, and supercooling, were evaluated with the three-point banding test, axial compression test, and electron microscopy. Additionally, cortical bone allografts were applied to the radial bone defect in New Zealand White rabbits to determine the biological effects. The degree of bone union was assessed with postoperative clinical signs, radiography, micro-computed tomography, and biomechanical analysis. Results: The biomechanical properties of cortical bone grafts preserved using glycerol and supercooling method were found to be comparable to those of normal bone while also significantly stronger than deep-frozen, cryopreserved, and lyophilized bone grafts. Preclinical research performed in rabbit radial defect models revealed that supercooled and glycerol-preserved bone allografts exhibited significantly better bone union than other groups. Conclusions: Considering the biomechanical and biological superiority, the supercooling technique could be one of the optimal preservation methods for cortical bone allografts. This study will form the basis for a novel application of supercooling as a bone material preservation technique.

• 한국약용작물학회지
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• 제17권4호
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• pp.238-242
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• 2009

Somatic embryos on growth regulator-free medium can be produced directly from cotyledon explants of Panax ginseng C. A. Meyer. When the embryo developmental stage was torpedo and cotyledon, the germination rate of embryos was quite high on MS medium supplemented with gibberellic acid ($GA_3$). However, the percentage of plantlet formation at the cotyledon stage was higher than that at the torpedo stage. This result demonstrates that the embryo at the cotyledon stage was the most appropriate for increasing germination by $GA_3$. Embryos cultured on medium including four levels of $GA_3$ concentrations (3, 5, 10, or 20 mg/$\ell$) showed all quite high germination rates (87-91%). When the well-developed embryos were continuously cultured on media including high concentrations of $GA_3$ from 10 to 20 mg/$\ell$, the percentage of formation of normal plantlets was lower than that seen under low concentrations from 3 to 5 mg/$\ell$. This treatment of high concentrations resulted in shoots with abnormal shape. The optimal $GA_3$ treatment provides a basis for the efficient method obtaining healthy plantlets derived from ginseng somatic embryos.

• 한국전산구조공학회논문집
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• 제27권3호
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• pp.155-162
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• 2014

본 논문에서는 아이소-지오메트릭 해석법을 이용하여 고주파수를 가지는 파워흐름 문제에 대하여 연속체 기반 형상 최적 설계를 수행하였다. 아이소-지오메트릭 기법을 형상 최적설계에 적용하면, CAD 기하 모델링에서 쓰이던 NURBS 기저 함수가 직접 쓸 수 있기에 정확한 기하학 정보가 수치계산에서 고려되고, 이에 따라 형상 최적설계 관점에서 볼 때, 전통적인 유한요소법에 비해 향상되고 부드러운 설계 섭동량을 가지는 설계 매개화가 가능하게 된다. 즉, 정확한 기하 모델이 응답 해석과 설계민감도 해석에 쓰이게 되고, 이에 따라 설계영역 전체에서 법선 벡터와 곡률이 연속적으로 되게 된다. 결과적으로 정밀한 민감도 해석이 가능하게 된다. 몇 가지 수치예제를 통하여 개발된 아이소-지오메트릭 설계민감도가 유한차분 설계민감도와 비교하여 정확성을 확인할 수 있었으며, 형상 최적설계 문제를 통해서 본 방법론을 적용하여 검증하였다.