• BMB Reports
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• v.39 no.3
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• pp.247-252
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• 2006

A rapid method for the detection of Hepatitis E Virus (HEV) was developed by utilizing nano-gold labeled oligonucleotide probes, silver stain enhancement and the microarray technique. The 5'-end -$NH_2$ modified oligonucleotide probes were immobilized on the surface of the chip base as the capture probe. The detection probe was made of the 3'-end -SH modified oligonucleotide probe and nano-gold colloid. The optimal concentrations of these two probes were determined. To test the detection sensitivity and specificity of this technique, a conservative fragment of the virus RNA was amplified by the RT-PCR/PCR one step amplification. The cDNA was hybridized with the capture probes and the detection probes on microarray. The detection signal was amplified by silver stain enhancement and could be identified by naked eyes. 100 fM of amplicon could be detected out on the microarray. As the results, preparation of nano-gold was improved and faster. Development time also was shortened to 2 min. Thus, considering high efficiency, low cost, good specificity and high sensitivity, this technique is alternative for the detection of HEV.

• 한국전산유체공학회:학술대회논문집
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• 2000.05a
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• pp.159-165
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• 2000

In this paper, numerical study has been done for the improvement of the superdetonative ram accelerator performance and for the design optimization of the system. The objective function to optimize the premixture composition is the ram tube length required to accelerate projectile from initial velocity $V_o$ to target velocity $V_e$. The premixture is composed of $H_2,\;O_2,\;N_2$ and the mole numbers of these species are selected at design variables. RSM(Response Surface Methodology) which is widely used for the complex optimization problems is selected as the optimization technique. In particular, to improve the non-linearity of the response and to consider the accuracy and efficiency of the solution, design space stretching technique has been applied. Separate sub-optimization routine is introduced to determine the stretching position and clustering parameters which construct the optimum regression model. Two step optimization technique has been applied to obtain the optimal system. With the application of stretching technique, we can perform system optimization with a small number of experimental points, and construct precise regression model for highly non-linear domain. The error to compared with analysis result is only $0.01\%$ and it is demonstrated that present method can be applied more practical design optimization problems with many design variables.

• Journal of computational fluids engineering
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• v.5 no.2
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• pp.55-63
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• 2000

In this paper, the numerical study has been done for the improvement of the superdetonative ram accelerator performance and for the design optimization of the system. The objective function to optimize the premixture composition is the ram tube length, required to accelerate projectile from initial velocity V/sub 0/ to target velocity V/sub e/. The premixture is composed of H₂, O₂, N₂ and the mole numbers of these species are selected as design variables. RSM(Response Surface Methodology) which is widely used for the complex optimization problems is selected as the optimization technique. In particular, to improve the non-linearity of the response and to consider the accuracy and the efficiency of the solution, design space stretching technique has been applied. Separate sub-optimization routine is introduced to determine the stretching position and clustering parameters which construct the optimum regression model. Two step optimization technique has been applied to obtain the optimal system. With the application of stretching technique, we can perform system optimization with a small number of experimental points, and construct precise regression model for highly non-linear domain. The error compared with analysis result is only 0.01% and it is demonstrated that present method can be applied to more practical design optimization problems with many design variables.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2006.06a
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• pp.327-335
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• 2006

Case Based Reasoning (CBR) has come to be considered as an appropriate technique for diagnosis, prognosis and prescription in medicine. However, canventional CBR has a limitation in that it cannot incorporate asymmetric misclassification cast. It assumes that the cast of type1 error and type2 error are the same, so it cannot be modified according ta the error cast of each type. This problem provides major disincentive to apply conventional CBR ta many real world cases that have different casts associated with different types of error. Medical diagnosis is an important example. In this paper we suggest the new knowledge extraction technique called Cast-Sensitive Case Based Reasoning (CSCBR) that can incorporate unequal misclassification cast. The main idea involves a dynamic adaptation of the optimal classification boundary paint and the number of neighbors that minimize the tatol misclassification cast according ta the error casts. Our technique uses a genetic algorithm (GA) for finding these two feature vectors of CSCBR. We apply this new method ta diabetes datasets and compare the results with those of the cast-sensitive methods, C5.0 and CART. The results of this paper shaw that the proposed technique outperforms other methods and overcomes the limitation of conventional CBR.

• The Transactions of the Korean Institute of Power Electronics
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• v.4 no.6
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• pp.491-499
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• 1999

This paper is on the high perfonnance propulsion IGBT VVVF inverter adopted new technique for railways. To prove the high performance and stabilit~r of traction, running tests are carried out under the simulated condition alike real field. The tests are perfonned on not only a steady states but also a transient states such a as input voltage variation using inertia load equivalent to 160tons train. The vector control technique is a adopted to improve traction for 4 motors. The low switching synchronous PW1\l method based on a space v voltage vector modulation is pro\XlSed as the optimal method for propulsion system railway. The output voltage l is controlled continuously to six step by prolxlsed ovennodu]ation technique without sudden torque variation.

• ETRI Journal
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• v.45 no.6
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• pp.996-1006
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• 2023

Renewable energy is promoted massively to overcome problems that fossil fuel power plants generate. One popular renewable energy type that offers easy installation is a photovoltaic (PV) system. However, the energy harvested through a PV system is not optimal because influenced by exposure to solar irradiance in the PV module, which is constantly changing caused by weather. The maximum power point tracking (MPPT) technique was developed to maximize the energy potential harvested from the PV system. This paper presents the MPPT technique, which is operated on a new high-gain voltage DC/DC converter that has never been tested before for the MPPT technique in PV systems. Fuzzy logic (FL) was used to operate the MPPT technique on the converter. Conventional and adaptive perturb and observe (P&O) techniques based on variables step size were also used to operate the MPPT. The performance generated by the FL algorithm outperformed conventional and variable step-size P&O. It is evident that the oscillation caused by the FL algorithm is more petite than variables step-size and conventional P&O. Furthermore, FL's tracking speed algorithm for tracking MPP is twice as fast as conventional P&O.

• Membrane and Water Treatment
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• v.14 no.2
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• pp.65-76
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• 2023

Given the limited water resources and the presence of multiple decision makers with different and usually conflicting objectives in the exploitation of water resources systems, especially dam's reservoirs; therefore, the decision to determine the optimal allocation of reservoir water among decision-makers and stakeholders is a difficult task. In this study, by combining a fuzzy VIKOR technique or fuzzy multi-criteria decision making (FMCDM) and the Young's bilateral bargaining model, a new method was developed to determine the optimal quantitative and qualitative water allocation of dam's reservoir water with the aim of increasing the utility of decision makers and stakeholders and reducing the conflicts among them. In this study, by identifying the stakeholders involved in the exploitation of the dam reservoir and determining their utility, the optimal points on trade-off curve with quantitative and qualitative objectives presented by Mojarabi et al. (2019) were ranked based on the quantitative and qualitative criteria, and economic, social and environmental factors using the fuzzy VIKOR technique. In the proposed method, the weights of the criteria were determined by each decision maker using the entropy method. The results of a fuzzy decision-making method demonstrated that the Young's bilateral bargaining model was developed to determine the point agreed between the decisions makers on the trade-off curve. In the proposed method, (a) the opinions of decision makers and stakeholders were considered according to different criteria in the exploitation of the dam reservoir, (b) because the decision makers considered the different factors in addition to quantitative and qualitative criteria, they were willing to participate in bargaining and reconsider their ideals, (c) due to the use of a fuzzy-logic based decision-making approach and considering different criteria, the utility of all decision makers was close to each other and the scope of bargaining became smaller, leading to an increase in the possibility of reaching an agreement in a shorter time period using game theory and (d) all qualitative judgments without considering explicitness of the decision makers were applied to the model using the fuzzy logic. The results of using the proposed method for the optimal exploitation of Iran's 15-Khordad dam reservoir over a 30-year period (1968-1997) showed the possibility of the agreement on the water allocation of the monthly total dissolved solids (TDS)=1,490 mg/L considering the different factors based on the opinions of decision makers and reducing conflicts among them.

• Korean Journal of Materials Research
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• v.22 no.4
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• pp.211-214
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• 2012

Optimal conditions for HA plasma spray-coating on Ti6Al4V alloy were investigated in order to obtain enhanced bone-bonding ability with Ti6Al4V alloy. The properties of plasma spray coated film were analyzed by SEM, XRD, surface roughness measurement, and adhesion strength test because the film's transformed phase and crystallinity were known to be influential to bone-bonding ability withTi6Al4V alloy. The films were formed by a plasma spray coating technique with various combinations of plasma power, spray distance, and auxiliary He gas pressure. The film properties were analyzed in order to determine the optimal spray coating parameters with which we will able to achieve enhanced bone-bonding ability with Ti6Al4V alloy. The most influential coating parameter was found to be the plasma spray distance to the specimen from the spray gun nozzle. Additionally, it was observed that a relatively higher film crystallinity can be obtained with lower auxiliary gas pressure. Moderate adhesion strength can be achievable at minimal plasma power. That is, adhesion strength is minimally dependent on the plasma power. The combination of shorter spray distance, lower auxiliary gas pressure, and moderate spray power can be recommended as the optimal spray conditions. In this study, optimal plasma spray coated films were formed with spray distance of 70 mm, plasma current of 800 A, and auxiliary gas pressure of 60 psi.

• Korean Journal of Applied Biomechanics
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• v.25 no.1
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• pp.39-47
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• 2015

Objective : The purpose of this study was to investigate the velocity conversion coefficient and invariance for the optimal phase ratio on the performance of the women's triple jump. Methods : Three-dimensional kinematic data were obtained from the three finalists of the women's triple jumper competition at the 2011 Daegu IAAF World Championships. Computer simulations were performed using the biomechanical model of the triple jump to optimize the phase ratio for the longest actual distance for all athletes with altered velocity conversion coefficients. Results : Top elite triple jumpers showed better technical consistency at the phase ratio. Also, no consistent relationship was observed between the loss in horizontal velocity and the gain in vertical velocity across supporting the three phase. In addition, regardless of the magnitude A1, all athletes were optimized with jump-dominated technique. Finally, as the magnitude of A1 increased, the athletes showed better performance. The obtained overall distance jumped showed the longest actual distance when the optimal phase ratio was transferred from hop-dominated to jump-dominated(the step ratio was 30%~31%), and when the optimal phase ratio was transferred from balanced to jump-dominated(the step ratio was 27%~29%). Conclusion : Future studies need to be conducted in order to explore the active landing motion and the inclination angle of the body with the velocity conversion coefficient simultaneously at each supporting phase.

• Journal of Environmental Policy
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• v.9 no.2
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• pp.41-55
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• 2010

This paper analyzes optimal watershed management focusing on reservoir-level sediment removal techniques. Although dams and reservoirs provide several benefits, sedimentation may reduce their storage capacity. As of today, the Aswan High Dam (AHD) in Egypt faces approximately 76% reduced life of the reservoir. Since the AHD is the major fresh water source in Egypt, sustainable use of this resource is extremely important. A model is developed to simultaneously determine optimal sediment removal strategies for upstream soil conservation efforts and reservoir-level sediment control. Two sediment removal techniques are considered: mechanical dredging and hydro-suction sediment removal system (HSRS). Moreover, different levels of upstream soil conservation efforts have introduced to control soil erosion, which is a major contributor of reservoir storage capacity reduction. We compare a baseline case, which implies no management alternative, to non-cooperative and social planners' solution. Our empirical results indicate that the socially optimal sediment removal technique is a mechanical dredging with unconstrained amount with providing a sustainable life of the reservoir. From the empirical results, we find that social welfare can be as high as $151.01 billion, and is sensitive to interest rates and agricultural soil loss.