• 약학회지
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• 제37권5호
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• pp.463-475
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• 1993

Pharmacological effects of lemakalim on cardiovascular system were investigated using isolated rat hearts and conscious SHRs subjected to hyperkalemic and hypokalemic condition. In the isolated hearts perfused with normal physiological salt solution(4.7 mM KCI), lemakalim increased cardiac function and coronary flow, and these effects were significantly potentiated under hypokalemic(1.2, 2.5 mM KCI), but attenuated under hyperkalemic(IO mM KCI) condition. In conscious SHRS, lemakalim(0.1, 0.2, 0.3mg/kg, p.o.) produced a dose-related decrease in systolic blood pressure, the maximal hypotensive effect being reached around 0.5 hr after dosing. The intensity and the duration of hypotensive effect of lemakalim were significantly increased when administered in combination with dihydrochlorothiazide (2 mg/kg, p.o.), but decreased with triamterene(32 mg/kg, p.o.). It appears that the differential effects of two types of diuretics on the hypotensive action of lemakalim are due to their hypokalemic and hyperkalemic action, respectively. It is conclued that the concomitant use of $K^{+}$ channel openers and hypokalemic diuretics may be an appropriate model of combination therapy in the treatment of hypertension.

• 대한원격탐사학회지
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• 제37권4호
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• pp.665-685
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• 2021

This study focused on the a 20-year evaluation of the dynamism of critical thermal anomalies in Busan metropolitan area prompted by unusual infrastructural development and demographic growth rate. Archived Landsat thermal data derived-LST was the major input for UTFVI and hot spot analysis (Getis-Ord Gi^*). Results revealed that the surface urban heat island-affected area has gradually expanded overtime from 23.32% to 32.36%; while the critical positive thermal anomalies (level-3 hotspots) have also spatially increased from 19.88% in 2000 to 23.56% in 2020, recording a net LST difference of > 5℃ between the maximum level-3 hotspot and minimum level-3 coldspot each year. It is been observed that thermal conditions of Busan have gradually deteriorated with time, which is potentially inherent in the rate of urban expansion. Thus, this work serves as an eye-opener to powers that be, to think and act constructively towards a sustainable thermal conform for city dwellers.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2011년도 춘계학술발표대회
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• pp.40-42
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• 2011

Smart hand-held devices like iPhone, iPad, Andriod and other mobile-OS machines are becoming a well known part of our daily lives. Utilization of these devices has gone beyond the expectations of their inventors. Evolution of Apple's iOS from a mobile phone Operating System to a wholesome platform for Portable Gaming is an adequate proof. Using these smart devices people are downloading applications from numerous online App Stores. Utilizing remote storage facilities and confining themselves to computing power far below than an entry level laptop, netbooks have emerged. Google's idea of Chrome OS coupled with Google's AppEngine is an eye-opener for researchers and developers. Keeping all these industry-proven innovations in mind we are proposing a Context-Driven Cloud-Oriented Application Architecture for smart devices. This architecture enables our smart devices to behave smarter by utilizing very less of local resources.

• Molecules and Cells
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• 제28권3호
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• pp.167-174
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• 2009

Genistein has been reported to potentiate glucose-stimulated insulin secretion (GSIS). Inhibitory activity on tyrosine kinase or activation of protein kinase A (PKA) was shown to play a role in the genistein-induced potentiation effect on GSIS. The aim of the present study was to elucidate the mechanism of genistein-induced potentiation of insulin secretion. Genistein augmented insulin secretion in INS-1 cells stimulated by various energygenerating nutrients such as glucose, pyruvate, or leucine/glutamine (Leu/Gln), but not the secretion stimulated by depolarizing agents such as KCl and tolbutamide, or $Ca^{2+}$ channel opener Bay K8644. Genistein at a concentration of $50{\mu}M$ showed a maximum potentiation effect on Leu/Gln-stimulated insulin secretion, but this was not sufficient to inhibit the activity of tyrosine kinase. Inhibitor studies as well as immunoblotting analysis demonstrated that activation of PKA was little involved in genistein-induced potentiation of Leu/Gln-stimulated insulin secretion. On the other hand, all the inhibitors of $Ca^{2+}$/calmodulin kinase II tested, significantly diminished genistein-induced potentiation. Genistein also elevated the levels of $[Ca^{2+}]_i$ and phospho-CaMK II. Furthermore, genistein augmented Leu/Gln-stimulated insulin secretion in CaMK II-overexpressing INS-1 cells. These data suggest that the activation of CaMK II played a role in genistein-induced potentiation of insulin secretion.

• Journal of Biosystems Engineering
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• 제33권2호
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• pp.83-93
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• 2008

In order to save labor and cost, direct seeding has been considered as an important alternative to the machine transplanting in rice cultivation. Current direct seeding machines for rice in Korea drill irregularly under various operating conditions. This study was conducted to develope a precision seeder which enables the accurate, even-spaced in row placement of rice seeds at uniform depths of 3-4 cm on dry paddy. Design, construction and performance evaluation of the precision seeder were carried out. The tractor rear-mounted type 8-rows precision seeder which performs seeding in addition to fertilizing, ditching, and rotary tilling works on dry paddy was developed. Main components of the seeder were ditcher and leveller, rotary tiller, powered roller type furrow opener, seeding device, powered roller type furrow covering and firming device, hydraulic unit, seeding speed control system, power transmission system, hitch and frame. Ditching, furrow opening, and seed covering and firming performances were good and seeding depths of 2-4 cm could be maintained. Planting accuracies and planting precisions were within 13.6%, and 31.2%, respectively, for planting space of 15 cm, and seeding velocity of 0.5 m/s. These mean variations of average planting space were within 2.1 cm, and 90% of seeds in a hill were seeded within 4.7 cm of hill length, respectively. Error ratios between setting planting space and measured average planting space were shown within 6.7%. Therefore the seeder showed good planting performance up to seeding velocity of 0.5 m/s in field tests. And field capacity of the seeder was about 0.28 ha/hour.

• The Korean Journal of Pain
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• 제33권4호
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• pp.305-317
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• 2020

Not all sciatica-like manifestations are of lumbar spine origin. Some of them are caused at points along the extra-spinal course of the sciatic nerve, making diagnosis difficult for the treating physician and delaying adequate treatment. While evaluating a patient with sciatica, straightforward diagnostic conclusions are impossible without first excluding sciatica mimics. Examples of benign extra-spinal sciatica are: piriformis syndrome, walletosis, quadratus lumborum myofascial pain syndrome, cluneal nerve disorder, and osteitis condensans ilii. In some cases, extra-spinal sciatica may have a catastrophic course when the sciatic nerve is involved in cyclical sciatica, or the piriformis muscle in piriformis pyomyositis. In addition to cases of sciatica with clear spinal or extra-spinal origin, some cases can be a product of both origins; the same could be true for pseudo-sciatica or sciatica mimics, we simply don't know how prevalent extra-spinal sciatica is among total sciatica cases. As treatment regimens differ for spinal, extra-spinal sciatica, and sciatica-mimics, their precise diagnosis will help physicians to make a targeted treatment plan. As published works regarding extra-spinal sciatica and sciatica mimics include only a few case reports and case series, and systematic reviews addressing them are hardly feasible at this stage, a scoping review in the field can be an eye-opener for the scientific community to do larger-scale prospective research.

• 한국의류산업학회지
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• 제9권1호
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• pp.6-14
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• 2007

The purpose of this study was to delve into what type of expression mode of fashion design could suit the life style of digital nomads, as the appearance of nomadic life style was concurrent with people's modified way of thinking and sociocultural changes in today's digital society. It's basically meant to define the roles of fashion design, which was discussed as a way of improving the quality of life as a sort of 'culture,' and to suggest some of the right directions for fashion design in the future. The culture of today's digital era is marked by a pursuit of high mobility and high speed, and by nomadic disposition that is built on flexible thinking. The kind of design that lets people carry nomadic things with them and thereby improve their mobility can satisfy their needs for mobility, and body-friendly design that functions as a device of information in itself can meet their needs for mobility as well. The leading example of the latter is a wearable computer, and wearable scientific technology will be taken to another level, thanks to the advance in digital technology. In the future, that will be more accessible to people in general, and subminiature digital equipment will gain popularity in fashion industry as part of textiles and clothing or as an accessory. And specific kinds of design will be widespread, including variable design, multi-functional design and modular design. The first serves as a tool to protect the human body and to facilitate the adaptability of it to the given circumstances, and the second is characterized by a superb physical and psychological protectability. The third lets wearers bring design to completion at their own option, owing to an increase in the number of open-minded people and the development of interactive media. All these types of design could be called a wearer-friendly, human-oriented design that is specifically appropriate for the digital age. Wearers can actively be involved in design process as productive consumers, which is expected to help increase opener practices in fashion design sector.

• Biomolecules & Therapeutics
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• 제15권2호
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• pp.108-117
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• 2007

The aim of the present study was to investigate the effect of glibenclamide, a hypoglycemic sulfonylurea, which selectively blocks ATP-sensitive K$^+$ channels, on secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal glands. The perfusion of glibenclamide (1.0 mM) into an adrenal vein for 90 min produced time-dependently enhanced the CA secretory responses evoked by ACh (5.32 mM), high K$^+$ (a direct membrane depolarizer, 56 mM), DMPP (a selective neuronal nicotinic receptor agonist, 100 ${\mu}$M for 2 min), McN-A-343 (a selective muscarinic M1 receptor agonist, 100 ${\mu}$M for 2 min), Bay-K-8644 (an activator of L-type dihydropyridine Ca$^{2+}$ channels, 10 ${\mu}$M for 4 min) and cyclopiazonic acid (an activator of cytoplasmic Ca$^{2+}$-ATPase, 10 ${\mu}$M for 4 min). In adrenal glands simultaneously preloaded with glibenclamide (1.0 mM) and nicorandil (a selective opener of ATP-sensitive K$^+$ channels, 1.0 mM), the CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were recovered to the considerable extent of the control release in comparison with that of glibenclamide-treatment only. Taken together, the present study demonstrates that glibenclamide enhances the adrenal CA secretion in response to stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization from the isolated perfused rat adrenal glands. It seems that this facilitatory effect of glibenclamide may be mediated by enhancement of both Ca$^{2+}$ influx and the Ca$^{2+}$ release from intracellular store through the blockade of K$_{ATP}$ channels in the rat adrenomedullary chromaffin cells. These results suggest that glibenclamide-sensitive K$_{ATP}$ channels may play a regulatory role in the rat adrenomedullary CA secretion.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.916-916
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• 2005

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.225-225
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• 2005