• The Korean Journal of Physiology
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• v.29 no.1
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• pp.13-27
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• 1995

single $K^{+}$ channels of skeletal muscle from the rat and frog were into planar lipid bilayers and their properties were studied. Fusion was induced by an osmotic gradient. Of the four types of $K^{+}$ channels recorded, the two most frequently observed were a voltage and $Ca^{2+}-activated$ $K^{+}$ channel and a $K^{+}$ channel with a prominent conductance substate. The first $K^{+}$ channel was identified as the large $Ca^{2+}-activated$ $K^{+}$ (BK) channel because the open-state probability was increased with depolarization (e-fold change per $10.6{\pm}3.5$ mV, n=8) and internal $Ca^{2+}$ (half-activation at $16.7{\pm}3.8$ mV, n=8, pCa 4) and its conductance was large ($247{\pm}4.9$ pS, n=24 in 0.1 M KCI). Lifetime distributions of open- and closed-states could be fitted with single exponentials of several milliseconds. The mean open- and closed-lifetimes were linearly dependent on the intracellular $[Ca^{2+}]$ and $1/[Ca^{2+}]$, respectively. The second $K^{+}$ channel showed a conductance substate at $30{\sim}60%$ of the open state. Its current-voltage relation was linear in the range of $-80\;{\sim}\;+80\;mV$. The slope conductance of the substate and open-state were 40 and 144 pS in 0.2 M KCl, respectively. The channel was highly selective for $K^{+}$ over Cl. The open-state probability was weakly voltage-dependent (e-fold change per 35 mV. The lifetime distributions of open- and closed-states were fitted with two exponentials and the major gating occurred slowly at several hundred milliseconds. Based on the above results, we think the second type of $K^{+}$ channel is the sarcoplasmic reticulum $K^{+}$ (SRK) channel. In addition, both types of channel were also incorporated into the lipids extracted from the skeletal muscle. The channel properties recorded in the bilayers termed from synthetic and extracted lipids were qualitatively similar. Our data indicate that BK and SRK channels are rich in the skeletal muscle and their properties and regulation could be effectively studied in planar lipid bilayer.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.9
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• pp.947-955
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• 2002

In this paper, we derive an outage probability for the Erlang capacity and the link margin respectively, calculate them with the same parameters and outage probability, and then analyze a capacity and cell coverage in city, suburban, and open area. So, the Erlang capacity is more real than in a cell, and the cell coverage can be calculated with high reliability by the margin. When the $E_b/N_o$ decreases from 7 dB to 5 dB within the outage probability of 5 %, it is observed that the capacity is increased from 18 Erlang to 31 Erlang with the same margin of 2.8 dB, then the coverage is increased to 0.4 km, 1 km, and 2.5 km in city, suburban, and open area respectively. Also if the outage probability is decreased from 5 % to 2 % in case of $E_b/N_o$ of 5 dB, the result shows a very reliable link with additional increment of 0.88 dB in the margin and a high QoS (quality of service) within decrement of 0.15 km, 0.5 km, and 1.5 km for the same areas with decrement of 3 Erlang from 31 Erlang.

• Tunnel and Underground Space
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• v.34 no.1
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• pp.54-70
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• 2024

Utilization of completed open-pit for mining waste disposal is an alternative method of tailing storage facility (TSF), which can minimize the area and cost required for the installation of TSF. However, long-term tailing disposal into open-pit has a potential risk of reducing mechanical stability of surrounding rock mass by acting as an additional load. In this research, a realistic open-pit tailing disposal scenario of 60,400 hours was established based on the case of Marymia gold mine, Australia. Mechanical stability of surface pillar between open-pit and underground stope was analyzed numerically by using Sigma/W, under different stope geometry and rock mass conditions. Simulation results showed that long-term tailing disposal into open-pit can significantly increase the failure probability of surface piller. This result suggests that mechanical stability of mine geometry should be conducted beforehand of open-pit tailing disposal.

• Journal of Digital Convergence
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• v.10 no.2
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• pp.237-242
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• 2012

This paper proposed image matching technique that find out the truth of the wild ginseng through smart phone when the common person discovered a plant like a wild ginseng. Also sharing a location and information by SNS, we can improve the probability of wild ginseng discovery. Image matching technique using OpenCV porting in android finds out the truth of the wild ginseng with comparing existing it. Thus we are able to compare and analysis them in our application program. For more verification, we added marking function of wild ginseng position for information sharing between users.

• Asia-Pacific Journal of Business
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• v.11 no.3
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• pp.243-260
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• 2020

Purpose - This paper aims to investigate the properties of crude oil based derivative security (DLS) focusing on step-down type for comprehensive understanding of its risk. Design/methodology/approach - Kernel estimation is conducted to figure out statistical feature of the process of oil price. We simulate oil price paths based on kernel estimation results and derive probabilities of hitting the barrier and early redemption. Findings - The amount of issuance for crude oil based DLS is relatively low when base prices are below $40 while it is high when base prices are around $60 or $100, which is not consistent with kernel estimation results showing that oil futures prices tend to revert toward $46.14 and the mean-reverting speed is faster as oil price is lower. The analysis based on simulated oil price paths reveals that probability of early redemption is below 50% for DLS with high base prices and the ratio of the probability of early redemption to the probability of hitting barrier is remarkably low compared to the case for DLS with low base prices, as the chance of early redemption is deferred. Research implications or Originality - Empirical results imply that the level of the base price is a crucial factor of the risk for DLS, thus introducing a time-varying knock-in barrier, which is similar to adjust the base price, merits consideration to enhance protection for DLS investors.

• Journal of Internet Computing and Services
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• v.10 no.3
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• pp.71-83
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• 2009

In this paper, we propose a paging scheme considering local environment and moving patterns of mobile hosts on HMIPv6. The proposed paging scheme can adaptively construct a paging domain according to handoff probability of mobile hosts and local environment, and process a paging based on handoff probability stage by stage. For analysis of the proposed paging scheme, we simulate our scheme in two different experiment environments: an open environment like a square and a restricted environment like downtown. In experiment results, the proposed scheme shows superior performance to that of compared scheme all over. Particularly, in case of high call request rate and a restricted environment, the proposed scheme shows better performance.

• Communications for Statistical Applications and Methods
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• v.25 no.5
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• pp.501-512
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• 2018

We propose Sequential Patient Recruitment Monitoring (SPRM), a new monitoring procedure for patient recruitment in a clinical trial. Based on the sequential probability ratio test using improved stopping boundaries by Woodroofe, the method allows for continuous monitoring of the rate of enrollment. It gives an early warning when the recruitment is unlikely to achieve the target enrollment. The packet data approach combined with the Central Limit Theorem makes the method robust to the distribution of the recruitment entry pattern. A straightforward application of the counting process framework can be used to estimate the probability to achieve the target enrollment under the assumption that the current trend continues. The required extension of the recruitment period can also be derived for a given confidence level. SPRM is a new, continuous patient recruitment monitoring tool that provides an opportunity for corrective action in a timely manner. It is suitable for the modern, centralized data management environment and requires minimal effort to maintain. We illustrate this method using real data from two well-known, multicenter, phase III clinical trials.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.41 no.2
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• pp.117-132
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• 2018

There always exist nonzero inspection errors whether inspectors are humans or automatic inspection machines. Inspection errors can be categorized by two types, type I error and type II error, and they can be regarded as either a constant or a random variable. Under the assumption that two types of random inspection errors are distributed with the "uniform" distribution on a half-open interval starting from zero, it was proved that inspectors overestimate any given fraction defective with the probability more than 50%, if and only if the given fraction defective is smaller than a critical value, which depends upon only the ratio of a type II error over a type I error. In addition, it was also proved that the probability of overestimation approaches one hundred percent as a given fraction defective approaches zero. If these critical phenomena hold true for any error distribution, then it might have great economic impact on commercial inspection plans due to the unfair overestimation and the recent trend of decreasing fraction defectives in industry. In this paper, we deal with the same overestimation problem, but assume a "symmetrical triangular" distribution expecting better results since our triangular distribution is closer to a normal distribution than the uniform distribution. It turns out that the overestimation phenomenon still holds true even for the triangular error distribution.

• Structural Engineering and Mechanics
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• v.42 no.1
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• pp.121-129
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• 2012

All contemporary seismic Codes have adopted smooth design acceleration response spectra, which have derived by statistical analysis of many elastic response spectra of natural accelerograms. The above smooth design spectra are characterized by two main branches, an horizontal branch that is 2.5 times higher than the peak ground acceleration, and a declining parabolic branch. According to Eurocode EN/1998, the period range of the horizontal, flat branch is extended from 0.1 s, for rock soils, up to 0.8 s for softer ones. However, from many natural recorded accelerograms of important earthquakes, the real spectral amplification factor appears to be much higher than 2.5 and this means that the spectrum leads to an unsafe seismic design of the structures. This point is an issue open to question and it is the object of the present study. In the present paper, the spectral amplification factor of the smooth design acceleration spectra is re-calculated on the grounds of a known "reliability index" for a desired probability of exceedance. As a pilot scheme, the seismic area of Greece is chosen, as it is the most seismically hazardous area in Europe. The accelerograms of the 82 most important earthquakes, which have occurred in Greece during the last 38 years, are used. The soil categories are taken into account according to EN/1998. The results that have been concluded from these data are compared with the results obtained from other strong earthquakes reported in the World literature.

• KIEE International Transactions on Power Engineering
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• v.3A no.3
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• pp.124-129
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• 2003

As the power industry moves towards open competition, there has been a call for methodology to evaluate power system reliability by using composite interruption cost. This paper presents algorithms to evaluate the interruption cost of distribution power systems by taking into consideration the failure source and the composite customer interruption cost. From the consumer's standpoint, the composite customer interruption cost is considered as the most valuable index to estimate the reliability of a power distribution system. This paper presents new algorithms that take into account the load by customer type and failure probability by distribution facilities while calculating the amount of unserved energy by customer type. Finally, evaluation results of unserved energy and system interruption cost based on composite customer interruption cost are shown in detail.