• Genomics & Informatics
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• v.19 no.2
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• pp.16.1-16.14
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• 2021

Even in the current age of advanced medicine, the prognosis of malignant peritoneal mesothelioma (MPM) remains abysmal. Molecular mechanisms responsible for the initiation and progression of MPM are still largely not understood. Adopting an integrated bioinformatics approach, this study aims to identify the key genes and pathways responsible for MPM. Genes that are differentially expressed in MPM in comparison with the peritoneum of healthy controls have been identified by analyzing a microarray gene expression dataset. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of these differentially expressed genes (DEG) were conducted to gain a better insight. A protein-protein interaction (PPI) network of the proteins encoded by the DEGs was constructed using STRING and hub genes were detected analyzing this network. Next, the transcription factors and miRNAs that have possible regulatory roles on the hub genes were detected. Finally, survival analyses based on the hub genes were conducted using the GEPIA2 web server. Six hundred six genes were found to be differentially expressed in MPM; 133 are upregulated and 473 are downregulated. Analyzing the STRING generated PPI network, six dense modules and 12 hub genes were identified. Fifteen transcription factors and 10 miRNAs were identified to have the most extensive regulatory functions on the DEGs. Through bioinformatics analyses, this work provides an insight into the potential genes and pathways involved in MPM.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.46 no.3
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• pp.15-23
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• 2009

In ubiquitous environments, invisible devices and software are connected to one another to provide convenient services to users. In this environments, users want to get a variety of customized services by using only an individual mobile device which has limitations such as tiny display screens, limited input, and less powerful processors. Therefore, The device sharing for solving these limitation problems and its efficient processing is one of the new research topics. This paper proposes a device recommender system which searches and recommends devices for composing user requested services. The device recommender system infers devices based on environmental context of a user. However, customized devices for each user are different because of a variety of user preference even if users want to get the same service in the same space, Therefore the paper considers the user preference for device recommendation. Our device recommender system is implemented and tested on the real mobile object developed for device sharing in ubiquitous environments. Therefore we can expect that the system will be adaptable in real device sharing environments.

• Journal of Internet Computing and Services
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• v.17 no.4
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• pp.61-68
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• 2016

In this paper, an implementation method of augmented reality (AR) technology using Web 3.0 information services in the field of disaster response is proposed. The structure and characteristics of semantic web-based Web 3.0 are realized and a AR based mobile visual search (MVS) applied in the disaster sites is described. Based on Web 3.0 and AR MVS, a semantic web ontology oriented configuration scheme for disaster-related information and the communication scheme of information provided by AR technology are proposed. For the purpose of providing disaster-related and customized information to the disaster response site quickly and accurately, a method of leveraging Web 3.0 information services in AR technology is presented.

• Journal of Advanced Navigation Technology
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• v.18 no.3
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• pp.209-214
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• 2014

Current black boxes have a problem of storing unnecessary imagery data recordings without data classification. For this reason, users have to erase videos every time. This method is inadequate for black boxes with limited memory capacity. In this paper, we design and implement a system that recognizes traffic accident situations and saves these recordings by classifying them according to weighted values. The system was made to save video recorded at a 30-sec interval of every event to black box folders by changing names based on weighted value data under the external environment in a 1:10 scale model car. Based on this, when the tests were performed as a major car accident while driving, the videos were created in w2 folder, and when the tests were performed as a minor car accident while stopped, the videos were created in w1 folder.

• Journal of Digital Contents Society
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• v.19 no.9
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• pp.1795-1801
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• 2018

Genome-Wide Association Study (GWAS) have been used to identify susceptibility genes for complex human diseases and many recent studies succeed to report common genetic factors for various diseases. Unfortunately, it is hard to understand all biological functions and mechanisms around the complex disease with GWAS only although the number of known associated genes with diseases is increased drastically because GWAS is a single locus based approach while not a gene but numerous factors may affect a disease associated pathways. PRaDA generates a combined report with genes, pathways and Gene Ontology (GO) using single nucleotide polymorphism (SNP) analysis output. The PRaDA reports not only directly associated pathways but also functionally related ones for identifying accumulated effects of low p-value SNPs. Through integrated information including indirect functional effects, user could have insights of overall disease mechanisms and markers.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.6
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• pp.2049-2068
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• 2021

AI combined with NLP techniques has promoted the use of Virtual Assistants and have made people rely on them for many diverse uses. Conversational Agents are the most promising technique that assists computer users through their operation. An important challenge in developing Conversational Agents globally is transferring the groundbreaking expertise obtained in English to other languages. AI is making it possible to transfer this learning. There is a dire need to develop systems that understand secular languages. One such difficult language is Hindi, which is the fourth most spoken language in the world. Semantic similarity is an important part of Natural Language Processing, which involves applications such as ontology learning and information extraction, for developing conversational agents. Most of the research is concentrated on English and other European languages. This paper presents a Corpus-based word semantic similarity measure for Hindi. An experiment involving the translation of the English benchmark dataset to Hindi is performed, investigating the incorporation of the corpus, with human and machine similarity ratings. A significant correlation to the human intuition and the algorithm ratings has been calculated for analyzing the accuracy of the proposed similarity measures. The method can be adapted in various applications of word semantic similarity or module for any other language.

• Korean Journal of Cognitive Science
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• v.21 no.1
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• pp.95-126
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• 2010

This study proposes a bottom-up and inductive manual mapping methodology for integrating two heterogenous fine-grained ontologies which were built by a top-down and deductive methodology, namely the Sejong semantic classes (SJSC) and the upper nodes in KorLexNoun 1.5 (KLN), for HLP applications. It also discusses various problematics in the mapping processes of two language resources caused by their heterogeneity and proposes the solutions. The mapping methodology of heterogeneous fine-grained ontologies uses terminal nodes of SJSC and Least Upper Bounds (LUB) of KLN as basic mapping units. Mapping procedures are as follows: first, the mapping candidate groups are decided by the lexfollocorrelation between the synsets of KLN and the noun senses of Sejong Noun Dfotionaeci(SJND) which are classified according to SJSC. Secondly, the meanings of the candidate groups are precisely disambiguated by linguistic information provided by the two ontologies, i.e. the hierarchicllostructures, the definitions, and the exae les. Thirdly, the level of LUB is determined by applying the appropriate predicates and definitions of SJSC to the upper-lower and sister nodes of the candidate LUB. Fourthly, the mapping possibility ic inthe terminal node of SJSC is judged by che aring hierarchicllorelations of the two ontologies. Finally, the ituorrect synsets of KLN and terminologiollocandidate groups are excluded in the mapping. This study positively uses various language information described in each ontology for establishing the mapping criteria, and it is indeed the advantage of the fine-grained manual mapping. The result using the proposed methodology shows that 6,487 LUBs are mapped with 474 terminal and non-terminal nodes of SJSC, excluding the multiple mapped nodes, and that 88,255 nodes of KLN are mapped including all lower-level nodes of the mapped LUBs. The total mapping coverage is 97.91% of KLN synsets. This result can be applied in many elaborate syntactic and semantic analyses for Korean language processing.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5518-5524
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• 2012

The world today, has come to an age of diverse paradigms and technologies being developed, and technology of a new field is realized by merging technologies of different fields.One of such, u-Health system refers to a system which can monitor its users, regardless of time and place, using many body sensor datas based on USN (Ubiquitous Sensor Network). In the past, this kind of u-Health system was able to collect sensor datas through wires and could be monitored only by using PC (Personal Computer), but with development in technology, the system is now becoming possible to collect sensor datas wireless and monitor unhindered by time and place. This research aims to collect sensor datas of the user, and through Jena inference network, provide web service and smartphone application which enables checking of user's body datas in times of emergency, whenever, wherever.

• Journal of the Korea Society of Computer and Information
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• v.20 no.3
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• pp.29-45
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• 2015

This paper proposes an implementation of SPARQL-DL, which is a query language for OWL ontologies, for query-answering over the OWL ontologies virtually generated from existing RDBs. The proposed SPARQL-DL processor internally translates input SPARQL-DL queries into SQL queries and then executes the translated queries. There are two advantages in the query processing method. First, another repository to store OWL ontologies generated from RDBs is not required. Second, a large ABox generated from an RDB instance is able to be served without using Tableau algorithm based reasoners which have a problem in large ABox reasoning. Our algorithm for query rewriting is designed to create one corresponding SQL query from one input SPARQL-DL query to minimize the overhead by establishing connections with RDBs.

• Journal of Microbiology and Biotechnology
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• v.18 no.6
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• pp.1059-1063
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• 2008

Abnormal phenotypes resulting from haploinsufficiency (HI) are due to the loss of one allele. Recent studies in budding yeast have shown that HI originates from insufficient protein levels or from a stoichiometric imbalance between subunits of protein complexes. In humans, however, HI often involves transcription factors. Therefore, the species differences in HI and the molecular mechanisms of species-specific HI remain under investigation. In this study, HI in fission yeast was systematically surveyed. HI in fission yeast affected genes related to signaling and to basic cellular processes, as observed in budding yeast. These results suggest that there are species differences in HI and that the HI that occurs in fission yeast is intermediate to HI in budding yeast and humans.