Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Genome-Wide Identification of Haploinsufficiency in Fission Yeast

  • Baek, Seung-Tae (Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Han, Sang-Jo (Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Nam, Mi-Young (Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Kim, Young-Dae (Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Kim, Li-La (Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Lee, Hyun-Jee (Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Heo, Kyung-Sun (Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Lee, Hye-Mi (Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Lee, Min-Ho (Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Park, Song-Kyu (Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Maeng, Pil-Jae (Department of Microbiology, School of Biological Science and Biotechnology, Chungnam National University) ;
  • Park, Young-Woo (Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Lee, Sung-Hou (Department of Biotechnology and Informatics, Sangmyung University)
  • Published : 2008.06.30
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Abstract

Abnormal phenotypes resulting from haploinsufficiency (HI) are due to the loss of one allele. Recent studies in budding yeast have shown that HI originates from insufficient protein levels or from a stoichiometric imbalance between subunits of protein complexes. In humans, however, HI often involves transcription factors. Therefore, the species differences in HI and the molecular mechanisms of species-specific HI remain under investigation. In this study, HI in fission yeast was systematically surveyed. HI in fission yeast affected genes related to signaling and to basic cellular processes, as observed in budding yeast. These results suggest that there are species differences in HI and that the HI that occurs in fission yeast is intermediate to HI in budding yeast and humans.

Keywords

References

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