• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 1997년도 추계학술발표회논문집(1)
• /
• pp.463-468
• /
• 1997

This paper presents a theoretical approach of the instability criterion from stratified to nonstratified flow in horizontal pipe at cocurrent flow conditions. The new theoretical instability criterion for the stratified and nonstratified flow transition in horizontal pipe has been developed by hyperbolic equations in two-phase flow, Critical flow condition criterion and onset of slugging at cocurrent flow condition correspond to zero and imaginary characteristics which occur when the hyperbolicity of a stratified two-phase flow is broken, respectively. Through comparison between results predicted by the present theory and the Kukita et al.[1] experimental data of pipes, it is shown that they are in good agreement with data.

• 한국유체기계학회 논문집
• /
• 제2권1호
• /
• pp.103-107
• /
• 1999

Transient flow inside a hollow shaft of a Gas Turbine engine during sudden engine stop may result in non uniform heat transfer coefficients in the shaft due to flow instability similar to steady Taylor vortex, which may decrease the lifetime of the shaft. In the present study, transient Taylor vortex phenomena inside a suddenly stopped hollow shaft are studied analytically. Flow visualization is also performed to study the shape and onset time of Taylor Vortices for various initial rotational speed.

• Korean Chemical Engineering Research
• /
• 제59권4호
• /
• pp.626-631
• /
• 2021

전기투석장치, 전기화학 전지, 미세유체역학 분석 장치 등에서 사용하는 이온 교환 막 근처의 대표적인 비선형 전기동역학 현상은 전기와류 불안정성이다. 전기투석 장치에서 전기와류 불안정성은 물질 전달 속도 증폭을 통해 물질 전달에 대한 이점을 제공한다. 그러나 전기화학 전지나 미세유체역학 장치에서 발생하는 불안정성은 원치 않는 물질 전달 기작을 유발시킨다. 본 연구에서는 전기와류 불안정성의 제어하기 위해, 인가 전압과 공간 제약 효과의 전기와류 불안정성에 대한 영향을 연구하였다. 그 결과, 인가 전압과 공간 제약의 정도에 따라 불안정성의 동역학이 안정 영역 - 고정 영역 - 혼돈 영역 순으로 전이됨을 밝혀내었다. 더불어, 동역학 전이에 대한 안정성 곡선을 수치적으로 결정하였다. 결론적으로, 공간 제약 효과는 전기동역학적 혼돈을 제어할 수 있는 효과적인 기작으로 활용 가능할 것이다.

• Korean Chemical Engineering Research
• /
• 제59권1호
• /
• pp.138-151
• /
• 2021

The effect of a reactant ratio on the growth of a buoyancy-driven instability in an irreversible A+B→C reaction system is analyzed theoretically and numerically. Taking a non-stoichiometric reactant ratio into account, new linear stability equations are derived without the quasi-steady state assumption (QSSA) and solved analytically. It is found that the main parameters to explain the present system are the Damköhler number, the dimensionless density difference of chemical species and the ratio of reactants. The present initial grow rate analysis without QSSA shows that the system is initially unconditionally stable regardless of the parameter values; however, the previous initial growth rate analysis based on the QSSA predicted the system is unstable if the system is physically unstable. For time evolving cases, the present growth rates obtained from the spectral analysis and pseudo-spectral method support each other, but quite differently from that obtained under the conventional QSSA. Adopting the result of the linear stability analysis as an initial condition, fully nonlinear direct numerical simulations are conducted. Both the linear analysis and the nonlinear simulation show that the reactant ratio plays an important role in the onset and the growth of the instability motion.

• Journal of Gastric Cancer
• /
• 제3권1호
• /
• pp.50-55
• /
• 2003

Background: An aberrant function of the mismatch repair system has been reported to underlie carcinogenesis in several tumors, including colorectal and gastric carcinomas, and to induce the typical genotype of microsatellite instability (MSI). Purpose: We aimed to determine the frequency of MSI in early-onset sporadic gastric carcinoma and elucidate the role of promoter methylation in hMLH1 as the mechanism of MSI. Materials and Methods: Thirty-six early-onset sporadic gastric carcinomas were analyzed to determine the status of MSI and the frequency of methylation of the promoter region in hMLH1. MSI was determined using five markers recommended by NCI: MSI-H (high), MSI-L (low), and MSS (Microsatellite stable). Methylation specific PCR (MSP) and direct automated genomic sequencing analysis with DNA modified by sodium bisulfite have been performed to confirm promoter region methylation. All the data were analyzed regarding characteristics of molecular changes, and clinicopathologic variables. Results: The microsatellite status was determined as MSI-H in five cases ($13.8\%$), MSI-L in 13 cases ($36.1\%$), and MSS in 18 cases ($50.0\%$). hMLH1 was methylated in seven cases ($19.4\%$). In all cases of MSI-H, promoter of hMLH1 was methylated, and in two of the 13 cases of MSI-L, hMLH1 promoter methylation was identified. Methylation was not found in any cases of MSS. Promoter methylation in hMLH1 was significantly correlated with MSI status (P<0.001). We could not find any relationship between MSI and clinicopathologic parameters. Conclusion: These results suggest that an abnormal function of the mismatch repair system may be associated with gastric carcinogenesis in more than $10\%$ of early-onset gastric carcinomas and MSI appeared to be closely related to the promoter methylation in hMLH1.

• 대한기계학회논문집
• /
• 제15권6호
• /
• pp.1948-1966
• /
• 1991

본 연구에서는 2상 횡유동을 받는 튜브군의 진동 메카니즘을 규명하기 위한 실험계획의 일환으로 실시된 실험으로부터 튜브군의 유체탄성 불안정성 상수에 관해 고찰하였다. 실험은 먼저 p/d=1.47 및 1.32 튜브군에 대해 수행되었는데, 이들 튜브 군의 결과는 참고문헌에 발표하였다. 본 논문은 후속 실험으로 수행된 p/d=1.22인 튜브군을 사용하여 유체탄성 불안정성 상수를 고찰한 참고문헌의 후속논문이다. 실 험은 액체상태로 부터 99% 보이드율(void fraction)까지 변화된 2상 유동에서 튜브가 유체탄성 불안정성 상태에 도달할 때까지 점진적으로 증가하였다.실험결과는 p/d= 1.32 alc 1.47 튜브군의 유체탄성 불안정성 결과들과 종합. 비교되었다.

• Structural Engineering and Mechanics
• /
• 제82권4호
• /
• pp.517-542
• /
• 2022

The effect of mean angle of wind attack on the flutter critical wind speed of two generic bridge deck cross-sections, viz, one closed box type streamlined section (deck-1) and closed box trapezoidal bluff type section with extended flanges/overhangs (deck-2) type of section have been studied using Computational Fluid Dynamics (CFD) based forced vibration simulation method. Owing to the importance of the effect of the amplitude of forcing oscillation on the flutter onset, its effect on the flutter derivatives and flutter onset have been studied, especially at non-zero mean angles of wind attack. The flutter derivatives obtained have been used to evaluate flutter critical wind speeds and flutter index of the deck sections at non-zero mean angles of wind attack studied and the same have been validated with those based on experimental results reported in literature. The value of amplitude of forcing oscillation in torsional degree of freedom for CFD based simulations is suggested to be in the range of 0.5° to 2°, especially for bluff bridge deck sections. Early onset of flutter from numerical simulations, thereby conservative estimate of occurrence of instability has been observed from numerical simulations in case of bluff bridge deck section. The study aids in gaining confidence and the extent of applicability of CFD during early stages of bridge design, especially towards carrying out studies on mean incident wind effects.

• 보험의학회지
• /
• 제27권2호
• /
• pp.107-111
• /
• 2008

The Cervical spondylotic myelopathy (CSM) is degenerative compressive myelopathy which initiation of symptoms seems to be induced by minor cervical trauma or spontaneous event. There was a case of Claim medical examination which was requested to discriminate the cause of ambulatory quadriparesis. Patient asserted that the onset of his myelopathy was followed by minor trauma. The author considered the medical recordings, MRI scan, Claim reports by claim manager. The space available for cord was the smallest at C3-4 level. But on MRI findings, the spinal cord at C3-4 level seemed to be already damaged. There were no recent injury evidences such as hemorrhages, spinal cord contusions, edema, soft tissue hemorrhages. If the space available for cord was small enough to compress the spinal cord, the serious neurologic deficits, non-ambulatory quadriplegia, etc were commonly induced by cervical extension trauma. Patient's asserts did not correspond to his clinical course after cervical trauma. The author reports a case of medical examination for the relationship between symptom onset of cervical spondylotic myelopathy and minor trauma within author's experience.

• 대한기계학회논문집
• /
• 제9권5호
• /
• pp.613-620
• /
• 1985

본 연구의 목적은 수평 Blasius유동의 열적 불안정성 문제에서 유동방향 좌표 에도 의존하는 교란양을 최초로 도입함으로써 보다 합리적인 안정성 해석을 수행하고 그 결과를 기존의 실험적 및 이론적인 자료들과 비교하며 이를 토대로 한 보다 실제적 인 열전달 상관관계를 얻고자 하는데 있다.

• Nuclear Engineering and Technology
• /
• 제54권8호
• /
• pp.3140-3153
• /
• 2022

A numerical feasibility study was conducted to investigate the thermal-hydraulic characteristics of a steam generator with corrugated plates for a small modular reactor. Accordingly, a one-dimensional thermal-hydraulic analysis code was developed based on the existing state-of-the-art thermal-hydraulic models and correlations for corrugated plate heat exchangers. Subsequently, the pressure loss, heat transfer, and instability characteristics of the steam generator with corrugated plates were investigated according to the chevron angle and mass flux. Additionally, the characteristics of rectangular and disk-type corrugated plate steam generators with equivalent heat transfer areas were analyzed. The steam generator with disk-type corrugated plates exhibited better performance in terms of pressure loss and heat transfer rate than the rectangular type. In addition, when the mass flux decreased from the onset of boiling points, reverse gradients of the total pressure change were observed in both types. Thus, it was confirmed that Ledinegg instability could occur in the steam generator with corrugated plates. However, it was dependent on the chevron angle, and the optimal chevron angle to minimize instability was 45° under the conditions of the present analysis.