• Title/Summary/Keyword: One-pot synthesis

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One-Pot Homo- and Cross-Coupling Reactions of Arenediazonium Tosylate Salts for the Synthesis of Biaryls and Polyaryls

  • Vajpayee, Vaishali;Song, Young-Ho;Ahn, Jeong-Soo;Chi, Ki-Whan
    • Bulletin of the Korean Chemical Society
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    • v.32 no.spc8
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    • pp.2970-2972
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    • 2011
  • One-pot homo- and cross-coupling reactions of arenediazonium tosylate salts bearing a halogen group have been exploited for the synthesis of biaryls and polyaryls under mild conditions. $Pd(OAc)_2$ has proven to be an efficient catalyst for the successful dual transformation of diazonium salts into p-quaterphenyl (3).

One-pot Synthesis of Multifunctional Mn3O4/mesoporous Silica Core/shell Nanoparticles for Biomedical Applications

  • Lee, Dong Jun;Lee, Nohyun;Lee, Ji Eun
    • Applied Chemistry for Engineering
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    • v.33 no.1
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    • pp.113-118
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    • 2022
  • Multifunctional nanomaterials based on mesoporous silica nanoparticles (MSN) and metal oxide nanocrystals are among the most promising materials for theragnosis because of their ease of modification and high biocompatibility. However, the preparation of multifunctional nanoparticles requires time-consuming multistep processes. Herein, we report a simple one-pot synthesis of multifunctional Mn3O4/mesoporous silica core/shell nanoparticles (Mn3O4@mSiO2) involving the temporal separation of core formation and shell growth. This simple procedure greatly reduces the time and effort required to prepare multifunctional nanoparticles. Despite the simplicity of the process, the properties of nanoparticles are not markedly different from those of core/shell nanoparticles synthesized by a previously reported multistep process. The Mn3O4@mSiO2 nanoparticles are biocompatible and have potential for use in optical imaging and magnetic resonance imaging.

Improved One-pot Regioselective Synthesis of 3,7-Diarylpyrazolo[1,5-α]pyrimidines and Their CB1R Activity (3,7-Diarylpyrazolo[1,5-α]pyrimidines의 개선된 One-pot Regioselective 합성과 CB1R 활성)

  • Hong, Yong Deog;Byoun, Kyoung Hee;Park, Miyoung;Park, Jun Seong;Shin, Song Seok
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.41 no.2
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    • pp.143-150
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    • 2015
  • This study demonstrates an effective one-pot regioselective synthesis of 3,7-diarylpyrazolo [1,5-${\alpha}$]pyrimidines. Moreover, the derivatives obtained were effective CB1R antagonists. These pyrazolo [1,5-${\alpha}$]pyrimidines with diaryl groups at the 3,7-positions are potential pharmacophores for CB1R candidates.

Facile One-Pot Synthesis of PABA from MFB (MFB를 이용한 PABA One-Pot 합성법)

  • Kim, Kyung-Duck;Ryu, Young;Kim, Seok-Chan
    • Applied Chemistry for Engineering
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    • v.25 no.3
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    • pp.337-339
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    • 2014
  • A facile one-pot synthesis of p-aminobenzoic acid from methyl 4-formylbenzoate which is a main by product in dimethyl terephthalate production process has been developed. This process involves the formation of amide intermediate obtained from the reaction of an aldehyde in methyl 4-formylbenzoate with chlorine in methylene chloride and the subsequent treatment of acid chloride with ammonia. The resulting amide was converted into amine using Hofmann degradation to afford a p-aminobenzoic acid. This facile one-pot process does not involve any expensive materials and should offer an attractive alternative to p-aminobenzoic acid production.

Efficient One-Pot Synthesis of Acridinediones by Indium(III) Triflate-Catalyzed Reactions of β-Enaminones, Aldehydes, and Cyclic 1,3-Dicarbonyls

  • To, Quang Huy;Lee, Yong-Rok;Kim, Sung-Hong
    • Bulletin of the Korean Chemical Society
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    • v.33 no.4
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    • pp.1170-1176
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    • 2012
  • An efficient one-pot synthesis of acridinediones by $In(OTf)_3$-catalyzed reactions was developed starting from ${\beta}$-enaminones, aldehydes, and cyclic 1,3-diketones. The key strategies of these reactions involve domino Knoevenagel condensation/Michael addition/cyclodehydration reaction.

Easy-to-execute 'One-pot' Synthesis of 1,2,4,5-Tetrazines Catalyzed by Activated Fly Ash (활성화된 비산회 촉매를 이용하여 간단히 수행된 1,2,4,5-Tetrazines의 One-pot 합성)

  • Gopalakrishnan, M.;Thanusu, J.;Kanagarajan, V.
    • Journal of the Korean Chemical Society
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    • v.51 no.6
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    • pp.520-525
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    • 2007
  • Three-component coupling of thiourea/urea, various structurally diverse aromatic aldehydes and ammonium acetate is catalyzed by activated fly ash in dry media under microwave irradiation to give 6-aryl-1,2,4,5-tetrazinan- 3-thiones/ones in good yields. The structure of 6-aryl-1,2,4,5-tetrazinan-3-thiones/ones have been elucidated on the basis of their melting points, elemental analysis, MS, IR, 1H NMR, D2O exchange, 13C NMR and two dimensional NMR spectral studies including Homonuclear Correlation (HOMOCOR) and Heteronuclear Single Quantum Correlation (HSQC) spectra.

One-Pot Multicomponent Synthetic Route for New Quinolidinyl 2,4-Thiazolidinediones

  • Mali, Jyotirling R.;Bhosle, Manisha R.;Mahalle, Shital R.;Mane, Ramrao A.
    • Bulletin of the Korean Chemical Society
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    • v.31 no.7
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    • pp.1859-1862
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    • 2010
  • A convenient one-pot condensation route has been developed for obtaining 5-[(2-(piperidin-1-yl) quinolin-3-yl) methylene]-2,4-thiazolidinediones using multicomponents, 2-chloro-3-formyl quinolines, piperidine, 2,4-thiazolidinedione and safer medium/mediator, polyethylene glycol-400.

One-pot Synthesis of Hydrous MnO2 Nanowires for Selective Oxidative Transformation of Furfuryl Alcohol (Furfuryl 알코올의 선택적 산화 전환에 대한 수화 이산화망간 나노와이어의 One-pot 합성)

  • Mobina, Irshad;Choi, Bong Gill;Kim, Jung Won
    • Applied Chemistry for Engineering
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    • v.30 no.1
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    • pp.49-53
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    • 2019
  • Hydrous $MnO_2$ nanowires were easily synthesized by an one-pot synthesis with a simple hydrothermal method. As prepared hydrous $MnO_2$ nanowires were characterized with scanning emission microscopy (SEM), transmit emission microscopy (TEM), X-ray diffraction (XRD), and Brunauer-Emmett-Teller (BET). They showed a good catalytic activity with the suitable nano-size of 4-5 nm and morphology. The furfuryl alcohol was selected as a substrate and the reaction was carried out in a toluene solvent at $100^{\circ}C$ under the atmospheric pressure of oxygen. The hydrous $MnO_2$ nanowire catalyst exhibited an excellent yield of furfural with the first-rate selectivity and conversion. The catalytic performance during recycle tests was also carried out and the catalyst showed a good mechanical strength with a negligible loss in the activity over five reaction cycles.