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http://dx.doi.org/10.14478/ace.2021.1108

One-pot Synthesis of Multifunctional Mn3O4/mesoporous Silica Core/shell Nanoparticles for Biomedical Applications  

Lee, Dong Jun (School of Chemical and Biological Engineering, Seoul National University)
Lee, Nohyun (School of Advanced Materials Engineering, Kookmin University)
Lee, Ji Eun (School of Chemical Engineering, Chonnam National University)
Publication Information
Applied Chemistry for Engineering / v.33, no.1, 2022 , pp. 113-118 More about this Journal
Abstract
Multifunctional nanomaterials based on mesoporous silica nanoparticles (MSN) and metal oxide nanocrystals are among the most promising materials for theragnosis because of their ease of modification and high biocompatibility. However, the preparation of multifunctional nanoparticles requires time-consuming multistep processes. Herein, we report a simple one-pot synthesis of multifunctional Mn3O4/mesoporous silica core/shell nanoparticles (Mn3O4@mSiO2) involving the temporal separation of core formation and shell growth. This simple procedure greatly reduces the time and effort required to prepare multifunctional nanoparticles. Despite the simplicity of the process, the properties of nanoparticles are not markedly different from those of core/shell nanoparticles synthesized by a previously reported multistep process. The Mn3O4@mSiO2 nanoparticles are biocompatible and have potential for use in optical imaging and magnetic resonance imaging.
Keywords
One-pot synthesis; Mesoporous silica; MRI contrast agent;
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