• Title/Summary/Keyword: One-pot 합성

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A Green Chemical Approach towards the 'One-Pot' Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino Pyrimidines (친환경적 One Pot 합성, In Vitro에서 Morpholino Pyrimidines의 분광학적 특성과 항균성 및 항진균성)

  • Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.
    • Journal of the Korean Chemical Society
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    • v.53 no.6
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    • pp.731-741
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    • 2009
  • ‘One-pot’ reaction procedure for the synthesis of novel morpholino pyrimidines (10-18) under microwave irradiation in ‘dry media’ in the presence of heterogeneous $NaHSO_4.SiO_2$ catalyst was developed. All the synthesized compounds were screened for their in vitro antibacterial activities against clinically isolated bacterial strains namely Bacillus subtilis, Bacillus cerues, Micrococcus luteus and Salmonella typhii and antifungal activities against fungal strains namely Aspergillus niger, Candida 6 and Candida 51. Structure activity relationship of the synthesized compounds against microbiological results was discussed.

A Facile Entry for One-pot Synthesis of 5,7-Diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles (5,7-Diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino [3,4-d]-1,2,3-selenadiazoles의 손쉬운 One-pot 합성)

  • Gopalakrishnan, M.;Thanusu, J.;Kanagarajan, V.
    • Journal of the Korean Chemical Society
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    • v.52 no.1
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    • pp.47-51
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    • 2008
  • A simple synthetic strategy is described for one-pot synthesis of 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles (11-15) in the presence of NaHSO4.SiO2 as a heterogeneous catalyst in dry media under microwave irradiation.Key words: One-pot synthesis, 3,3-Dimethyl-2,6-diarylpiperidin-4-one; 1,2,3-Selenadiazoles; Selenium dioxide; NaHSO4.SiO2 Heterogeneous catalyst.

An Efficient One-Pot Strategies for the Synthesis of [1,3] Oxazine Derivatives ([1,3] Oxazine 유도체 합성을 위한 효율적인 One-Pot 합성)

  • Sapkal, Suryakant B.;Shelke, Kiran F.;Shingate, Bapurao B.;Shingare, Murlidhar S.
    • Journal of the Korean Chemical Society
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    • v.54 no.4
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    • pp.437-442
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    • 2010
  • Sodium hydrogen sulphate ($NaHSO_4$), n-tetra butyl ammonium bromide (TBAB) as a phase transfer catalyst (PTC) in water, and 1-butyl-3-methyl imidazolium hydrogen sulphate [bmim]$HSO_4$ as ionic liquid (IL) has been used as a mild reaction promoter for the cyclocondensation of formalin, ${\beta}$-naphthol and aromatic amines to afford respective 2,3-dihydro-2-phenyl-1H-naphtho-[1,2-e] [1,3] oxazine derivatives. The present protocols are greener, high yielding and involved the nonchromatographic isolation procedure.

Sulphanilic Acid Catalyzed Facile One-pot Synthesis of 2,4,5-Triarylimidazoles From Benzil/Benzoin and Aromatic Aldehydes (Sulphanilic Acid촉매하에서 벤질/벤조인과 방향족 알데히드로부터 2,4,5-Triarylimidazoles의 간편한 One-pot 합성)

  • Mohammed, A.F.;kokare, N.D.;Sangshetti, J.N.;Shinde, D.B.
    • Journal of the Korean Chemical Society
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    • v.51 no.5
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    • pp.418-422
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    • 2007
  • A simple and high yielding one-pot method for synthesis of 2,4,5-triarylimidazoles from condensation of benzoin or benzil, ammonium acetate and aromatic aldehydes using sulphanilic acid catalyst is described. The lower priced catalyst, higher yields and shorter reaction time are the advantages of the presented method.

Facile One-Pot Synthesis of PABA from MFB (MFB를 이용한 PABA One-Pot 합성법)

  • Kim, Kyung-Duck;Ryu, Young;Kim, Seok-Chan
    • Applied Chemistry for Engineering
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    • v.25 no.3
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    • pp.337-339
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    • 2014
  • A facile one-pot synthesis of p-aminobenzoic acid from methyl 4-formylbenzoate which is a main by product in dimethyl terephthalate production process has been developed. This process involves the formation of amide intermediate obtained from the reaction of an aldehyde in methyl 4-formylbenzoate with chlorine in methylene chloride and the subsequent treatment of acid chloride with ammonia. The resulting amide was converted into amine using Hofmann degradation to afford a p-aminobenzoic acid. This facile one-pot process does not involve any expensive materials and should offer an attractive alternative to p-aminobenzoic acid production.

One-pot Synthesis of 5,7-Diaryl-3,4,6-trihydronaphthalen-2-ones (5,7-Diaryl-3,4,6-trihydronaphthalen-2-ones의 One-pot 합성)

  • Gopalakrishnan, M.;Manikandan, H.;Sureshkumar, P.;Thanusu, J.;Kanagarajan, V.
    • Journal of the Korean Chemical Society
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    • v.51 no.4
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    • pp.356-360
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    • 2007
  • 5,7-Diaryl-3,4,6-trihydronaphthalen-2-ones have been synthesized from 3,5-diaryl-cyclohex-2-en-1- ones and methyl vinyl ketone in the presence of sodium ethoxide. The products were characterized by IR, UV-Visible, 1H-NMR, 13C-NMR and mass spectral techniques. To confirm 1H and 13C signals, HSQC spectrum was recorded and analyzed.

Easy-to-execute 'One-pot' Synthesis of 1,2,4,5-Tetrazines Catalyzed by Activated Fly Ash (활성화된 비산회 촉매를 이용하여 간단히 수행된 1,2,4,5-Tetrazines의 One-pot 합성)

  • Gopalakrishnan, M.;Thanusu, J.;Kanagarajan, V.
    • Journal of the Korean Chemical Society
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    • v.51 no.6
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    • pp.520-525
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    • 2007
  • Three-component coupling of thiourea/urea, various structurally diverse aromatic aldehydes and ammonium acetate is catalyzed by activated fly ash in dry media under microwave irradiation to give 6-aryl-1,2,4,5-tetrazinan- 3-thiones/ones in good yields. The structure of 6-aryl-1,2,4,5-tetrazinan-3-thiones/ones have been elucidated on the basis of their melting points, elemental analysis, MS, IR, 1H NMR, D2O exchange, 13C NMR and two dimensional NMR spectral studies including Homonuclear Correlation (HOMOCOR) and Heteronuclear Single Quantum Correlation (HSQC) spectra.

Preparation of Natural Chemicals Intercalated Aminoclay via One-pot Synthesis and its Antimicrobial Property (One-pot 합성을 통해 천연 화합물이 삽입된 아미노클레이 제조 및 항균성 연구)

  • Kim, Seong Yeol;Choi, Yoo-Sung
    • Applied Chemistry for Engineering
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    • v.28 no.5
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    • pp.495-500
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    • 2017
  • In this study, we synthesized the aminoclay (AC) with magnesium ions and 3-aminopropyl triethoxysilane (APTES). At the same time, propolis intercalated aminoclay (PIAC) and coptis extract intercalated aminoclay (CIAC) were synthesized by intercalating natural chemicals between clay sheets. Clay synthesis and natural chemical intercalation were confirmed through SEM, particle size analyze, FT-IR, TGA and XRD. In particular, the characterization of intercalation of natural chemicals was determined by analyzing the interlayer distance from XRD data. The antimicrobial property of PIAC and CIAC was checked by minimum inhibitory concentration (MIC) test and increased compared with that of the pristine aminoclay (AC).

One-pot Synthesis of Hydrous MnO2 Nanowires for Selective Oxidative Transformation of Furfuryl Alcohol (Furfuryl 알코올의 선택적 산화 전환에 대한 수화 이산화망간 나노와이어의 One-pot 합성)

  • Mobina, Irshad;Choi, Bong Gill;Kim, Jung Won
    • Applied Chemistry for Engineering
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    • v.30 no.1
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    • pp.49-53
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    • 2019
  • Hydrous $MnO_2$ nanowires were easily synthesized by an one-pot synthesis with a simple hydrothermal method. As prepared hydrous $MnO_2$ nanowires were characterized with scanning emission microscopy (SEM), transmit emission microscopy (TEM), X-ray diffraction (XRD), and Brunauer-Emmett-Teller (BET). They showed a good catalytic activity with the suitable nano-size of 4-5 nm and morphology. The furfuryl alcohol was selected as a substrate and the reaction was carried out in a toluene solvent at $100^{\circ}C$ under the atmospheric pressure of oxygen. The hydrous $MnO_2$ nanowire catalyst exhibited an excellent yield of furfural with the first-rate selectivity and conversion. The catalytic performance during recycle tests was also carried out and the catalyst showed a good mechanical strength with a negligible loss in the activity over five reaction cycles.