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http://dx.doi.org/10.5012/jkcs.2009.53.6.731

A Green Chemical Approach towards the 'One-Pot' Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino Pyrimidines  

Kanagarajan, V. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University)
Thanusu, J. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University)
Gopalakrishnan, M. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University)
Publication Information
Journal of the Korean Chemical Society / v.53, no.6, 2009 , pp. 731-741 More about this Journal
Abstract
‘One-pot’ reaction procedure for the synthesis of novel morpholino pyrimidines (10-18) under microwave irradiation in ‘dry media’ in the presence of heterogeneous $NaHSO_4.SiO_2$ catalyst was developed. All the synthesized compounds were screened for their in vitro antibacterial activities against clinically isolated bacterial strains namely Bacillus subtilis, Bacillus cerues, Micrococcus luteus and Salmonella typhii and antifungal activities against fungal strains namely Aspergillus niger, Candida 6 and Candida 51. Structure activity relationship of the synthesized compounds against microbiological results was discussed.
Keywords
‘One-pot’ synthesis; (E)-1-(4-morpholinophenyl)-3-aryl-prop-2-en-1-ones; Morpholino pyrimidines; Antibacterial activities; Antifungal activities;
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