• Title/Summary/Keyword: One-pot

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A Facile Entry for One-pot Synthesis of 5,7-Diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles (5,7-Diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino [3,4-d]-1,2,3-selenadiazoles의 손쉬운 One-pot 합성)

  • Gopalakrishnan, M.;Thanusu, J.;Kanagarajan, V.
    • Journal of the Korean Chemical Society
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    • v.52 no.1
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    • pp.47-51
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    • 2008
  • A simple synthetic strategy is described for one-pot synthesis of 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles (11-15) in the presence of NaHSO4.SiO2 as a heterogeneous catalyst in dry media under microwave irradiation.Key words: One-pot synthesis, 3,3-Dimethyl-2,6-diarylpiperidin-4-one; 1,2,3-Selenadiazoles; Selenium dioxide; NaHSO4.SiO2 Heterogeneous catalyst.

A Green Chemical Approach towards the 'One-Pot' Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino Pyrimidines (친환경적 One Pot 합성, In Vitro에서 Morpholino Pyrimidines의 분광학적 특성과 항균성 및 항진균성)

  • Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.
    • Journal of the Korean Chemical Society
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    • v.53 no.6
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    • pp.731-741
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    • 2009
  • ‘One-pot’ reaction procedure for the synthesis of novel morpholino pyrimidines (10-18) under microwave irradiation in ‘dry media’ in the presence of heterogeneous $NaHSO_4.SiO_2$ catalyst was developed. All the synthesized compounds were screened for their in vitro antibacterial activities against clinically isolated bacterial strains namely Bacillus subtilis, Bacillus cerues, Micrococcus luteus and Salmonella typhii and antifungal activities against fungal strains namely Aspergillus niger, Candida 6 and Candida 51. Structure activity relationship of the synthesized compounds against microbiological results was discussed.

Facile One-Pot Synthesis of PABA from MFB (MFB를 이용한 PABA One-Pot 합성법)

  • Kim, Kyung-Duck;Ryu, Young;Kim, Seok-Chan
    • Applied Chemistry for Engineering
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    • v.25 no.3
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    • pp.337-339
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    • 2014
  • A facile one-pot synthesis of p-aminobenzoic acid from methyl 4-formylbenzoate which is a main by product in dimethyl terephthalate production process has been developed. This process involves the formation of amide intermediate obtained from the reaction of an aldehyde in methyl 4-formylbenzoate with chlorine in methylene chloride and the subsequent treatment of acid chloride with ammonia. The resulting amide was converted into amine using Hofmann degradation to afford a p-aminobenzoic acid. This facile one-pot process does not involve any expensive materials and should offer an attractive alternative to p-aminobenzoic acid production.

A Green One-Pot Protocol for Regioselective Synthesis of New Substituted 7,8-Dihydrocinnoline-5(6H)-ones

  • Khalafy, Jabbar;Rimaz, Mehdi;Ezzati, Mahnaz;Prager, Rolf H.
    • Bulletin of the Korean Chemical Society
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    • v.33 no.9
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    • pp.2890-2896
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    • 2012
  • A simple regioselective synthesis of cinnoline derivatives was achieved by a one-pot three component synthetic methodology. New substituted 7,8-dihydrocinnolin-5(6H)-ones are prepared via one-pot three component reaction of arylglyoxals with 1,3-cyclohexanedione and dimedone in the presence of hydrazine hydrate in moderate to good yields.

One-Pot Multicomponent Synthetic Route for New Quinolidinyl 2,4-Thiazolidinediones

  • Mali, Jyotirling R.;Bhosle, Manisha R.;Mahalle, Shital R.;Mane, Ramrao A.
    • Bulletin of the Korean Chemical Society
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    • v.31 no.7
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    • pp.1859-1862
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    • 2010
  • A convenient one-pot condensation route has been developed for obtaining 5-[(2-(piperidin-1-yl) quinolin-3-yl) methylene]-2,4-thiazolidinediones using multicomponents, 2-chloro-3-formyl quinolines, piperidine, 2,4-thiazolidinedione and safer medium/mediator, polyethylene glycol-400.

Facile One-Pot Synthesis of 1,3,5-Trisubstituted Pyrazoles from α,β-Enones

  • Yu, Jin;Kim, Ko Hoon;Moon, Hye Ran;Kim, Jae Nyoung
    • Bulletin of the Korean Chemical Society
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    • v.35 no.6
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    • pp.1692-1696
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    • 2014
  • A practical and efficient one-pot synthesis of 1,3,5-trisubstituted pyrazoles from ${\alpha},{\beta}$-enones and arylhydrazine hydrochlorides has been developed. The pyrazoles were formed via a tandem formation of the corresponding pyrazolines and an acid-catalyzed aerobic oxidation process.

One-Pot Efficient Beckmann Rearrangement of Ketones Catalyzed by Silica Sulfuric Acid (황산-실리카에 의해 촉진된 Ketone의 효율적인 One-Pot 베크만 자리옮김 반응)

  • Eshghi, H.;Hassankhani, A.
    • Journal of the Korean Chemical Society
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    • v.51 no.4
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    • pp.361-364
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    • 2007
  • A one-pot Beckmann rearrangement for the preparation of amides from ketones is described using the silica sulfuric acid under Microwave irradiation. Advantages of this method are regioselectivity with high yields in a simple operation and short reaction time, in which the mole ratio of acid and ketone was 1:2 and it should be greener than the currently used systems.

Sulphanilic Acid Catalyzed Facile One-pot Synthesis of 2,4,5-Triarylimidazoles From Benzil/Benzoin and Aromatic Aldehydes (Sulphanilic Acid촉매하에서 벤질/벤조인과 방향족 알데히드로부터 2,4,5-Triarylimidazoles의 간편한 One-pot 합성)

  • Mohammed, A.F.;kokare, N.D.;Sangshetti, J.N.;Shinde, D.B.
    • Journal of the Korean Chemical Society
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    • v.51 no.5
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    • pp.418-422
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    • 2007
  • A simple and high yielding one-pot method for synthesis of 2,4,5-triarylimidazoles from condensation of benzoin or benzil, ammonium acetate and aromatic aldehydes using sulphanilic acid catalyst is described. The lower priced catalyst, higher yields and shorter reaction time are the advantages of the presented method.