• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.3111-3111
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• 2001

The implementation of NIR and chemometrics in the Pharmaceutical industries is still in strong progress, both regarding qualitative and quantitative applications and beneficial results are seen. Looking at the development so far, NIR will change the pharmaceutical industry even more in the future. This presentation will address the experiences and progress achieved regarding the application and implementation of quantitative methods for determination of content uniformity and assay of tablets with less than 10% w/w of active, using Near Infrared transmittance spectroscopy in combination with PLS. Also qualitative methods for identification of the same tablets by Near Infrared reflectance spectroscopy will be discussed. Four commercial tablet strengths are formulated and produced from two different compositions by direct compression. Three different strengths are dose proportional, i.e. fixed concentration by varying in size. The aim was to replace the conventional primary methods for analysing content uniformity, assay and identification by NIR. Studies were performed on comparing transmittance versus reflectance spectroscopy for both applications on the dose proportional tablets. The model for determination of content uniformity and assay was developed to cover both coated and uncoated tablets, whereas the qualitative model was developed to identify coated tablets only. The impact of the tablet formulation, tablet size and coating, resulted in individual models far each composition The best calibration was achieved using diffuse reflectance for the identification purposes and diffuse transmittance for the quantitative determination of the active content within the tablets. As NIR in combination with other techniques opens up the possibility of total quality management within the production, the transfer of the above-mentioned models from a laboratory based approach to an at-line approach at H.Lundbeck will be addressed too.

• 한국콘텐츠학회논문지
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• 제10권9호
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• pp.487-495
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• 2010

본 연구는 온라인 정보영재 교육의 질적 제고를 위해 온라인 콘텐츠 평가 준거를 제시하였다. 선행연구를 통해 나타난 정보영재의 특징과 사고양식, 학습양식의 특성을 기반으로 정보영재를 위한 온라인 콘텐츠 평가 준거를 개발하였다. 개발된 평가 준거는 정보영재 전문가를 대상으로 문항 타당성 검사를 진행하였다. 분석 결과 전체 문항의 신뢰도는 .94로 신뢰롭게 나타났다. 그리고 문항 특성 부분인 변별도는 .53~.83이었고, 난이도에서도 만족할만한 결과 값을 보여주었다. 개발된 정보영재를 위한 온라인 콘텐츠 평가 준거는 '재능개발', '상호작용' 등 5개 평가 영역, 11개 평가 요인, 40개 평가 문항으로 구성하였다. 본 연구에서 제시한 평가 준거는 정보영재 온라인 콘텐츠 개발을 위한 가이드라인 및 온라인 교재 선택에 도움을 줄 수 있을 것으로 기대된다.

• 정보처리학회논문지A
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• 제11A권5호
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• pp.407-412
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• 2004

e-러닝 시스템은 학습의 효율성과 학습자의 편의성을 위해 멀티미디어 콘텐트를 활용한 학습을 지원하고 있다. 웹을 기반으로 한 e-러닝에서는 네트워크 상태와 시스템의 성능과 같은 물리적인 환경요인의 제약으로 인해 다양한 멀티미디어의 사용이 어렵다. 또한 오프라인을 기반으로 한 e-러닝은 교습자와 학습자의 상호작용성과 최신 정보에 대한 적응성이 부족하다는 단점을 가지고 있다. 본 연구에서는 웹 기반 방식의 상호작용성과 적응성을 유지하면서도 오프라인 기반 방식의 다양한 멀티미디어 서비스를 제공할 수 있는 혼합적 기법의 e-러닝시스템을 설계하였다. 실험결과 제안 시스템이 기존의 방식에 비해 멀티미디어서비스 및 사용자 편의성, 최신정보에 대한 적응성, 상호작용성을 개선하였음을 확인할 수 있었다.

• Food Science and Biotechnology
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• 제15권6호
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• pp.889-895
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• 2006

Cytotoxic effects of extracts from Tremella fuciformis strain FB001 were evaluated on the DLD-1 human colon adenocarcinoma cell line and the content of polyphenolic compounds in the extracts were analyzed. Hexane, chloroform, and ethyl acetate subfractions (experimental setting I) exhibited cytotoxic effects on the human colon adenocarcinoma DLD-1 cell line with $IC_{50}$ values of 350, 400, and 450 ppm, respectively. When T. fuciformis was extracted sequentially with ether, ethyl acetate, chloroform, and ethanol (experimental setting II), the ether extract demonstrated potent cytotoxicity with an $IC_{50}$ value of 150 ppm, followed by ethyl acetate and chloroform fractions. If the first extraction solvent was chloroform instead of ether (experimental setting III), exposure of the cell line to chloroform, ethyl acetate, and ether extracts at 1,000 ppm led to cell death. High levels of phenolic compounds were estimated for all hydrophobic extracts, which exhibited cytotoxic effects. We propose that this useful information gives additional support to our understanding of the biology and utility of this particular mushroom.

• Geomechanics and Engineering
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• 제19권5호
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• pp.447-462
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• 2019

The vacuum preloading method has been used in many countries for ground improvement and land reclamation works. A sand cushion is required as a horizontal drainage channel for conventional vacuum preloading. In terms of the dredged-fill foundation soil, the treatment effect of the conventional vacuum preloading method is poor, particularly in Tianjin, China, where a shortage of sand exists. To solve this problem, straight-line vacuum preloading without sand is widely adopted in engineering practice to improve the foundation soil. Based on the engineering properties of dredged fill in Lingang City, Tianjin, this paper presents field instrumentation in five sections and analyzes the effect of a prefabricated vertical drain (PVD) layout and a vacuum pumping method on the soft soil ground treatment. Through the arrangement of pore water pressure gauges, settlement marks and vane shear tests, the settlement, pore water pressure and subsoil bearing capacity are analyzed to evaluate the effect of the ground treatment. This study demonstrates that straight-line vacuum preloading without sand can be suitable for areas with a high water content. Furthermore, the consolidation settlement and consolidation degree system is developed based on the grey model to predict the consolidation settlement and consolidation degree under vacuum preloading; the validity of the system is also verified.

• 한국작물학회지
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• 제30권4호
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• pp.431-435
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• 1985

우리나라 수도 품종을 배경으로 한 세포질적 유전적 웅성불임계통들에 우리나라 품종의 임성회복친을 교잡시킨 HR1619A/남풍벼, HR1619A/가야벼, HR1619A/계통234, 통일A/남풍벼, 통일A/청청벼, 수원296A/계통209, 수원296A/계통237, 수원296A/계통252 및 계통201A/계통234 등 9개 Hybrid를 육성하고 이들의 수량 및 수량 구성요소, 흰빛잎마름병 저항성 및 미질을 조사하여 다음과 같은 결과를 얻었다. 1 공시된 9개 Hybrid들 중 계통201A/계통234, 통일A/남풍벼 및 HR 1619A/남풍벼 등 3개 Hybrid의 수량성이 높았는데 각각 우수친에 비해 36％, 17％ 및 10％의 증수(Heterobeltiosis)를, 표준품종인 청청벼에 비해 각각 19％, 17％ 및 14％의 증수(Standard Heterosis)를 보였다. 2. 공시된 Hybrid중 HR1619A/가야벼와 수원296A/계통237의 수량은 양친보다 낮았다. 3. 수량구성요소 중 수당입수의 잡종강세가 현저하였고 주당수수, 천립중 및 임실율의 잡종강세는 인정되지 않았다. 4. Hybrid의 흰빛잎마름병 저항성은 양친 중 강한친과 같은 반응을 보였다. 5. Hybrid들의 Amylose 함량은 20.8％∼24.7%였고 딘백질함량은 9.3％∼10.0％, 알칼리 붕괴도는 3.7∼7.0으로서 각각 양친품종과 비슷하였다.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제38권2호
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• pp.93-120
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• 2024

수학 교육에서의 온라인 교육은 COVID19를 전후로 다양한 측면에서 변화하였다. 본 연구는 COVID19를 전후로 2017년부터 2023년까지 발간된 수학 교육 분야에서의 온라인 교육에 관한 98편의 논문을 대상으로 체계적 문헌 고찰을 수행하였다. 본 연구는 먼저 문헌에 나타난 온라인 교육과 관련된 여러 유사 용어들의 정의들을 대상으로 내용 분석을 진행하였다. 이후, 코로나 전, 코로나, 포스트 코로나 시대 별로 온라인 수학 교육의 연구 동향을 탐색하였으며, 온라인 교육의 효과에 대한 문헌들에 대해서는 추가적인 비교 분석을 진행하였다. 그 결과, 첫째, 온라인 교육과 유사한 용어들의 정의와 각 용어들 간의 차이점 및 위계를 정리할 필요성을 확인하였고 이에 대한 논의를 제시하였다. 둘째, 코로나를 계기로 교사에 대한 온라인 교육의 연구가 급격히 활발해졌으며 교사의 전문성이 강조되고 있음을 확인하였다. 셋째, 코로나 전에는 블렌디드와 플립트 러닝에 대한 연구가 많았지만 코로나 시대와 포스트 코로나 시대에는 실시간 쌍방향 수업에 대한 연구가 많은 비중을 차지하고 있었다. 마지막으로, 온라인 교육이 학업성취도에 미치는 영향은 문헌 별로 연구 배경과 모델에 따라 다양하게 나타났으며, 이에 따른 해석에는 주의가 필요함을 확인하였다. 본 논문은 이와 같은 연구 결과를 토대로 앞으로 수학 교육에서의 온라인 교육에 관한 연구 방향을 제시하였다.

• 한국초지조사료학회지
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• 제14권1호
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• pp.57-63
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• 1994

We use a variety of methods to determine the optimum time for havesting corn for silage. In addition, adequate dry matter for silage must be considered along with maturity stage. The objective of this study was to evaluate using the kernel milk line to determine when to harvest com for silage in 1992 on the Livestock Experimental F m , Keiymung Junior College at Keongsan, Keongsangbukdo. Four hybrids were field grown and com plants were harvested at various stages of kernel development so that kemel milk line movement could be analyzed whilc the corn was in the premature stages. As the plants approached maturity, the ears were collected from each of the hybrids and the position of the milk line wa5 noted. Then the whole plants were chopped and the content of DM was determined. The milk line was a readily identifiable feature of maturing com kemels. We focused on the five development \tage\. The fint was "soft dough". The second was "dent". The third wa, "75% milk". and the fourth wa5 "half milk". The half milk occurs when the milk line is positioned falf way down the kemel face. and the final stages win "no milk", milk disappearance as indicators of physiological maturity in maix. Milk free stage of the kemel occurred from I to 3 days prior to black layer having developed. The range for harvesting com for silage occurs a kemels mature from 75% milk to no milk. Position of milk line was easy to see. and can be used as a visible indicator to determine com matunty stage\ and whole plant dry matter. Whole plant dry matter increased with advancing maturity. averaged over hybrids it was 24.1, 25.6. 28.5. 34.6 and 39.0% at soft dough, dent, 75% milk. half milk and no milk. Milk line was more usehl indicator in monitoring corn maturity prior to physiological maturity.ing corn maturity prior to physiological maturity.

• 농업과학연구
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• 제48권4호
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• pp.693-702
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• 2021

The aim of this study was to analyze the genetic diversity and distance of the Korean native black goat line. Thus far, this Korean native black goat line has not been studied intensively, especially in genetic diversity and relationship studies in comparison with other breeds. In total, eleven microsatellite (MS) markers were used to evaluate alleles from 391 Korean native black goats and foreign hybrid animals. The genetic diversity index was evaluated based on the allele distributions. Four Korean native black goat lines showed expected ranges of observed heterozygosity, expected heterozygosity, and polymorphism information content (PIC) values for use in genetic diversity research (0.509 - 0.643, 0.434 - 0.623 and 0.356 - 0.567). Lines from the Korean native black goat and foreign hybrid were clearly separated according to principal coordinates analysis (PCoA), phylogenetic tree and tended to be clustered in each Korean native black goat line. Thus, this study can be used for analyzing the genetic relationships between Korean native black goats and foreign breeds for line preservation and for fundamental information to determine breed improvement strategies.

• Computers and Concrete
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• 제31권5호
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• pp.395-403
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• 2023

The paper investigates the effect of two parameters - sand content (SC) and grain migration during shearing - on the mechanical properties of gravel-sand mixtures. Consolidated undrained (CU) triaxial tests were carried out on eight series of mixtures containing gravel (1<d<16 mm) and sand (0.1<d<1 mm). The prepared mixtures have sand contents of 0, 10, 15, 20, 40, 54, 94 and 100%, and a relative density of 60%. The transition sand content (TSC) is experimentally defined and marks the transition from gravel-driven to sand-driven behavior. For SC<TSC, the dry density of the mixture increases with SC. This induces an increase in undrained peak strength and dilative trend. The slope and position of the critical state line (CSL) are also deeply dependent on SC. At SC=TSC, the mixtures exhibit the largest dry density and yield the highest undrained peak strength and the largest dilative trend. During shearing, large internal migration of grains was observed at the TSC, causing heterogeneity in the sample. Analysis of the CSL deduced from the final points of the triaxial tests shows that, at the TSC, failure appears to correspond to the behavior of the coarsest fraction of the soil. This fraction is located in the upper part of the sample, where the sand particles had been eliminated by suffusion. On the other hand, in the more stable materials, the CSL is consistent with the bulk grain size distribution of the soil.