• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2285-2289
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• 2016

Background: Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is an entity introduced in the latest WHO classification of lymphoid tumors and defined in patients older than 50 years without prior lymphoma or immunodeficiency. However, recently it has also been seen in patients under 50. There is thus debate as to whether these are separate entities. Materials and Methods: In this retrospective study, we analyzed de novo DLBCL admitted to our institute over a period of two years. Clinical data included age, sex, nodal and extranodal presentation. The results of an immunohistochemistry (IHC) panel were also reviewed. IHC findings were mainly used to sub-classify DLBCL as germinal center vs. non germinal center types. IHC for identification of LMP-1 (latent membrane protein) and in situ hybridization for detection of EBV-encoded RNA (EBER) was performed. EBV prevalence, clinical data and IHC findings were compared between patients under and over 50 years of age. Results: Out of 95 DLBCL, 11.6% were EBV positive (7.5% and 14.5% in the young and old groups). We did not find any significant differences in IHC subclasses and clinical data between EBV positive DLBCL (EBV+DLBCL) of young and old groups. Conclusions: EBV+DLBCL are not exclusive to patients older than 50 years. With regard to clinical data as well as IHC subclasses, no differences were evident between EBV+DLBCL of young and old groups. Our suggestion is to eliminate any cut off age for EBV+DLBCL.

• The Journal of Korean Physical Therapy
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• 제25권1호
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• pp.29-35
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• 2013

Purpose: The purpose of this study was to investigate the correlation between shoulder pain and disability index (SPADI) with participation in badminton and to find the effects of badminton on the shoulder joint. Methods: A questionnaire was answered by 143 people with shoulder pain and disability in badminton clubs located in Busan, Gyeongsangnam-do. Out of the 143 subjects (91 males, 52 females), about half (72 people) were over 40 years old, with 71 people over 50 years old. The questionnaire contained 27 questions involving demographic participation characteristics, playing characteristics, and SPADI. Data analysis was performed using the SPSS statistics program to conduct frequency analysis, cross analysis, the t-test, and one-way analysis of variance. Results: The correlation between badminton career, frequency of play, and SPADI was statistically significant. There was a significant increase in SPADI scores for players over 40 years old. The over 40 year old group with less than 5 years of badminton had a significantly increase in SPADI score. The over 50 year old group showed a significantly lower SPADI score compared with the over 40 group. Conclusion: We suggest that beginner badminton players learn correct posture and badminton skills from professionals, participate regularly, and maintain an appropriate intensity/frequency of badminton.

• The Korean Journal of Physiology
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• 제23권1호
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• pp.51-66
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• 1989

Mammalian cardiocytes secrete atrial natriuretic peptides (ANPs) into plasma, which cause marked natriuresis, diuresis, vasorelaxation and inhibition of hormone secretions. Aging influences the ability of the kidney both to conserve and to excrete sodium; i.e., in old animals, the excretory capacity of sodium is reduced and the time required to excrete sodium load is prolonged. Therefore, it is possible that animals differing in ages may respond differently to ANP. In the present study, we determined whether the renal, hormonal and vascular effects of ANP may be influenced by aging in conscious rabbits. The plasma renin concentration decreased with aging but plasma ANP concentration was significantly lower only in 24-month-old rabbits. Plasma aldosterone concentration and atrial ANP content did not change by aging. In 1-month-old rabbits, ANP (atriopeptin III, 3 ug/kg) administered intravenously caused hypotension and decreased in plasma renin and aldosterone concentrations, but did not cause diuresis and natriuresis. In 2 to 5 month-old rabbits, ANP caused hypotension, decreases in Plasma renin and aldosterone concentrations and marked renal effects. However, in 24-month-old rabbits, all the above effects of ANP was blunted. With hydration of physiological saline at a rate of 15 ml/kg/h for 2hr, urine volume and glomerular filtration rate did not change but the electrolyte excretion as well as fractional excretion of sodium significantly increased. The plasma concentrations of active renin and aldosterone were decreased but plasma inactive renin and ANP concentrations were increased. The changes in renal function and plasma level of hormone showed no differences in different ages. These results suggest that the peripheral vascular receptors to ANP may develop earlier than those in the kidney, and the attenuated vascular and renal responses to ANP in the old age may be due to age-related modifications in renal function and blood vessel.

• 대한수의학회지
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• 제40권2호
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• pp.257-265
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• 2000

Harderian glands are the unique organs in several mammals, which human and non-human primates do not have. We report the ultrastructural changes in the postnatal developmental periods of Harderian glands in Mongolian gerbil(Meriones unguiculatus). Male and female Mongolian gerbils were sacrificed on days 3, 10, 30 and 60 after birth and their Harderian glands were observed by transmission electron microscope. The obtained results were summarized as follows; 1. In 3-day-old Mongolian gerbils, Harderian gland was composed of one excretory duct and immature tubules which have two type cells, dark and light cells, identified electron-dense and electron-lucent respectively. 2. In 10-day-old Mongolian gerbils, small lipid vacuoles began to be found in the cytoplasm of the secretory cells of the Harderian gland. Mitochondria, Golgi apparatus, polysomes and slash were more abundant in the cytoplasm of dark cells than those of light cells. The arrangement of tubules in the gland was much more condensed than that of 3-day-old Mongolian gerbils. 3. In 30-day-old Mongolian gerbils, the secretory cells of the tubule were typically columnar in shape and there was one type cell in the tubule. Most of the columnar secretory cells contained various size vacuoles. 4. In 60-day-old Mongolian gerbils, the Harderian gland possessed the typical structural characteristics of adults. The mature glandular structures were more significant than those of 30-day-old animals.

• 한국응급구조학회지
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• 제17권3호
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• pp.53-60
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• 2013

Purpose: The purpose of the study is to emphasize the importance of out-of-hospital cardiac arrest resuscitation. This resuscitation by paramedic is very effectively performed under the medical direction of the doctors. Methods: The cardiac arrest victim was 4 month old infant. Informed consent from the parents of the infant was received. CPR combined with 150J defibrillation was performed to the 4 month old infant. Results: We reported that the 4 month old infant survived the cardiac arrest. Out-of-hospital cardiac arrest infant survived after 150J automated external defibrillator and CPR performance. Conclusion: Specific operative protocol is important because the paramedic can apply the proper manual defibrillator effectively. It is important to extend the work scpoe of the EMT.

• Clinical and Experimental Pediatrics
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• 제55권6호
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• pp.215-218
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• 2012

Mucoceles are common benign cystic lesions of the oral cavity that develop following extravasation or retention of mucous material from the major or minor salivary glands. Mucoceles are usually located in the lower lip (60 to 70% of cases), and the floor of the mouth is only involved in 6 to 15% of cases. Submandibular gland mucocele is extremely rare but should be considered in the differential diagnosis of swelling at the submandibular triangle in young children. We present the rare case of a 16-month-old child who was diagnosed with bilateral submandibular gland mucocele, presenting as serial swellings in both submandibular regions. We removed the cystic mass with the submandibular and sublingual glands to prevent recurrence.

• 한방안이비인후피부과학회지
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• 제18권3호
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• pp.158-164
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• 2005

Meniere's disease is not a life-threatening but lift-altering inner ear disease characterized by episodic vertigo, fluctuating hearing loss, tinnitus and ear fullness. The etiology and pathophysiology symptoms is still disputed. Thereby the treatment of Meniere's disease is empirical. As yet no treatment has prospectively modified the clinical course of condition and thereby prevented the progressive hearing loss. We experienced two cases of Meniere's disease treated with oriental medical treatment, acupuncture and herbal medication. 15 year-old and 23 year old male patients had diagnosed Meniere's disease by western medical doctor. After treatment their vertigo is decreased and the level of hearing loss was rise up. Therefore, oriental medical treatments could be safe and effective methods.

• 대한한의학원전학회지
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• 제29권1호
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• pp.1-15
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• 2016

Objectives : The purpose of this study is to investigate the method of setting up logic and estimate Fang Youzhi's work through Shanghanluntiaobian. Methods : Wang Shuhe's old edition Shanghanlun and Fang Youzhi's Shanghanluntiaobian were compared and several essential provisions were analyzed and addressed the positive and negative aspects of Fang Youzhi's revising old edition Shanghanlun mixed bamboo tablets. Results : Fang Youzhi's changing Bianmaifa("辨脈法") and Pingmaifa("平脈法") and placement Bianchishiyemaizhengbingzhi chapter after Liujingbingmaizhengbingzhi for discriminating convulsion dampness summer heat stroke from febrile diseases is appropriate. Fang Youzhi's deletion Shanghanli("傷寒例") chapter that has a guiding characteristics shows his editorial policy. Fang Youzhi's addition Bianwenbingfengwenzabingmaizhengbingzhi chapter is for discriminating febrile disease from epidemic febrile disease wind warmth syndrome miscellaneous disease and it indicates Shanghanlun is a book of treatment after differentiation of syndromes containing epidemic febrile disease and miscellaneous disease. Through Fang Youzhi's revising method I can see several positive aspects. First he tried to refine the logic of the content of Shanghanlun and accord with an actual situation. Second he shows Shanghanlun is a book of treatment after differentiation of syndromes containing epidemic febrile disease and miscellaneous disease and tried to see Shanghanlun clearly. A criticism of the Preserving Old Edition Shanghanlun group could interrupt flexibility and creative thinking reading Shanghanlun and a criticism to the Sangangdingli Principles of the several exegetists is a productive criticism because medicine treats human being so it cannot be completed by a logic. Conclusions : All of these processes are Fang Youzhi's endeavour for strengthening the system and logicality of the old edition Shanghanlun and it is meaningful to show a method to read Shanghanlun to beginners.

• 대한한의학원전학회지
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• 제20권4호
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• pp.17-35
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• 2007

Objectives : To consider same or not the positions of acupoints on the meridian in the old acupuncture books. Methods: On the basis of old acu-books, We count the number of acupoints that are on pulse. Thru the three books-"Yijongkumkam(醫宗金鑑)","Chimkuhak 1st(鍼灸學-上)", Kyunghyulhakchongseo(經穴學叢書)"-We Compared the way of positioning of acupoints, also did on the location of acupoints, vein, vascular system, around the acupoints, based on the anatomical structures(esp. artery) Results : On the basis of old acu-books, the number of acupoints(only in the twelve meridian) on the pulse is 35, and the number of points not in the old books but on the pulse is 6, sum is 41 points. Comparion from Sambukuhu consultation method(三部九候診法) in "Somun(素問)", Some points, Taeyang(太陽, not in the twelve meridian), Yimun(耳門) and Koryo(Yimun and Koryo are in) are on pulse. Like Chonbu(天府) and Hyupbaek(俠白), We can feel the pulse on ulna side of biceps muscle, noton radial side. Shikdu(食竇) was described as on pulse in the "Chimkushimbopyokyul(鍼灸心法要訣)", but we could hardly feel it. Conclusions : It'll be right to add the Yimun(耳門) and Koryo to the points on pulse, of course two points are not in the twelve meridian. We must take the points Chonbu(天府) and Hyupbaek(俠白), on ulna side of biceps muscle. Shikdu(食竇) must be excepted, because we cannot feel the pulse in consultation.

• 대한의생명과학회지
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• 제26권2호
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• pp.109-113
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• 2020

Dangyuja (Citrus maxima (Burm.) Merr.) is a native fruit of great economic importance in Jeju island in Korea. To provide experimental evidence for the antioxidant and anti-inflammation properties on extraction ethanol concentration of Dangyuja, 2 cultivars, including 30-year-old and 120-year-old were evaluated. 30-year-old Dangyuja 50%, 70% ethanol extracts had the highest polyphenol and flavonoid content, and the strongest 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. To investigate the anti-inflammatory activity of Dangyuja ethanol extracts, we used BV-2 microglia cells and induced inflammation using lipopolysaccharide (LPS). Then, we measured levels of inflammatory mediators as nitric oxide (NO). Among the 6 extracts, 30-year-old Dangyuja 50% ethanol extracts show the highest anti-inflammatory activity. The results suggest that 30-year-old Dangyuja 50% ethanol extracts provides significant health benefits and may be used for developing new functional materials.