• Parasites, Hosts and Diseases
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• v.58 no.1
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• pp.7-14
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• 2020

Toxoplasma gondii is an intracellular protozoan parasite that infects approximately one third of the human population worldwide. Considering the toxicity and side effects of anti-toxoplasma medications, it is important to develop effective drug alternatives with fewer and less severe off-target effects. In this study, we found that 4-hydroxybenzaldehyde (4-HBA) induced autophagy and the expression of NAD-dependent protein deacetylase sirtuin-1 (SIRT1) in primary murine bone marrow-derived macrophages (BMDMs). Interestingly, treatment of BMDMs with 4-HBA significantly reduced the number of macrophages infected with T. gondii and the proliferation of T. gondii in infected cells. This effect was impaired by pretreating the macrophages with 3-methyladenine or wortmannin (selective autophagy inhibitors) or with sirtinol or EX527 (SIRT1 inhibitors). Moreover, we found that pharmacological inhibition of SIRT1 prevented 4-HBA-mediated expression of LC3-phosphatidylethanolamine conjugate (LC3-II) and the colocalization of T. gondii parasitophorous vacuoles with autophagosomes in BMDMs. These data suggest that 4-HBA promotes antiparasitic host responses by activating SIRT1-mediated autophagy, and 4-HBA might be a promising therapeutic alternative for the treatment of toxoplasmosis.

• Journal of the Korean Solar Energy Society
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• v.34 no.1
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• pp.81-90
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• 2014

The Jeju-Korea power system is a small-sized network with a system demand ranging from a autumn minimum of 350MW to a summer peak of 716MW. Because Jeju island is well exposed to north-east winds with high speed, applications to connect to Jeju power system are flooded. Considering physical/environmental constraints, Jeju Self-governing Province has also target for the wind power capacity of 1,350MW by 2020. It amounts to two or three times of Jeju average-demand power and wind power limit capacity announced by Korea Power Exchange (KPX) company. Wind farm connection agreements will be signed to maximize utilization of wind resource. In spite of submarine cable HVDC connected to Korea mainland, Jeju power system is independently operated by frequency and reserve control. This study reevaluates wind power limit based on the KPX criteria from 2016 to 2020. First of all wind power generation limit are affected by off-peak demand in Jeju power system. Also the possibility capacity rate of charging wind power output is evaluated by using energy storage system (ESS). As a result, in case of using 110MWh ESS, wind power limit increases 33~55MW(30~50% of ESS), wind power constraint energy decreases from 68,539MWh to 50,301MWh and wind farm capacity factor increases from 25.9 to 26.1% in 2020.

• Journal of the Korea Society of Computer and Information
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• v.13 no.1
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• pp.143-151
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• 2008

Execute IP traceback at this paper as target an intruder's attacking that Bypass Attack in order to avoid an exposure of own Real IP address Design IP traceback server and agent module, and install in Internet network system for Real IP traceback. Set up detection and chase range aggressive loop around connection arbitrariness, and attack in practice, and generate Real IP data cut off by fatal attacks after data and intrusion detection accessed general IP, and store to DB. Generate the Forensic data which Real IP confirms substance by Whois service, and ensured integrity and the reliability that buy to early legal proof data, and was devoted to of an invader Present the cyber criminal preventive effect that is dysfunction of Ubiquitous Information Society and an effective Real IP traceback system, and ensure a Forensic data generation basis regarding a judge's robe penalty through this paper study.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.733-736
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• 2008

This study, with the purpose for early quality improvement of concrete which used large quantity of fly ash, changed various admixture material type and reviewed the basic characteristics. First off, the flow overall was highest when polycarb onic Acid high early strength AE water reducing agent was displaced, while air amount satisfied target level only in the case of plain, and setting time was shown best by getting 30 more minutes than plain and about 3 more hours than conventional when KOH is displaced. Compressive strength was shown best at age 1 day and 3 days when KOH was displaced, and at age 28 days when fine particle cement was displaced. By and large, this study concludes that concrete quality improvement admixture material that used large amount of fly ash showed worse effects than plain, therefore it is determined that there need be more study for development of concrete early quality improvement admixture material that used large amount of fly ash.

• Korean Journal of Optics and Photonics
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• v.1 no.1
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• pp.46-51
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• 1990

Laser plasma was generated by a 1GW iodine photodissociation laser ($\lambda$=1.315$\mu\textrm{m}$, E=12.7J) whose output beam was focused on a molybdenum target surface. The experiment was conducted in a vacuum chamber under 1D-sTorr and several tens of laser shooting were necessary for sufficient exposure for the PBS resist of 111m thickness. Aluminium was coated on the top of the resist by 0.1$\mu\textrm{m}$ thickness which acts as an X-ray filter to cut off the visible and the ultraviolet lights. A bio-specimen was put directly on the aluminium coated resist and located at a distance of 3 cm from the X-ray source. The replicas of a steel mesh, spider's web. and a red blood cell were obtained by this technique and were observed by Nomarski microscope and SEM. The limitation of its resolution is determined by the X-ray source size and Fresnel diffraction effect, and its theoretical prediction is well matched with the experimental results. In this experiment, a resolution better than 0.1$\mu\textrm{m}$ could be obtained. ained.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.7
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• pp.955-961
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• 2021

In modern warfare, the importance of electronic warfare, which carries out a mission that using radio wave to find out enemy information or to protect ally information, has increased. Radar jamming technique is one of the most representative techniques of EA(Electronic Attack), it disturbs and deceives enemy radar system in order to secure ally location information. Velocity deception jamming technique, which is one of the radar jamming techniques, generally operate against pulse-doppler radar which use doppler effect in order to track target's velocity and location. Velocity Deception Jamming Technique can be implemented using DRFM(Digital Radio Frequency Memory) that performs Frequency Modulation. In this paper, I describe implementation method of VGPO/VGPI(Velocity Gate Pull-Off/Pull-In) velocity deception jamming technique using phase-sampled DRFM, and verify the operation of VGPO/VGPI velocity deception jamming technique with board test under signal injection condition.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.101-107
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• 2022

Tertomotide is a peptide vaccine developed for anti-cancer therapy. Since it has been found to ameliorate inflammatory symptoms in animal studies and clinical test, we investigated anti-inflammation activity of the tertomotide and the mechanism of action in monocyte in order to assess if tertomotide may serve as an anti-inflammatory agent by checking inflammatory cytokines and related signaling pathway following tertomotide treatment. We found that tertomotide reduced the level of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-8 in LPS- or PMA-stimulated monocyte cell line and suppressed NF-κB signaling including the activation of ERK1/2 and P38 MAPK following TNF-α treatment. These results may correlate to the beneficial findings in animal studies, implicating that tertomotide may act as a potential anti-inflammatory agent. This study is an exemplary case for convergence that a computationally designed peptide for immunological purpose exerting unexpected biological activity may elicit novel anti-inflammatory drug.

• Journal of Ecology and Environment
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• v.48 no.2
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• pp.137-143
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• 2024

Background: The study was carried out to analyze the temporal changes of trade-offs (TOs) between two ecosystem services (ESs) before and after thinning in a Pinus koraiensis plantation on Mt. Gari from 2006 to 2021. As target variables, aboveground carbon (AGC) storage and species richness (SR) were chosen for regulating and supporting services. Thinning was applied from 2007 through 2008 with three treatments: 1) light thinning (LT), 2) heavy thinning (HT), and 3) control (Con). Results: Thinning influenced both AGC and SR. In 2021, AGC in the Con (111.1 t C ha^-1) was significantly higher compared to the LT (82.0 t C ha^-1) and HT (60.4 t C ha^-1) after thinning from 2007 to 2008. Also, SR was marginally higher in the LT (94 species) than in the Con (55 species) and HT (87 species) in 2011. Relative benefits of AGC and SR showed similar trends with the obtained values. In addition, the effects of thinning on TO varied among treatments and over time, demonstrating different degrees of TO between the two ESs. In the LT, TO was 0.13 in 2006 and slightly increased to 0.2 by 2021. TO in the HT exhibited a relatively rapid increase from 0.22 in 2006 to 0.58 by 2021, while To in the Con fluctuated, rising to 0.36 in 2011 from 0.1 in 2006 and decreasing to 0.25 by 2021. Among the three treatments, the degree of TOs between the two ESs was the lowest in the LT. Conclusions: Depending on thinning intensities, the responses of ESs and the degree of TOs vary. Regarding the balance between enhancements and TOs in ESs among treatments, the LT treatment showing intermediate carbon storage, higher SR, and lower TOs will be a proper silvicultural application.

• Parasites, Hosts and Diseases
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• v.62 no.2
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• pp.226-237
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• 2024

Ticks, blood-sucking ectoparasites, spread diseases to humans and animals. Haemaphysalis longicornis is a significant vector for tick-borne diseases in medical and veterinary contexts. Identifying protective antigens in H. longicornis for an anti-tick vaccine is a key tick control strategy. Enolase, a multifunctional protein, significantly converts D-2-phosphoglycerate and phosphoenolpyruvate in glycolysis and gluconeogenesis in cell cytoplasm. This study cloned a complete open reading frame (ORF) of enolase from the H. longicornis tick and characterized its transcriptional and silencing effect. We amplified the full-length cDNA of the enolase gene using rapid amplification of cDNA ends. The complete cDNA, with an ORF of 1,297 nucleotides, encoded a 432-amino acid polypeptide. Enolase of the Jeju strain H. longicornis exhibited the highest sequence similarity with H. flava (98%), followed by Dermacentor silvarum (82%). The enolase motifs identified included N-terminal and C-terminal regions, magnesium binding sites, and several phosphorylation sites. Reverse transcription-polymerase chain reaction (RT-PCR) analysis indicated that enolase mRNA transcripts were expressed across all developmental stages of ticks and organs such as salivary gland and midgut. RT-PCR showed higher transcript levels in syn-ganglia, suggesting that synganglion nerves influence enolase's role in tick salivary glands. We injected enolase double-stranded RNA into adult unfed female ticks, after which they were subsequently fed with normal unfed males until they spontaneously dropped off. RNA interference significantly (P<0.05) reduced feeding and reproduction, along with abnormalities in eggs (no embryos) and hatching. These findings suggest enolase is a promising target for future tick control strategies.

• The Korean Journal of Financial Management
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• v.24 no.1
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• pp.109-147
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• 2007

According to the perspective of capital structure theory, we analyzed the dynamism of the capital structure determinants by using panel data of 244 KOSDAQ firms based on two-step GMM system methodology suggested by Blundell Bond(1998). This dynamic methodology had not been used to analyse capital structure determinants in Korea. In the dynamic model of capital structure, profit had negative effect on the book leverage and market leverage, which meant supporting pecking order theory. Growth opportunity (MBR) affected negatively to the market leverage. For the determinants of leverage, earnings volatility had significantly positive effect on KOSDAQ 50 firms. KOSDAQ and KOSDAQ 50 firms had the target leverage. The adjustment speed in KOSDAQ firms was 0.4958 on the book leverage, it was faster than in KOSDAQ 50 firm's 0.2863 on the book leverage and the adjustment speeds for the market leverage were 0.7651 for KOSDAQ firms and 0.5643 for KOSDAQ 50 firms. There was difference in adjustment cost between KOSDAQ firms and KOSDAQ 50 firms.