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http://dx.doi.org/10.15207/JKCS.2022.13.01.101

[Retraction]Anti-inflammatory activity of a short peptide designed for anti-cancer: a beneficial off-target effect of tertomotide  

Lee, Hyosung (Department of Food & Pharmaceutical Science & Engineering, Seowon University)
Publication Information
Journal of the Korea Convergence Society / v.13, no.1, 2022 , pp. 101-107 More about this Journal
Abstract
Tertomotide is a peptide vaccine developed for anti-cancer therapy. Since it has been found to ameliorate inflammatory symptoms in animal studies and clinical test, we investigated anti-inflammation activity of the tertomotide and the mechanism of action in monocyte in order to assess if tertomotide may serve as an anti-inflammatory agent by checking inflammatory cytokines and related signaling pathway following tertomotide treatment. We found that tertomotide reduced the level of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-8 in LPS- or PMA-stimulated monocyte cell line and suppressed NF-κB signaling including the activation of ERK1/2 and P38 MAPK following TNF-α treatment. These results may correlate to the beneficial findings in animal studies, implicating that tertomotide may act as a potential anti-inflammatory agent. This study is an exemplary case for convergence that a computationally designed peptide for immunological purpose exerting unexpected biological activity may elicit novel anti-inflammatory drug.
Keywords
Convergence; Tertomotide; Anti-inflammation; Cytokine; Monocyte; $NF-{\kappa}B$ signaling;
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