• Title/Summary/Keyword: Odin

Search Result 9, Processing Time 0.024 seconds

In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus

  • Park, Sunjung;Lee, Haeryung;Park, Soochul
    • Molecules and Cells
    • /
    • v.38 no.5
    • /
    • pp.426-431
    • /
    • 2015
  • Odin has been implicated in the downstream signaling pathway of receptor tyrosine kinases, such as the epidermal growth factor and Eph receptors. However, the physiologically relevant function of Odin needs to be further determined. In this study, we used Odin heterozygous mice to analyze the Odin expression pattern; the targeted allele contained a ${\beta}$-geo gene trap vector inserted into the 14t intron of the Odin gene. Interestingly, we found that Odin was exclusively expressed in ependymal cells along the brain ventricles. In particular, Odin was highly expressed in the subcommissural organ, a small ependymal glandular tissue. However, we did not observe any morphological abnormalities in the brain ventricles or ependymal cells of Odin null-mutant mice. We also generated BAC transgenic mice that expressed the PTB-deleted Odin (dPTB) after a floxed GFP-STOP cassette was excised by tissue-specific Cre expression. Strikingly, Odin-dPTB expression played a causative role in the development of the hydrocephalic phenotype, primarily in the midbrain. In addition, Odin-dPTB expression disrupted proper development of the subcommissural organ and interfered with ependymal cell maturation in the cerebral aqueduct. Taken together, our findings strongly suggest that Odin plays a role in the differentiation of ependymal cells during early postnatal brain development.

Design, Implementation and Test of New System Software Architecture for Autonomous Underwater Robotic Vehicle, ODIN-III (시험용 자율 무인 잠수정, ODIN-III의 새로운 시스템 소프트웨어 구조의 설계와 구현 및 실험)

  • 최현택;김진현;여준구;김홍록;서일홍
    • Journal of Institute of Control, Robotics and Systems
    • /
    • v.10 no.5
    • /
    • pp.442-449
    • /
    • 2004
  • As underwater robotic vehicles (URVs) become attractive for more sophisticated underwater tasks, the demand of high performance in terms of accuracy and dexterity has been increased. An autonomous underwater robotic vehicle, ODIN (Omni-Directional Intelligent Navigator) was designed and built at the Autonomous Systems Laboratory of the University of Hawaii in 1991. Since 1991, various studies were conducted on ODIN and have contributed to the advancement in underwater robotics. Its refurbished model ODIN II was based on VxWorks in VMEbus. Recently, ODIN was born again as a PC based system, ODIN III with unique features such as new vehicle system software architecture with an objective-oriented concept, a graphical user interface, and an independent and modular structure using a Dynamic Linking Library (DLL) based on the Windows operating system. ODIN III software architecture offers an ideal environment where various studies for advanced URV technology can be conducted. This paper describes software architecture of ODIN III and presents initial experimental results of fine motion control on ODIN III.

Identification of WDR7 as a Novel Downstream Target of the EphA8-Odin Signaling Complex

  • Park, Eun-Jeong;Park, Soo-Chul
    • Animal cells and systems
    • /
    • v.13 no.1
    • /
    • pp.9-15
    • /
    • 2009
  • Eph receptors and their ephrin ligands have been implicated in a variety of cellular processes such as cellular morphogenesis and motility. Our previous studies demonstrated that Odin, one of the Anks family proteins, functions as a scaffolding protein of the EphA8 signaling pathway leading to modulation of cell migration or axonal outgrowth. Here we show that WDR7 is associated with Odin and that it is possibly implicated in the EphA8 signaling pathway. WD40 repeats present in the COOH-terminal region of WDR7 appear to be crucial for its association with Odin, whereas the binding motif of Odin is located in between ankyrin repeats and PTB domain. Co-immunoprecipitation experiments revealed that association of WDR7 with Odin is enhanced by ephrin ligand treatment, possibly through forming large protein complexes including both EphA8 and ephrin-A5. Consistently, immunofluorescence staining experiments suggested that WDR7 constitute a component of the large protein complexes containing Odin, EphA8 and ephrin-A5. Taken together, our results suggest the WDR7-Odin complexes might be involved in the signaling pathway downstream of the EphA8 receptor.

CONCEPTUAL STRUCTURAL DESIGN AND COMPARATIVE POWER SYSTEM ANALYSIS OF OZONE DYNAMICS INVESTIGATION NANO-SATELLITE (ODIN)

  • Park, Nuri;Hwang, Euidong;Kim, Yeonju;Park, Yeongju;Kang, Deokhun;Kim, Jonghoon;Hong, Ik-seon;Jo, Gyeongbok;Song, Hosub;Min, Kyoung Wook;Yi, Yu
    • Journal of The Korean Astronomical Society
    • /
    • v.54 no.1
    • /
    • pp.9-16
    • /
    • 2021
  • The Ozone Dynamics Investigation Nano-Satellite (ODIN) is a CubeSat design proposed by Chungnam National University as contribution to the CubeSat Competition 2019 sponsored by the Korean Aerospace Research Institute (KARI). The main objectives of ODIN are (1) to observe the polar ozone column density (latitude range of 60° to 80° in both hemispheres) and (2) to investigate the chemical dynamics between stratospheric ozone and ozone depleting substances (ODSs) through spectroscopy of the terrestrial atmosphere. For the operation of ODIN, a highly efficient power system designed for the specific orbit is required. We present the conceptual structural design of ODIN and an analysis of power generation in a sun synchronous orbit (SSO) using two different configurations of 3U solar panels (a deployed model and a non-deployed model). The deployed solar panel model generates 189.7 W through one day which consists of 14 orbit cycles, while the non-deployed solar panel model generates 152.6 W. Both models generate enough power for ODIN and the calculation suggests that the deployed solar panel model can generate slightly more power than the non-deployed solar panel model in a single orbit cycle. We eventually selected the non-deployed solar panel model for our design because of its robustness against vibration during the launch sequence and the capability of stable power generation through a whole day cycle.

Information Retrieval Support System Using Thesaurus (시소러스를 이용한 정보검색 지원 시스템)

  • Shin, Sung-Hyuk;Shim, Bin-Gu;Lee, Seoung-Jun;Choi, Young-Ju;Kwon, Rae-Nam
    • Proceedings of the Korea Contents Association Conference
    • /
    • 2006.11a
    • /
    • pp.503-506
    • /
    • 2006
  • The amounts of information and services are rapidly increasing. This causes inefficiency of retrievals of information overload problem. To overcome this kind of problems, This article suggests Odin system, keyword suggestion system based on Thesaurus. Odin system will suggest appropriate search-words and this leads to the user's satisfied result.

  • PDF

Re-evaluation of Ammonium Data in Seawater: an Unique Short-Term Index (해수 암모늄 자료의 재평가: 독특한 단주기 수질지표 가능성)

  • JEONG, YONG HOON;YANG, JAE SAM
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
    • /
    • v.21 no.2
    • /
    • pp.58-66
    • /
    • 2016
  • We have evaluated the ammonium data in seawater as a potential short-term index for marine environment through the following steps. 1. reviewing of chemical characteristics of ammonium in seawater, 2. comparative relationships of ammonium data with other water quality indices such as DO, COD, and nutrients from Typical Marine Environment(TME) and Special Marine Environment(SME). Ammonium data generally represent negative correlation with DO, while positive correlation with COD. In particular, under frequent cases of seawater conditions showing similar concentration of COD or DO, we have limited choice of explanation for such situation. However ODIN(ODIN/RDIN) or RDIN(RDIN/TDIN) ratio could provide advanced information to understand these seawater conditions. Based on these results, we suggest ammonium data as a potential short-period index for transilient marine environment, such as benthic flux of bottom sediment, hypoxia, and algal bloom. Under overcoming several handicaps, ammonium data could be an useful tool for better understand short transformation of marine environment.

Effect of the Combination Hot Water - Calcium Chloride on the In Vitro Growth of Colletotrichum gloeosporioides and the Postharvest Quality of Infected Papaya

  • Ayon-Reyna, Lidia Elena;Lopez-Valenzuela, Jose Angel;Delgado-Vargas, Francisco;Lopez-Lopez, Martha Edith;Molina-Corral, Francisco Javier;Carrillo-Lopez, Armando;Vega-Garcia, Misael Odin
    • The Plant Pathology Journal
    • /
    • v.33 no.6
    • /
    • pp.572-581
    • /
    • 2017
  • Anthracnose of papaya fruit caused by the fungus Colletotrichum gloeosporioides is one of the most economically important postharvest diseases. Hot water immersion (HW) and calcium chloride (Ca) treatments have been used to control papaya postharvest diseases; however, the effect of the combination HW-Ca on the pathogen growth and the development of the disease in infected papaya fruit has been scarcely studied. The aim of this study was to evaluate the effect of the HW-Ca treatment on the in vitro growth of C. gloesporioides conidia and the quality of infected papaya. In vitro, the HW-Ca treated conidia showed reduced mycelial growth and germination. In vivo, the HW-Ca treatment of infected papaya delayed for 5 days the onset of the anthracnose symptoms and improved the papaya postharvest quality. The combined treatment HW-Ca was better than any of the individual treatments to inhibit the in vitro development of C. gloeosporioides and to reduce the negative effects of papaya anthracnose.

Evolution pathway of CZTSe nanoparticles synthesized by microwave-assisted chemical synthesis

  • Reyes, Odin;Sanchez, Monica F.;Pal, Mou;Llorca, Jordi;Sebastian, P.J.
    • Advances in nano research
    • /
    • v.5 no.3
    • /
    • pp.203-214
    • /
    • 2017
  • In this study we present the reaction mechanism of $Cu_2ZnSnSe_4$ (CZTSe) nanoparticles synthesized by microwave-assisted chemical synthesis. We performed reactions every 10 minutes in order to identify different phases during quaternary CZTSe formation. The powder samples were analyzed by x-ray diffraction (XRD), Raman spectroscopy, energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The results showed that in the first minutes copper phases are predominant, then copper and tin secondary phases react to form ternary phase. The quaternary phase is formed at 50 minutes while ternary and secondary phases are consumed. At 60 minutes pure quaternary CZTSe phase is present. After 60 minutes the quaternary phase decomposes in the previous ternary and secondary phases, which indicates that 60 minutes is ideal reaction time. The EDS analysis of pure quaternary nanocrystals (CZTSe) showed stoichiometric relations similar to the reported research in the literature, which falls in the range of Cu/(Zn+Sn): 0.8-1.0, Zn/Sn: 1.0-1.20. In conclusion, the evolution pathway of CZTSe synthesized by this novel method is similar to other synthesis methods reported before. Nanoparticles synthesized in this study present desirable properties in order to use them in solar cell and photoelectrochemical cell applications.

Horizon Run Spin-off Simulations for Studying the Formation and Expansion history of Early Universe

  • Kim, Yonghwi;Park, Jaehong;Park, Changbom;Kim, Juhan;Singh, Ankit;Lee, Jaehyun;Shin, Jihye
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.46 no.2
    • /
    • pp.45.1-45.1
    • /
    • 2021
  • Horizon Run 5 (HR5) is a cosmological hydrodynamical simulation which captures the properties of the Universe on aGpc scale while achieving a resolution of 1kpc. This enormous dynamic range allows us to simultaneously capture the physics of the cosmic web on very large scales and account for the formation and evolution of dwarf galaxies on much smaller scales. On the back of a remarkable achievement of this, we have finished to run follow-up simulations which have 2 times larger volume than before and are expected to complementary to some limitations of previous HR simulations both for the study on the large scale features and the expansion history in a distant Universe. For these simulations, we consider the sub-grid physics of radiative heating/cooling, reionization, star formation, SN/AGN feedbacks, chemical evolution and the growth of super-massive blackholes. In order to do this project, we implemented a hybrid MPI-OpenMP version of the RAMSES code, 'RAMSES-OMP', which is specifically designed for modern many-core many thread parallel systems. These simulation successfully reproduce various observation result and provide a large amount of statistical samples of Lyman-alpha emitters and protoclusters which are important to understand the formation and expansion history of early universe. These are invaluable assets for the interpretation of current ΛCDM cosmology and current/upcoming deep surveys of the Universe, such as the world largest narrow band imaging survey, ODIN (One-hundred-square-degree Dark energy camera Imaging in Narrow band).

  • PDF