• 대한임상독성학회지
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• 제5권1호
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• pp.74-78
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• 2007

The carbamates are a group of insecticides derived from carbamic acid, with a broad spectrum of uses as agricultural and household garden insecticides. Carbamate insecticides are reversible cholinesterase inhibitors. Their inhibitory action is mediated by reversible carbamylation of acetylcholine, as with the organophosphate insecticides. Carbamates are absorbed by the body through multiple routes, including inhalation, ingestion, and dermal absorption. Although poisoning can result from occupational exposure or accidental ingestion, in most cases there is suicidal intent. This is particularly true in developing countries, where the highest incidence of morbidity and mortality from this cause occurs. Cardiac complications often accompany poisoning by carbamate compounds, which may be serious and often fatal. The extent, frequency, and pathogenesis of cardiac toxicity from carbamate compounds has not been clearly defined. Possible mechanismsinclude sympathetic and parasymphatetic overactivity, hypoxemia, acidosis, electrolyte derangements, and a direct toxic effect of the compounds on the myocardium. Patients with carbamate poisoning should immediately be transferred to an intensive or coronary care unit where appropriate monitoring and resuscitative facilities are available. We here report a case of acute coronary syndrome resulting from acute carbamate ingestionthat resulted in a healthy discharge.

• Journal of Preventive Medicine and Public Health
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• 제11권1호
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• pp.76-82
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• 1978

In order to study the change of laboratory parameters of lead poisoning, 8 persona who had not been treated previously for lead poisoning (Group 1 and 6 persons who had been inadequately treated for few months for chronic lead poisoning at local clinic (Group 2) were examined. They had occupational exposure to lead for 3 to 18 years (mean, 7.6). In group 1 blood lead, urine lead, urine coproporphyrin and ${\delta}$-aminolevulinic acid levels before our treatment exceeded the critical levels of lead poisoning. In group 2 urine lead level exceeded but blood lead, urine coproporphyrin and ${\delta}$-aminolevulinic acid levels were within normal limits. All of them were treated with D-penicillamine for 4 months as inpatients at Industrial Accident Hospital. The dose of D-penicillamine was the same in all patients; 600 mg per day p.o. and the chelating agent was administer every other week. For laboratory analysis, 24 hour urine and 10 gm of whole blood were collected every 1 month on last day of non-administration period. The results were as follows: 1. It was found that urine lead level was decreased below the cirtical level of lead poisoning after 4 month's treatment with D-penicillamine and blood lead level was decreased more progressively below the critical level after 1 month treatment. 2. Urine coproporphyrin and ${\delta}$-aminolevulinic acid levels were decreased progressively to normal range after 1 month treatment. 3. Two months after treatment, blood lead, urine lead, urine coproporphyrin and ${\delta}$-aminolevulinic acid levels showed some increasing trends. 4. Urine lead level should be checked in a person who had been inadequately treated with chelating agents because blood lead, coproporphyrin and ${\delta}$-aminolevulinic acid might be in normal range.

• 농촌의학ㆍ지역보건
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• 제33권1호
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• pp.82-89
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• 2008

농촌의 고령화, 기계화 및 농약 사용량의 증가는 농어업인의 손상 및 중독의 증가에 영향을 미치고 있다. 본 연구에서는 농어민 자격자료와 건강보험수진자료 등 2차 자료원을 이용하여 농어업인과 비농어업인에서 손상질환의 유병률을 비교하였다.구체적으로 농어업인과 비농어업인 사이의 전체손상질환 유병률의 차이를 비교하였고 농어업인에서 많은 5대 다빈도 손상질환과 농약에 의한 중독 상병에 대해 비교하였다. 유병률 비교는 남녀 각각에서 비농어업인을 표준 인구로 간접 표준화법을 이용하여 연령보정 표준화 이환비와 95% 신뢰구간을 구하였다.연구결과 농어업인의 전체손상질환 연령보정 표준화이환비는 남자에서 137.6(95% 신뢰구간 137.1 - 138.1) 이었으며 여자에서는 123.3(95% 신뢰구간 122.9 - 123.8)로 유의하게 높았다. 세부질환별로는 요추/골반, 어깨, 목의 염좌, 흉골, 갈비뼈, 흉추의 골절과 살충제 중독에서 연령보정 표준화이환비가 유의하게 높았다.향후 농어업인 손상질환과 관련된 다양한 형태의 연구가 필요하며, 농어업으로 인한 손상의 지역별 또는 경시적 비교가 가능하도록 전체 손상과 작업관련성 손상의 정의를 표준화하는 것이 필요하다.

• 대한임상독성학회지
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• 제2권1호
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• pp.31-36
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• 2004

Three workers, field operators in lubricating oil processing of petroleum refinery industry were found unconscious by other worker. One of them who were exposed to an high concentration of H2S was presented with Glasgow Coma Score of 5, severe hypoxemia on arterial blood gas analysis, normal chest radiography, and normal blood pressure. On hospital day 7, his mental state became clear, and neurologic examination showed quadriparesis, profound spasticity, increased tendon reflexes, abnormal Babinski response, and bradykinesia. He was also found to have decreased memory, attention deficits and blunted affect which suggest general cognitive dysfunction, which improved soon. MRI scan showed abnormal signals in both basal ganglia and motor cortex, compatible with clinical findings of motor dysfunction. Neuropsychologic testing showed deficits of cognitive functions. SPECT showed markedly decreased cortical perfusion in frontotemporoparietal area with deep white matter. Another case was recovered completely, but the other expired the next day.

• 대한임상독성학회지
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• 제12권1호
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• pp.22-30
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• 2014

Purpose: The purpose of this systematic review was to evaluate the evidence regarding injury and poisoning associated with the clinical mercury thermometer. Methods: Electronic literature searches were conducted for identification of relevant studies and case reports of injury and poisoning associated with the clinical mercury thermometer. The search outcomes were limited to literature with English and Korean languages published from 1966. Studies related to occupational mercury exposure, or mercury exposure from sphygmomanometer, barometer, and fluorescent light were excluded. Results: A total of 60 reports, including 59 case reports, were finally included. Of those, nine cases pertained to an intact thermometer as a foreign body, 25 injuries were related to a thermometer, and 26 cases involved exposures to mercury from a broken thermometer. Case reports were classified according to severity into 16 mild, 41 moderate, and two severe cases. Two cases of mortality were reported, one was deliberate intravenous injection of mercury and the other was acute vapor inhalation of mercury from broken thermometers. Conclusion: Findings of this systematic review suggested that the mercury thermometer could cause various forms of poisoning and injury. In particular, inhalation of mercury vapor from a broken thermometer can lead to systemic toxicity requiring chelating therapy.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.26.1-26.15
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• 2023

Background: The objective of this study is to investigate the differences in incidence rates of targeted diseases by classification of occupations among construction workers in Korea. Methods: In a subject-based cohort of the Korean Construction Worker's Cohort, we surveyed a total of 1,027 construction workers. As occupational exposure, the classification of occupations was developed using two axes: construction business and job type. To analyze disease incidence, we linked survey data with National Health Insurance Service data. Eleven target disease categories with high prevalence or estimated work-relatedness among construction workers were evaluated in our study. The average incidence rates were calculated as cases per 1,000 person-years (PY). Results: Injury, poisoning, and certain other consequences of external causes had the highest incidence rate of 344.08 per 1,000 PY, followed by disease of the musculoskeletal system and connective tissue for 208.64 and diseases of the skin and subcutaneous tissue for 197.87 in our cohort. We especially found that chronic obstructive pulmonary disease was more common in construction painters, civil engineering welders, and civil engineering frame mold carpenters, asthma in construction painters, landscape, and construction water proofers, interstitial lung diseases in construction water proofers. Conclusions: This is the first study to systematically classify complex construction occupations in order to analyze occupational diseases in Korean construction workers. There were differences in disease incidences among construction workers based on the classification of occupations. It is necessary to develop customized occupational safety and health policies for high-risk occupations for each disease in the construction industry.

• Annals of Occupational and Environmental Medicine
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• 제34권
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• pp.16.1-16.11
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• 2022

Background: Antimony is used in catalysts, pesticides, brake systems, pharmaceuticals, and synthetic fire retardants in the plastic, paint, and rubber industries. Accumulation of trivalent antimony compounds in the body can cause cardiotoxic effects and increase the risk of electrocardiogram (ECG) abnormalities and sudden death. Antimony exposure can result in action potential prolongation, causing a cardiac repolarization delay, which appears as QTc prolongation and T-wave abnormalities on the ECG. There are no studies on antimony-associated cardiac toxicity in Korea. Case presentation: Accordingly, the present study reports cases of ECG abnormalities in workers handling antimony trisulfide at a company located in the Gyeongsangbuk-do region. Nineteen workers employed at an automobile brake lining manufacturer were exposed to antimony trisulfide dust through thermoforming, grinding, and drilling processes. In 2020, the workers were reported to work 12-hour shifts, 5 days a week. The time-weighted average (TWA) of antimony trisulfide exposure measured in workers was 0.0028 mg/m³. Two workers were excluded from the analysis due to pre-existing medical conditions (cardiovascular disease). Of the remaining 17 workers, ECG abnormalities were found in 41% (seven out of 17: four with QTc prolongation and T-wave abnormalities; two with only T-wave abnormalities; and one with only QTc prolongation). Conclusions: This case report outlines the first few cases in Korea in which potential cardiac toxicity caused by occupational exposure to antimony was identified. However, data regarding cardiac toxicity caused by antimony exposure are still lacking in Korea; thus, additional studies are needed to identify causal relationships.

• 한국직업건강간호학회지
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• 제8권2호
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• pp.176-192
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• 1999

The purpose of this study is to analysis change of industrial health and safety before and after economic crisis(1997~1998). The data were obtained through mail interview with health supervisor(occupational health nurses) during February, 1999. The final sample was consisted of 127 respondents, 97 are selected in this study. The major findings were as follows: First, the percent of industries whose empl safe supervisors, physicians and industry hygi decreased in number is 79.4%, 3.8%, 50.0 21.5% in each. Second, man receiving over 1.5 million won as an average wage of health supervisor is 27.5% in 1997, but it decreased to 25.3% in 1998. Man receiving under 100~150 million won is 48.4% in 1997, but this percent decreased to 36.3% in 1998 and 13.6% of health supervisor regularly were transformed to contingent worker in 1998. Third, especially, budgets for health and saf work place decreased to 13.8% in 1998 than 19. Fourth, industrial accident case, unre accident case, occupational disease decreased than 1997, but mortality from industrial a increased in 250%. Fifth, according to the health diagnosis report, number of case with evidence of disease increased in liver disease, tuberculosis and so on, and number of case with evidence of occupational disease increased in noise induced hearing loss, pneumoconiosis. organic solvent poisoning and so on. Sixth, this survey shows that health council, health education in duty of health supervisor was conducted passive in 1998 thin 1997, and percent of hold two or more positions is 47.6% in medical insurance, 10.7% in accountant's business 8.3 in secretory. 7.1% in telephone operator awl 22.6% in etc. Seventh, distress of health supervisor after economic crisis is 30.9% in employment instability, 19.8% in hold two or more positions and decrease of budgets. For subjugation of the trouble, the respond of active policy of government occupied most.

• 한국산업보건학회지
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• 제7권1호
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• pp.153-165
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• 1997

This study investigated the current industrial hygiene status of China, a socialistic country, to explore the future direction of industrial hygiene of in Korea. In China, the industrial hygiene is called as labor hygiene, which includes industrial health and industrial hygiene. The main goal of labor hygiene is to protect the health of laborers, promote the productivity and ensure the development of industry and agriculture. Started since the foundation of People's Republic of China in 1949, the labor hygiene developed with the occupational disease science which belongs to clinical medicine, has grown today as an independent science. The labor hygiene has made a rapid progress, especially for the last 20 years. The scope of industrial hygiene was expanded from the prevention and treatment of silicosis to pneumoconiosis and o.ther occupational poisoning caused toxic substances. In addition, not only the prevention of industrial toxication but also the prevention of hazards of phisical causes were included in the scope of industrial hygiene. Based on activation of health centers, the organization for the prevention & treatment of occupational diseases was established at the city, county and state. The industrial hygiene monitoring is being carried out through clear division and partition system.

• 농촌의학ㆍ지역보건
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• 제26권2호
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• pp.7-14
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• 2001

증례들은 40대 남자 1명과 여자 1명, 50대 여자 2명이었다. 담배 농사는 모두 10년 이상 종사하였다. 모두 어지러움과 구역을 호소하였으며, 구토, 두통, 설사, 쇠약감 등의 증상이 있었다. 이런 증상은 담배를 집중적으로 수확하는 시기에 발생하였으며, 날씨가 덥거나 땀을 많이 흘리는 경우에 증상이 심했다. 이슬에 젖은 담배잎을 수학하면서 증상이 발현되는 경우도 있었다. 최근 2-3년 동안에 상기 증상들이 1년에 2-3차례 발생하였다. 남자 1명이 고혈압으로 치료하고 있는 것을 제외하면 병력상 특이점은 없었으며, 모두 비흡연자였다. 증례들은 약국과 병원에서 수액요법 등으로 1일 이내에 호전되었다. 우리 나라에서 담배잎농부병의 유병률, 발생률 및 위험요인을 파악하기 위한 역학조사와 병 의원 감시체계를 가동하여야 한다. 담배잎을 수확하다가 어지러움과 구토를 주소로 내원하는 많은 사람들이 실제 담배잎농부병으로 진단되지 못하고 단순한 농약중독과 고온손상에 준하여 치료받는 경우가 많을 것으로 생각한다. 담배를 재배하는 농부는 물론 의료인에 대해서도 담배잎농부병의 예방과 치료에 대한 교육을 실시하여야 한다.