• Journal of Chest Surgery
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• v.16 no.4
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• pp.539-546
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• 1983

Maximal expiratory flow-volume [MEFV] curves were studied in 22 patients who underwent pneumonectomy with various pulmonary lesions, such as lung cancer, bronchiectasis and tuberculosis etc, at the preoperative stage and 3 week, 4 month and 12 month after pneumonectomy for the analysis of the reduction and progressive improvement of postoperative ventilatory function. And the factors affecting them like as age difference and the site of pneumonectomy were also analyzed. From these curves peak flow rate [PF R], maximal expiratory flows at 25% and 50% of expired forced vital capacity [V25, V50] and forced vital capacity [FVC] were obtained. In addition, partial pressure of oxygen and carbon dioxide in arterial blood were measured. The results were as follows; 1. The mixed type, especially obstructive type of ventilatory impairment was observed at 3 week after operation. For 1 year of postpneumonectomy FVC was increased by 12.3% of predicted compared to 2.6% of predicted V50. 2. The improvement of FVC during 1 year of postpneumonectomy showed decreasing tendency with the increase of age but the changes of V25 and V50 were unremarkable. 3. The differences of immediate postoperative reduction and progressive improvement of ventilatory capacity after right and left pneumonectomy were analyzed. The reduction of V50, V25 and FVC at 3 week of postoperation were greater in patients with right pneumonectomy [20.9%, 18.2% and 26.2% of predicted] than in patients with left pneumonectomy 16.5%, 18.2% and 18.1%]. But there was no significant difference of these values at 12 month after pneumonectomy. 4. The partial pressure of oxygen in arterial blood [$PaO_2$] was decreased by 13.6 mmHg at 3 week after pneumonectomy compared to the preoperative stage but returned to the normal range within 4 month after pneumonectomy. However, TEX>$PaCO_2$ was within the normal range during 1 year of postoperation.

• Journal of Pharmaceutical Investigation
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• v.30 no.4
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• pp.247-252
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• 2000

The advantages of transdermal administration are avoiding hepatic first pass effect, minimizing inter- and intra-patient variation, maintaining steady-state plasma level to provide long-term therapy from a single dose, and allowing a rapid termination of drug input. Clenbuterol, a selective ${\beta}_2-adrenergic$ receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease. For the development of transdermal systems containing clenbuterol, two limiting factors - long lag time and low flux - must be overcome. In this study, we attempted to select optimal formulation for preparation of clenbuterol patch using hairless mouse skin and flow-through diffusion cell. The flux of clenbuterol increased as the percent of clenbuterol dose dependently in the concentration range of 5-15%. Based on this result, we fixed the concentration of clenbuterol as 15%. The effect of various penetration enhancers on percutaneous absorption of clenbuterol through hairless mouse skin was investigated. Labrafil was the most effective enhancer, which increased the permeability of clenbuterol approximately 4-fold compared with the control without penetration enhancer. Optimal enhancer concentration was 3%. The effect of various adhesives on penetration of clenbuterol was also investigated. Among the adhesives studied, MA-31 was the most effective adhesive. Furthermore, the clenbuterol patch composed of 15% clenbuterol, 3% Labrafil and 82% MA-31, which gave most excellent penetration of drug in in vitro penetration study, maintained therapeutic plasma levels in in vivo study using S.D. rats. These studies demonstrated a good feasibility of clenbuterol administration through the intact skin using a transdermal patch, and show a possibility of the development of clenbuterol patches.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.13 no.5
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• pp.59-80
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• 2010

This research This research aims at developing systemic evaluation model in terms of biotope preservation through reports, literatures, and expert survey analysis by implementing biotope structure analysis in area level with selecting Hyunpoong and Yuga-myeon, Dalseong county, Daegu metropolitan city as a site. First of all, as a result of biotope type classification of research site, biotope type groups are classified into total 13, and its biotope types are divided into total 61. Also, as a result of literature analysis, total 18 items are drawn such as diversity of biotope typical species as a index item to assess the preservation value of biotope, and the first evaluation index are divided into 10 and the second ones are divided into 8 according to characteristic of index items. As a result of expert survey analysis, All 10 index items, first evaluation index, show high importance average (above 4.7). As a result of implementation of main cause for categorizing evaluation index by characteristic, there are 3 factors such as 'obstructive factor.' Based on above survey analysis result, as a result of estimating the weight of each item, 'restoration factor' showed the highest, 3.4541, but 'factor of habitat stability' showed 3.1468, which is the lowest The systemic value evaluation was set by comprehensively analyzing these results. As a result of biotope preservation value evaluation through applying research site, total 19 types which are abundant in vegetation are classified into I class, 12 types in II class, 5 types in III class, 10 types in IV class, and 15 types in V class respectively. Lastly, as a result of second evaluation, it is analyzed that there are 17 special meaningful space to preserve species and biotope(1a, 1b) and 61 meaningful space to preserve species (2a, 2b, 2c).

• Safety and Health at Work
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• v.13 no.2
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• pp.148-154
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• 2022

Background: Bus driving is a mentally demanding activity that requires prolonged attention to ensure safety. The aim of the study was to assess mental fatigue caused by driving a public bus and to find a profile of workers at higher risk. Methods: We evaluated changes of critical flicker fusion (CFF) (index of central arousal) and heart rate variability (HRV) (index of autonomic balance) in a 6-hour driving shift on a real route, in 31 professional bus drivers, and we tested the influence of personal factors such as sleep quality, BMI, and age. Paired t-test was used to test differences of CFF and HRV between both initial and final phase of driving, while multiple linear regression tested the influence of personal variables on the indexes of mental fatigue. Results: Results showed that CFF significantly decreased after 6 hours of bus driving (41.91 Hz, sd 3.31 vs. 41.15 Hz, sd 3.15; p = 0.041), and heart rate significantly decreased in the final phase of driving, with respect to the initial phase (85 vs. 78 bpm, p = 0.027). Increasing age (beta = -0.729, p = 0.022), risk of obstructive sleep apnea syndrome (beta = -0.530, p = 0.04), and diurnal sleepiness (beta = -0.406, p = 0.017) showed a significant effect on influencing mental fatigue. Conclusion: Elderly drivers at higher risk of sleep disorders are more prone to mental fatigue, when exposed to driving activity. Monitoring indexes of central arousal and autonomic balance, coupled with the use of structured questionnaires can represent a useful strategy to detect profile of workers at higher risk of mental fatigue in such duty.

• Journal of Medicine and Life Science
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• v.18 no.3
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• pp.61-65
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• 2021

Although re-expansion pulmonary edema (RPE) is rare (incidence rate <1%), it is associated with a mortality rate of >20%; therefore, early diagnosis and treatment are important. We report a case of RPE following chest tube insertion in a patient with spontaneous pneumothorax. We have specifically focused on the mechanism underlying RPE and the possible etiology. An 82-year-old man with a history of chronic anemia, chronic obstructive pulmonary disease, diabetes mellitus, and hypertension was referred to the emergency department for management of recurrent right-sided pneumothorax. We performed emergency closed thoracostomy for suspected tension pneumothorax, which led to stabilization of the patient's vital signs; however, he coughed up frothy pink sputum accompanied by severe right-sided chest pain 30 min postoperatively. The patient showed new-onset right pulmonary consolidation on chest radiography, as well as desaturation, tachycardia, and tachypnea and was diagnosed with RPE. He was transferred to the intensive care unit for mechanical ventilation and supportive treatment using diuretics, ionotropic agents, and prophylactic antibiotics. RPE gradually resolved, and the patient was extubated 3 days after admission. He has not experienced recurrent pneumothorax or pulmonary disease for 4 months. We emphasize the importance of RPE prevention and that aggressive ventilator care and supportive treatment can effectively treat RPE following an accurate understanding of the underlying pathogenetic mechanisms and risk factors.

• Korean Circulation Journal
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• v.52 no.12
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• pp.890-900
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• 2022

Background and Objectives: Some individuals exhibit discrepancies between risk classifications assessed using clinical factors and those obtained by vascular imaging. We aimed to evaluate whether statins provide clinical outcome benefits in patients classified as having low to moderate cardiovascular risk but with carotid plaque. Methods: This was a retrospective propensity score matching study. A total of 12,158 consecutive patients undergoing carotid ultrasound between January 2012 to February 2020 were screened. Individuals with low to moderate cardiovascular risk who were not currently recommended for statin therapy but had carotid plaques were included. Among 1,611 enrolled individuals, 806 (statin group: 403, control group: 403) were analyzed. The primary outcomes were major adverse cardiovascular and cerebrovascular events (MACCEs: cardiovascular death, myocardial infarction, coronary revascularization, and ischemic stroke or transient ischemic attack) and all-cause mortality. Results: During the median follow-up of 6.0 years, the incidence of MACCEs did not differ between the groups (6.1 and 5.7/1,000 person-years in the control and statin groups, respectively; adjusted hazard ratio [HR], 0.95; p=0.90). The incidence of all-cause mortality did not differ (3.9 and 3.9/1,000 person-years, respectively; adjusted HR, 1.02; p=0.97). Kaplan-Meier curves revealed similar rates of MACCEs (log-rank p=0.72) and all-cause mortality (log-rank p=0.99) in the 2 groups. Age and smoking were independent predictors of MACCEs. Subgroups exhibited no differences in clinical outcomes with statin use. Conclusions: Benefit of statin therapy was likely to be limited in low to moderate risk patients with carotid plaques. These results could guide physicians in clinical decision-making regarding cardiovascular prevention.

• Journal of dental hygiene science
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• v.14 no.4
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• pp.433-441
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• 2014

This study was aimed to analyze factors affecting intention on clinical application by task autonomy of dental hygienists, expected effect and obstructive factor on clinical application of assessment, dental hygiene diagnosis, planning, implementation, and evaluation (ADPIE). Meanwhile, it proved mediating effects of "attitude toward ADPIE" when it came to "intention on clinical application". The data was collected from 237 dental personnel in capital region from March 28, 2014 to May 2, 2014. To analyze the suitability of a theoretical model and hypothesis testing, SPSS 21.0 and AMOS 18.0 program were used. The theoretical model was accepted as it resulted in ${\chi}^2=421.67$ while showing goodness of fit index=0.858, comparative fit index=0.915, Tucker-Lewis index=0.896, root mean square residual=0.039, and root mean square error of approximation=0.099. The result showed "task autonomy of dental hygienists (${\beta}=0.398$, p<0.05)" and "expected effect on ADPIE (${\beta}=0.363$, p<0.01)" had a positive effect on "attitude toward ADPIE". Also, "attitude toward ADPIE" had a positive effect on "intention on clinical application". In addition, "task autonomy of dental hygienists" and "expected effect on ADPIE" had an indirect influence on "intention on clinical application" via such intermediary as "attitude toward ADPIE". According to the above results, the task autonomy of dental hygienists, expected effect on ADPIE, and attitude toward ADPIE were confirmed to be significant factors when it came to the intention on its clinical application. Therefore in order to settle ADPIE in the clinical practice, improvement of task autonomy for dental hygienists as well as their expectation and attitude on ADPIE must be promoted.

• Journal of Chest Surgery
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• v.50 no.2
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• pp.86-93
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• 2017

Background: The influence of lifestyle diseases on postoperative complications and long-term survival in patients with non-small cell lung cancer (NSCLC) is unclear. The aim of this study was to determine whether lifestyle diseases were significant risk factors of perioperative and long-term surgical outcomes in elderly patients with stage I NSCLC. Methods: Between December 1995 and November 2013, 110 patients aged 65 years or older who underwent surgical resection of stage I NSCLC at Dong-A University Hospital were retrospectively studied. We assessed the presence of the following lifestyle diseases as risk factors for postoperative complications and long-term mortality: diabetes, hypertension, chronic obstructive pulmonary disease, stroke, and ischemic heart disease. Results: The mean age of the patients was 71 years (range, 65 to 82 years). Forty-six patients (41.8%) had hypertension, making it the most common lifestyle disease, followed by diabetes (n=23, 20.9%). The in-hospital mortality rate was 0.9% (n=1). The 3-year and 5-year survival rates were 78% and 64%, respectively. Postoperative complications developed in 32 patients (29.1%), including 7 (6.4%) with prolonged air leakage, 6 (5.5%) with atrial fibrillation, 5 (4.5%) with delirium and atelectasis, and 3 (2.7%) with acute kidney injury and pneumonia. Univariate and multivariate analyses showed that the presence of a lifestyle disease was the only independent risk factor for postoperative complications. In survival analysis, univariate analysis showed that age, smoking, body mass index, extent of resection, and pathologic stage were associated with impaired survival. Multivariate analysis revealed that resection type (hazard ratio [HR], 2.20; 95% confidence interval [CI], 1.08 to 4.49; p=0.030) and pathologic stage (HR, 1.89; 95% CI, 1.02 to 3.49; p=0.043) had independent adverse impacts on survival. Conclusion: This study demonstrated that the presence of a lifestyle disease was a significant prognostic factor for postoperative complications, but not of survival, in elderly patients with stage I NSCLC. Therefore, postoperative complications may be influenced by the presence of a lifestyle disease.

• Journal of Gifted/Talented Education
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• v.22 no.3
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• pp.663-677
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• 2012

The purpose of the study was to verify validity of Creative School Environment Perceptions (CSEP) scale developed based on the scale developed in 2010 by Mayfield and Mayfield. Factor analysis was used to assess construct validity. Another purpose of the study was to investigate factors related to students' perception of creative school environment through use of the group differences. The research participants were 203 elementary school students and all of them were 5th and 6th grade students. Factor analysis indicated that CSEP scale consist of three factors: creativity support, work characteristics, and creativity blocks. In addition the correlation between CSEP scale and the previous scale were investigated to verify the validity of CSEP scale. The results showed that the convergent validity were obtained. Independent-sample t test was performed to test for specific loci of significant between group differences in gender, grade, and the level of ideational behavior. The finding showed that 6th grade students said that their environment hinder creativity. Students with the high level of ideational behavior perceived their school environment was supportive while students with the low level of ideational behavior perceived their school environment was obstructive. Therefore teachers should understand students' perception of creative school environment using CSEP scale and should change students' perception of creative school environment through considering grade and the level of ideational behavior.

• Journal of Environmental Science International
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• v.28 no.1
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• pp.85-97
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• 2019

Meteorological factors and air pollutants are associated with respiratory diseases, and appropriate use of weather and air quality information is helpful in the management of patients with such diseases. This study was performed to investigate both the utilization of weather and air quality information by, and the needs of, patients with respiratory diseases. Questionnaires were administered to 112 patients with respiratory diseases, 60.7% of whom were female. The rates of bronchial asthma and chronic obstructive pulmonary disease among patients were 67.0% and 10.7%, respectively. The majority of subjects (90%) responded that prevention was important for respiratory disease management and indicated that they used weather and air quality information either every day or occasionally. However, respondents underestimated the importance of weather and air quality information for disease management and were unaware of some types of weather information. The subjects agreed that respiratory diseases were sensitive to weather and air quality. The most important weather-related factors were diurnal temperature range, minimum temperature, relative humidity, and wind, while those for air quality were particulate matter and Asian dust. Information was gleaned mainly from television programs in patients aged 60 years and older and from smartphone applications for those below 60 years of age. The subjects desired additional information on the management and prevention of respiratory diseases. This study identified problems regarding the utility of weather and air quality information currently available for patients with respiratory diseases, who indicated that they desired disease-related information, including information in the form of action plans, rather than simple health- and air quality-related information. This study highlights the necessity for notification services that can be used to easily obtain information, specifically regarding disease management.