• Title/Summary/Keyword: Objective SCORAD Index

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Two cases of Atopic Dermatitis Treated with Huini-san (회역산(回逆散)으로 호전을 보인 아토피피부염의 치험 2례)

  • Jo, So-Hyun;Jo, Eun-Hee;Kim, Seong-Joung;Park, In-Hae;Park, Min-Cheol
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.3
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    • pp.180-190
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    • 2014
  • Background and Objective : Atopic dermatitis is a type of dermatitis, an inflammatory, relapsing, non-contagious and itchy skin disorder and affecting up to 30% of children in the Korea. In this study, Huini-san, which is mentioned in Shanghanlun(傷寒論), and acupunture treatment on Atopic Disease was investigated. Methods : We have classified the patients according to the Shanghanlun six meridian patterns diagnostic system and the patients are treated with Huini-san. The severity of Atopic dermatitis was evaluated by SCORAD index, visual analogue scale(VAS) and pictures. Results : After the treatment the SCORAD index and VAS of 2 patients dicreased significantly. Conclusions : Huini-san and acupunture treatment has improved the symptoms of Atopic dermatitis in this study.

Two cases of Atopic Dermatitis Treated with Chijabyukpi-tang (치자벽피탕(梔子檗皮湯)으로 호전을 보인 아토피피부염의 치험 2례)

  • Park, Sung-gu;Noh, Hyeon-Min;Jo, Eun-Hee;Park, Min-Cheol
    • Herbal Formula Science
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    • v.25 no.3
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    • pp.429-436
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    • 2017
  • Objective : This case report presents the effect of Chijabyukpi-tang(梔子檗皮湯) on Atopic Dermatitis. The patient was diagnosed with Yangmyung-Yeoljeung(陽明熱證) based on Shanghanlun provisions. Methods : We have classified the patients according to the shanghanlun six meridian patterns diagnostic system and the patients are treated with Chijabyukpi-tang. The severity of Atopic dermatitis was evaluated by SCORAD index, visual analouge scale(VAS) and pictures. Results : After the treatment, the SCORAD index of 2 patients decreased from 78 to 20.2 and from 67.4 to 38.2 respectively. Conclusions : Although Chijabyukpi-tang is unusual treatment for Atopic dermatitis, this case report showed the effectiveness of using Chijabyukpi-tang on Atopic dermatitis according to shanghanlun six meridian patterns diagnostic system.

A Case Report of Atopic dermatitis treated by Gamchosasim-tang based on Shanghanlun provisions (『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 감초사심탕(甘草瀉心湯)을 투여한 대양병(大陽病) 결흉(結胸) 아토피 피부염 치험 1례)

  • Lee, Sung-Jun;Ryu, Hee-Chang
    • 대한상한금궤의학회지
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    • v.6 no.1
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    • pp.71-78
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    • 2014
  • Objective : This study reports the effect of Gamchosasim-tang on atopic dermatitis. Methods : According to shanghanlun six meridian patterns diagnostic system, We diagnosed Taeyang-byung kyeolhyung. The symptoms of atopic dermatitis were worsen when the patient had bad sleeping habits by stress(心煩不得安). So the patient treated with Gamchosasim-tang for 3 months. The severity of atopic dermatitis was evaluated by SCORAD index, EASI and pictures. Results : After the treatment, SCORAD index and EASI decreased $75.9{\rightarrow}27.9$, $19{\rightarrow}5.7$ each. And sleeping habits also improved. Conclusions : Gamchosasim-tang improved the symptoms of atopic dermatitis on this study. Although Gamchosasim-tang is not an usual treatment for atopic dermatitis, we could prescribe the medicine due to shanghanlun six meridian patterns diagnostic system. And Further research would be needed the relation between bad sleeping habits cased by stress(心煩不得安) and Gamchosasim-tang.

A Clinical Research about Herbal Cosmetics Containing Phellinus linteus Extracts in Atopic Dermatitis Patients (아토피 피부염 환자에서 상황버섯 추출물을 함유한 한방화장품의 임상적 연구)

  • Jung, Ho-Jun;HwangBo, Min;Do, Eun-Ju;Suk, Jang-Mi;Kim, Mi-Ryeo;Kim, Young-Hun;Do, Kook-Bae;Lee, Chang-Eon;Jee, Seon-Young
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.23 no.3
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    • pp.154-164
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    • 2010
  • Objective : The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Phellinus linteus extracts on patients with atopic dermatitis. Methods : A total of 35 patients who visited Daegu Hanny Oriental Medical Center from November 4th, 2008 to December 28th, 2008 were included in this study. In this study, we observed transepidermal water loss, skin moisture content, modified scorad index of atopic dermatitis and pruritic degree. Statistical analysis was performed by using paired t-test and wilcoxon signed ranks test. Statistical significance was achieved if the probability was less than 5%(p<0.05). Results : Statistically, herbal cosmetics containing Phellinus linteus extracts showed siginificant effect on transepidermal water loss, skin moisture content, modified scorad index of atopic dermatitis and pruritic degree(p<0.05). And satisfaction after using herbal cosmetics was near good. Conclusions : Considering the above results, we have concluded that herbal cosmetics containing Phellinus linteus extracts have the remarkable effects on atopic dermatitis.

Effect of Taeyeol-go on Atopic Dermatitis (아토피 피부염 환자에 대한 태열고의 효과)

  • Yoon, Jong-Man;Kim, Dae-Bok;Park, Yang-Chun
    • Journal of Haehwa Medicine
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    • v.15 no.2
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    • pp.187-192
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    • 2006
  • Objective : Atopic dermatitis is a prevalent disease. Taeyeol-go(TYG) is a herbal ointment which was expected to useful for treatment of atopic dermatitis. The aim of this study was to evaluate the effect of TYG on atopic dermatitis. Methods : Patients with atopic dermatitis applied TYG twice daily for 1 week. Clinical extent, intensity and subjective symptom were assessed by scoring atopic dermatitis (SCORAD) index before and after treatment. Results : 10 patients(4 male, 6 female), 3 to 37 years of age(mean 14.6${\pm}$9.52 years old), 2 to 31 years of onset(mean 11.4${\pm}$8.54 years), finished study. After treatment extent(p<0.01), intensity(p<0.005), subjective symptom(p<0.002) and total SCORAD index(p<0.002) was significantly decreased than before treatment. Conclusion : These results suggest that TYG is an effective therapeutic method for atopic dermatitis. Further studies in the form of randomized controled trail are needed.

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Retrospective Study about the Effectiveness of a Korean Medicine Treatment on 45 Facial Atopic Dermatitis Patients (얼굴아토피 피부염환자 45명의 한의학적 치료효과에 대한 후향적 연구)

  • Han, Su-Ryun;Seo, San;Park, Gun;Lee, Jung-Hwan;Jang, Jin-Young
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.2
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    • pp.64-74
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    • 2014
  • Objective : The purpose of this study is to report the effectiveness of a Korean Medicine Treatment on 45 facial atopic dermatitis patients. Methods : Total 45 facial atopic dermatitis patients, who has visited korean medical clinic in year 2011 were analyzed by Objective SCORAD Index(OSI) and Investigator's Global Assessment(IGA). Subanalysis of OSI and IGA were done according to topical ointment user/non-user, treatment period and change in IGA distribution. Results : 1. Male and female percent was 20%:80%. 17.8% were teens, 55.6% were twenties, 13.3% were thirties, 13.3% were above age forty. 64.4% were on topical ointment treatment of corticosteroid or calcineurin inhibitor, and 35.6% were not at the initial visit. Patients with family history were 44.4% and 62.2% had atopic dermatitis past history. 2. OSI and IGA were significantly lower after 1~3, 3~6, 6~9 month of treatment. Average post-treatment score was lower in longer-treated group. 3. IGA distribution has changed from average 3.42 at the first visit to 1.76 at final visit. 91.1% of total patients reported decrease in IGA at the final visit. 4. OSI and IGA improvement rate were significantly higher in non-topical ointment user than the user. Age, treatment period, initial OSI and IGA score difference were not significantly different. Conclusion : A significant percent of 45 facial atopic dermatitis patients who were treated with Korean Medicine Treatment reported decrease in OSI and IGA. The difference increased with the treatment period. Non-topical ointment users' improvement was significantly higher than topical ointment user.

Retrospective Study of the Effectiveness of Korean Medical Treatment on Infant and Young Child Atopic Dermatitis Patients with or without Topical Co-administration of Steroid (영유아 아토피피부염 환자의 스테로이드 외용제 사용유무에 따른 한의학적 치료효과에 대한 후향적 연구)

  • Yang, Yoon-Hong;Cho, Ah-Ra;Han, Su-Ryun;Seo, San;Park, Gun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.29 no.4
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    • pp.142-155
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    • 2016
  • Objectives: The purpose of this study is to examine whether there is a significant efficacy difference on infant and young child atopic dermatitis patients treated with Korean Medicine Treatment through 6 months between topical steroid used group and non-steroid group. Methods: The degree of atopic dermatitis was measured by the Objective SCORAD Index (OSI) with photographs of patients. Detailed analysis of the OSI score was compared based on the use of topical steroid. Results: 1. There was not a significant difference between the topical steroid group and the non-steroid group in regards of gender, age and initial OSI score. 2. The non-steroid group's OSI score decreased significantly from 50.17 to 29.20. 3. The topical steroid group's OSI score decreased significantly from 54.21 to 34.95. 76.19% of the patients in the topical steroid group discontinued steroid use within the 6-month period. The average time of discontinuation since the beginning of treatment was 3.36 months. 4. The OSI Improvement rate comparison of topical steroid group with non-steroid group did not show a significant difference over a 3-month and 6-month period. 5. Distribution of severe cases decreased in Both topical steroid and non-steroid group after 6 month treatment. Conclusions: The OSI score of infant and young child atopic dermatitis patients in both topical steroid and non-steroid group was decreased significantly with Korean medicine treatment through 6 months. There was no significant difference between topical steroid group and non-steroid group in OSI improvements over a 3-month period and 6-month period.

Retrospective Study about the Effectiveness of Korean Medicine Treatment on 89 Severe Atopic Dermatitis Patients (중증 아토피피부염 환자 89명의 한의학적 치료 효과에 대한 후향적 연구)

  • Cho, Ah-Ra;Han, Su-Ryun;Park, Gun;Seo, San
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.29 no.2
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    • pp.161-179
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    • 2016
  • Objectives : The purpose of this study is to report the effectiveness of a Korean Medicine Treatment on 89 severe atopic dermatitis patients all through 12 months. Methods : The degree of atopic dermatitis was measured in Objective SCORAD Index (OSI) with photos of patients. Then, the OSI score was estimated according to gender, age and intensity. Results : 1. The ratio of male to female was 41.57 : 58.43. The 24.72% of patients were in 0~11 year-old group, 16.85% were in 12~18 year-old group and 58.43% were in the group above 19 years old. 2. The initial OSI score was 64.43 and the final was 37.03 after 12 months. After 3, 6, 9, 12 months, the OSI score was significantly lower than the initial visit. 3. There was no significant difference between male and female patients on age, OSI scores and OSI improvements. 4. The patients who treated acupuncture were significantly older then who not treated. The OSI improvement had no significant difference whether treated with acupuncture or not. 5. There was no significant difference among 3 different age groups on initial OSI scores. The OSI improvement of 0~11 year-old group was significantly higher than the other groups after 12 month treatment. 6. The OSI score of 97.75% was decreased after 12 month treatment compared to initial visit. 7. After 12 month treatment, the distribution of severe atopic dermatitis was decreased from 100% to 37.08%. 8. There was no significant difference betweent steroid group and non-steroid group on OSI scores at initial visit and after 12 month treatment. Conclusions : The OSI Score of severe atopic dermatitis patients was decreased on the significant rate with Korean medicine treatment for 12 months.

The Burden of Atopic Dermatitis on Children and Their Families : Quality of Life and Financial Impact in Seoul Area (서울 지역을 대상으로 모집된 유.소아기 아토피피부염 환아의 삶의 질과 경제적 비용 부담에 관한 조사)

  • Yu, Seung-Min;Choi, In-Hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.23 no.3
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    • pp.122-137
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    • 2010
  • Objective : Atopic dermatitis (AD) in children may profoundly affect the quality of life (QOL), and also cause financial burden, to the families of those suffering from this ailment. The aim of our study was to examine the quality of life and the financial burden of atopic dermatitis in children and their families to evaluate this relationship with the degree of AD. Methods : 37 infant and child atopic dermatitis patients were included and evaluated using the SCORing of Atopic Dermatitis (SCORAD) Index and Eczema Area and Severity Index (EASI). Patients and carers were asked to fill in the questionnaires about their quality of life and financial costs during the past year. Data about sleep disturbance and pruritus were also obtained. Pearson's correlation was used for statistical analysis. Results : 1. The mean score of Children's Dermatology Life Quality Index (CDLQI) was $10.52{\pm}4.82$, Infants' Dermatologic Quality of Life (IDQOL) was $8.21{\pm}3.95$. 2. The mean score of Family Dermatology Life Quality Index (FDLQI) was $13.30{\pm}5.72$, Dermatitis Family Impact (DFI) was $12.5{\pm}4.98$. 3. By analyzing the questionnaire, the monthly average cost was determined to be 730,800 won for each patient : the direct cost was 283,500 won, and the indirect cost was 447,300 won. 4. By analyzing the correlation between the severity of AD and QOL, subjective SCORAD were significantly and positively correlated with QOL(IDQOL, FDLQI, DFI, CDLQI). 5. By analyzing the correlation between the severity of AD and any economic impact, EASI were significantly and positively correlated with the direct cost. Conclusion : The above results show that the QOL of the patients and carers is significantly related to their disease severity. Atopic dermatitis patients pay an average of 730,800 won a month, and the economic impact on the patients is significantly related to their disease severity. The CDLQI, IDQOL, FDLQI and DFImay potentially be of value to help in the appropriate management of AD and can be used as an added measurement in clinical trials involving AD management.

Non-comparative Study for the Observation of Clinical Efficacy and Safety of CheungYeolYiSeup-tang and Hwangbaek External dressings on Dampness-Heat Pattern Atopic Dermatitis

  • Choi, In-Hwa
    • The Journal of Korean Medicine
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    • v.29 no.5
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    • pp.41-51
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    • 2008
  • Objective : To observe the efficacy and safety of CheungYeolYiSeup-tang and Hwangbaek external dressings on dampness-heat pattern atopic dermatitis(AD) in a non-comparative study. Methods : 10 patients with AD were included for 4 weeks of treatment. Efficacy and safety assessment included the scoring atopic dermatitis index(SCORAD), typical signs and symptoms of AD, results of some laboratory tests related to toxicity, and the incidence of adverse events. Results : Improvements in efficacy parameters were observed and produced no significant changes in laboratory tests related to toxicity in these patients. Their SCORAD results significantly decreased after 4weeks(P value<.01, according to the Wilcoxon sum of ranks test). Similarly, significant reductions from baseline in subjective pruritus scores and (P value<.05 by the Wilcoxon sum of ranks test) and the mean average of individual signs and symptoms of AD were reported after 4 weeks(P value<.05, P<0.01 by the Wilcoxon sum of ranks test). There were no significant changes in eosinophil, neutrophil, lymphocyte, immunoglobulin E and ESR in blood serum by paired ttest. Conclusion :CheungYeolYiSeup-tang administration and Hwangbaek external dressings are an effective and safe treatment for the management of dampness-heat pattern atopic dermatitis.

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