• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.33 no.4
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• pp.1-15
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• 2020

Objectives : To investigate aggravating and mitigating factors of atopic dermatitis and to utilize the outcome in treatment planning. Methods : The research has a cross-sectional study design. Patients' SCORing Atopic Dermatitis (SCORAD) Index, demographic, physical characteristics, social history, serologic index and skin related instrumental measurements were analyzed with correlation and regression analysis method. Results : 48 patients in total were enrolled in the study. Skin Surface Hydration (SSH) and sex were found to be statistically significant aggravating and mitigating factors. As SSH increased, Total SCORAD (tSCORAD) and Objective SCORAD (oSCORAD) increased as well. As SSH decreased, tSCORAD and oSCORAD decreased as well. Female patient had a higher probability of suffering from severer subjective symptoms than that of male. Age, body mass index (BMI), alcohol consumption and smoking, transepidermal water loss (TEWL), IgE, IL-4, IL-5, IL-6, IFN-γ were found not to be statistically significant. There was no correlation between Subjective SCORAD (sSCORAD) and oSCORAD neither with Eczema Area and Severity Index (EASI). Conclusions : Increasing cutaneous moisture should be included in the treatment plan of atopic dermatitis. More emphasis should be put on alleviating subjective discomforts of female patients than that of male. Establishing separate strategies of managing objective eczema status and subjective discomforts respectively should be considered.

• The Journal of Pediatrics of Korean Medicine
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• v.19 no.2
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• pp.69-84
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• 2005

Objective : The objective of this study is to investigate treatment results and reasons of difference of treatment result. Method : 22 patients with atopic dermatitis were evaluated for the symptoms and signs according to SCORAD index before and after Oriental medical treatment. And they were divided into two groups(G1: the lower group, G2: the higher group) with 30 scores in standard and analyzed for differences of treatment result. Reasult : 22 patients's Change of total SCORAD index before and after treatment were $35.79{\pm}10.86$ and period were $4.55{\pm}2.94$ months. There were no significant differences between two groups in sex, age, congenital fever, onset and hospital treatment. There were many differences between two groups in the weakness of Digestive system. There were more familial histories in G2 than G1. Past years were $3.20{\pm}3.72$ years in G1 and $1.75{\pm}1.68$ years in G2. There were more deterioration fetors in G1 than G2. Sleep conditions before treatment were worse in G2 than G1 but all children except one were good after treatment. SCORAD index before treatment were worse in G2 than G1. The used herbal medicines were Bangpungtongsungsan gagambang, Yukmijihawangtang gagambang, Saenghyeolyunbuum gagambang. The most frequently used herbal medicine was Bangpungtongsungsan gagambang in G1, Yukmijihawangtang gagambang in G2. Conclusion : On the basis of this study, we thought factors which affected treatment result were the weakness of Digestive system, past years, deterioration factors and SCORAD index before treatment. But this study's cases are small in number so more study is need.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.3
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• pp.27-36
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• 2011

Objective : The purpose of this clinical research was to analyze the correlation between disease severity and disease specific quality of life adjusted by general quality of life measure in adult patients with atopic dermatitis attending Wonkwang Univ. Sanbon Oriental Medical Center. Methods : A total of 35 patients participated in atopic dermatitis clinical trial from June 1st, 2010 to June 30th, 2011 were included in this study. SCORing Atopic Dermatitis(SCORAD) index, Dermatologic Life Quality Index(DLQI), Health Utility Index III(HUI-III) and EuroQoL 5-Dimension(EQ-5D) have been estimatied. Baseline statistical analysis and normality test were done by using Student t-test, Shapiro-Wilk test and ladder test. Pearson analysis and Spearman analysis were conducted to examined the correlation of each variables. Hierachial regression analysis was performed using related variables. Statistical significance was achieved if the probability was less than 5%. Results : There were statistically significance between DLQI and SCORAD index, and also between DLQI and EQ-5D. However there was no significant between DLQI and HUI-III. In the hierachial regression analysis, after adjusting for demographic variables (gender, age) and general quality of life (EQ-5D), SCORAD index significantly predict the intensity of disease specific quality of life (DLQI). Conclusions : We confirmed the correlation between SCORAD index and DLQI, and developed the inference for regression equation of DLQI using SCORAD index, EQ-5D and demographic variables.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.3
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• pp.65-73
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• 2011

Background : There are findings indicating that the autonomic nervous system (ANS) is affected negatively in atopic dermatitis (AD). Heart rate variability (HRV) is a tool to examine ANS. But, studies investigation the relationship between AD and HRV is rare. Objective : The aim of this study was to investigate the correlation between atopic dermatitis severity and HRV and to find out the role of ANS in AD. Methods : Retrospective chart review was performed. The Severity Scoring Atopic Dermatitis (SCORAD) index and HRV parameter was investigated and analyzed. Results : There were 55 patients (25males and 30 females) who met the criteria. Objective SCORAD had significant positive correlation with HRT and Subjective SCORAD had significant negative correlation with SDNN, TP and VLF. Intensity item of SCORAD index had negative correlation with most HRV parameters, but TP, LF and LF/HF ratio had significant positive correlation with dryness. Conclusion : This study supports the concept that atopic dermatitis is a stress-responsive disorder and involves autonomic nervous system dysfunction.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.2
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• pp.220-227
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• 2002

Background: Atopic dermatitis is chronic eczematous dermatosis characterized by severe itching, localized eruption and chronic relapsing progress and has family history of atopic diseases and hereditary disposition. This Study is attempted in order to estimate the efficacy of herb medication treatment on atopic dermatitis. Objective: We studied 35 patients with atopic dermatitis from October 2001 to September 2002. Methods: We treated them with herb-medication and used the SCORAD index to assess the severity of atopic dermatitis. Results: Of the 35 patients that were treated, the SCORAD index was lowered to $30.5{\pm}20(3.5-94)$ than before of which the SCORAD index was $46.8{\pm}18.1(14.9-97.5)$. Conclusion: On the basis of this study, It should be considered that treatment of atopic dermatitis should be focused on the gastrointestinal system. Moreover a balanced diet should be considered

• The Journal of Pediatrics of Korean Medicine
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• v.19 no.1
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• pp.131-141
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• 2005

Objective : The objective of this study is to assess the clinical effect of Naesowhajungtang Gamibang on atopic dermatitis. Method : A total of 30 patients with atopic dermatitis were evaluated for the symptoms and signs according to SCORAD index and measured for peripheral eosinophil counts and serum total IgE before and after treatment. Results : 1. Among 30 patients diagnosed as Atopic Dermatitis, 11, were male(37%) and 19 were female(63%). the ratio of male and female patients were 1:1.7. 2. Among 30 patients diagnosed as Atopic Dermatitis, 25 Have family history of allergic disease(83%) and 20 have past history of allergic discase. 3. There was statistically significant relationship between serum total IgE and SCORAD score(p=0.019). 4. There was statistically significant relationship between peripheral eosinophil count and SCORAD score(p=0.001). 5. We could find no statistically significant change of serum total IgE and peripheral eosinphil count before and after treatment. 6. There was statistically significant change of SCORAD score and subjective symptom before and after treatment.(p<0.05). Conclusion : Naesowhajungtanggamibang is effective in the treatment of atopic dermatitis. And peripheral eosinophil counts and serum total IgE were good serum maker reflection the severity of atopic dermatitis.

• 대한상한금궤의학회지
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• v.7 no.1
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• pp.75-85
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• 2015

Objective : This case report presents the effect of Soshiho-tang on Atopic Dermatitis. The patient was diagnosed with Yangmyung-byung based on Shanghanlun provisions. Methods : According to Shanghanlun six meridian patterns diagnostic system, we dianosed the patient as Yangmyung-byung and he had trouble getting out of bed and nighttime itch. The patient was treated with Soshiho-tang. We evaluated the results of treatment by Objective SCORAD Index and pictures. Results : After the treatment, Objective SCORAD Index decreased from 61 to 21.5. And he became to have no trouble in getting up and also nighttime itch vanished. Conclusions : This case report sowed and effectiveness of using Soshiho-tang according to Diagnostic system based on Shanghanlun provisions on Atopic Dermatitis.

• Journal of Fashion Business
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• v.19 no.1
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• pp.141-150
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• 2015

The present study was undertaken to evaluate effects of eco-friendly underwears(three kinds of natural dying underwears) in patients with atopic dermatitis. We recruited 45 patients with atopic dermatitis admitted to Dongshin Oriental Hospital from August to September 2013. These patients were divided into three groups (A, B and C). Each group include 15 patients and three kinds of natural underwears dyed with polygonum tinctorium, loess, and non-dyed general cotton were given, respectively. We also used SCORAD index and digital infrared thermal imaging to investigate the effects of each eco-friendly underwear in patients with atopic dermatitis. In SCORAD index, Group A after wearing loess-dyed underwears for 4 weeks showed statistically significant reduction to 27.96 (P<0.05) compared to 34.20 before wearing loess-dyed underwears. In Group B after wearing polygonum tinctorium-dyed underwears for 4 weeks, SCORAD index and objective severity assessment were markedly reduced into 22.97 (P<0.01) and 18.17 (P<0.01) compared to 35.95 and 27.89 before wearing polygonum tinctorium.-dyed underwears, respectively. In Group C after wearing general cotton (non-dyed) underwears for 4 weeks, there was statistically no difference in SCORAD index, objective severity assessment and body temperature between before and after wearing general cotton (non-dyed) underwears. Taken together, polygonum tinctorium-dyed underwears used to patients with atopic dermatitis shows significant amelioration in atopic symptoms than loess-dyed underwears as well as general cotton (non-dyed) underwears.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.3
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• pp.191-204
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• 2014

Objective : The purpose of this study is to investigate the effect of Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) for atopic dermatitis patients diagnosed as the febrile tendency. Method : This case study was done on 6 atopic patients with febrile tendency who have visited Korean Medicine Clinic from 2013.08.01. to 2014.04.30.. Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) was prescribed to all 6 patients and evaluated the symptom change through photographs and questionnaire. Objective SCORAD Index(OSI) was used to evaluate the objective symptom and VAS was used to evaluate the subjective change. Results & Conclusion : The Objective SCORAD index and VAS were decreased in all patients. The average OSI reduction score was 26.3. Most symptoms of 6 patients were improved. Gagamchengyoung-tang ($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) can be effective in patients who were diagnosed as febrile tendency.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.1
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• pp.199-214
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• 2010

Objective : Atopic dermatitis (AD) may profoundly affect patient's quality of life (QOL), and also cause economic impact. The aim of our study was to evaluate the quality of life and the economic impact of adult atopic dermatitis patient in Seoul. We also evaluate the relationship of QOL and economic impact with severity of AD. Methods : 30 adult atopic dermatitis patient were included and evaluated by using the SCORAD Index and EASI. Patients were asked to fill in the questionnaires about their quality of life and financial costs during the past year by AD. Data about sleep disturbance and pruritus were also obtained. Pearson's correlation were used for statistical analysis. Results : 1. Among 30 patients, women were 19(63.3%), men were 11(36.7%). The mean age of the patients were 27.3 years old, patients between the ages of 17 and 30 years were 23, over 30 were seven. 2. The mean score of Objective SCORAD was $32.89{\pm}7.30$, Subjective SCORAD was $8.13{\pm}3.53$ and EASI was $9.15{\pm}6.90$이었다. 3. The mean score of Skindex-29 was $28.26{\pm}7.58$, DLQI was $10.17{\pm}5.55$. 4. By analyzing the questionnaire, a monthly average cost of 583,200 won for each patient was determined. Direct cost was 236,800 won and indirect cost was 346,300 won. 5. By analyzing the correlation between the severity of AD and QOL, Objective SCORAD and EASI were positively correlated with QOL(Skindex-29, DLQI) but not significant, meanwhile subjective SCORAD were significantly and positively correlated with QOL(Skindex-29, DLQI). 6. By analyzing the correlation between the severity of AD and economic impact, Objective SCORAD were significantly and positively correlated with direct cost and indirect cost. Also, EASI were significantly and positively correlated with direct cost and oriental medical hospital visits. Conclusions : The above results show that the QOL of the patients with atopic dermatitis is significantly related to their disease severity. Atopic dermatitis patients pay 583,200 won a month, and the economic impact of the patients is significantly related to their disease severity.