• 제목/요약/키워드: OASIS

검색결과 675건 처리시간 0.029초

Alternative Sample Preparation Techniques in Gas Chromatographic-Mass Spectrometric Analysis of Urinary Androgenic Steroids

  • Cho, Young-Dae;Choi, Man-Ho
    • Bulletin of the Korean Chemical Society
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    • 제27권9호
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    • pp.1315-1322
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    • 2006
  • The following study describes the gas chromatography-mass spectrometry (GC-MS) based screening and confirmation analysis of urinary androgenic steroids. Four commercially available solid-phase extraction (SPE) cartridges, Serdolit PAD-1, Sep-pak $C_{18}$, amino-propyl, and Oasis HLB, and three different extractive organic solvents, diethyl ether, methyl tert-butyl ether (MTBE), and n-pentane, were tested for sample preparation. Overall, Oasis HLB combined with MTBE extraction provided the highest recoveries in 39 of 46 total androgenic steroids examined and it showed a good extraction yield (>82.1%) for polar steroids, such as metabolites of fluoxymesterone, oxandrolone, and stanozolol, which gave a poor recovery in both n-pentane (9.2-64.3%) and diethyl ether (22.2-73.6%) extractions. All SPE sorbents tested showed potential, because they were efficient in extraction for most or selective steroids. When applied to positive urine samples based on the results obtained, the present method allowed selective and sensitive analysis for detection of urinary androgenic steroids. The experiments showed that the high-resolution MS method is clearly more efficient than the low-resolution MS technique for the detection of many urinary steroids. However, comprehensive sample clean-up procedures also might be needed especially in confirmation analysis to increase detectability.

고체상추출법과 HPLC/MSD/FLD를 이용한 수질중의 페놀 분석 (Determination of phenol using solid-phase extraction and HPLC/MSD/FLD in water)

  • 이태준;박근영;표동진
    • 분석과학
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    • 제28권6호
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    • pp.370-376
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    • 2015
  • Priority pollutant이며 페놀성화합물의 전구체인 페놀을 고체상추출법을 이용하여 추출 정제하여 형광검출기와 질량분석기가 각각 장착된 고속액체크로마토그래프를 이용하여 분석하는 방법을 설정하여 보았다. 고체상추출은 고분자성물질이 충진된 Oasis HLB cartridge를 이용하여 최적의 조건을 확립하였으며 이때의 평균회수율은 87.0% 이었다. 형광검출기를 이용한 경우가 질량분석기를 이용한 경우보다 검출한계가 낮았으나 선택성의 측면에서 질량분석기가 우수하였다.

정밀절대측위(PPP)기법에 의한 GPS 기준점 좌표의 산정 (The Coordinates Computation of the GPS Base Station by Precise Point Positioning)

  • 이용창
    • 한국측량학회지
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    • 제17권2호
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    • pp.145-152
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    • 1999
  • 제트추진연구소(JPL : Jet Propulsion Laboratory)에서는 매일 전세계에 분포된 정밀 측지용 GPS수신기의 광역망으로 부터 관측자료를 수집하고 분석하여 정밀한 GPS transmitter parameters (위성의 위치력 및 시계 보정값)를 산정하고 있으며 이를 이용한 자동화된 GPS 자료 해석 서비스를 제공하고 있다. 본 연구에서는 한측점의 2주파 GPS수신기로부터 획득한 위성관측자료를 E-mail 및 ftp(file transfer protocol)로 JPL의 주컴퓨터에 연결시켜 JPL의 정밀 GPS transmitter parameters 및 Gipsy/Oasis-II (GOA-II) s/w를 활용한 정밀절대측위(PPP : Precise Point Positioning)기법의 정밀도를 분석하고 PPP에 의한 GPS기준점 좌표의 산정 방안을 검토한 것이다. 검토결과, X, Y, Z 직교좌표계에서 수 cm급의 위치결정이 가능하였다.

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최근 5년간(2011~2015) 사상체질분야 논문의 통계기법 분석 및 오류에 관한 연구 (Analysis of the Statistical Techniques and Errors in the Field of Sasang Constitution Researches: from 2011 to 2015)

  • 김수정;김상혁;이시우
    • 사상체질의학회지
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    • 제28권1호
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    • pp.51-56
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    • 2016
  • Objectives This study was to identify the types of errors in the statistical analysis and trends of previous reported papers that used various statistical techniques.Methods We have selected 118 original articles for statistical review from the OASIS(http://oasis.kiom.re.kr) and the Pubmed(http://www.pubmed.gov) in the field of Sasang constitutional medicine. Published year was restricted from 2011 to 2015.Results 1. The ANOVA(25.72%) was the statistic of choice overall, followed by the chi-square test(21.74%), regression analysis(14.13%), t-test(11.59%), and etc. 2. By examining the errors of the statistical methods, there were 42(59.2%) thesis with errors among 71 thesis using ANOVA, 19(31.7%) thesis among 60 thesis using chi-square test, and 35(89.7%) over 39 thesis using regression analysis.Conclusions To improve the quality of Sasang Constitution, the participation of statisticians in research design will reduce the significant errors in statistical interpretation of the results.

효율적인 기술문서 개발을 위한 DITA 표준 적용 (Adopting DITA Standard for Developing Technical Documentation Efficiently)

  • 구흥서
    • 전기학회논문지
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    • 제65권1호
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    • pp.171-178
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    • 2016
  • In engineering industry, technical documentation refers to any type of documentation that describes handling, functionality and architecture of a technical product. The intended audiences for product technical documentation is the end user, the administrator, service or maintenance technician. Competition and rapid technological evolutions have created pressure to release new and improved products on an increasingly frequent basis. As the technical capabilities of products advance, the technical documentation for those products is becoming longer and complex. The Darwin Information Typing Architecture (DITA) is and XML-based, end-to-end architecture for authoring, producing, and delivering technical documents. DITA is an OASIS standard that allows documentation groups to single-source document for multiple products and users, to automatically publish that documentation in several media formats including PDF and HTML, and to efficiently maintain and update that documentation. This paper study on the various implementation projects for technical documentation using OASIS DITA standard and examines the potential for using DITA as a solution for reconstructing existing technical documentation. Also We offer an incremental adoption approach to effectively implement DITA standard of technical documentation project for domestic firms, while reducing failures.

한약처방 정보 검색 시스템 구축 (The Implementation of Korean Medicine Prescription Information System)

  • 예상준;신현규;김철
    • 대한한의학방제학회지
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    • 제20권2호
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    • pp.47-54
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    • 2012
  • Objectives : This study aimed to build up information system for the 25 cases of Korean Medicine (KM) prescriptions which are used mostly often in clinic and aimed to offer information about its effect and safety to public and researcher. Methods : We used KM prescription data-bank which came from 'The Bio-informatics for herbal formula' and 'The evidence based medicine for herbal formula' projects of Korean Institute of Oriental Medicine (KIOM) Results : First, we analyzed prescription data and categorized 7 classes, then we built up prescription database based on it. Second, we designed and developed user functions of prescription information system, then we link it to OASIS. Third, we developed adminstration system to manage the prescription data. Conclusions : From this study we hope that KM prescription information system will be used for fusion research based on KM. Because the implemented system is linked to OASIS, we expect it will be widely used.

Tunicamycin negatively regulates BMP2-induced osteoblast differentiation through CREBH expression in MC3T3E1 cells

  • Jang, Won-Gu;Kim, Eun-Jung;Koh, Jeong-Tae
    • BMB Reports
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    • 제44권11호
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    • pp.735-740
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    • 2011
  • Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. In the present study, tunicamycin increased the level of CREBH activation (cleavage) as well as mRNA expression in osteoblast cells. Adenoviral (Ad) overexpression of CREBH suppressed BMP2-induced expression of alkaline phosphatase (ALP) and osteocalcin (OC). Interestingly, the BMP2-induced OASIS (structurally similar to CREBH, a positive regulator of osteoblast differentiation) expression was also inhibited by CREBH overexpression. In addition, inhibition of CREBH expression using siRNA reversed the tunicamycin-suppressed ALP and OC expression. These results suggest that CREBH inhibited osteoblast differentiation via suppressing BMP2-induced ALP, OC and OASIS expression in mouse calvarial derived osteoblasts.