• Journal of Korean Society of Transportation
• /
• v.19 no.5
• /
• pp.61-70
• /
• 2001

The origin and destination(O-D) matrix is one of the most important elements in transportation planning process. Traditionally, transport planners survey the O-D movements in order to estimate the O-D matrix. Even though the cost of the O-D survey requires high amounts of resources, the accuracy is relatively low. Therefore, many researchers have studied the estimation of the O-D matrix for automobile from traffic counts. however, there is a little attention for the application on the transit O-D matrix estimation from traffic counts. The objective of this study is therefore the estimation of the transit O-D matrix from traffic counts using Gradient method. which is verified by the reliability analysis using a contrived small example network.

• Journal of Korean Society of Transportation
• /
• v.19 no.1
• /
• pp.77-88
• /
• 2001

Until now, though most of the studies related to demand estimation method using traffic counts use methods based on singleclass, travel demands or flows are made by mixing various vehicles in real networks. In general, existing demand estimation methods based on traffic counts estimate O/D by converting a multiclass O/D matrix and traffic counts into a singleclass O/D matrix and traffic counts through PCE conversion, and analyze a O/D matrix by dividing into a multiclass O/D matrix and traffic counts after multiplying an estimated O/D matrix by the fixed ratio of a singleclass O/D matrix and traffic counts before PCE conversion. However, the merits of a demand estimation method based on multiclass calculate each route choice ratio about multiclass O/D, and maximize the estimation capability of multiclass by calculating each gradient, the reduction direction of objective function. Therefore, this study aims to establish a demand estimation method which considers congestion between vehicle and vehicle by using multiclass instead of singleclass.

• Journal of Microbiology and Biotechnology
• /
• v.15 no.6
• /
• pp.1258-1266
• /
• 2005

The present study was carried out in order to assess the protective effects of calycosin-7-O-$\beta$-D-glucopyranoside, isolated from Astragali radix (AR), on hyaluronidase (HAase) and the recombinant human interleukin-$1\beta$ (IL-$1\beta$)-induced matrix degradation in human articular cartilage and chondrocytes. We isolated the active component from the n-butanol soluble fraction of AR (ARBu) as the HAase inhibitor and structurally identified as calycosin-7-O-$\beta$-D-glucopyranoside by LC-MS, IR, ${1}^H$ NMR, and ${13}^C$ NMR analyses. The $IC_{50}$ of this component on HAase was found to be 3.7 mg/ml by in vitro agarose plate assay. The protective effect of ARBu on the matrix gene expression of immortalized chondrocyte cell line C28/I2 treated with HAase was investigated using a reverse transcription polymerase chain reaction (RT-PCR), and its effect on HAase and IL-$1\beta$-induced matrix degradation in human articular cartilage was determined by a staining method and calculating the amount of degraded glycosaminoglycan (GAG) from the cultured media. Pretreatment with calycosin-7-O-$\beta$-D-glucopyranoside effectively protected human chondrocytes and articular cartilage from matrix degradation. Therefore, calycosin-7-O-$\beta$-D-glucopyranoside from AR appears to be a potential natural ant-inflammatory or antii-osteoarthritis agent and can be effectively used to protect from proteoglycan (PG) degradation.

• Journal of the Korean Society of Hazard Mitigation
• /
• v.9 no.1
• /
• pp.73-79
• /
• 2009

Hazardous materials (HazMats) are substances that are flammable, explosive, toxic, or harmful, if released into the environment. Since the transportation of HazMats increases in many developed countries, HazMat transportation has the key function in the process of HazMat usage to trace information of production, storage, shipment, usage, and waste disposal. The Korean Ministry of Environment (KMOE) and the National Emergency Management Agency (NEMA) have developed many laws, regulations, and standards for hazardous materials. However, the Korean HazMat laws, regulations, and standards do not guarantee accurate information of HazMat origin-destination (O-D) shipments, though the HazMat O-D movement is the critical information in safety and security of HazMat transportation. The objectives of this research are: (1) to investigate emerging and recurrent issues in Korean HazMat transportation, and (2) to develop the estimation method of O-D matrices for hazardous materials under limited data sets. The sodium hydroxide waste shipment among forty candidate HazMats is selected as the sample research case. The growth-factor method is applied to estimate the 2005 O-D matrix of sodium-hydroxide waste shipment. The column-and-row factoring process is used to calibrate the estimated sodium-hydroxide O-D matrix. The result shows the applicability of the O-D estimation process for hazardous materials. The Sodium Hydroxide Waste Origin-Destination Matrix is obtained to trace routes and paths of the Sodium Hydroxide transportation.

• Preventive Nutrition and Food Science
• /
• v.10 no.1
• /
• pp.40-45
• /
• 2005

Age-related changes in bone metabolism are well established by biochemical markers of bone matrix in serum and urine, but analysis of the residual bone matrix, which is still turning over, has not been investigated. In the present study, we measured in vivo rates of bone protein synthesis using a precursor-product method based on the exchange of ²H from ²H₂O into amino acids. Four percent ²H₂O was administered to mice in drinking water after intraperitonial (i.p) bolus injection of 99.9% ²H₂O. Mice were divided into the two groups: growing young mice were administered 4% ²H₂O for 12 weeks after an i.p bolus injection at 5 week of age, whereas weight stable adult mice started drinking 4% ²H₂O 8 weeks later than the growing group and continued 4% ²H₂O drinking for 8 weeks. Mass isotopomer abundance in alanine from bone protein was analyzed by gas chromatography/mass spectrometry. Body ²H₂O enrichments were in the range of 1.88-2.41% over the labeling period. The fractional synthesis rates (ks) of bone protein were 2.000±0.071%/d for growing mice and 0.243±0.014%/d for adult mice. These results demonstrate that the bone protein synthesis rate decreases with age and present direct evidence of age-related changes in bone protein synthesis.

• Journal of the Korean Applied Science and Technology
• /
• v.32 no.4
• /
• pp.694-701
• /
• 2015

In order to get stabilized pure retinol in skin care cosmetics, developing the three layered matrix bead capsules were studied. This study relates to make a cosmetic composition using the three layered matrix capsule that could increase the stability of the active ingredient. A primary encapsulation, vitamin A (pure retinol) of active ingredient was perfectly capsulated into water-in-oil (Water-in-Oil: W/O) emulsion vesicle using PEG-10 dimethicone copolyol emulsifier. A secondary encapsulation of multiple emulsion of the water-in-oil-in-water (W/O/W) emulsion blending W/O emulsion using sucrose distearate of surfactant was developed using homogenizing emulsifying system. Pure retinol of active ingredient was stably capsulized to inside the W/O/W-multiple emulsion in order to load the triple matrix capsulation. By coating it with a polymer matrix base, encapsulated in the triple layered type, which were developed bead encapsulation of 2~10mm uniformly size. To show beautifully appearance capsulated bead type, these finish particles in this triple matrix layer were developed as a gold, green, dark brown, silver and blue color were encapsulated in the bead types. Structural particle certification of triple matrix layer was observed through SEM analysis. Stability of pure retinol was remained stable more than 99.7% for 30 days at $42^{\circ}C$ incubating conditions compared with non-capsule. This technology was applied in different formulations such as various sizes and colors that by applying the skin care cosmetics. In the future, this technology to encapsulate an unstable active ingredient, we expect to be expanded this application in the food and drug as a time delivery system.

• Journal of Korean Society of Transportation
• /
• v.19 no.5
• /
• pp.49-59
• /
• 2001

In the transportation planning process, origin and destination(O-D) trip matrix is one of the most important elements. There have been developments and applications of the methodology to adjust old matrices using link traffic counts. Commonly, the accuracy of an adjusted O-D matrix depends very much on the reliability of the input data such as the numbers and locations of traffic counting points in the road network. In the real application of the methodology, decisions on the numbers and locations of traffic counting points are one of the difficult problems, because usually as networks become bigger, the numbers of traffic counting points are required more. Therefore, this paper investigates these issues as an experiment using a nationwide network in Korea. We have compared and contrasted the set of link flows assigned by the old and the adjusted O-D matrices with the set of observed link flows. It has been analyzed by increasing the number of the traffic counting points on the experimental road network. As a result of these analyses, we can see an optimal set of the number of counting links through statistical analysis, which are approximately ten percentages of the total link numbers. In addition, the results show that the discrepancies between the old and the adjusted matrices in terms of the trip length frequency distributions and the assigned and the counted link flows are minimized using the optimal set of the counted links.

• Journal of the Korean Ceramic Society
• /
• v.30 no.6
• /
• pp.457-468
• /
• 1993

In oxide matrix-SiC(W) composites, instability and glassy phase formation due to oxidation at the high temperature and the diffusion of Si, respectively, cause brittle fracture and low reliability for ceramic materials. The mode of contribution in each mechanisms induced by matrix-whisker debonding, varies with the morphology of matrix-whisker interfaces. This work has described the dispersion behaviours and stabilization mechanisms in slip systems, and multiple toughening mechanisms by dint of two second phase different from each other when spherical ZrO2 and chemically stable Al2O3(W) is respectively added in Al2O3 matrix. To obtain complexshaped components, slip casted bodies were sintered at 1$600^{\circ}C$, 2hrs up to 98~99% R.D.. Multiple toughening mechanisms in comparison with theories reported until now will be discussed as a result of the phase analysis of ZrO2 by athermal behaviours and microstructural characterizations as well as measured mechanical properties.

• Proceedings of the KOR-KST Conference
• /
• 2007.11a
• /
• pp.675-683
• /
• 2007

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.4 no.3
• /
• pp.313-321
• /
• 2012

Vibration analysis of a thin-walled structure can be performed with a consistent mass matrix determined by the shape functions of all degrees of freedom (d.o.f.) used for construction of conventional stiffness matrix, or with a lumped mass matrix. In similar way stability of a structure can be analysed with consistent geometric stiffness matrix or geometric stiffness matrix with lumped buckling load, related only to the rotational d.o.f. Recently, the simplified mass matrix is constructed employing shape functions of in-plane displacements for plate deflection. In this paper the same approach is used for construction of simplified geometric stiffness matrix. Beam element, and triangular and rectangular plate element are considered. Application of the new geometric stiffness is illustrated in the case of simply supported beam and square plate. The same problems are solved with consistent and lumped geometric stiffness matrix, and the obtained results are compared with the analytical solution. Also, a combination of simplified and lumped geometric stiffness matrix is analysed in order to increase accuracy of stability analysis.