• 한국식품영양학회지
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• 제26권4호
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• pp.615-619
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• 2013

Obesity is the most common nutritional disorder in the developed world and has become a global epidemic in recent years. In this study, Zanthoxylum planispinum extracts (ZPE) were evaluated on the effect on inhibition of pancreatic lipase and lipid metabolism by oral treatment for 2 months in high-fed diet obesity-induced Balb/c mice. The ZPE showed pancreatic lipase inhibitory activity with $IC_{50}$ of $0.3{\mu}g/ml$. No significant difference in feed intake was observed among the groups. The high-fat diet-treated Z. planispinum extracts groups (HFD+ZPE, 100mg/kg) significantly decreased body weight compared to the high-fat diet vehicle groups (HFD, p<0.05). The high-fat diet-treated Xenical$^{(R)}$ groups (HFD+Xenical, n=10, 30mg/kg) also showed a significant reduction of body weight compared to HFD (p<0.05). Biochemical parameters (triglyceride, total cholesterol, and high-density lipoprotein cholesterol) in HFD plus ZPE diet groups were significantly lower than those of the HFD groups (p<0.05). These results indicated that ZPE more effectively suppressed the effects of HFD on body fat gain with the inhibitory effect on pancreatic lipase.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제20권1호
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• pp.55-60
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• 2017

Intestinal hypoganglionosis is a rare innervation disorder that provides numerous nutritional, medical and surgical challenges. In this case report, we present a case of a newborn with intestinal hypoganglionosis leading to intestinal failure and intestinal failure-associated liver disease who responded to $Omegaven^{TM}$, a fat emulsion comprised of omega-3 fatty acids. $Omegaven^{TM}$ has been shown to be beneficial in the management of cholestatic liver injury. Clinical success with $Omegaven^{TM}$ was seen in this patient with a clear decrease in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and complete resolution of cholestasis with a direct bilirubin of zero within two weeks of initiation of $Omegaven^{TM}$. No current guidelines for the diagnosis and management of hypoganglionosis are available. We recommend a multidisciplinary approach and the use of novel therapies such as fat emulsions composed of omega-3 fatty acids for improved patient outcomes. Appropriate compassionate use protocols should be obtained from the Food and Drug Administration prior to initiation of $Omegaven^{TM}$.

• Journal of Chest Surgery
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• 제29권6호
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• pp.672-674
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• 1996

유미흉은드물지만 심장수술,횡격막의 식도,대동맥 열공 부위의 수술합병증으로잘알려졌다. 특히 식도의 양성 또는 악성 종양에서 식도제거술이 필요한 영양 결핍상태의 환자에서 유미흥은호흘기능, 영양상태, 면역학적 인 면에서 치사율이 높은 위 험한 질병 이다. 본교실에서는 식도헙착 환자에서 식도열공을 통한 식도 제거술후 발생한 유미흥 1례를 경험하였다. 유미홍의 진단은 공장루를 통한 영양공급후 흥막 삼출액의 변화와 술후 5일째 흉막액의 Triglyceride 치의 증가로 진단하였다. 금식 상태에서도 하루 1500내지 2000cc의 유미삼출액이 배액되어 13일째 우 측 개흉술을 통해 횡격막 상부 흉관 결찰을 시 행하였으며, 좋은 결과를 얻을 수 있었다.

• 대한한방내과학회지
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• 제10권1호
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• pp.53-64
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• 1989

In an attempt to investigate the current of clinical researches on spleen yang or vital energy deficiency syndrome, the results were as follows. 1. It is possible to occure spleen deficiency syndrome which come from genetic factor. 2. The absorption disturbance in spleen deficiency syndrome can be likely caused by gastrointestinal mucosa injury, disorder of vagus nerve funtion and impairment of excretion of exocrine gland in pancreas. 3. Owing to the failure of tansporting and converting funtion of spleen, minerals, hematogenic substance and nutritional substance are scanty and then imbalanced metabolism state which heat production is decreasing is appeared. 4. By the failure of vital energy and blood growth, decreasement of $O_2$ transportation ability of RBC, disoder of blood coagulation, immune system disturbance which humoral immunity is enhanced and cellular immunity is decreased, are noted. 5. While there is not still an attemt to study the spleen deficiency sydrome in muscle disease or disease of four extremities, but it is likely suggested that spleen-stomach supplyment thereapy is very excellent effect on muscle disease and disease of four extremities.

• 말소리와 음성과학
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• 제3권3호
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• pp.125-132
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• 2011

Studies on the risk factors of voice disorders in Korean adults are rare. I evaluated the association between the duration of self-reported voice problem and voice disorders in Korean adults. Data were from the 2008 Korea National Health and Nutritional Examination Survey. Subjects were 3,135 people (1,310 men and 1,825 women) aged 19 years and older. Multi-nominal logistic regression analyses were used to examine the association between the duration of self-reported voice problem and voice disorders. The prevalence of self-reported voice problems was 5.9% among Korean adults. Adjusting for covariates (age, sex, education level, length of employment, tobacco consumption, alcohol consumption, thyroid disorders, pain and discomfort during the last two weeks), self-reported voice problems lasting longer than three weeks were independently associated with functional voice disorders (OR=5.30, 95% CI: 3.30-8.50) and organic voice disorders (OR=4.84, 95% CI: 1.82-12.89). Self-reported voice problems in the past three weeks were significantly associated with functional voice disorders (OR=3.64, 95% CI: 1.84-7.19), but not significantly associated with organic voice disorders. Self-reported voice problems are prevalent among adults. This study highlights that self-perception of a voice problem for more than three weeks is related to functional voice disorders and organic voice disorders.

• 대한가정학회지
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• 제45권1호
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• pp.101-109
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• 2007

본 연구는 서울시내 소재 중학교에 재학 중인 청소년들을 대상으로 체형인식 및 식이장애 실태를 조사한 후 성별에 따라 비교 분석하였다. 본 조사대상자 남녀학생 모두 과체중보다는 저체중군에 속한 학생이 매우 많았다. 특히 여학생의 경우 남학생에 비해 저체중율이 매우 높았으며, 자신의 체형을 실제체형보다 살핀 것으로 인식하고 있었다. 또한 남학생에 비해 자신의 체형에 대한 만족도는 낮은 반면 비만으로 인한 스트레스 및 섭식장애 정도는 더욱 높은 것으로 나타났다. 따라서 청소년들 특히, 여학생들에게 올바른 신체상을 정립시킬 수 있는 영양교육이 적극적으로 이루어져 체형만족도를 높이고 비만으로 인한 스트레스 해소시켜주는 것이 이 시기 청소년들의 바람직한 식습관 형성에 매우 큰 도움이 될 것으로 여겨진다.

• 대한지역사회영양학회지
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• 제9권2호
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• pp.204-213
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• 2004

The purpose of this study was to examine the dietary behavior of children according to their preference for fast food. The study was carried out on 470, 6th grade students (boys : 236, girls : 234) in September, 2002. The results are summarized as follows : The mean body mass index was 18.72 kg/$m^2$ for boys and 17.76 kg/$m^2$ $^2$ for girls. The subjective health disorder symptoms for the group preferring fast food was not significantly different than that of the other groups. The group preferring fast food consumed an inadequate volume of food, and they had an irregular and unbalanced diet. Their intake of green vegetables, vegetables, protein foods, and seaweed was significantly lower than that of the other groups. The food habit score for the group preferring fast food was lower than that of the other groups, and they had irregular meal times and had unbalanced diets. The group preferring fast food had a preference for sweet tastes, whilst members of the other group preferred a savory taste. The first choice for fast food by the group preferring fast food was hamburgers, the reason being that it tasted good. Results show that children who have a preference for fast food need to correct their dietary behavior. As a result, proper nutritional education and intervention is required in order to improve the consuming habits of children and their preference for fast food.

• Journal of Interdisciplinary Genomics
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• 제1권1호
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• pp.10-13
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• 2019

A 10-year and 5 month-old girl with developmental delay, intellectual disability, attention deficit hyperactivity disorder, poor weight gain, and microcephaly was transferred to our pediatric clinic for genetic evaluation. Her height was within the 5-10th percentile, and her weight was under the 3rd percentile. On the social maturity scale, her developmental status was scored as 3 years 9 months for social age, and the social quotient was 35.98. A chromosomal microarray analysis was performed and the microduplication at chromosome 16p was observed: arr[GRCh37] 16p11.2 (29580020_30190029)${\times}3$. Currently, the patient is diagnosed with Grade 2 intellectual disability and is attending a computerized cognitive rehabilitation class twice weekly. In addition, nutritional support and growth follow up are also ensured in the Pediatric Gastrointestinal and Endocrinology clinic.

• 혜화의학회지
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• 제7권2호
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• pp.609-620
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• 1999

Over the period between January 1997 and December 1998, herbal medicine was more than three times administered to the patients coming to Na dong gyu's Oriental Medical Clinic on account of the symptom of growth deficiency. According to radiological opinions about the patients providing cooperation for measuring their height and weight as well as their bone age every three months, it was found that the growth plates were not closed. A research was conducted for 200 children randomly selected of patients in prepuberty (they grew by less than 5cm a year before treatment at a age of 12years for female children and 14years for male children). As a result, the following conclusion was drawn: 1. The randomly selected subjects were made up of 116 male and 84 female children in terms of gender. The age direstribution was most 10 to 12 years in 86 children(34.00%), followed by 8-10 years(27.50%) and 12 to 14 years(19.50%). 2. Considering the distribution of sick children's parental height, the fathers of 141 children(70.50%) measured less than 170cm high, the subaverage height, while the mothers of 172 children(86%) measured less than 160cm high, the subaverage height. It was shown that sick childen's height was genetically influenced by their parents. 3. Children patients's weight at a time of birth was most 3.1-3.5kg for 85 children(44%) and less than 2.5kg which came under the range of growth dificiency for 19 children(9.5%). 4. The highest proportian of the children patients with growth dificiency(56.33%) had the symptom of digestive disorders, of which 77 children patients(18.78%) had anorexia, 16.59% of children patients had the high level of respiratory disorders. Both the digestive disorder and the respiratory disorder put together, they had the high rate of 72.92%. Therefore, this indicates that both the digestive disorder and the respiratory disorder have a great effect on children's growth dificiency. 10.74% of chilren patients were shown to have allergic disorders, which indicates that they also exert an effect on growth deficiency. Specifically, 7.07% of the children patients had the high level of obesity, which shows that an excessive uptake of nutrition may rather induce children to have growth dificiency though an appropriate amount of nutritional uptake is necessary. 5. Comparing their bone age and their chronological age, 58 children patients(29.00%) showed that they were the same at the highest percent. 79 children patients(39.50%) showed that thier bone age was lower than their chronological age. And 63 children patients(31.50%) showed that their bone age was higher than their chronological age. 6. As regards the prescription administered to children patients for treating their growth dificiency, Growth tang A related to the kidney, the congenital factor, of the causes for growth dificiency in traditional Oriental Medicine was administered to 108 children patients(54%), whereas the Growth tang B related to the spleen, the acquired factor, was administered to 92 children patients(46%). 7. 116 male children patients with growth dificiency had the average value of growth for one year before treatment, 4.39cm, while 84 female children patients had the average value of growth for one year before treatment, 4.24cm. A total of 200 children had the average value of growth for one year before treatment, 4.33cm. The annual average value of growth in growth curve surveyed by the Korea Pediatrics Society was 5.79cm. Compared to this value, the one year average value of growth for 108 male and female children patients taking Growth tang A was shown be 8.44cm, which indicates a greater growth by 4.12cm(95.37%) in comparison with the average value of growth before treatment, 4.32cm, and a greater growth by 2.65cm(45.77%) compared to 5.79cm, the average value of growth in growth curve surveyed by the Korea Pediatrics Society. Also, the average value of growth before treatment for 92 male and female children patients taking Growth tang B was shown to be 8.47cm, which indicates a greater increase by 4.15cm(96.06%) compared to 4.32cm, the average value of growth before treatment and a greater increase by 2.67cm(46.29%) in comparison with 5.79cm, the average value of growth in growth curve surveyed by the Korea Pediatrics Society. Considering the average value of growth for male and female children patients taking Growth tang A and B, it was shown to be 8.46cm, which indicates a greater increase by 4.14cm(95.81%) compared to 4.32cm, the average value of growth before treatment, and a greater increase by 2.67cm(46.11%) compared to 5.79cm, the average value of growth in growth curve surveyed by the Korea Pediatrics Society.

• 한국축산식품학회지
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• 제40권1호
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• pp.145-153
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• 2020

Depression is a kind of mood disorder characterized by decline in motivation, interest, attention, mental activity, and appetite. Although depression is caused by a variety of causes, including genetic, endocrine and environmental stress, mild depression has been reported to improve with diet. Therefore, various type of food sources including functional and nutritional supplement are required to treat the depressive patients. Cheese contains bioactive peptides that have beneficial effects on host health. In particular, Jersey milk has been reported to contain higher solids than does Holstein milk. This study investigated the effects of Gouda cheese from Jersey and Holstein milk on chronic, unpredictable, mildly stressed (CUMS) mice. Here, spontaneous alterations in cheese-fed stressed mice were noted to be effectively recovered with statistical significance regardless cow species. Interestingly, for the analysis of fecal microbiota, Bacteroidetes were noted to increase with a reduction in Firmicutes at the phylum level with Jersey cheese. Taken together, we suggest that cheese intake provided a beneficial effect on stressed mice in recovering recognition ability. In particular, changes in internal microbiota were observed, suggesting that the bioactive ingredients in cheese act as improvement agents with respect to mood and brain function.