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http://dx.doi.org/10.9799/ksfan.2013.26.4.615

Effect on the Inhibition of Pancreatic Lipase and Lipid Metabolism of Zanthoxylum piperitum Extracts  

Park, Jang-Soon (Dept. of Beauty Design, Tongwon University)
Publication Information
The Korean Journal of Food And Nutrition / v.26, no.4, 2013 , pp. 615-619 More about this Journal
Abstract
Obesity is the most common nutritional disorder in the developed world and has become a global epidemic in recent years. In this study, Zanthoxylum planispinum extracts (ZPE) were evaluated on the effect on inhibition of pancreatic lipase and lipid metabolism by oral treatment for 2 months in high-fed diet obesity-induced Balb/c mice. The ZPE showed pancreatic lipase inhibitory activity with $IC_{50}$ of $0.3{\mu}g/ml$. No significant difference in feed intake was observed among the groups. The high-fat diet-treated Z. planispinum extracts groups (HFD+ZPE, 100mg/kg) significantly decreased body weight compared to the high-fat diet vehicle groups (HFD, p<0.05). The high-fat diet-treated Xenical$^{(R)}$ groups (HFD+Xenical, n=10, 30mg/kg) also showed a significant reduction of body weight compared to HFD (p<0.05). Biochemical parameters (triglyceride, total cholesterol, and high-density lipoprotein cholesterol) in HFD plus ZPE diet groups were significantly lower than those of the HFD groups (p<0.05). These results indicated that ZPE more effectively suppressed the effects of HFD on body fat gain with the inhibitory effect on pancreatic lipase.
Keywords
obesity; Zanthoxylum planispinum; pancreatic lipase; biochemical parameter;
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Times Cited By KSCI : 7  (Citation Analysis)
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1 Ahn MY, Kim JY, Han JW, Jee SD, Hwang JS, Cho SI, Yun EY. 2007. Isaria sinclairii extract reduces body weight and ameliorates metablic abnormalities. Int J Indust Entomol 14:121-126   과학기술학회마을
2 Birari RB, Bhutani KK. 2007. Pancreatic lipase inhibitors fromnatural sources: unexplored potential. Drug Discov Today 12:879-889   DOI   ScienceOn
3 Bray GA. 2002. The underlying basis for obesity: relationship to cancer. J Nutr 132:3451S-3455S   DOI
4 Bryant BP, Mezine I. 1999. Alkylamides that produce tingling paresthesia activate tactile and thermal trigeminal neurons. Brain Res 842:452-460   DOI   ScienceOn
5 Chaput JP, St-Pierre S, Tremblay A. 2007. Currently available drugs for the treatment of obesity: Sibutramine and orlistat. Mini Rev Med Chem 7:3-10   DOI   ScienceOn
6 Cho MG, Chang CS, Chae YA. 2003. Variation of volatile composition in the leaf of Zanthoxylum schinofolium Siebold et Zucc. and Zanthoxylum piperitum DC. Korean J Medicinal Crop Sci 10:162-166   과학기술학회마을
7 Choi HJ, Song JH, Kwon DH, Baek SH, Ahn YJ. 2008. Antiviral activity of Zanthoxylum species against influenza virus. Korean J Medicinal Crop Sci 16:273-278   과학기술학회마을
8 Chung HK, Shim MJ, Cha YJ, Lee KH. 2011. Effect of onion peel extracts on blood lipid profile and blood coagulation in high fat fed SD rats. Korean J Food Nutr 24:442-450   과학기술학회마을   DOI   ScienceOn
9 Fernstrom JD, Choi S. 2008. The development of tolerance to drugs that suppress food intake. Pharmacol Ther 117:105-122   DOI   ScienceOn
10 Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG. 1973. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. J Clin Invest 52:1533-1543   DOI
11 Gwon SY, Ahn JY, Kim TW, Ha TY. 2012. Zanthoxylum piperitum DC ethanol extract suppresses fat accumulation in adipocytes and high fat diet-induced obese mice by regulating adipogenesis. J Nutr Sci Vitaminol (Tokyo) 58:393-401   DOI
12 Hadvary P, Sidler W, Meister W, Vetter W, Wolfer H. 1991. The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active-site serine of pancreatic lipase. J Biol Chem 12:2021-2027
13 Han CK, Kim SS, Choi SY, Park JH, Lee BH. 2009. Effects of rice added with mulberry leaves and fruit on blood glucose, body fat and serum lipid levels in rats. J Korean Soc Food Sci Nutr 38:1336-1341   과학기술학회마을   DOI   ScienceOn
14 Jacobson M. 1948. Herculin, a pungent insecticidal constituent of southern prickly ash bark. J Am Chem Soc 70:4234-4237   DOI
15 Jang DS, Lee GY, Kim JH, Lee YM, Kim JM, Kin YS, Kim JS. 2008. A new pancreatic lipase inhibitor isolated from the roots of Actinida arguta. Arch Pharm Res 31:666-670   DOI   ScienceOn
16 Lee H, Kang R, Hahn Y, Yang Y, Kim SS, Cho SH, Chung SI, Yoon Y. 2009. Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway. Phytother Res 23:1615-1623   DOI   ScienceOn
17 Karamadoukis L, Shivashankar GH, Ludeman L, Williams AJ. 2009. Anunusual complication of treatment with orlistat. Clin Nephrol 71:430-432   DOI
18 Kim HK, Cho DW, Hahm YT. 2000. The effects of coix bran on lipid metabolism and glucose challenge in hyperlipidemic and diabetic rats. J Korean Soc Food Sci Nutr 29:140-146   과학기술학회마을
19 Krauss RM, Winston M. 1998. Obesity impact on cardiovascular disease. Circulation 98:1472-1476   DOI   ScienceOn
20 Moon HS, Chung CS, Lee HG, Kim TG, Choi YJ, Cho CS. 2007. Inhibitory effect of (-)-peigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells. Obesity (Silver Spring) 15:2571-2582   DOI   ScienceOn
21 Olsen AM, Eisenberg BL, Kuemmerle NB, Flanagan AJ, Morganelli PM, Lombardo PS, Swinnen JV, Kinlaw WB. 2010. Fatty acid synthesis is a therapeutic target in human liposarcoma. Int J Oncol 12:1309
22 Padwal RS, Majumdar SR. 2007. Drug treatments for obesity: Orlistat, sibutramine, and rimonabant. Lancet 12:71-77
23 Saito M, Ueno M, Ogino S, Kubo K, Nagat J, Takeuchi M. 2005. High dose of Garcina cabogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol 43:411-419   DOI   ScienceOn
24 Song MY, Bose S, Kim HJ. 2013. Anti-obesity effects of fermented Samjung-hwan in hign fat diet rats. J Korean Med Obes Res 13:17-23   과학기술학회마을