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http://dx.doi.org/10.5851/kosfa.2019.e81

Ingestion of Gouda Cheese Ameliorates the Chronic Unpredictable Mild Stress in Mice  

Yun, Bohyun (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University)
Yoo, Ja Yeon (National Institute of Animal Science, Rural Development Administration)
Park, Mi Ri (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University)
Ryu, Sangdon (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University)
Lee, Woong Ji (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University)
Choi, Hye Jin (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University)
Kang, Min Kyoung (Department of Functional Food and Biotechnology, Jeonju University)
Kim, Younghoon (Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University)
Oh, Sangnam (Department of Functional Food and Biotechnology, Jeonju University)
Publication Information
Food Science of Animal Resources / v.40, no.1, 2020 , pp. 145-153 More about this Journal
Abstract
Depression is a kind of mood disorder characterized by decline in motivation, interest, attention, mental activity, and appetite. Although depression is caused by a variety of causes, including genetic, endocrine and environmental stress, mild depression has been reported to improve with diet. Therefore, various type of food sources including functional and nutritional supplement are required to treat the depressive patients. Cheese contains bioactive peptides that have beneficial effects on host health. In particular, Jersey milk has been reported to contain higher solids than does Holstein milk. This study investigated the effects of Gouda cheese from Jersey and Holstein milk on chronic, unpredictable, mildly stressed (CUMS) mice. Here, spontaneous alterations in cheese-fed stressed mice were noted to be effectively recovered with statistical significance regardless cow species. Interestingly, for the analysis of fecal microbiota, Bacteroidetes were noted to increase with a reduction in Firmicutes at the phylum level with Jersey cheese. Taken together, we suggest that cheese intake provided a beneficial effect on stressed mice in recovering recognition ability. In particular, changes in internal microbiota were observed, suggesting that the bioactive ingredients in cheese act as improvement agents with respect to mood and brain function.
Keywords
Gouda cheese; chronic unpredictable mild stress; fecal microbiota;
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