• Toxicological Research
• /
• 제17권
• /
• pp.83-88
• /
• 2001

Most reactive oxygen species (ROS) are free radicals and implicated in the development of a number of disease processes including artherosclerosis, neurodegenerative disorders, aging and cancer. ROS are byproducts of a number of in vivo metabolic processes and are formed deliberately as part of nor-mal inflammatory response. On the other hand, ROS are generated either as by products of oxygen reduction during xenobiotic metabolism or are liberated as the result of the futile redox cycling of the chemical agents including several chemical carcinogens. A better understanding of the mechanisms of free radical toxicity may yield valuable clue to risks associated with chemical exposures that leading to the development of chronic diseases including cancer. The molecular biology of ROS-mediated alterations in gene expression, signal transduction and carcinognesis is one of the important subjects in free radical toxicology. Epidemiological studies suggest that high intake of vegetables and fruits are associated with the low incidence of human cancer. Many phytopolyphenols such as tea polyphenols, curcumin, resveratrol, apigenin, genistein and other flavonoids have been shown to be cancer chemopreventive agents. Most of these compounds are strong antioxidant and ROS scavengers in vitro and effective inducers of antioxidant enzymes such as superoxide dismutatse, catalase and glutathione peroxidase in vivo. Several cellular transducers namely receptor tyrosine kinase, protein kinase C, MAPK, PI3K, c-jun, c-fos, c-myc, NFkB, IkB kinase, iNOS, COX-2, Bcl-2, Bax, etc have been shown to be actively modulated by phyto-polyphenols. Recent development in free radical toxicology have provided strong basis for understanding the action mechanisms of cancer chemoprevention.

• 한국전자통신학회논문지
• /
• 제16권4호
• /
• pp.675-682
• /
• 2021

제한된 종류, 제한된 수량의 센서를 사용하여야 하는 환경에서 다양한 상황정보를 획득하여야 하는 수요가 나타날 수 있다. 본 연구에서는 제한된 숫자의 센서를 사용하여야 하는 환경에서 한정된 센서를 사용하면서도 이전보다 다양한 상황정보를 획득하기 위한 새로운 방안을 제안하였다. 이를 위하여 생물학 분야에서 큰 관심을 얻고 있는 Exon-Intron이론에서 실마리를 얻어 이를 기초로 다양한 상황정보 획득 방안을 제안하였다. Exon-Intron의 선택적 자르기 및 조합 방안과 같이 각 센서의 이벤트들을 효율적으로 자르고 각 이벤트 데이터들을 조합하여 활용함으로써 획득하는 상황정보의 다양화를 실현할 수 있었다.

• 대한수학교육학회지:학교수학
• /
• 제14권2호
• /
• pp.191-212
• /
• 2012

학생들의 산술 활동 (수의 사칙연산) 학습에 관한 연구 중 분수량을 포함한 나눗셈 문제의 해결을 위한 자연수 지식의 활용을 상세히 다룬 연구가 매우 부족한 실정이다. 교수실험이 연구방법으로 사용된 본 정성연구에서는, 일년간 행해진 교수실험 중 일부 자료의 분석을 바탕으로 다양한 포함제 분수나눗셈 상황을 해결하기 위해 어떻게 자연수 나눗셈의 기본이 되는 단위분할 도식을 수정, 구성해 나갈 수 있는지에 대한 가능한 발달 경로(나머지가 있는 단위분할 도식, 분수 단위분할 도식)를 제시하고 있다. 따라서 본 연구는 다른 수 체계(자연수, 분수)에서 같은 종류의 연산(나눗셈)에 대한 조작적 연결성을 고찰함으로써 현재 학생들이 가지고 있는 수 연산에 관한 분절적 이해를 올바르게 지도할 수 있는 방안을 제시한다.

• 한국실내디자인학회논문집
• /
• 제26권5호
• /
• pp.83-92
• /
• 2017

This research is about the characteristics of the saccades that occurring in the process of observing the spatial. The size of the saccades is the visual activity for acquiring the information, and the search trace that left by the spatial visitor. Reviewed over the saccade through the analysis of observation process that appeared in the eye-tracking experiment of sports store from the department store, the saccade is defined as the sight movement in the process of finding a component to view in the spatial. If some spatial component induces saccade, and able to know which specific component acquired through the saccade, then the designer will have a clue which able to provide the spatial desired by the consumer. The results of analyzing the process in the deriving the spatial component and saccade characteristic from industrial space, can be summarised as follows. The first, the average fixed number of [IN].[OUT] zone appeared similarly, and it leads to knowing that the time used for attention with one frequency is about 0.3 seconds. Second, there were more saccades toward [$IN{\rightarrow}OUT$] (13 persons, 76.5%) than [$OUT{\rightarrow}IN$] (4 persons, 23.5%). The Los Angeles area has lots of interesting things to watch, so it able to thinks to begins with small saccade and then occur to bigger saccade activity to find new interests shortly after [OUT] saccade. Third, according to time range changes, keep eyes on the characteristics of saccade, [IN].[OUT] frequency has slightly decreased the changes of viewing time, but there was no significant change in an average number of observations. This means that the frequency and the number of observations are decreased together. Therefore, it can be seen that the amount of information to be acquired (frequency) is decreased (count) as the observation time elapses.

• 한국게임학회 논문지
• /
• 제6권3호
• /
• pp.43-50
• /
• 2006

본 연구는 초등학교 수학과 수 연산 영역에서의 수준별 학습을 지원하기 위한 게임형 학습 프로그램을 개발하는 것이다. 수학과는 위계성이 강한 단계형 교과로 학습자 개개인의 수준을 고려한 수준별 학습이 꼭 필요한 교과이다. 그러나 일선 학교에서는 다인수 학급 및 보충지도 시간 부족 등으로 인하여 학습자 수준에 맞는 개별적인 수준별 학습이 잘 이루어지기 않고 있는 실정이다. 따라서, 본 연구는 수준별 개별화 학습을 지원하여 올바른 수와 연산개념의 형성을 위한 게임형 학습 프로그램을 개발한다. 본 학습 프로그램은 학습자의 학습 진척도와 성취도를 검사하여, 학습자에게 맞는 학습 단계를 자동으로 조절해 준다. 그리고 학습 중에도 학습자의 수준을 고려한 힌트와 구체물 조작을 통해 문제를 해결할 수 있도록 도움 기능을 제공한다. 본 학습 프로그램을 학습자들에게 적용한 결과 수학과 학습에 대한 흥미도를 높아지고 특히, 힌트 및 도우미 기능은 문제 해결에 도움이 되는 것으로 나타났다.

• 한국비블리아학회지
• /
• 제7권1호
• /
• pp.103-146
• /
• 1994

Koryokukshinjodaechangkyochongbyollock is an epoch-making catalogue for historical study of proofing Buddhist scriptures in Korea. This bibliography was appended to the 30 volumes which was corrected in 70 Ham, 66 scriptures, and 79 cases. Comparing the differences between the first carved Tripitaka' s texts in Korea, texts made in the Sung dynasty, and the Kitan's texts, this catalogue discovered the name of scriptures, translators, volume number, the changed am order as well as omission, defaults, mistranslation of the Tripitaka made in the Sung dynasty. From Chon-ham to Young-ham, 480 sets among Kaewon-sokkyorock and 43 sets among Chongwonrock were correctly laid. Songshinyokkyong and the Sung Emperor, T'ai Tsung's statements were excluded. Even though it was possible to get these scriptures only by import from Sung, these imported scriptures had no reason to be proofed because of their new version and the author's direct selection in Sung. Shinchipchangkyon-geumeuisuhamlock has no authentic Sung's and Koryo's text books for correction. kyochongbyollock delivered the scriptures listed on Kudaechangmoklock, which gives an important clue to research transformation from the first to the second carved Tripitaka. Through the systematic study of the transformated facts beteween the first carved Tripitaka and the second one, This study would help rebulid the original Chojodaechan-gkynng which has been not yet perfectly discovered itself.

• 한국실내디자인학회논문집
• /
• 제20권4호
• /
• pp.101-108
• /
• 2011

When observing an object in a space, a part of it is remembered into our perception in the time for paying attention or conscious observation and it reaches to our visual understanding. In this study, it examined characteristics by each subject through the process of visual understanding by changes in such observation time. The results from this study are summarized as belows: First, through analysis of the observation data focused on the distance between the observed points, it was able to apply those visual theories organized before to the analysis of characteristics of the time for understanding by each subject. Second, there showed big differences in the time for visual understanding by each subject according to changes in the observation time so that it was found that there were big differences according to the characteristics of subject's intention or purpose of the observation of a space. Third, as the number of continuous observation gives an important clue in judgement of how well the space was understood, it was able to compare and organize the mutual characteristics of the time the attention was concentrated, the time observed intentionally and the time understood visually. Fourth, it was found that the shorter subjects gave the intentional observation in observing a space, the longer they spent the time for paying attention, while the less they could understand it visually.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1996년도 추계학술대회 논문집 학회본부
• /
• pp.52-54
• /
• 1996

A number of algorithm using the VSS(Variable Structure System) for uncertain dynamic system are developed. But, in these algorithms, the assumption that the uncertainties are bounded and their bounds are available to the designer is involved. And bounds on the uncertainties are an important clue to guarantee the stability of the closed loop system. However, sometimes bounds on the uncertainties may not be easily obtained because of the complexity of the structure of the uncertainties. Therefore, a methodology by which the boundary values on the uncertainties can be easily obtained is required. The VSS proposed in this proposal employ the new adaptive VSS scheme for uncertain dynamic system being estimated on line. The resulting control law is simple and easy to apply to on line computer control. It can also suppress chattering and maintain good tracking precision even if unmodeled dynamics are considered. And, a new method using nonlinear switching surface is introduced so that the speed response is improved and the good transient response can be obtained. Simulation results are presented and show the advantage of the proposed adaptive VSS with nonlinear switching surfaces.

• Clinical and Experimental Reproductive Medicine
• /
• 제7권1_2호
• /
• pp.27-34
• /
• 1980

The status of artificial insemination was surveyed by investigating 20796 heads of adult dairy cattle out of 30464 heads at 1649 dairy farms located Seoul and Gyung-Gi and Chung-Cheong province area, and the results are as follows: 1. There were 286 small farms feeding less than 5 heads occupying 17.3% of total farm number, and 1083 medium sized dairy farms feeding between $6{\sim}20$ heads occupying 65.64% and also 280 large dairy farms feeding more than 21 heads occupying 17.06% of total. 2. Population of cow aging from 2 to 6 years were 87.26% and among 20907 heads of dairy cattles which had calved previously 13196 heads had histories of one to four calving 90.40%. 3. The successful conception rate with first A. I. occupied only 53.43% and 92.4% after third A. I. service. The average A. I. frequency for successful conception per/head was 1.8 times. 4. The breeding status was pregnancy 61.72%, uncertain pregnancy 19.39%, and as physiological vacancy 12.48% and reproductive disorders 10.62%. 5. Among 1264 heads of reproductive disorders 856 heads were clue to ovarian diseases and occupied 68.98% of total disorders and uterus diseases 10.64% and repeat breeders occupied 17.64%.

• 산업경영시스템학회지
• /
• 제46권2호
• /
• pp.1-12
• /
• 2023

To make semiconductor chips, a number of complex semiconductor manufacturing processes are required. Semiconductor chips that have undergone complex processes are subjected to EDS(Electrical Die Sorting) tests to check product quality, and a wafer bin map reflecting the information about the normal and defective chips is created. Defective chips found in the wafer bin map form various patterns, which are called defective patterns, and the defective patterns are a very important clue in determining the cause of defects in the process and design of semiconductors. Therefore, it is desired to automatically and quickly detect defective patterns in the field, and various methods have been proposed to detect defective patterns. Existing methods have considered simple, complex, and new defect patterns, but they had the disadvantage of being unable to provide field engineers the evidence of classification results through deep learning. It is necessary to supplement this and provide detailed information on the size, location, and patterns of the defects. In this paper, we propose an anomaly detection framework that can be explained through FCDD(Fully Convolutional Data Description) trained only with normal data to provide field engineers with details such as detection results of abnormal defect patterns, defect size, and location of defect patterns on wafer bin map. The results are analyzed using open dataset, providing prominent results of the proposed anomaly detection framework.