• Molecules and Cells
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• v.43 no.11
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• pp.935-944
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• 2020

Aryl hydrocarbon receptor nuclear translocator (ARNT) plays an essential role in maintaining cellular homeostasis in response to environmental stress. Under conditions of hypoxia or xenobiotic exposure, ARNT regulates the subset of genes involved in adaptive responses, by forming heterodimers with hypoxia-inducible transcription factors (HIF1α and HIF2α) or aryl hydrocarbon receptor (AhR). Here, we have shown that ARNT interacts with DDB1 and CUL4-associated factor 15 (DCAF15), and the aryl sulfonamides, indisulam and E7820, induce its proteasomal degradation through Cullin-RING finger ligase 4 containing DCAF15 (CRL4^DCAF15) E3 ligase. Moreover, the two known neo-substrates of aryl sulfonamide, RNA-binding motif protein 39 (RBM39) and RNA-binding motif protein 23 (RBM23), are not required for ARNT degradation. In line with this finding, aryl sulfonamides inhibited the transcriptional activities of HIFs and AhR associated with ARNT. Our results collectively support novel regulatory roles of aryl sulfonamides in both hypoxic and xenobiotic responses.

• Journal of the Korean association of regional geographers
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• v.14 no.4
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• pp.367-381
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• 2008

The purpose of this paper is to analyze the change in the distribution and hierarchical structure of commercial land use. Tools for analyzing the spatial structure are index of concentration, coefficient of localization and location quotient. This research is applied to Daegu, focusing on the period 1985-2003. During the 1985-2003 period, the growth rate of commercial land use volume amounted to 330%, compared with a population growth rate of 118%. The biggest component of commercial land use is the retail sector. As the lodging, medical, transportation-warehouse and entertainment sectors have the propensity for concentration and comprise the specialized commercial areas in the suburbs, the other sectors arc evenly distributed. Jung-gu has functioned as a downtown core in the hierarchical structure of commercial areas. So, in the structure of commercial land use, Daegu has continued to be a single nuclear structure. But, Dongdaegu Station influence area has evolved into the second order center since 2000. This is the sign of change in spatial structure from single-nuclear pattern to multi nuclear pattern.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.6
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• pp.2181-2193
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• 2013

The shear wall with openings built with reinforced concrete(RC) have been elaborately studied by many researchers, whereas the steel plate concrete(SC) wall structure has not been investigated as much. Recent SC wall structures developed in Korea have been partly applied to nuclear power plant structures, although its design specification or guideline for the SC wall structure with openings has not been completed yet. This study based on the account for the area lost to openings evaluates the effects of opening on the structural capacity of the SC structure within nuclear power plant. The results obtained from the study on the area lost to openings have been compared with experimental and numerical studies.

• Journal of the Korean Society for Nondestructive Testing
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• v.28 no.5
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• pp.427-435
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• 2008

Inspection of dissimilar metal welds using phased array ultrasound is not easy at all, because crystalline structure of dissimilar metal welds cause deviation and splitting of the ultrasonic beams. Thus, in order to have focusing and/or steering phased array beams in dissimilar metal welds, proper time delays should be determined by ray tracing. In this paper, we proposed an effective approach to solve this difficult problem. Specifically, we modify the Oglivy's model parameters to describe the crystalline structure of real dissimilar metal welds in a fabricated specimen. And then, we calculate the proper time delay and incident angle of linear phased array transducer in the anisotropic and inhomogeneous material for focusing and/or steering phased array ultrasonic beams on the desired position.

• Nuclear Engineering and Technology
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• v.48 no.3
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• pp.660-672
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• 2016

In Part I of this paper, the two-temperature homogenized model for the fully ceramic microencapsulated fuel, in which tristructural isotropic particles are randomly dispersed in a fine lattice stochastic structure, was discussed. In this model, the fuel-kernel and silicon carbide matrix temperatures are distinguished. Moreover, the obtained temperature profiles are more realistic than those obtained using other models. Using the temperature-dependent thermal conductivities of uranium nitride and the silicon carbide matrix, temperature-dependent homogenized parameters were obtained. In Part II of the paper, coupled with the COREDAX code, a reactor core loaded by fully ceramic microencapsulated fuel in which tristructural isotropic particles are randomly dispersed in the fine lattice stochastic structure is analyzed via a two-temperature homogenized model at steady and transient states. The results are compared with those from harmonic- and volumetric-average thermal conductivity models; i.e., we compare $k_{eff}$ eigenvalues, power distributions, and temperature profiles in the hottest single channel at a steady state. At transient states, we compare total power, average energy deposition, and maximum temperatures in the hottest single channel obtained by the different thermal analysis models. The different thermal analysis models and the availability of fuel-kernel temperatures in the two-temperature homogenized model for Doppler temperature feedback lead to significant differences.

• Earthquakes and Structures
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• v.4 no.5
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• pp.557-585
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• 2013

The recent huge earthquake ground motion records in Japan result in the reconsideration of seismic design forces for nuclear power stations from the view point of seismological research. In addition, the seismic design force should be defined also from the view point of structural engineering. In this paper it is shown that one of the occurrence mechanisms of such large acceleration in recent seismic records (recorded in or near massive structures and not free-field ground motions) is due to the interaction between a massive building and its surrounding soil which induces amplification of local mode in the surface soil. Furthermore on-site investigation after earthquakes in the nuclear power stations reveals some damages of soil around the building (cracks, settlement and sand boiling). The influence of plastic behavior of soil is investigated in the context of interaction between the structure and the surrounding soil. Moreover the amplification property of the surface soil is investigated from the seismic records of the Suruga-gulf earthquake in 2009 and the 2011 off the Pacific coast of Tohoku earthquake in 2011. Two methods are introduced for the analysis of the non-stationary process of ground motions. It is shown that the non-stationary Fourier spectra can detect the temporal change of frequency contents of ground motions and the displacement profile integrated from its acceleration profile is useful to evaluate the seismic behavior of the building and the surrounding soil.

• Nuclear Engineering and Technology
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• v.45 no.5
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• pp.653-664
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• 2013

The design of computer-based instrumentation and control (I&C) systems is determined by the allocation of I&C functions to I&C systems and components. Due to the characteristics of computer-based technology, component failures can negatively affect several I&C functions, so that the reliability proof of the I&C systems requires the accomplishment of I&C system design analyses throughout the I&C life-cycle. On one hand, this paper proposes the restructuring of the sequential IEC 61513 I&C life-cycle according to the V-model, so as to adequately integrate the concept of verification and validation. On the other hand, based on a metamodel for the modeling of I&C systems, this paper introduces a method for the modeling and analysis of the effects with respect to the superposition of failure combinations and event sequences on the I&C system design, i.e. the temporal change of physical structure is analyzed. In the first step, the method is concerned with the modeling of the I&C systems. In the second step, the method considers the analysis of temporal change of physical structure, which integrates the concepts of the diversity and defense-in-depth analysis, fault tree analysis, event tree analysis, and failure mode and effects analysis.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1021-1025
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• 2009

A novel supramolecular network containing binuclear copper unit $[Cu(phen)_{2}({\mu}-ID\;A)Cu(phen){\cdot}(NO_{3})](NO_{3}){\cdot}4(H_{2}O)$ (1) was synthesized through the self-assembly of iminodiacetic acid ($H_2IDA$) and 1,10-phenanthroline (phen) in the condition of pH = 6. It has been characterized by the infrared (IR) spectroscopy, elemental analysis, single crystal X-ray diffraction, and thermogravimetric analysis (TGA). 1 shows a 2-D supramolecular structure assembled through strong and unique $\pi-\pi$ packing interactions. Density functional theory (DFT) calculations show that theoretical optimized structures can well reproduce the experimental structure. The TGA and powder X-ray diffraction (PXRD) curves indicate that the complex 1 can maintain the structural integrity even at the loss of free water molecules. The magnetic property is also reported in this paper.

• Nuclear Engineering and Technology
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• v.51 no.4
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• pp.1008-1016
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• 2019

In the SG (steam generator) of PWR (pressurized water reactor) for a nuclear plant, hundreds of U-shaped tubes are used for the heat exchanger system. They interact with primary pressurized cooling water flow, generating flow-induced vibration in the secondary flow region. A simplified U-tube model is proposed in this study to apply for experiment and its counterpart computation. Using the commercial code, ANSYS-CFX, we first verified the Moody chart, comparing the straight pipe theory with the results derived from CFD (computational fluid dynamics) analysis. Considering the virtual mass of fluid, we computed the major modes with the low natural frequencies through the comparison with impact hammer test, and then investigated the effect of pump flow in the frequency domain using FFT (fast Fourier transform) analysis of the experimental data. Using two-way fluid-structure interaction module in the CFD code, we studied the influence on mean flow rate to generate the displacement data. A feasible CFD method has been setup in this research that could be applied potentially in the field of nuclear thermal-hydraulics.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.386-400
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• 2022

Seismic fragility analysis, a part of seismic probabilistic risk assessment (SPRA), is commonly used to establish the relationship between a representative property of earthquakes and the failure probability of a structure, component, or system. Current guidelines on the SPRA of nuclear power plants (NPPs) used worldwide mainly reflect the earthquake characteristics of the western United States. However, different earthquake characteristics may have a significant impact on the seismic fragility of a structure. Given the concern, this study aimed to investigate the effects of earthquake characteristics on the seismic fragility of concrete containments housing the OPR-1000 reactor. Earthquake time histories were created from 30 ground motions (including those of the 2016 Gyeongju earthquake) by spectral matching to the site-specific response spectrum of Hanbit nuclear power plants in South Korea. Fragility curves of the containment structure were determined under the linear response history analysis using a lumped-mass stick model and 30 ground motions, and were compared in terms of earthquake characteristics. The results showed that the median capacity and high confidence of low probability of failure (HCLPF) tended to highly depend on the sustained maximum acceleration (SMA), and increase when using the time histories which have lower SMA compared with the others.