• Title/Summary/Keyword: Nuclear industry

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Investigation of Knowledge and Awareness of Radiation of University Students - To the Radiation Non-Commissioned Personnel - (대학생의 방사선의 지식 및 인식 조사 - 방사선 비전공자를 대상으로 -)

  • Kang, Yeon-Hee;Park, Cheolwoo
    • Journal of the Korean Society of Radiology
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    • v.13 no.2
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    • pp.233-239
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    • 2019
  • The purpose of this study was to investigate the knowledge and awareness about radiation use among non - radiation undergraduates. This analysis were used based on the collected questionnaires with Frequency, mean and standard deviation, t-test, one-way ANOVA. As a result, there was no significant difference between the groups in terms of gender and age. There were statistical differences in some items in the major field. In addition, the perception of radiation was more negative in women and under 25 years of age (p<0.05). The correlations between the sub - factors showed that the higher the knowledge of radiation, the higher the perception of knowledge and use of radiation. It is believed that university students will have a positive effect of contributing to the development of the radiation industry if they have a correct understanding of radiation because they are more likely to contribute to public opinion by advancing into society.

Characterization and Antioxidant Activity of Released Exopolysaccharide from Potential Probiotic Leuconostoc mesenteroides LM187

  • Zhang, Qing;Wang, Jie;Sun, Qing;Zhang, Shu-Ming;Sun, Xiang-Yang;Li, Chan-Yuan;Zheng, Miao-Xin;Xiang, Wen-Liang;Tang, Jie
    • Journal of Microbiology and Biotechnology
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    • v.31 no.8
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    • pp.1144-1153
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    • 2021
  • A released exopolysaccharide (rEPS)-producing strain (LM187) with good acid resistance, bile salt resistance, and cholesterol-lowering properties was isolated from Sichuan paocai and identified as Leuconostoc mesenteroides subsp. mesenteroides. The purified rEPS, designated as rEPS414, had a uniform molecular weight of 7.757 × 105 Da. Analysis of the monosaccharide composition revealed that the molecule was mainly composed of glucose. The Fourier transform-infrared spectrum showed that rEPS414 contained both α-type and β-type glycosidic bonds. 1H and 13C nuclear magnetic resonance spectra analysis showed that the purified rEPS contained arabinose, galactose, and rhamnose, but less uronic acid. Scanning electron microscopy demonstrated that the exopolysaccharide displayed a large number of scattered, fluffy, porous cellular network flake structures. In addition, rEPS414 exhibited strong in vitro antioxidant activity. These results showed that strain LM187 and its rEPS are promising probiotics with broad prospects in industry.

Demonstration of the Effectiveness of Monte Carlo-Based Data Sets with the Simplified Approach for Shielding Design of a Laboratory with the Therapeutic Level Proton Beam

  • Lai, Bo-Lun;Chang, Szu-Li;Sheu, Rong-Jiun
    • Journal of Radiation Protection and Research
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    • v.47 no.1
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    • pp.50-57
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    • 2022
  • Background: There are several proton therapy facilities in operation or planned in Taiwan, and these facilities are anticipated to not only treat cancer but also provide beam services to the industry or academia. The simplified approach based on the Monte Carlo-based data sets (source terms and attenuation lengths) with the point-source line-of-sight approximation is friendly in the design stage of the proton therapy facilities because it is intuitive and easy to use. The purpose of this study is to expand the Monte Carlo-based data sets to allow the simplified approach to cover the application of proton beams more widely. Materials and Methods: In this work, the MCNP6 Monte Carlo code was used in three simulations to achieve the purpose, including the neutron yield calculation, Monte Carlo-based data sets generation, and dose assessment in simple cases to demonstrate the effectiveness of the generated data sets. Results and Discussion: The consistent comparison of the simplified approach and Monte Carlo simulation results show the effectiveness and advantage of applying the data set to a quick shielding design and conservative dose assessment for proton therapy facilities. Conclusion: This study has expanded the existing Monte Carlo-based data set to allow the simplified approach method to be used for dose assessment or shielding design for beam services in proton therapy facilities. It should be noted that the default model of the MCNP6 is no longer the Bertini model but the CEM (cascade-exciton model), therefore, the results of the simplified approach will be more conservative when it was used to do the double confirmation of the final shielding design.

Anti-inflammatory Effects of Ethanol Extract of Various Korean Compositae Herbs in LPS-induced RAW 264.7 Macrophages

  • Seo, Min-gyu;Kang, Yun-Mi;Chung, Kyung-Sook;Cheon, Se-Yun;Park, Jong Hyuk;Lee, Young-Cheol;An, Hyo-Jin
    • The Korea Journal of Herbology
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    • v.32 no.2
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    • pp.17-24
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    • 2017
  • Objective : This study was designed to evaluate candidate materials as anti-inflammation agent from extracts of various Korean Compositae herbs in Hwaak mountain. Among Korea medicinal herbs, Ainsliaea acerifolia (AA) belongs to the Compositae family, has been used for the treatment of rheumatic arthritis. However, AA has not been previously reported to have an anti-inflammatory effect. Therefore, we investigated the anti-inflammatory effects of AA and its underlying molecular mechanisms in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Methods : Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in RAW 264.7 macrophages. Nitric oxide (NO) was measured with Griess reagent and pro-inflammatory cytokines were detected by enzyme immunoassay (EIA) kits in LPS-stimulated RAW 264.7 macrophages. Protein expressions of inducible nitric oxide synthase, and cyclooxygenase-2 (COX-2) and p65 subunit of nuclear factorκB (NFκB) were determined by Western blot analysis. Results : Among 8 extracts of Korean Compositae herbs tested, AA showed the inhibition of NO production without cytotoxicity. Consistent with the observation, AA reduced the expression levels of iNOS and COX-2 proteins in LPS-simulated RAW 264.7 macrophages in dose-dependent manner. In addition, AA inhibited the productions of TNFα and IL-6 in LPS-simulated RAW 264.7 macrophages. However, AA did not inhibit activation of p65 NFκB in LPS-simulated RAW 264.7 macrophages. Conclusion : These results suggest that down-regulation of iNOS, COX-2 protein expression and TNFα and IL-6 production by AA are responsible for its anti-inflammatory effects.

A study on the Rasing-Anxiety of Parenting of children in school age with Low levels of Self-differentiation (낮은 자기분화수준을 가진 학령기 아동 어머니의 양육불안 경험에 관한 연구)

  • Lee, Won-Seon;Hong, Sang-Uk
    • Industry Promotion Research
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    • v.7 no.2
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    • pp.31-42
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    • 2022
  • This study was conducted in-depth interviews and examinations by selecting mothers with low levels of self-differentiation and experiencing anxiety about parenting among mothers with low levels of self-differentiation, and analyzed them around categories and analyzed them into general structural techniques. As a current period task, it is the cause of the rasing-anxiety of parenthood in school age and the number of children due to nuclear familyization, and by generalizing the family's problems and experiences of parenting insolvency into categories, it is the reason for recognizing problems such as the child's social response and emotional support and the cause of the mother's low level of self-differentiation and anxiety, and setting the correct direction for parenting.

Effects of inclined bedrock on dissimilar pile composite foundation under vertical loading

  • Kaiyu, Jiang;Weiming, Gong;Jiang, Xu;Guoliang, Dai;Xia, Guo
    • Geomechanics and Engineering
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    • v.31 no.5
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    • pp.477-488
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    • 2022
  • Pile composite foundation (PCF) has been commonly applied in practice. Existing research has focused primarily on semi-infinite media having equal pile lengths with little attention given to the effects of inclined bedrock and dissimilar pile lengths. This investigation considers the effects of inclined bedrock on vertical loaded PCF with dissimilar pile lengths. The pile-soil system is decomposed into fictitious piles and extended soil. The Fredholm integral equation about the axial force along fictitious piles is then established based on the compatibility of axial strain between fictitious piles and extended soil. Then, an iterative procedure is induced to calculate the PCF characteristics with a rigid cap. The results agree well with two field load tests of a single pile and numerical simulation case. The settlement and load transfer behaviors of dissimilar 3-pile PCFs and the effects of inclined bedrock are analyzed, which shows that the embedded depth of the inclined bedrock significantly affects the pile-soil load sharing ratios, non-dimensional vertical stiffness N0/wdEs, and differential settlement for different length-diameter ratios of the pile l/d and pile-soil stiffness ratio k conditions. The differential settlement and pile-soil load sharing ratios are also influenced by the inclined angle of the bedrock for different k and l/d. The developed model helps better understand the PCF characteristics over inclined bedrock under vertical loading.

MicroRNA-127 promotes antimicrobial ability in porcine alveolar macrophages via S1PR3/TLR signaling pathway

  • Honglei Zhou;Yujia Qian;Jing Liu
    • Journal of Veterinary Science
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    • v.24 no.2
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    • pp.20.1-20.13
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    • 2023
  • Background: As Actinobacillus pleuropneumonniae (APP) infection causes considerable losses in the pig industry, there is a growing need to develop effective therapeutic interventions that leverage host immune defense mechanisms to combat these pathogens. Objectives: To demonstrate the role of microRNA (miR)-127 in controlling bacterial infection against APP. Moreover, to investigate a signaling pathway in macrophages that controls the production of anti-microbial peptides. Methods: Firstly, we evaluated the effect of miR-127 on APP-infected pigs by cell count/enzyme-linked immunosorbent assay (ELISA). Then the impact of miR-127 on immune cells was detected. The cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 were evaluated by ELISA. The expression of cytokines (anti-microbial peptides [AMPs]) was assessed using quantitative polymerase chain reaction. The expression level of IL-6, TNF-α and p-P65 were analyzed by western blot. The expression of p65 in the immune cells was investigated by immunofluorescence. Results: miR-127 showed a protective effect on APP-infected macrophage. Moreover, the protective effect might depend on its regulation of macrophage bactericidal activity and the generation of IL-22, IL-17 and AMPs by targeting sphingosine-1-phosphate receptor3 (SIPR3), the element involved in the Toll-like receptor (TLR) cascades. Conclusions: Together, we identify that miR-127 is a regulator of S1PR3 and then regulates TLR/nuclear factor-κB signaling in macrophages with anti-bacterial acticity, and it might be a potential target for treating inflammatory diseases caused by APP.

Impact of nanocomposite material to counter injury in physical sport in the tennis racket

  • Hao Jin;Bo Zhang;Xiaojing Duan
    • Advances in nano research
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    • v.14 no.5
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    • pp.435-442
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    • 2023
  • Sports activities, including playing tennis, are popular with many people. As this industry has become more professionalized, investors and those involved in sports are sure to pay attention to any tool that improves athletes' performance Tennis requires perfect coordination between hands, eyes, and the whole body. Consequently, to perform long-term sports, athletes must have enough muscle strength, flexibility, and endurance. Tennis rackets with new frames were manufactured because tennis players' performance depends on their rackets. These rackets are distinguished by their lighter weight. Composite rackets are available in many types, most of which are made from the latest composite materials. During physical exercise with a tennis racket, nanocomposite materials have a significant effect on reducing injuries. Materials as strong as graphite and thermoplastic can be used to produce these composites that include both fiber and filament. Polyamide is a thermoplastic typically used in composites as a matrix. In today's manufacturing process, materials are made more flexible, structurally more vital, and lighter. This paper discusses the production, testing, and structural analysis of a new polyamide/Multi-walled carbon nanotube nanocomposite. This polyamide can be a suitable substitute for other composite materials in the tennis racket frame. By compression polymerization, polyamide was synthesized. The functionalization of Multi-walled carbon nanotube (MWCNT) was achieved using sulfuric acid and nitric acid, followed by ultrasonic preparation of nanocomposite materials with weight percentages of 5, 10, and 15. Fourier transform infrared (FTIR) and Nuclear magnetic resonance (NMR) confirmed a synthesized nanocomposite structure. Nanocomposites were tested for thermal resistance using the simultaneous thermal analysis (DTA-TG) method. scanning electron microscopy (SEM) analysis was used to determine pores' size, structure, and surface area. An X-ray diffraction analysis (XRD) analysis was used to determine their amorphous nature.

Immunomodulatory Activity of Water Extract of Ulmus macrocarpa in Macrophages (유근피 추출물이 대식세포 면역조절에 미치는 영향)

  • Kwon, Da Hye;Kang, Hye-Joo;Choi, Yung Hyun;Chung, Kyung Tae;Lee, Jong Hwan;Kang, Kyung Hwa;Hyun, Sook Kyung;Kim, Byung Woo;Hwang, Hye Jin
    • Journal of Life Science
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    • v.26 no.1
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    • pp.50-58
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    • 2016
  • The root bark of Ulmus macrocarpa has been used in traditional medicine for the treatment of various diseases such as edema, infection and inflammation. Nevertheless, the biological activities and underlying mechanisms of the immunomodulatory effects remain unclear. In this study, as part of our ongoing screening program to evaluate the immunomodulatory potential of new compounds from traditional medicinal resources, we investigated the effects of U. macrocarpa water extract (UME) on immune modulation in a murine RAW 264.7 macrophage model. As immune response parameters, the productions of as nitric oxide (NO) and cytokines such tumor necrotic factor (TNF)-α, interleukin (IL)-1β and IL-10 were evaluated. Although the release of IL-1β remained unchanged in UME-treated RAW 264.7 macrophages, the productions of NO, TNF-α and IL-10 were significantly increased, along with the increased expression of inducible NO synthase, TNF-α and IL-10 expression at concentrations with no cytotoxicity. UME treatment also induced the nuclear translocation of nuclear factor κB (NF-κB), and phosphorylation of Akt and mitogen-activated protein kinases (MAPKs) indicating that UME activated macrophages through the activation of NF-κB, phosphoinositide-3-kinase (PI3K)/Akt and MAPKs signaling pathways in RAW 264.7 macrophages. Furthermore, pre-treatment with UME significantly attenuated the production of NO, but not TNF-α, IL-1β and IL-10, in lipopolysaccharide-stimulated RAW 264.7 cells suggesting that UME may be useful in preventing inflammatory diseases mediated by excessive production of NO. These findings suggest that the beneficial therapeutic effects of UME may be attributed partly to its ability to modulate immune functions in macrophages.

Study of Factors Controlling Exposure Dose and Image Quality of C-arm in Operation Room according to Detector Size of It (Mainly L-Spine AP Study) (수술 중 C-Arm Neutral AP 검사 시 조절인자에 따른 피폭선량 및 화질비교(L-Spine AP검사를 기준으로))

  • CHOI, Sung-Hyun;JO, Hwang-Woo;Dong, Kyung-Rae;Chung, Woon-Kwan;Choi, Eun-Jin;Song, Ha-jin
    • Journal of Radiation Industry
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    • v.9 no.2
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    • pp.85-90
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    • 2015
  • Purpose: Time of operation has been reduced and accuracy of operation has been improved since C-arm, which offer real-time image of patient, was introduced in operation room. However, because of the contamination of patient, C-arm could not be used more appropriately. Therefore, this study is to know factors of controlling exposure dose, image quality and the exposed dose of health professional in operation room. Materials and methods: Height of Wilson frame (bed for operation) was fixed at 130 cm. Then, Model 76-2 Phantom, which was set by assembling manual of Fluke Company, was set on the bed. Head/Spine Fluoroscopy AEC mode was set for exposure condition. According to detector size of C-arm, the absorbed dose per min was measured in the 7 steps OFD (cm) from 10 cm to 40 cm (10, 15, 20, 25, 30, 35, 40 cm). In each step of OFD, the absorbed dose per min of same diameter of collimation was measured. Moreover, using Nero MAX Model 8000, exposure dose per min was measured according to 3 step of distance from detector (20 cm, 60 cm, 100 cm). Finally, resolution was measured by CDRH Disc Phantom and magnification of each OFD was measured by aluminum stick bar. Result: According to detector size of C-arm, difference of absorbed dose shows that the dose of 20 cm OFD is 1.750 times higher than the dose of 40 cm OFD. It means that the C-arm, which has smaller size of detector, shows the bigger difference of absorbed dose per min (p<0.05). In the difference of absorbed dose in the same step of OFD (from 20 cm to 40 cm), the absorbed dose of 9 inch detect or C-arm was 1.370 times higher than 12 inch' s (p<0.05). When OFD was set to 20 cm OFD, the absorbed dose of non-collimation case was approximately 0.816 times lower than the absorbed dose of collimation cases (p<0.05). When the distance was 20 cm from detector, exposed does includes first-ray and scatter-ray. When the distance was 60 cm and 100 cm from detector, exposed does includes just scatter-ray. So, there was the 2.200 times difference of absorbed does. Finally, when OFD was increased, spatial resolution was 4 to 5 step was increased. However, low contrast resolution was not relative. Moreover, there was 1.363 times difference of magnification (p<0.05). Conclusion: When C-Arm is used, avoiding contamination of patient is more important factor than reducing exposed dose of health professional in operation room. Just controlling exposure time is just way to reduce the exposed does of workers. However, in the case, non-probability influence could be occurred. Therefore, this study proved that the exposed dose will be reduced if the factors such as using small detector size of C-arm, setting OFD from 20 cm to 25 cm and non-collimating. Moreover, dose management of C-arm in the non-interesting area will be considered additionally.