• Proceedings of the Korean Nuclear Society Conference
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• 2005.05a
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• pp.1144-1145
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• 2005

• The Korean Journal of Nuclear Medicine
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• v.38 no.4
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• pp.294-299
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• 2004

Purpose: Both human NIS and mutant $D_2R$ transgenes are proposed as reporting system in transplanted cell tracking. Using hepatoma cell lines, we constructed a dual reporter system containing human sodium-iodide symporter (hNIS) and dopamine 2 receptor ($D_2R$) and compared its characteristics. Materials and Methods: The recombinant plasmid ($pIRES-hNIS/D_2R$) was constructed with IRES (internal ribosome entry site) under control of the CMV promoter $pIRES-hNIS/D_2R$ was transfected to human hepatoma SK-Hep1 cell line with lipofectamine. HEP-ND ($SK-Hep1-hNIS/D_2R$) cells stably expressing hNIS and $D_2R$ was established by selection with G418 for two weeks. RT-PCR was performed to investigate the expression of both hNIS and $D_2R$ genes. The expressions of hNIS and $D_2R$ were measured by $^{125}I$ uptake assays and receptor binding assays. Specific binding of $D_2R$ to $[^3H]spiperone$ was verified by Scatchard plot with (+) butaclamol as a specific inhibitor. $K_d\;and\;B_{max}$ values were estimated. The correlation between hNIS and $D_2R$ expression was compared by using each clone. Results: Similar quantities of hNIS and $D_2R$ genes were expressed on HEP-ND as RT-PCR assays. HEP-ND cells showed 30 to 40 fold higher radioiodine uptakes than those of parental SK-Hep1 cells. $^{125}I$ uptake in HEP-ND cells was completely inhibited by $KClO_4$, a NIS inhibitor Specific binding to HEP-ND cells was saturable and the $K_d\;and\;B_{max}$ values for HEP-ND cells were 2.92 nM, 745.25 fmol/mg protein and 2.91nM, 1323 fmole/mg protein in two clones, respectively. The radioiodine uptake by hNIS activity and $D_2R$ binding was highly correlated. Conclusion: We developed a dual positron and gamma imaging reporter system of hNIS and $D_2R$ in a stably transfected cell line. We expect that $D_2R$ and hNIS genes can complement mutually as a nuclear reporting system or that $D_2R$ can be used as reporter gene when hNIS gene were used as a treatment gene.

• Journal of Korea Technology Innovation Society
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• v.2 no.3
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• pp.118-128
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• 1999

This study attempts to provide an efficient method for managing the Nuclear R&D projects. It should be noted that the technology and experiences to develop a well-balanced plan and mon-itoring for the R&D project are not yet well established when compared with the commercial con-structionand engineering projects. This study recommends that the R&D project manager utilize the scheduling techniques to establish an integral management system taking in to account the un-certainties in the research environment. Based upon the results of a case study for the Liquid Metal Reactor Design Technology Development Project which is led by the KAERI this study also con-firms that it is possible to run the national nuclear R&D projects with the Scheduling & Planning.

• Nuclear Engineering and Technology
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• v.55 no.6
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• pp.2034-2046
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• 2023

Industrial control systems in nuclear facilities are facing increasing cyber threats due to the widespread use of information and communication equipment. To implement cyber security programs effectively through the RG 5.71, it is necessary to quantitatively assess cyber risks. However, this can be challenging due to limited historical data on threats and customized Critical Digital Assets (CDAs) in nuclear facilities. Previous works have focused on identifying data flows, the assets where the data is stored and processed, which means that the methods are heavily biased towards information security concerns. Additionally, in nuclear facilities, cyber threats need to be analyzed from a safety perspective. In this study, we use the system theoretic process analysis to identify system-level threat scenarios that could violate safety constraints. Instead of quantifying the likelihood of exploiting vulnerabilities, we quantify Security Control Measures (SCMs) against the identified threat scenarios. We classify the system and CDAs into four consequence-based classes, as presented in NEI 13-10, to analyze the adversary impact on CDAs. This allows for the ranking of identified threat scenarios according to the quantified SCMs. The proposed framework enables stakeholders to more effectively and accurately rank cyber risks, as well as establish security and response strategies.

• Nuclear Engineering and Technology
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• v.52 no.11
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• pp.2660-2666
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• 2020

Korea successfully achieved energy independence in the shortest period of time from being the poorest country in terms of energy 50 years ago through steady development of nuclear technology. In the past, the nuclear industry has been driven through government-centered policy development, public institution-based research, and industrial facility and infrastructure construction. Consequently, South Korea became a nuclear energy powerhouse exporting nuclear power plants to the UAE, surpassing the level of domestic technological independence. However, in recent years, the nuclear industry in Korea has experienced a decline in new plant construction since the Fukushima accident in Japan, which caused changes in public perspectives regarding nuclear power plant operation, more stringent safety standards on the operation of nuclear power plants, and a shift in governmental energy policy. These changes are expected to change the domestic nuclear industry ecosystem. Therefore, in this study, we investigate the priority of technology development investment from the perspective of experts in private nuclear power companies, shifting the focus from government-led nuclear R&D policies. To establish a direction in nuclear technology development, a survey was conducted by applying an analytic hierarchy analysis to experts who have worked in nuclear power plants for more than 15 years. The analysis items of focus were the 3 attributes of strategic importance, urgency, and business feasibility of four major fields related to nuclear energy: nuclear safety, decommissioning, radioactive waste management, and strengthening industrial competitiveness.

• Journal of the Korean Society for Nondestructive Testing
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• v.33 no.1
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• pp.26-33
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• 2013

BMI nozzles in bottom head of the nuclear vessel are one of major components in nuclear power plants. The BMI nozzles have high possibility to generate PWSCC(primary water stress corrosion crack) according to recent foreign case although operation temperature is lower then the upper head of the nuclear vessel. Thus, nondestructive inspection of the BMI nozzles is required. But, inspection of BMI nozzles is not easy since the BMI nozzles placed in high radiated area and inside the nozzles filled with boric acid. Thus, in this study, a TOFD transducer for inspection of BMI and automated scanner system with water were developed. Also, validation of performance of the developed transducer and system are performed using specimens with artificial defects.

• Nuclear Engineering and Technology
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• v.47 no.3
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• pp.240-252
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• 2015

In the original licensing application for the prototype fast-breeder reactor, MONJU, the event progression during an unprotected loss of flow (ULOF), which is one of the technically inconceivable events postulated beyond design basis, was evaluated. Through this evaluation, it was confirmed that radiological consequences could be suitably limited even if mechanical energy was released. Following the Fukushima-Daiichi accident, a new nuclear safety regulation has become effective in Japan. The conformity of MONJU to this new regulation should hence be investigated. The objectives of the present study are to conduct a preliminary evaluation of ULOF for MONJU, reflecting the knowledge obtained after the original licensing application through CABRI experiments and EAGLE projects, and to gain the prospect of in-vessel retention for the conformity of MONJU to the new regulation. The preliminary evaluation in the present study showed that no significant mechanical energy release would take place, and that thermal failure of the reactor vessel could be avoided by the stable cooling of disrupted-core materials. This result suggests that the prospect of in-vessel retention against ULOF, which lies within the bounds of the original licensing evaluation and conforms to the new nuclear safety regulation, will be gained.

• Journal of the Korean Society for information Management
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• v.6 no.1
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• pp.15-36
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• 1989

The r a p i d i n c r e a s e o f microcomputer technology has r e s u l t e d i n t h e broad a p p l i c a t i o n t o various f i e l d s . The purpose of t h l s paper 1s to design a computerized r e t r i e v a l system f o r nuclear information m a t e r i a l s using a microcomputer.

• Korean System Dynamics Review
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• v.15 no.2
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• pp.27-50
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• 2014

Korea government established the energy technology development plan (2011-2020) and declared to be a leader of the green energy technologies. The plan aims for 10% market share in the green energy industry, 12% energy efficiency improvement, and 15% greenhouse gas reduction. In order to achieve these goals, the government has tried to calculate the whole scale of national energy R&D investment, annual budget and specific expenditures for new technologies by computer simulation. The simulation modules include the R&D investment model, GDP model, energy consumption and $CO_2$ emission model by System Dynamics. Based on these simulation modules, I tested various scenarios for effectiveness of energy R&D investments until 2020. The results show that Korea should increase national energy R&D investment to 2.3 billion U.S. dollars, and switch the investment from electricity and nuclear power to the renewable energy.

• Proceedings of the Korean Nuclear Society Conference
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• 2003.05a
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• pp.443.1-443.1
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• 2003