• Journal of the Korean BIBLIA Society for library and Information Science
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• v.24 no.2
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• pp.113-128
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• 2013

This study targets ten titles of Hangul banggakbon novels in the Harvard Yenching Library to examine the bibliography, system, and characteristics. Among the ten titles, gyeongpanbon Guunmong, Leehaeryongjeon, Chunhyangjeon, Janggyeongjeon, two titles of Sodaeseongjeon, Honggildongjeon, anseongpanbon Yangpungunjeon, and two titles of wanpanbon Hwaryongdo have been found in Korea, too. However, gyeongpanbon Chunhyangjeon, 30 jangbon of Hyogyosingan(孝橋新刊), and wanpanbon Hwaryongdo seogyeseopobon are the ones that can be hardly found in Korea, and the library has possessed it there so far. With the two titles of Hangul banggakbon novels, it will be needed to reexamine the aspects of publishing Hangul banggakbon novels afterwards. Hangul banggakbon novels that Harvard-Yenching Library has now are mostly the ones that can be easily found in Korea, too. It is because the data started to be collected from the 1950's. In comparison with the materials in England, Russia, or Japan in the early 1890's, there are no rare books that cannot be found in Korea. The reason for this may be found from this.

• Journal of Life Science
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• v.24 no.2
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• pp.128-136
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• 2014

Alginates are linear acidic polysaccharides composed with (1-4)-linked ${\alpha}$-L-guluronic acid and ${\beta}$-Dmannuronic acid. Alginate can be degraded by diverse alginate lyases, which cleave the alginate using a ${\beta}$-elimination reaction and produce unsaturated uronate oligomers. A gene for a polyMG-specific alginate lyase possessing a novel structure was previously identified and cloned from Stenotrophomonas maltophilia KJ-2. Homology modeling of KJ-2 polyMG-specific alginate lyase showed it belongs to the PL6 family, whereas three Azotobacter vinelandii polyMG lyases belong to the PL7 family of polysaccharide lyases. From $^1H$-NMR spectra data, KJ-2 polyMG lyase preferably degraded the M-${\beta}$(1-4)-G glycosidic bond than the G-${\alpha}$(1-4)-M glycosidic bond. Seventeen mutants were made by site-directed mutagenesis, and alginate lyase activity was analyzed. Lys220Ala, Arg241Ala, Arg241Lys, and Arg265Ala lost alginate lyase activity completely. Arg155Ala, Gly303Glu, and Tyr304Phe also lost the activity by 60.7-80.1%. These results show that Arg155, Lys220, Arg241, Arg265, Gly303, and Tyr304 are important residues for catalytic activity and substrate binding.

• Journal of Marine Bioscience and Biotechnology
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• v.11 no.2
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• pp.42-51
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• 2019

We compared the antibacterial activities of spermidine and astaxanthin against two gram-positive bacteria such as Streptococcus parauberis and S. iniae to find new antibacterial candidates. We also evaluated the preventive effects of spermidine against oxidative stress-induced cytotoxicity in C2C12 myoblasts. Our results indicated that spermidine has more significant antibacterial activities than astaxanthin against both two fish pathogenic bacteria as well as gram-negative bacteria Escherichia coli used as a control group. Minimum inhibitory concentration and minimum bactericidal concentration of spermidine were 0.25 mM and 1 mM against S. parauberis, 1 mM and 3 mM against S. iniae, and 0.5 mM and 1.5 mM against E. coli, respectively. In addition, the postantibiotic effect lasted from 7 h, 5 h and 6 h for S. parauberis, S. iniae and E. coli, respectively. The results also showed that the decreased C2C12 cell viability by H₂O₂ could be attributed to the induction of DNA damage and apoptosis accompanied by the increased production of reactive oxygen species, which was remarkably protected by spermidine. Additionally, the antioxidant effect of spermidine was associated with the activation of Nrf2 signaling pathway. According to the data, spermidine may be a potential lead compound which can be further optimized to discover novel antibacterial and antioxidant agents.

• Journal of Broadcast Engineering
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• v.14 no.5
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• pp.573-588
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• 2009

In this paper, we propose a novel video quality degradation monitoring scheme titled VR-VQMS(Visual Rhythm based Video Quality Monitoring Scheme) over an IPTV service prone to packet losses during network transmission. Proposed scheme quantifies the amount of quality degradation due to packet losses, and can be classified into a RR(reduced-reference) based quality measurement scheme exploiting visual rhythm data of H.264-encoded video frames at a media server and reconstructed ones at an Set-top Box as feature information. Two scenarios, On-line and Off-line VR-VQMS, are proposed as the practical solutions. We define the NPSNR(Networked Peak-to-peak Signal-to-Noise Ratio) modified by the well-known PSNR as a new objective quality metric, and several additional objective and subjective metrics based on it to obtain the statistics on timing, duration, occurrence, and amount of quality degradation. Simulation results show that the proposed method closely approximates the results from 2D video frames and gives good estimation of subjective quality(i.e.,MOS(mean opinion score)) performed by 10 test observers. We expect that the proposed scheme can play a role as a practical solution to monitor the video quality experienced by individual customers in a commercial IPTV service, and be implemented as a small and light agent program running on a resource-limited set-top box.

• Journal of KIISE:Databases
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• v.37 no.5
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• pp.258-266
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• 2010

In this paper, we introduce a novel method to predict next update of blogs. The number of RSS feeds registered on meta-blogs is on the order of several million. Checking for updates is very time consuming and imposes a heavy burden on network resources. Since blog search engine has limited resources, there is a fix number of blogs that it can visit on a day. Nevertheless we need to maximize chances of getting new data, and the proposed method which predicts update probability on blogs could bring better chances for it. Also this work is important to avoid distributed denial-of-service attack for the owners of blogs. Furthermore, for the internet as whole this work is important, too, because our approach could minimize traffic. In this study, we assumed that there is a specific pattern to when a blogger is actively posting, in terms of days of the week and, more specifically, hours of the day. We analyzed 15,119 blogs to determine a blogger's posting preference. This paper proposes a method to predict the update probability based on a blogger's posting history and preferred days of the week. We applied proposed method to 12,115 blogs to check the precision of our predictions. The evaluation shows that the model has a precision of 0.5 for over 93.06% of the blogs examined.

• Journal of Pharmaceutical Investigation
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• v.41 no.1
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• pp.31-36
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• 2011

$5HT_{2C}$ receptor among fourteen 5-HT subtypes plays important roles in several disorders such as depression, anxiety, epilepsy, schizophrenia and sleep disorders. The purpose of the study is to investigate pharmacokinetic parameters and bioavailability of a newly synthesized selective agonist of $5-HT_{2C}$ receptor, KOPC-20010 (KP10) in rats after intravenous and oral administration for the development of therapeutic anti-obesity agents. KP10 was administered orally (40 mg/kg) or intravenously (20 mg/kg), blood was collected via a catheter, and analyzed by GC/MSD. The calibration curve of KP10 in plasma and urine showed high linearity ($r^2$ >0.999). The retention times of KP10 in plasma and urine were 8.7 and 9.7 min, respectively. After oral administration of 40 mg/kg, pharmacokinetic parameters were calculated as follows; $C_{max}$ value was $1242.9{\pm}1195.5$ ng/mL at $1.1{\pm}0.6$ hr ($T_{max}$). $AUC_{0->24hr}$ and $AUC_{0>{\infty}}$ were $8034.2{\pm}960.7$ and $10464.1{\pm}681.5\;ng{\cdot}hr/mL$, respectively. The terminal half-life was $21.9{\pm}7.6$ hr. $AUC_{0->24hr}$ and $AUC_{0>{\infty}}$ were $4292.4{\pm}523.0$ and $6111.2{\pm}756.2\;ng{\cdot}hr/mL$, respectively, after 20 mg/kg of intravenous administration. The terminal half-life after intravenous administration was $25.1{\pm}9.4$ hr. Bioavailability of KP10 was determined to 86%. The excretion amount into the urine within 48 hr was approximately 4.7 to 6.7% of the dose administered. These data may be beneficial to the anti-obesity drug development of KP10.

• Journal of KIISE:Information Networking
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• v.35 no.6
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• pp.521-528
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• 2008

Such conventional maritime communication technologies as radio have short some comings in their transmission quality. It can be overcome by wireless channels provided by satellites such as INMARSAT, which nevertheless suffer from the high costs. In this paper, we propose a novel technology resolving the above problems, featuring in the establishment of maritime communication networks with multi-hop structures. The inter vessel and ship-to- shore networks previously modeled after MANET are remodeled by SANET (Ship Ad Hoc Networks) in the present work. Fan-shaped Search Zone Routing (FSR) protocol also is presented, which utilizes not only static geographical information including the locations of ports and the navigations of courses but also the unique characteristics of ships in terms of mobile nodes. The FSR finds the fan-shaped search zone on which the shortest path is located. The performance of LAR protocol is compared with that of FSR in several ways. First, FSR does not make use of a type of control packets as beaconing data, resulting in a full utilization of the bandwidth of the wireless channels. Second, the delivery rate by the FSR is 100% for the fan-shaped search zone includes at least one route between source and destination nodes on its border line, where as that of LAR has been turned out to be 64%. Third, the optimality of routes searched by the FSR is on a 97% level. Of all, the FSR shows a better performance than LAR by about 50%.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39A no.12
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• pp.746-755
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• 2014

Compressive sensing (CS) has drawn much interest as a new sampling technique that enables signals to be sampled at a much lower than the Nyquist rate. By noting that the block-based compressive sensing can still keep spatial correlation in measurement domain, in this paper, we propose a novel encoding technique for measurement data obtained in the block-based CS of natural image. We apply discrete wavelet transform (DWT) to decorrelate CS measurements and then assign a proper quantization scheme to those DWT coefficients. Thus, redundancy of CS measurements and bitrate of system are reduced remarkably. Experimental results show improvements in rate-distortion performance by the proposed method against two existing methods of scalar quantization (SQ) and differential pulse-code modulation (DPCM). In the best case, the proposed method gains up to 4 dB, 0.9 dB, and 2.5 dB compared with the Block-based CS-Smoothed Projected Landweber plus SQ, Block-based CS-Smoothed Projected Landweber plus DPCM, and Multihypothesis Block-based CS-Smoothed Projected Landweber plus DPCM, respectively.

• KIPS Transactions on Software and Data Engineering
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• v.4 no.5
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• pp.231-240
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• 2015

Medical imagery require to protect the privacy with preserving the quality of the original contents. Therefore, reversible watermarking is a solution for this purpose. Previous researches have focused on general imagery and achieved high capacity and high quality. However, they raise a distortion over entire image and hence are not applicable to medical imagery which require to preserve the quality of the objects. In this paper, we propose a novel reversible watermarking for medical imagery, which preserve the quality of the objects and achieves high capacity. First, object and background region is segmented and then predicted error histogram-based reversible watermarking is applied for each region. For the efficient watermark embedding with small distortion in the object region, the embedding level at object region is set as low while the embedding level at background region is set as high. In experiments, the proposed algorithm is compared with the previous predicted error histogram-based algorithm in aspects of embedding capacity and perceptual quality. Results support that the proposed algorithm performs well over the previous algorithm.

• The KIPS Transactions:PartA
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• v.15A no.3
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• pp.141-149
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• 2008

In this research we present a novel method which combines and visualizes the design model and the FDM-based simulation result of solidification. Moreover we employ VR displays and visualize stereoscopic images to provide an effective analysis environment. First we reconstruct the solidification simulation result to a rectangular mesh model using a conventional simulation software. Then each point color of the reconstructed model represents a temperature value of its position. Next we map the two models by finding the nearest point of the reconstructed model for each point of the design model and then assign the point color of the design model as that of the reconstructed model. Before this mapping we apply mesh subdivision because the design model is composed of minimum number of points and that makes the point distribution of the design model not uniform compared with the reconstructed model. In this process the original shape is preserved in the manner that points are added to the mesh edge which length is longer than a predefined threshold value. The implemented system visualizes the solidification simulation data on the design model, which allows the user to understand the object geometry precisely. The immersive and realistic working environment constructed with use of VR display can support the user to discover the defect occurrence faster and more effectively.