• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.10
• /
• pp.4291-4295
• /
• 2015

Background: Chemokines and their receptors influence carcinogenesis and cysteine-cysteine chemokine receptor 5 (CCR5) directs spread of cancer to other tissues. A 32 base pair deletion in the coding region of CCR5 that might alter the expression or function of the protein has been implicated in a variety of immune-mediated diseases. The action of antiviral drugs being proposed as adjuvant therapy in cancer is dependent on CCR5 wild type status. In the present study, distribution of CCR5${\Delta}32$ polymorphism was assessed in North Indian esophageal cancer patients to explore the potential of using chemokine receptors antagonists as adjuvant therapy. Materials and Methods: DNA samples of 175 sporadic esophageal cancer patients (69 males and 106 females) and 175 unrelated healthy control individuals (69 males and 106 females) were screened for the CCR5${\Delta}32$ polymorphism by direct polymerase chain reaction (PCR). Results: The frequencies of wild type homozygous (CCR5/CCR5), heterozygous (CCR5/${\Delta}32$) and homozygous mutant (${\Delta}32/{\Delta}32$) genotypes were 96.0 vs 97.72%, 4.0 vs 1.71% and 0 vs 0.57% in patients and controls respectively. There was no difference in the genotype and allele frequencies of CCR5${\Delta}32$ polymorphism in esophageal cancer patients and control group. Conclusions: The CCR5${\Delta}32$ polymorphism is not associated with esophageal cancer in North Indians. As the majority of patients express the wild type allele, there is potential of using antiviral drug therapy as adjuvant therapy.

• Journal of Periodontal and Implant Science
• /
• v.42 no.5
• /
• pp.151-157
• /
• 2012

Purpose: Cyclooxygenase (COX) enzyme catalyzes the production of prostaglandins, which are important mediators of tissue destruction in periodontitis. Single nucleotide polymorphisms of $COX_2$ enzyme have been associated with increasing susceptibility to inflammatory diseases. The present study evaluates the association of two single nucleotide polymorphisms in $COX_2$ gene (-1195G>A and $8_{473}$C>T) with chronic periodontitis in North Indians. Methods: Both SNPs and their haplotypes were used to explore the associations between $COX_2$ polymorphisms and chronic periodontitis in 56 patients and 60 controls. Genotyping was done by polymerase chain reaction followed by restriction fragment length polymorphism. Chi-square test and logistic regression analysis were performed for association analysis. Results: By the individual genotype analysis, mutant genotypes (GA and AA) of $COX_2$-1195 showed more than a two fold risk (odds ratio [OR]>2) and $COX_2$ $8_{473}$ (TC and CC) showed a reduced risk for the disease, but the findings were not statistically significant. Haplotype analysis showed that the frequency of the haplotype AT was higher in the case group and a significant association was found for haplotype AT (OR, 1.79; 95% confidence interval, 1.03 to 3.11; P=0.0370) indicating an association between the AT haplotype of $COX_2$ gene SNPs and chronic periodontitis. Conclusions: Individual genotypes of both the SNPs were not associated while haplotype AT was found to be associated with chronic periodontitis in North Indians.

• Journal of the Korean Home Economics Association
• /
• v.30 no.3
• /
• pp.45-53
• /
• 1992

The purpose of this research is to reveal that the clothing in a cultural system is a visual symbol expressing the aspects of its technology, social-structure, and ideology. For this, the chilkat blanket of Tlingit is selected and analyzed. Tlingit is the one of the indian tribes of the Northwest Coast of the North America. This chilkat blanket used as an ostentatious item in the potlatch has the various functions. First, it expresses the thechnological features in this society, as the process of weaving, collecting of materials, etc. Second, it provides the view of the social-structure through its role differntiation of sex, and affirmation of the rank systems in this cultural system. And we can see the ideological value of this culture through the chilkat blanket. They persuit the value of labor and the harmony between their lives and the nature in this design. In conclusion, the clothing must be considered and analysed its value in the context of the society.

• The Journal of the Convergence on Culture Technology
• /
• v.10 no.3
• /
• pp.299-304
• /
• 2024

Beyond the first nuclear age, which pitted the United States and the Soviet Union against each other, we are now in the second nuclear age, in which the decision-makers of nuclear weapons are diversified among countries large and small. India and Pakistan, two such countries, are antagonistic toward each other and possess nuclear weapons, but their nuclear posture and nuclear strategies are different. The examples of these two countries can provide clues to the future nuclear posture of North Korea, which faces South Korea. In particular, Pakistan's chosen posture of pre-emptive deterrence is a highly offensive nuclear posture that threatens to use nuclear weapons against an adversary to deter aggression. This is an option that can be accomplished even with a small nuclear arsenal that can be used as a first strike, so it seems to be the optimal posture for a nuclear-powered Pakistan to choose in response to an Indian threat. North Korea, which is outgunned by the United States and South Korea, is likely to continue to threaten to use nuclear weapons preemptively like Pakistan. However, it is expected to be defensive and quite conservative, like India, until it actually uses them to maintain its regime.

• Korean Journal of Agricultural and Forest Meteorology
• /
• v.7 no.4
• /
• pp.240-249
• /
• 2005

The normal Indian Ocean is characterized by warmer waters over the eastern region and cooler waters over the western region. Changes in sea surface temperature (SST) over the western and eastern Indian Ocean give birth to a phenomenon now referred to as the Indian Ocean Dipole Mode (IODM). The positive phase of this mode is characterized by positive SST anomalies over the western Indian Ocean and negative anomalies over the southeastern Indian Ocean, while the negative phase is characterized by a reversed SST anomaly pattern. On the other hand, the normal Pacific Ocean has warm (cool) waters over the western (eastern) parts. Positive (negative) SST anomalies over the central/eastern (western) Pacific Ocean characterize the E1 Nino phenomenon. The reverse situation leads to the La Nina phenomenon. The coupled ocean-atmosphere phenomenon over the Pacific is referred to as the E1 Nino Southern Oscillation (ENSO) phenomenon. In this study the impact of IODM and ENSO on the East Asian monsoon variability has been studied using observational data and using the Community Atmospheric Model (CAM) of the National Center for Atmospheric Research (NCAR). Five sets of model experiments were performed with anomalous SST patterns associated with IODM/ENSO superimposed on the climatological SSTs. The empirical and dynamic approaches reveal that it takes about 3-4 seasons fur the peak IODM mode to influence the summer monsoon activity over East Asia. On the other hand, the impact of ENSO on the East Asian monsoon could occur simultaneously. Further, the negative (positive) phase of IODM and E1 Nino (La Nina) over the Pacific enhances (suppresses) monsoon activity over the Korea-Japan Sector. Alternatively, IODM appears to have no significant impact on monsoon variability over China. However, El Nino (La Nina) suppresses (enhances) monsoon activity over China. While the IODM appears to influence the North Pacific subtropical high, ENSO appears to influence the Aleutian low over the northwest Pacific. Thus, the moisture supply towards East Asia from the Pacific is determined by the strengthening/weakening of the subtropical high and the Aleutian low.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.11
• /
• pp.5647-5652
• /
• 2012

The glutathione S-transferases (GSTs) are involved in the metabolism of many xenobiotics, including an array of environmental carcinogens, pollutants, and drugs. Genetic polymorphisms in these genes may lead to inter-individual variation in susceptibility to various diseases. In the present study, GSTM1 and GSTT1 polymorphisms were analysed using a multiplex polymerase chain reaction in 500 normal individuals from Delhi. The frequency of individuals with GSTM1 and GSTT1 null genotypes were 168 (33.6%) and 62 (12.4%) respectively, and 54(10.8%) were having homozygous null genotype for both the genes GSTM1 and GSTT1simultaneously. The studied population was compared with reported frequencies from other neighbouring state populations, as well as with those from other ethnic groups; Europeans, Blacks, and Asians. The prevalence of homozygous null GSTM1 genotype is significantly higher in Caucasians and Asians as compared to Indian population. The frequency of GSTT1 homozygous null genotypes is also significantly higher in blacks and Asians. We believe that due to large number of individuals in this study, our results are reliable estimates of the frequencies of the GSTM1, GSTT1 in Delhi. It would provide a basic database for future clinical and genetic studies pertaining to susceptibility and inconsistency in the response and/or toxicity to drugs known to be the substrates for GSTs.

• The Plant Pathology Journal
• /
• v.21 no.3
• /
• pp.207-213
• /
• 2005

Cultural, morphological and pathogenic variation in Indian isolates of Ascochyta rabiei, the causal agent of blight of chickpea, was investigated. Fungal isolates representative of seven agroclimatic regions in north western plain zones (NWPZ) of India showed variation in colony colour as mouse gray with green hue, light mouse gray with slate gray centre and gray with dark brown centre, when grown on chickpea dextrose agar (CDA). Conidiomatal color of the isolates varied from brown to slate gray and black. The number of conidiomata and conidia formed on CDA ranged from 49.7 to 90.7 and $5.5\times10^4\;to\;3\times10^5cm^{-2}$, respectively. The size of conidiomata and conidia of A. rabiei isolates varied from $274\times232{\mu}m\;to\;156\times116{\mu}m$, and from $14.0\times6.2{\mu}m\;to\;10.7\times4.6{\mu}m$, respectively. Fourteen A. rabiei isolates from the seven agroclimatic regions of NWPZ were evaluated for their virulence on 180 chickpea genotypes in controlled environment. Cluster analysis based on the disease rating on a 1-9 scale indicated higher similarity coefficient (> 0.65) between isolates from different agroecological regions, while few isolates from the same region had less similarity. The 14 isolates were grouped into eight pathotypes at > 0.5 similarity coefficient. Sixteen genotypes were identified as probable differentials to distinguish A. rabiei isolates.

• Journal of Preventive Medicine and Public Health
• /
• v.46 no.sup1
• /
• pp.43-49
• /
• 2013

Multicultural scholarship in sport and exercise psychology should help us understand and apply cultural competencies for all to be physically active. In the present study, two Asian countries, Japan and Singapore, were chosen. The participation rate for physical activities among adolescent girls tends to be lower than that of boys in both countries. Thus, the purpose of the project was to gain knowledge and understanding about sociocultural factors that may explain adolescent girls' perceptions and behaviors toward sport, physical activity, and physical education (PE). A qualitative approach using semi-structured interviews with focus groups was used to understand meanings of physical activity among Buddhist Japanese, and Hindu Indians and Christian Chinese from Singapore. Each focus group consisted of four or five girls and female researchers. Based on the analysis, we created four themes which were "cultural identities", "Asian girls and sport/physical activities", "PE experiences", "motivation for future involvement". The Buddhist Japanese, Hindu Indian, and Christian Chinese participants each reported unique physical activity experiences, and all the participants were aware of how Asian culture may affect being physically active. Experiences of PE classes were similar but perceptions of their PE attire were different for Christian Chinese and Hindu Indian adolescent girls. Based on the results, the importance of nurturing cultural competencies and ways to encourage girls to be physically active throughout life were discussed.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.10
• /
• pp.4583-4586
• /
• 2016

Background: Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin's lymphoma, with a pathognomonic chromosomal translocation t (11;14). Prognosis is uniformly dismal but there is a paucity of information on MCL from India. Materials and methods: We retrospectively analysed clinicopathological information on all treated patients with MCL at our centre. STATA 14.0 was used for analysis. Survival was assessed by Kaplan-Meier analysis and the Cox's proportional hazards method. Statistical significance was defined as a P value of < 0.05. Results: Fifty-one patients with MCL were reviewed. The median age at presentation was 57.0 years. Extranodal involvement was seen in 39.0 (74.0%) while bone marrow positivity at presentation was found in 27.0 (54.0%). Initial treatment was chemotherapy with or without rituximab. Patients receiving rituximab-based therapy (n = 24) had 5-year progression-free survival (PFS) of 21.0 (88.0%), compared with 14.0 (61.0%) for those not receiving rituximab (n = 23, P = 0.036). Twenty-three patients were alive with a median follow-up of 20.7 months (range 2.5-89.2). PFS at 1 and 2 years was 51.0% and 27.0%, and overall survival (OS) 78.0% and 72.0%, respectively. Use of more than 2.0 lines of therapy, use of bendamustine-rituximab, and high TLC (>10,000.0/cu.mm) significantly affected PFS. Conclusions: In our experience, MCL patients from north India have an early age at presentation. When treated with regimens including rituximab results in an improved response rate and PFS. This study provided comprehensive insights into the treatment of MCL in a developing country.

• Atmosphere
• /
• v.27 no.3
• /
• pp.277-290
• /
• 2017

Characteristics of precipitation in South Korea during the 2016 Changma period (6/18~7/30) are analyzed in great details. El $Ni{\tilde{n}}o$-induced tropical Indian Ocean (IO) basin-wide warming lasts from spring to early summer and induces the western North Pacific subtropical high (WNPSH) circulation anomaly through an equatorial Kelvin wave during the 2016 Changma period. Along the northern edge of the WNPSH, strong precipitation occurred, in particular, over eastern China and southern Japan. During the Changma period, South Korea had the near-normal mean precipitation amount (~332 mm). However, about 226 mm of rain fell in South Korea during 1 July to 6 July, which amounts to 67% of total Changma precipitation in that year. Upper-level synoptic migratory lows and low-level moisture transport played an essential role, especially from 1 July to 3 July, in triggering an abrupt development of fronts over the Korean Peninsula and the eastern continent China. The front over the eastern China migrates progressively eastward, which results in heavy rainfall over the Korean peninsula from 1 to 3 July. In contrast, from 4 to 6 July, the typhoon (NEPARTAK) affected an abrupt northward advance of the North Pacific subtropical high (NPSH). The northward extension of the NPSH strengthens the Changma front and induces the southerly flows toward the Korean peninsula, giving rise to an increase in heavy rainfall. The NEPARTAK is generated due to interaction of the Madden-Julian Oscillation (MJO), equatorial Rossby wave and Kelvin waves.