• 대한치과보철학회지
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• 제29권2호
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• pp.285-294
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• 1991

The human temporomandibular joint as a ginglymoarthrodial one has much in common with the other synovial joints of the body, but it does possess an unique charachteristic in that it must accomodate the various occlusal relations of dentition during an end point of closure. For that reason, the movement of the condyle in the temporomandibular joint is susceptible to influences from the nature of occlusion. Undue loading to the temporomandibular joint can be applied on the occasion of premature contacts in centric relation, balancing side interferences, change of occlusal surfaces due to excessive attrition, loss of tooth. Such occlusal disharmonies in association with the systemic and emotional factors may give rise to the temporomandibular disorder. On the other hand, the changes of occlusal patterns in the growing body can also have an effect on the growth of the temporomandibular joint through the alterations of functional stresses. The purpose of this study was to observe histopathologic response of the temporomandibular joint in unilateral chewing on one side exclusively for 10 months. Three dogs showing normal masticatory function were chosen. One dog aged about 12 months was for control, two dogs for experimental specimens were about 12 and 18 months old respectively. For chewing on the left side only, unilateral lower right premolar and molar were extracted in two experimental specimens. And then three dogs were sacrificed 10 months later. Frontal histologic sectioning of joints were done for the observation of the effects of one-side chewing. 24 specimens from three dogs were obtained and fixed in 10% formalin and routinly processed with H-E staining for histologic examination. The light microscopic findings were interpretated as follows: 1. Experimental specimen 1 aged about 22 months: In comparison with control and right non-chewing side, the proliferative and hypertrophic zone were increased at the mesial and lateral part of left chewing side condyle. There was no change of the articular tissue of temporal bone. 2. Experimental specimen 2 aged about 28 months: The articular tissues of adult joint were observed. The differences between the chewing and non-chewing side were not seen in the articular tissues of condyle and temporal bone.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3495-3501
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• 2014

Melanoma-associated antigen (MAGE) family genes have been considered as potentially promising targets for anticancer immunotherapy. MAGED4 was originally identified as a glioma-specific antigen. Current knowledge about MAGED4 expression in glioma is only based on mRNA analysis and MAGED4 protein expression has not been elucidated. In the present study, we investigated this point and found that MAGED4 mRNA and protein were absent or very lowly expressed in various normal tissues and glioma cell line SHG44, but overexpressed in glioma cell lines A172,U251,U87-MG as well as glioma tissues, with significant heterogeneity. Furthermore, MAGED4 protein expression was positively correlated with the glioma type and grade. We also found that the expression of MAGED4 inversely correlated with the overall methylation status of the MAGED4 promoter CpG island. Furthermore, when SHG44 and A172 with higher methylation were treated with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-AZA-CdR) reactivation of MAGED4 mRNA was mediated by significant demethylation in SHG44 instead of A172. However, 5-AZA-CdR treatment had no effect on MAGED4 protein in both SHG44 and A172 cells. In conclusion, MAGED4 is frequently and highly expressed in glioma and is partly regulated by DNA methylation. The results suggest that MAGED4 might be a promising target for glioma immunotherapy combined with 5-AZA-CdR to enhance its expression and eliminate intratumor heterogeneity.

• 대한한방소아과학회지
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• 제20권3호
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• pp.143-160
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• 2006

Objectives : As the side effect brought up by internet game addiction, many reports come out, but most of past articles are for middle or high school students. There is seldom a poisoning game treatise to a primary school student, if there is treatise, it is real condition that treatise for lead pipe with psychological reasons is seldom discussion about physical symptoms. This research searches high grade elementary students' game use actual conditions and when divide to general user group, latent danger use group, high dangerous use group, according to serious illness degree of game poisoning, three groups and game poisoning happens, recognized about body symptoms that happen much. Methods : Target population of these questionnaire are fifth and sixth grade elementary student of Seoul city 2 school. Chose 263 elementary students, 144 men, 119 women who understand purpose of research and admit participation is 25 October, 2006 since 1 September, 2006 Results : As poisoning serious illness degree is high, there are many number of game times, much more boys are addicted to internet game than girs, insomnia is apt to happen frequently in game poisoning danger group, and correlation is high by megrim, shoulder ache, digestive trouble. Insomnia, symptoms that show next even if some symptoms show first because there is high correlation between megrim, shoulder ache, digestive trouble is high possibility to happen among four symptoms. Insomnia, megrim, shoulder ache, digestive trouble that happen by internet game poisoning, is apt to increase by increasing addiction. Symptoms treatment can divide by internal treatment that treat insomnia, megrim, digestive trouble, external treatment that is typical symptoms of VDT syndrome shoulder ache, headache, fatigue persimmon. Root treatment is mind symptoms treatment. Game addiction treatment is relationship method 'seven emotions injury treatment' in oriental medicine. 'promote the normal flow of qi' and 'adjustment of suitable emotion' can talk as pivotal point of treatment.

• 한국콘텐츠학회논문지
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• 제13권1호
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• pp.115-126
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• 2013

본 연구는 Q방법론을 통해 공직선거운동의 전광판 광고에 대한 주관적 수용형태의 특성과 함의를 알아보고, 이에 따라 공직선거운동 과정에 있어서 전광판 광고의 효용성을 제고할 수 있는 방안을 모색하고자 하였다. 이에 본 연구는 기존의 연구방법론에서는 간과하기 쉬운 개별 응답자의 주관적 인식을 객관적으로 측정할 수 있는 Q방법론을 활용하여 공직선거 광고에 대한 수용자의 인식유형을 다각적인 방향에서 분석함으로써 향후 실증적 연구를 위한 탐색적 과정을 제시하였다. 분석 결과, 공직선거 광고에 대한 인식은 공직선거의 정치 현상을 쉽게 인식하기 위한 광고기법 개선형, 공직선거에서 유권자들의 관심을 유발하기 위한 관심 유발형, 그리고 공직선거를 통해 유권자와 소통하기 위한 진실 유도형 등 3가지 유형으로 분류되었다. 이와 같은 수용인식의 구분을 통해 함의할 수 있는 것은 공직선거 광고에 대한 수용자들의 인식이 단순히 전광판 광고의 홍보적 측면보다는 활용성과 참여성 그리고 광고효과에 깊은 관심을 갖고 있다는 것이다. 따라서 디지털 시대의 선거환경 속에서 전광판 광고의 효용성 제고를 위해서는 정당이나 후보자들 뿐만 아니라 수용자들을 포함하여 공직선거 광고의 효과, 선거공약을 활용한 광고기법의 긍정적 활용 그리고 활성화 방안에 대하여 보다 더 포괄적인 연구가 진행되어야 할 것이다.

• 한국멀티미디어학회논문지
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• 제13권1호
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• pp.58-65
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• 2010

본 연구의 궁극적 목적은 시각 장애인들의 안전보행을 위한 단순한 충돌 경보 장치가 아니라 전방의 3차원적 공간 정보를 청각 정보로 변환하여 시각을 재현할 수 있도록 하는 장치 (Audio-vision System)를 개발하기 위함이다. 이를 위하여 본 연구에서는 구동 소프트웨어를 개발하였고 그 유용성을 검증하였다. 30명의 정상지원자를 대상으로 하였으며 평균나이는 25.8세이었다. 다양한 가상의 공간을 분석프로그램에 입력하고 맹검상태에서 피험자가 공간 내 구조물을 그리게 하였다. 먼저 피험자에게 30분간 10개의 대상을 이용한 학습을 실시한 후 별도의 10개의 가상공간에 대한 시험을 채점하고 100점 만점으로 환산하였다. 실험결과 점수는 77점에서 97점이었으며 평균 88.7점이었다. 본 연구에서 자체 제작된 분석프로그램으로 청각정보를 시각정보로 변환하는 기반 기술을 확보하였으며 거리 센서를 확보한다면 제품화 가능성이 있음을 검증하였다.

• Journal of Korean Neurosurgical Society
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• 제52권6호
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• pp.509-512
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• 2012

Objective : The purpose of this study is to evaluate neuroprotective effect of sacral neuromodulation in rat spinal cord injury (SCI) model in the histological and functional aspects. Methods : Twenty-one female Sprague Dawley rats were randomly divided into 3 groups : the normal control group (CTL, n=7), the SCI with sham stimulation group (SCI, n=7), and the SCI with electrical stimulation (SCI+ES, n=7). Spinal cord was injured by dropping an impactor from 25 mm height. Sacral nerve electrical stimulation was performed by the following protocol : pulse duration, 0.1 ms; frequency, 20 Hz; stimulation time, 30 minutes; and stimulation duration, 4 weeks. Both locomotor function and histological examination were evaluated as scheduled. Results : The number of anterior horn cell was $12.3{\pm}5.7$ cells/high power field (HPF) in the CTL group, $7.8{\pm}4.9$ cells/HPF in the SCI group, and $6.9{\pm}5.5$ cells/HPF in the SCI+ES group, respectively. Both the SCI and the SCI+ES groups showed severe loss of anterior horn cells and myelin fibers compared with the CTL group. Cavitation and demyelinization of the nerve fibers has no significant difference between the SCI group and the SCI+ES group. Cavitation of dorsal column was more evident in only two rats of SCI group than the SCI+ES group. The locomotor function of all rats improved over time but there was no significant difference at any point in time between the SCI and the SCI+ES group. Conclusion : In a rat thoracic spinal cord contusion model, we observed that sacral neuromodulation did not prevent SCI-induced myelin loss and apoptosis.

• 부모자녀건강학회지
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• 제4권1호
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• pp.1-18
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• 2001

Fatigue after delivery affect women's birth experience and interrupt the process of labor. Finally woman cannot have a positive birth result and will experience a postpartum fatigue. But researches about fatigue during the labor are lacked. Nurse help adapting a mother's role, bonding with new baby, recovering after birth, and improving woman's quality of life through decreasing fatigue during the labor and intercepting a continued postpartum fatigue. So it is very important that measuring a fatigue and confirming relationships between fatigue and factors affecting fatigue. The purpose of this study was measuring the level of fatigue within 4hours after delivery and identifing factors affecting fatigue. The ultimate goal was to contribute to improving a birth experience and adapting after birth through decreasing the level of fatigue and interventions. The data was collected for this study at the hospital of two universities and the third hospital in Seoul from Aug. 15. to Nov. 10. 2000. The subjects were 106 of mothers who deliveried a normal newborn and were tested within four hours after birth. The instruments were The Visual Analogue Scale for fatigue, The State Anxiety Inventory, and The Labor Support Inventory. The data were analyzed by using percentage, mean, SD, t-test, ANOVA, Pearson correlation. The results of this study were as follows; (1) The level of fatigue during the labor was 61.48point. (2) The deferences according to general and obstetric character affecting fatigue founded that there were Significant differences according to job(t=2.659, p=0.009), and the type of delivery(t=-2.035, p=0.044). (3) The deferences according to factors affecting fatigue revealed that there was significant difference according to quality of sleep(F=2.935, p=0.037). The significant fatigue and the fatigue after delivery was anxiety(r=0.343, p=0.000). The above findings indicate that the level of fatigue during the labor is higher than during pregnancy and postpartum. Woman having a job, delivering by vacuum was more fatigued. The level of fatigue according to a quality of sleep was significant difference. The poor quality of sleep, higher level of fatigue. And the more anxiety after delivery, the more fatigue. So, the variable nursing interventions for lessening the level of fatigue through appling the situation for rest, relaxation during the labor to reserve energy, and decreasing anxiety should be provided for mothers.

• Journal of Acupuncture Research
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• 제32권3호
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• pp.175-183
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• 2015

Objectives : The purpose of this study is to investigate the effects of Sumsu (Bufonis venenum) pharmacopuncture on insomnia and depression. Methods : We investigated 32 patients with a sleep disorder who had been recruited at a Korean medical hospital from March $1^{st}$, 2014 to April $16^{th}$, 2015. We divided subjects into two groups : The control group(N=15) was treated with Normal Saline and the experimental group(N=17) was treated with Sumsu(Bufonis venenum) pharmacopuncture. The subjects were injected with 0.05 ml~0.1 ml, for a total of 0.6 ml on each acupuncture point. These were Pungbu ($GV_{16}$), Pungi ($GB_{20}$), Gyeonjeong ($GB_{21}$), and Anmyun(EX-$HN_{20}$). Both groups were evaluated with the beck depression inventory(BDI) and given an insomnia score before treatment, after one week, two weeks and four weeks from the initial visit. Results : The Insomnia score and BDI decreased significantly in the experimental group. In comparing the control group with the experimental group, there was a more significant improvement of the insomnia score in the experimental group during all periods of this study. However, the difference of change in BDI between the control group and experimental group was only significant in the first week. Conclusions : Sumsu (Bufonis venenum) pharmacopuncture can be used as an effective treatment for patients with insomnia and depression.

• Journal of Acupuncture Research
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• 제32권3호
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• pp.41-51
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• 2015

Objectives : This study was performed to investigate the effects of $LR_3$ and $SP_6$ acupuncture on renal damage in streptozotocin(STZ)-induced diabetic mice. Methods : ICR male mice were stabilized for a week and divided into four groups: a normal mice group(N), no-acupuncture diabetic mice group(Control), $LR_3$ acupuncture diabetic mice group($LR_3$), and $SP_6$ acupuncture diabetic mice group($SP_6$). Diabetes was experimentally induced by intraperitoneal injection of STZ(150 mg/kg) in citrate buffer(pH 4.5). For two weeks, $LR_3$ and $SP_6$ acupunctures were administered bilaterally at each point once a day. After two weeks, the animals' weight was measured and they underwent a laparotomy. Serum glucose and blood urea nitrogen(BUN) were measured from the blood taken from the heart. We measured glucose, reactive oxygen species(ROS), peroxynitrite($ONOO^-$) and thiobarbituric acid reactive substances(TBARS) in the kidney and compared expression levels of superoxide dismutases(SOD), glutathione peroxidase(GPx), nuclear factor-kappa B(NF-${\kappa}B$), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase(iNOS) and Interleukin-1 beta(IL-$1{\beta}$). Results : BUN significantly decreased in $LR_3$, $SP_6$ compared to the control group. $LR_3$ showed significantly decreased glucose compared to the control group. $LR_3$, $SP_6$ significantly decreased in ROS and $ONOO^-$ compared to the control group. $LR_3$ significantly decreased in TBARS compared to the control group. $SP_6$ significantly increased in expressions of SOD-1, catalase, and GPx compared to the control group. $LR_3$, $SP_6$ significantly decreased in COX-2 compared to the control group. $SP_6$ significantly decreased in IL-$1{\beta}$ compared to the control group. Conclusions : This study suggests that $LR_3$ acupuncture may be effective in controlling glucose and lipid peroxidation and that $SP_6$ acupuncture may have anti-oxidative and anti-inflammatory effects on renal damage in STZ-induced diabetic mice.

• 대한간호학회지
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• 제30권3호
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• pp.720-730
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• 2000

Malnutrition is a common problem in cancer patients. In addition anticancer drugs used in chemotherapy as a major therapeutic mode are famous as the side effect like nausea, vomiting, which lead the patients to malnourished state. This study was to determine the relationship of anorexia, nausea, vomiting and oral intake and identify the influence these side effects on the nutritional status in patients receiving chemotherapy. To assess the nutritional status, anthropometry such as weight, height, body mass index(BMI), body fat proportion, and triceps skinfold thickness, and biochemistry test such as hemoglobin and lymphocyte were measured at the pre- and post- chemotherapy and the readmission time, all three times. During chemotherapy, anorexia, nausea, and vomiting using a VAS or 5-point scale and 24 hour oral intake using a food record were measured daily. Forty-nine patients knowing their diagnosis and receiving chemotherapy were recruited from an oncological ward in a general hospital for 5 months and they were reduced 31 at readmission time for a next chemotherapy. The results were as follows. Most subjects (93.6%) were in the 4th stage of cancer and 57.1% of subjects were in the first or the second chemotherapy. In most subjects(82.6%), their weight was decreased 10.7% than as usual. The degree of anorexia, nausea, and vomiting was significantly higher and the amount of oral intake was significantly less during the chemotherapy than at the pre-chemotherapy. Weight, BMI, triceps skinfold were reduced more at the post- chemotherapy than the pre-chemotherapy and were recovered the nearly same but less level at the readmission time. Body fat proportion was increased at the post chemotherapy and then decreased at the readmission phase. Hemoglobin and the number of lymphocyte were below normal at the pre-chemotherapy and more reduced at the readmission time. Anorexia, nausea, and vomiting were related positively and oral intake was negatively related with nausea and vomiting. The nutritional status at the post- chemotherapy and the readmission time was explained 20% over by the side effect like anorexia, nausea, vomiting and oral intake during the chemotherapy. The significant nutrition predictors at the post- chemotherapy were vomiting and the significant predictors at the readmission time were anorexia, vomiting, and oral intake. These results indicated the patients receiving chemotherapy were continued to deteriorate the nutritional status. Therefore nurse should have knowledge how much the nutritional status can be affected and assess the nutritional status periodically and try to find out the intervention for side effects from the series of chemotherapies.