• BMB Reports
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• 제47권1호
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• pp.8-14
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• 2014

Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis. Telomerase is essentially composed of an RNA component, Telomerase RNA or TERC, which serves as a template for telomeric DNA synthesis, and a catalytic subunit, telomerase reverse transcriptase (TERT). The canonical function of TERT is the synthesis of telomeric DNA repeats, and the maintenance of telomere length. However, accumulating evidence indicates that TERT may also have some fundamental functions that are independent of its enzymatic activity. Among these telomere-independent activities of hTERT, the role of hTERT in gene transcription has been investigated in detail. Transcriptional regulation is a fundamental process in biological systems. Several studies have shown a direct involvement of hTERT in gene transcription. This mini-review will focus on the role of hTERT in gene transcription regulation, and discuss its possible mechanisms.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.533-538
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• 2014

Power generator is one of the most important component of electricity generation system to convert mechanical energy to electrical energy. I t designed robustly to maintain high system reliability during operation time. But unexpected failure of the power generator could happen and it cause huge amount of economic and social loss. To keep it from unexpected failure, health prognostics should be carried out In this research, We developed a health prognostic method of stator windings in power generator with statistical data analysis and degradation modeling against water absorption. We divided whole 42 windings into two groups, absorption suspected group and normal group. We built a degradation model of absorption suspected winding using Fick's second law to predict upcoming absorption data. Through the analysis of data of normal group, we could figure out the distribution of data of normal windings. After that, we can properly predict absorption data of normal windings. With data prediction of two groups, we derived upcoming Directional Mahalanobis Distance (DMD) of absorption suspected winding and time vs DMD curve. Finally we drew the probability distribution of Remaining Useful Life of absorption suspected windings.

• Molecules and Cells
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• 제20권2호
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• pp.183-188
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• 2005

INI1/hSNF5/BAF47 is a core component of the hSWI/ SNF ATP-dependent chromatin remodeling complex, and it has been implicated in regulating gene expression, cell division and tumorigenesis. We investigated whether INI1/hSNF5/BAF47 functions in activation of the colony stimulating factor 1 (CSF1) promoter in HeLa cells. Overexpression of INI1/hSNF5/BAF47 promoted CSF1 transcription, and siRNA targeting INI1/hSNF5/ BAF47 (siINI1) strongly inhibited the activity of the CSF1 promoter. We demonstrated that all conserved domains of INI1/hSNF5/BAF47 are needed for CSF1 transcription. ChIP experiment showed that INI1/ hSNF5/BAF47 is recruited to the region of the CSF1 promoter. Taken together, these results indicate that INI1/hSNF5/BAF47 is involved in activation of the CSF1 promoter.

• 대한치과교정학회지
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• 제26권3호
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• pp.255-265
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• 1996

본 연구는 III급 부정교합자에서 중심교합상태의 두부 방사선 사진과 MPI 수치를 이용하여 중심위로 전환한 두부 방사선 사진(Centrically related cephalometrics)을 계측하여 중심위 변위시 유의한 계측치 변화가 있는지 확인하고자 시행되었다. 교정치료의 경험이 없는 25명의 III급 부정교합군과 25명의 정상교합군을 대상으로 하여, 중심교합위 상태의 측모 두부 방사선 사진과 중심위 및 중심교합위 기록을 채득하고, 모형을 SAM II 교합기에 부착하였다. 중심위 변위 량은 MPI(Mandibular Position Indicator)를 이용하여 계측하였으며, MPI 수치와 중심교합위 상태의 측모 두부 방사선 사진의 투사도를 이용하여 Conversion work sheet상에서 중심위 전환을 시행하였다. 두부 방사선 계측 항목은 하악골의 위치와 관계되는 것을 선택하였다. 정상교합군과 III급 부정교합군에서 중심위와 중심교합위간의 계측치 변화를 연구하여 다음과 같은 결과를 얻었다. 1. 하악 과두에서의 중심위 변위량은 정상교합군에서 전후방 변위량$({\Delta}X)0.56{\pm}0.50mm$, 수직적 변위량$({\Delta}Z)-0.61{\pm}0.53mm$였으며, III급 부정교합군에서 전후방 변위량$({\Delta}X)0.93{\pm}0.77mm$, 수직적 변위량$({\Delta}Z)-0.64{\pm}0.89mm$로, 두군 모두 후하방 변위양상을 나타냈다. III급 부정교합군에서 정상교합군보다 전후방 변위량이 더 크게 나타났으나 통계학적인 유의성은 없었다. 2. 중심교합위와 중심위 두부 방사선 사진의 계측치를 비교해 본 결과 정상교합군에서 ANB, Facial angle, Facial convexity, ODI 둥의 항목이 유의한 차이를 나타냈다. III급 부정교합군에서는 ANB, Facial angle, Facial convexity, ODI, SNB, APDI, L1-FP 등 유의한 차이를 보이는 항목이 더 많았고 유의성도 더 높게 나타났다. 3. 두부 방사선 사진의 계측치 변화는 중심위 변위와는 연관성이 있었으나, 정상교합군과 III급 부정교합군에 대한 연관성이 없었다. 이상의 결과는 중심위 변위량이 임상적으로 재현할 수 있는 중심위 위치에서 정상적으로 변위되는 양보다 큰 경우 중심위는 교정 환자에서 적절한 진단과 치료 계획 수립을 위한 기준 점으로 고려되어야 함을 시사하였다.

• 한국수산과학회지
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• 제29권3호
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• pp.386-392
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• 1996

A numerical method based on genetic algorithms was introduced to characterize the grain-size distribution more effectively. This technique was proved significant particularly for multimodal size distributions, as was verified for samples from Korea Strait continental shelf. Sediment samples collected from the Korea Strait continental shelf revealed that $96\%$ of the grain-size distributions were multimodal. Therefore, the use of grain-size parameters was not the ideal method. As an alternative method, the decomposition of sue curves into elementary normal component curves was used. Means and standard deviations of 593 decomposed normal components were calculated by a numerical method from 268 size curves of Korea Strait sediments. The mean values of decomposed normal components showed peaks at $1\~3\phi\;and\;7\~9\phi$ size classes. The plot of mean and standard deviation values of the coarse fraction normal components on the map showed a characteristic areal distribution. The characteristic distribution was found to derive from underlying Pleistocene sediment on the basis of sea bottom geologic distribution of the area. The method of decomposition into normal components was found to be more effective than the analysis using traditional grain-size parameters in investigation of multimodal size distribution of Korea Strait shelf sediment.

• 한국정보과학회논문지:소프트웨어및응용
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• 제37권7호
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• pp.568-572
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• 2010

Mission-critical 시스템의 경우 자가 치유는 신뢰성을 보장하기 위한 기술 중 하나이다. 자가치유는 오류 탐지와 오류 회복으로 이루어져 있으며 오류 탐지는 오류 회복을 가능하게 하는 자가 치유의 중요한 첫 단계이지만 시스템에 과부하를 주는 문제가 있다. 모델 기반의 방법 등으로 오류를 탐지할 수 있는데 시스템의 모든 행위를 통지하고 정상 행위 모델과 통지된 시스템의 행위를 비교하여야 하므로 그양이 많고 부하가 크기 때문이다. 본 논문에서는 모델 기반의 오류 탐지 방법을 보완하는 아키텍처 기반의 다계층적 자가적응형 모니터링 방법을 제안한다. 소프트웨어 아키텍처 상에서 오류 탐지의 중요도는 컴포넌트 마다 다르다. 각 컴포넌트마다 발생하는 오류의 심각도와 빈도가 다르기 때문이다. 모니터링 중요도가 높은 컴포넌트에는 강도가 높고 모니터링 중요도가 낮은 컴포넌트에는 강도가 낮도록 모니터가 적응한다면 오류 탐지의 부하는 줄이고 효율은 유지시킬 수 있다. 또한 소프트웨어의 환경 변화 및 아키텍처상의 변화 등에 따라 오류 발생 빈도가 변화하여 컴포넌트의 오류 탐지 중요도가 변화하기 때문에 학습을 통해 이를 추적하여 자가적응적으로 중요도가 높은 컴포넌트를 집중 모니터링 한다.

• 한국항행학회논문지
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• 제24권4호
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• pp.314-321
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• 2020

LASAR (logic automated stimulus and response) 소프트웨어는 디지털 전자 회로 카드에 대한 로직 기능시험 및 고장검출을 위한 자동점검프로그램 개발도구이다. LASAR 소프트웨어는 소자의 논리회로 기능 및 입·출력 정의된 정보가 필요하다. 소자 정보가 없으면 정상적인 부품 모델링이 불가능하다. 따라서 본 논문에서는 소자 정보가 없는 PLD (programmable logic device) 소자를 역설계 방법을 통하여 부품 모델링을 수행한다. 개발된 LASAR 프로그램은 고장 시뮬레이션 결과와 단일 고착 고장삽입 방법을 통해 고장 검출율을 확인하였다. 고장 검출율은 기존의 제한적인 모델링은 91%, 역설계를 통한 모델링은 94%로 3% 상승하였다. 또한, EP 310 PLD 소자에 대한 입·출력핀에 대한 22가지 고착결함의 경우 100% 검출하여 양호한 성능을 확인하였다.

• 대한전기학회논문지:시스템및제어부문D
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• 제53권4호
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• pp.293-299
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• 2004

This paper is about the extraction of basis function for ECG signal processing. In the first step, it is assumed that ECG signal consists of linearly mixed independent source signals. 12 channel ECG signals, which were sampled at 600sps, were used and the basis function, which can separate and detect source signals - QRS complex, P and T waves, - was found by applying the fast fixed point algorithm, which is one of learning algorithms in independent component analysis(ICA). The possibilities of significant point detection and classification of normal and abnormal ECG, using the basis function, were suggested. Finally, the proposed method showed that it could overcome the difficulty in separating specific frequency in ECG signal processing by wavelet transform. And, it was found that independent component analysis(ICA) could be applied to ECG signal processing for detection of significant points and classification of abnormal beats.

• 전기학회논문지
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• 제64권2호
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• pp.247-253
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• 2015

Dielectric breakdown accidents have been mainly occurred in the vicinity of service entrance section in underground power transmission systems. One cause among them is due to the excessive component value of sheath located around service entrance of cable. In this paper, as one of the alternative to prevent these accidents, the change of cross bond grounding system and the location change of IJ(Insulation Joint) are suggested. Also, to evaluate effectiveness of this changing system, circulating current and induced voltage of sheath were analyzed in steady and transient state. By comparison of the analytical results for the several possible changing systems, a grounding system and location of IJ which has the smallest sheath component values is proposed. In this paper, analysis to evaluate the proposed system is carried out by EMTP/ATPDraw. It can be used as a valuable operational material to prevent accident of the service entrance section in underground power transmission system.

• 대한기계학회논문집B
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• 제28권2호
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• pp.167-173
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• 2004

Fouling of heat exchangers is generated by water-borne deposits, commonly known as foulants including particulate matter from the air, migrated corrosion produces; silt, clays, and sand suspended in water; organic contaminants; and boron based deposits in plants. The fouling is known to interfere with normal flow characteristics and reduce thermal efficiencies of heat exchangers. This paper describes the fouling analysis technique developed in this study which can analyze the thermal performance for heat exchangers and estimate the future fouling variations. To develop the fouling analysis technique fur heat exchangers, fouling factor was introduced based on the ASME O&M codes and TEMA standards. For the purpose or verifying the fouling analysis technique, the routing analyses were performed for four heat exchangers in several nuclear power plants; two residual heat removal heat exchangers of the residual heat removal system and two component cooling water heat exchangers of the component cooling water system.