• BMB Reports
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• v.47 no.1
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• pp.8-14
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• 2014

Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis. Telomerase is essentially composed of an RNA component, Telomerase RNA or TERC, which serves as a template for telomeric DNA synthesis, and a catalytic subunit, telomerase reverse transcriptase (TERT). The canonical function of TERT is the synthesis of telomeric DNA repeats, and the maintenance of telomere length. However, accumulating evidence indicates that TERT may also have some fundamental functions that are independent of its enzymatic activity. Among these telomere-independent activities of hTERT, the role of hTERT in gene transcription has been investigated in detail. Transcriptional regulation is a fundamental process in biological systems. Several studies have shown a direct involvement of hTERT in gene transcription. This mini-review will focus on the role of hTERT in gene transcription regulation, and discuss its possible mechanisms.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.533-538
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• 2014

Power generator is one of the most important component of electricity generation system to convert mechanical energy to electrical energy. I t designed robustly to maintain high system reliability during operation time. But unexpected failure of the power generator could happen and it cause huge amount of economic and social loss. To keep it from unexpected failure, health prognostics should be carried out In this research, We developed a health prognostic method of stator windings in power generator with statistical data analysis and degradation modeling against water absorption. We divided whole 42 windings into two groups, absorption suspected group and normal group. We built a degradation model of absorption suspected winding using Fick's second law to predict upcoming absorption data. Through the analysis of data of normal group, we could figure out the distribution of data of normal windings. After that, we can properly predict absorption data of normal windings. With data prediction of two groups, we derived upcoming Directional Mahalanobis Distance (DMD) of absorption suspected winding and time vs DMD curve. Finally we drew the probability distribution of Remaining Useful Life of absorption suspected windings.

• Molecules and Cells
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• v.20 no.2
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• pp.183-188
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• 2005

INI1/hSNF5/BAF47 is a core component of the hSWI/ SNF ATP-dependent chromatin remodeling complex, and it has been implicated in regulating gene expression, cell division and tumorigenesis. We investigated whether INI1/hSNF5/BAF47 functions in activation of the colony stimulating factor 1 (CSF1) promoter in HeLa cells. Overexpression of INI1/hSNF5/BAF47 promoted CSF1 transcription, and siRNA targeting INI1/hSNF5/ BAF47 (siINI1) strongly inhibited the activity of the CSF1 promoter. We demonstrated that all conserved domains of INI1/hSNF5/BAF47 are needed for CSF1 transcription. ChIP experiment showed that INI1/ hSNF5/BAF47 is recruited to the region of the CSF1 promoter. Taken together, these results indicate that INI1/hSNF5/BAF47 is involved in activation of the CSF1 promoter.

• The korean journal of orthodontics
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• v.26 no.3
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• pp.255-265
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• 1996

The purpose of this study was to investigate if there were a significant difference between cephalometric measurements of mandibular position derived from a centric occlusion tracing compared to those of a converted centric relation tracing in the Class III malocclusion. The sample consisted of 25 Class III malocclusion and 25 normal occlusion persons who had no orthodontic treatment. The records included an lateral cephalometrics in centric occlusion, centric relation and centric occlusion bite registration and diagnostic casts mounted on the SAM II articulator in CR. The amount of CR-CO discrepancy of condyle was recorded using a MPI(Mandibular Position Indicator, MPI $200^{(R)}$, Great Lakes Orthodontics, USA). The conversion of the CO cephalogram to CR using the MPI readings was performed on the Conversion work sheet. Measures of mandibular position were chosen for the purpose of this study. The comparison of the difference between CO and CR cephalometric measurements in the normal occlusion and Class III malocclusion group were studied. The results were as follows: 1. In the features of CR-CO discrepancy of the condyle, the condyle was displaced posterior and inferior when the teeth were in centric occlusion. The horizontal component(${\Delta}X$) in Class HI malocclusion group was greater than the vertical component(${\Delta}Z$) and also greater than the horizontal component(${\Delta}X$) in normal occlusion group. There was no statistically significant correlation between MPI measurements and the groups of normal occlusion and Class III malocclusion group. 2. In the comparison of the cephalometric measurements in each group, Normal occlusion group showed significant difference in measurements such as ANB, Facial angle, Facial convexity and ODI. Class HI malocclusion group showed significant difference in measurements such as ANB, Facial angle, Facial convexity, ODI, SNB, APDI, L1-FP and it had more significance than the normal occlusion group. 3. The Value of cephalometric measurements was significantly different between CO and CR but there were no differences between the groups of normal occlusion and Class III malocclusion. The results of this study suggest that if the discrepancies are greater than the amount of normal displacement from clinically captured centric relation, centric relation should be considered as the starting point for proper diagnosis and treatment planning.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.29 no.3
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• pp.386-392
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• 1996

A numerical method based on genetic algorithms was introduced to characterize the grain-size distribution more effectively. This technique was proved significant particularly for multimodal size distributions, as was verified for samples from Korea Strait continental shelf. Sediment samples collected from the Korea Strait continental shelf revealed that $96\%$ of the grain-size distributions were multimodal. Therefore, the use of grain-size parameters was not the ideal method. As an alternative method, the decomposition of sue curves into elementary normal component curves was used. Means and standard deviations of 593 decomposed normal components were calculated by a numerical method from 268 size curves of Korea Strait sediments. The mean values of decomposed normal components showed peaks at $1\~3\phi\;and\;7\~9\phi$ size classes. The plot of mean and standard deviation values of the coarse fraction normal components on the map showed a characteristic areal distribution. The characteristic distribution was found to derive from underlying Pleistocene sediment on the basis of sea bottom geologic distribution of the area. The method of decomposition into normal components was found to be more effective than the analysis using traditional grain-size parameters in investigation of multimodal size distribution of Korea Strait shelf sediment.

• Journal of KIISE:Software and Applications
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• v.37 no.7
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• pp.568-572
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• 2010

Self-healing is one of the techniques that assure dependability of mission-critical system. Self-healing consists of fault detection and fault recovery and fault detection is important first step that enables fault recovery but it causes overhead. We can detect fault based on model, the detection tasks that notify system's behavior and compare normal behavior model and system's behavior are heavy jobs. In this paper, we propose architecture-based multi-level self-adaptive monitoring method that complements model-based fault detection. The priority of fault detection per component is different in the software architecture. Because the seriousness and the frequency of fault per component are different. If the monitor is adapted to intensive to the component that has high priority of monitoring and loose to the component that has low priority of monitoring, the overhead can be decreased and the efficiency can be maintained. Because the environmental changes of software and the architectural changes bring the changes at the priority of fault detection, the monitor learns the changes of fault frequency and that is adapted to intensive to the component that has high priority of fault detection.

• Journal of Advanced Navigation Technology
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• v.24 no.4
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• pp.314-321
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• 2020

Logic automated stimulus and response (LASAR) software is an automatic test program development tool for logic function test and fault detection of avionics components digital circuit cards. LASAR software needs to the information for the logic circuit function and input and output of the device. If there is no component information, normal component modeling is impossible. In this paper, component modeling is carried out through reverse design of programmable logic device (PLD) device without element information. The developed LASAR program identified failure detection rates through fault simulation results and single-seated fault insertion methods. Fault detection rates have risen by 3% to 91% for existing limited modeling and 94% for modeling through the reverse design. Also, the 22 case of stuck fault with the I/O pin of EP310 PLD were detected 100% to confirm the good performance.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.53 no.4
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• pp.293-299
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• 2004

This paper is about the extraction of basis function for ECG signal processing. In the first step, it is assumed that ECG signal consists of linearly mixed independent source signals. 12 channel ECG signals, which were sampled at 600sps, were used and the basis function, which can separate and detect source signals - QRS complex, P and T waves, - was found by applying the fast fixed point algorithm, which is one of learning algorithms in independent component analysis(ICA). The possibilities of significant point detection and classification of normal and abnormal ECG, using the basis function, were suggested. Finally, the proposed method showed that it could overcome the difficulty in separating specific frequency in ECG signal processing by wavelet transform. And, it was found that independent component analysis(ICA) could be applied to ECG signal processing for detection of significant points and classification of abnormal beats.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.2
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• pp.247-253
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• 2015

Dielectric breakdown accidents have been mainly occurred in the vicinity of service entrance section in underground power transmission systems. One cause among them is due to the excessive component value of sheath located around service entrance of cable. In this paper, as one of the alternative to prevent these accidents, the change of cross bond grounding system and the location change of IJ(Insulation Joint) are suggested. Also, to evaluate effectiveness of this changing system, circulating current and induced voltage of sheath were analyzed in steady and transient state. By comparison of the analytical results for the several possible changing systems, a grounding system and location of IJ which has the smallest sheath component values is proposed. In this paper, analysis to evaluate the proposed system is carried out by EMTP/ATPDraw. It can be used as a valuable operational material to prevent accident of the service entrance section in underground power transmission system.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.2
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• pp.167-173
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• 2004

Fouling of heat exchangers is generated by water-borne deposits, commonly known as foulants including particulate matter from the air, migrated corrosion produces; silt, clays, and sand suspended in water; organic contaminants; and boron based deposits in plants. The fouling is known to interfere with normal flow characteristics and reduce thermal efficiencies of heat exchangers. This paper describes the fouling analysis technique developed in this study which can analyze the thermal performance for heat exchangers and estimate the future fouling variations. To develop the fouling analysis technique fur heat exchangers, fouling factor was introduced based on the ASME O&M codes and TEMA standards. For the purpose or verifying the fouling analysis technique, the routing analyses were performed for four heat exchangers in several nuclear power plants; two residual heat removal heat exchangers of the residual heat removal system and two component cooling water heat exchangers of the component cooling water system.