• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.198-198
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• 1998

Muc1 mucin is found in a variety of epithelial tissue and is overexpressed in several epithelial cancer. Recently it is alsol reported that primary Hamster tracheal surface epithelial(HTSE) cells express Muc1 protein and cDNA encoding HTSE muc1 protein has been cloned. Although numerous monoclonal antibodies (mAbs) to human muncins, particularly Muc1 have been produced, no such antibodies to murine Muc1 have been described. We now describe monoclonal antibody, called mAb M1CT, produced to C-terminal region of HTSE Muc1 protein by immunising mice with a glutathion-s-transferase linked fusion protein. In this study, using this antibody(mAb M1CT) we investigated the effect of RA on the expression of Muc1 in HTSE cells. Retinoic acid(RA) plays an essential role in maintaining normal differentiation of tracheal epithelial cells. With RA-deficiency tracheocytes undergo squamous metaplasia, an abnormal differentiation that can be reversed by RA. We had primary culture of HTSE cells under different concentrations of RA. Culture was maintained until the direction of differentiation was determined. Then Western blot analysis with mAb M1CT was performed with the cell lysates from the culture. The expression of Muc1 protein was decreased in dose-dependent manner as the concentration of retinoic acid was decreased. Our result indicates that the expression of Muc1 protein is coordinately regulated with airway mucous cell differentiation by RA pathway. And the antibody, mAb M1CT, produced in this study should provide useful tool to study the expression of Muc1 mucin in differentiation process or disease.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.16 no.1 s.106
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• pp.40-49
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• 2006

A novel disturbance measurement method, model based disturbance observer (MBDO) for optical disk drives (ODDs), is proposed and the disturbance analysis using the proposed method is performed under various conditions. In ODDs, the quantitative and qualitative analysis for the generated disturbance during normal operation is very important to successful servo loop design. However, the disturbance measurement is difficult, and high precision measurement is necessary. Furthermore, the conventional disturbance measurement method using a LDV (laser Doppler vibrometer) has many difficulties in eccentricity direction due to the vertical movement of an optical disk. To solve this problem, the MBDO is proposed. First, the relationship between the servo loop for ODDs and the generated disturbance are briefly reviewed. Second, the principle of the MBDO is introduced, and the disturbance measurement results, which are measured by the MBDO and a LDV, are compared. In these experiments, test DVD-ROM disks are used to generate quantitative/qualitative disturbance. Then, the disturbance analysis under various conditions is performed using waterfall technique. This technique clearly shows the disturbance trend from the inner part of an optical disk to the outer part of it. Finally, the various disturbances measurement results are summarized and some remarks for it are commented.

• Korean Journal of Materials Research
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• v.7 no.1
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• pp.62-68
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• 1997

In the first part of the paper, the crack growth process in rolling contact fatigue has been investigated on ring type plate specimens, in which crack growth is two dimensional and cracks are observed on the side surface of the specimens. The results have shown that cracks are initated from the contact surface in tensile mode in the direction approximately normal to the contact surface and after some short length of growth, shear mode growth occurs from the tip of the crack and it grows until the separation of the surface layer, namely flakung type failure, occurs. In the second part, mode U fatigue crack growth tests have been made by using an apparatus designed based on the concept that the subsurface fatigue crack growth in rolling contact fatigue is the mode U fatigue crack growth under the stress state where the tensile mode growth is suppressed by compression stress. The rest results have shown that the mode U fatigue crack growth occurs if the superposed compression stress is enough to suppress the tensile mode growth.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.6
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• pp.477-483
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• 2016

Velocity profiles of laminar, transition and turbulent boundary layers were investigated by using Particle Image Velocimetry(PIV) measurements on the flat plate at Mach 2.96. The Schlieren visualization and PIV measurements are also used to confirm whether the oblique shock wave generated from the leading edge affects the flow field over the flat plate. The laminar velocity profile measured from the experiment was well matched with the compressible Blasius solution. The velocity profile of the transition boundary layer was well correlated with the theoretical turbulent velocity profile from near the wall and the transition began from Re = $1.41{\times}106$. For the turbulent boundary layer, considering compressibility effects, the Van Driest-transformed velocity satisfies the incompressible log-law. It is found that the log region is extended farther in the wall-normal direction compared to the log region in incompressible boundary layer.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.51 no.2
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• pp.212-220
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• 2015

We examined the appearance of cold water in the southwest region of the East Sea, based on the sea surface temperature (SST) at the east coast of Korea and buoy data in Donghae ($37^{\circ}31$'N, $130^{\circ}00$'E, 80 km east away from Donghae port) and Pohang ($36^{\circ}21$'N, $129^{\circ}46$'E, 35 km east away from Ganggu port) from June to August in 2013. Also, the serial oceanographic data of National Fisheries Research and Development Institute (NFRDI) were used to see the oceanographic conditions for June and August in 2013. The SST anomaly at the east coast showed negative values in $3{\sim}6^{\circ}C$ from 2 July. At Janggigab, the SST anomaly showed negative value amount to $10^{\circ}C$ in 8 July. The negative values of SST anomaly continued to the middle of August at Janggigab. The wind speed was 6~11 m/s and the direction was south-southwestly in 1 July. The wind speed amounts to 6~16 m/s in 2 July. It means that the strong wind induced the upwelling effect by a day. The temperature was lower than normal at the depth in 20 m of the East Sea in June and August. The air pressure was 996~998 hPa in the beginning of July. It was the lowest air pressure during the studied period. The correlation was 0.3 between the SST anomaly and air pressure. It was suggested that the appearance of cold water in the East Sea was influenced by a stirring due to wind and low air pressure as well as coastal upwelling.

• Economic and Environmental Geology
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• v.36 no.6
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• pp.491-499
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• 2003

The Okinawa Trough is a rift basin formed by extension. Analysis of multichannel seismic reflection profiles from the northwestern margin of the northern Okinawa Trough reveal that the trough is characterized by a series of tilted fault blocks bounded by listric normal faults and half-grabens developed between blocks, showing typical rifted structures. The trough display three kinds of sedimentary sequences with different seismic reflection characteristics: prerift, synrift and postrift sediments. The prerift sequence develops parallel to the dip direction of tilted fault blocks. The synrift sediments, mostly deposited in the half-grabens between tilted fault blocks, are generally well characterized by divergence of the reflectors towards the blocks indicating contemporaneous deposition during tilting. The postrift sediments are featured by continuous and parallel reflectors. The width of the half-graben and the throw-displacement rate of the basin bounding fault are closely connected. The throw-displacement rate is the maximum when the rifting event is the most active and the width of the half-graben is proportional to the rate.

• Journal of the korean academy of Pediatric Dentistry
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• v.32 no.2
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• pp.278-283
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• 2005

Impaction of mandibular canine is not common, and transmigration of mandibular canine is rare. Treatment of impacted canine can be removal of physical obstacle and periodic observation, surgical exposure of impacted tooth and orthodontic traction, autotransplantation, surgical extraction. Management of impacted canine depends on existence of physical obstacle, position and direction of impacted tooth, space available for canine eruption, stage of root development. Of the two case in this report, one case involved impaction of lower canine with odontoma and dentigerous cyst that is treated by surgical exposure and orthodontic traction. The other case involved transmigration of lower canine with supernumerary teeth. It was thought difficult to treat only by orthodontic treatment, so the impacted canine was transplanted to its normal position and orthodontic treatment was conducted.

• Journal of Korea Port Economic Association
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• v.32 no.4
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• pp.41-56
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• 2016

China is pushing a policy called China's Western Development in order to balance the continent's development level. They are connecting the rich natural resources of the mid-western areas and the capital of the eastern coastal areas of China. Since Korea depends on China the most for trade, it is necessary for Korea to always consider the trade scale and pattern changes of China. Response to changes in the transport and logistics system between the two countries is also demanded. This study aims to analyze the import and export trends between Korean and Chinese provinces of each item from the trade scale point of view. China's global trade routes reorganization and China's western development are considered and the corresponding direction is presented accordingly. The study also suggests strategies to expand the import and export scale with China based on the analysis.

• Journal of the Korean Society of Marine Environment & Safety
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• v.22 no.7
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• pp.836-845
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• 2016

The variation and structure of the cold water mass around Ganjeol Point during the summer of 2011 were studied using data from CTD observations and temperature monitoring buoys deployed at 20 stations off the southeast coast of Korea. There was a $-12^{\circ}C$ surface temperature difference between the cold water mass and normal water during the monitoring period. Variations in the isothermal lines for surface temperature along the coast showed that the seabed topography at Ganjeol Point played an important part in the distribution of water temperature. Cold water appeared when the wind components running parallel to the coast had positive values. The upwelling -response for temperature fluctuations was very sensitive to changes in wind direction. Vertical turbulent mixing due to the seabed topography at Ganjeol Point can reinforce the upwelling of cold bottom water. From wavelet analysis, coherent periods found to be 2-8 days during frequent upwelling events and phase differences for a decrease in water temperature with a SSW wind were 12-36 hours.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.6
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• pp.700-706
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• 2005

We are concerned about how to apply the theories of oriental medicine appropriately, which direction should it be taken, and how it should be developed. And it is believed to be essential for the government to make efforts to set a standard and laws to validate the medicinal effects and process of the assessment so that the systematic development can be encouraged, and to prepare guidance for the food development for national health improvement Ihis study was peformed to provide basic data that predict the usefulness of oriental medicinal herbs to remove the dampness through diuresis for excess syndrome obesity with oriental diet therapy cuisine(Yak-Sun). Five oriental medicininal herbs, Coix lachryma-jobi L, Atractylodes lancea DC., Ligusticum wallichii F., Angelica sinensis D., Zingiber officinale R. were collected and made into mixing extracts(OMCE). And we examined the effects of OMCE on body weight serum glucose, insulin and lipid profile improvement in rats fed high fat diets. Sprague-Dawley rae(230-250 g) were randomly divided into five groups : basal diet(normal diet control group, NCG), only high fat diet(High fat control group, HCG), high fat diet and supplemented with 25mg/100g body weight 50mg/100g body weight 75mg/100g body weight by OMCE(HLG, HMG, HHG). These experimental diets were fed for 6 weeks. The OME fed groups decreased more significantly in weight serum glucose insulin and lipids than the high fat control group did. These results imply that the OMCE can be used as a safe and clinically applicable ingredients for diet called Yaksun of excess syndrome obesity in human.