• The Korean Journal of Franchise Management
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• v.3 no.1
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• pp.1-25
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• 2012

The studies of franchise companies are underway with the development of the franchise industry. Franchisor performance, franchisee performance, and relationship characteristics on performance, financial performance, non-financial performance, including research on the topic or purpose of the franchise performance and related discussions from a variety of perspectives have been proposed. Presented so comprehensive a discussion regarding the existing performance of the franchise and qualitative aspects such as satisfaction, long-term orientation to emphasize the limits. Therefore, this study was conducted by the franchise company's performance than the need to be clearly presented. Propose a quantifiable and quantified to reflect the characteristics of the franchise quantitative performance indicators. Franchise contract management systematically analyze the status of the enterprise contract management(ECM) and proposed contract management, leverage as an indicator for a more quantitative analysis. Contract management leverage is the franchise as an indicator of the merchant and the growth of the contract showing any significant changes in the coming changes in the Franchisee's sales growth target analysis results, notable implications could be found. This study are new methodology for the practical dimensions of performance of franchise companies.

• Journal of Convergence for Information Technology
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• v.12 no.2
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• pp.1-16
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• 2022

Social network service (SNS) using mobile or web is growing rapidly, and the emergence of various platform services is causing innovative changes in social network service (SNS). This study is to identify the target relation factors of social network users and to empirically study the causal relationship of how much these factors affect user satisfaction through pleasure and self-efficacy. To present an effective and efficient development plan in. In order to empirically verify the research model of this study, a survey was conducted with the general public who had experience using social network services (SNS). Path analysis was performed. As a result, it was possible to verify the correlation of the object relational factors on user satisfaction through pleasure and self-efficacy.First, non-excluded had a significant effect on pleasure, but did not significantly affect self-efficacy. Second, stability attachment did not significantly affect both enjoyment and self-efficacy. Third, social ability did not significantly affect both enjoyment and self-efficacy. Fourth, self-centeredness did not have a significant effect on both enjoyment and self-efficacy. Fifth, pleasure had a significant effect on both self-efficacy and user satisfaction. Sixth, self-efficacy had a significant effect on user satisfaction.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.170-170
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• 2022

Grain filling traits of rice were traced to determine the critical temperature that ceased grain filling process, from the late transplanted temperate rice varieties in the field conditions of2020 and 2021. The tested three varieties were transplanted six times with four target heading dates of 20 Aug. (control), 10 Sep., 20 Sep. and 30 Sep. Nine times of sampling were made from a week after heading with three replicates for each treatment. Development of grain filling percentage, grain dry weight and milled rice weight demonstrated sigmoid curves in the first and second transplants of 2020, and in the first to third transplants of 2021. The three grain filling traits in the 2020 third transplants and in the 2021 fourth transplants initially increased with the progress of grain development, and reached the peaks at certain time points, then decreased thereafter. Non-linear regression analyses, performed for the traits in the transplants that showed sigmoid curves except control, indicated that 95% of the final data (95% FD) was attained when the seven-day moving temperature (Sd-MovT) was 8.4-9.6℃, which excluded the cases when the temperature before the dates of 95% FD was lower than that on the dates of 95% FD. Sd-MovT on the date of peak data was 8.5-9.8℃ in the 2020 third transplants and 6.9-8.3℃ in the 2021 fourth transplants. Grain development was observed when seven-day mean temperature (Sd-MT) from 35 to 41 days after heading date was 9.4-10.8℃ in the 2020 third transplants and 10.1-11.9℃ in the 2021 fourth transplants. But Sd-MT of 8.7-9.1℃ in 2020 and 6.9-7.6℃ in 2021, at 42-48 days after heading, resulted in no progress of grain development. Overall, Sd-MovT at the point of stagnated grain development appeared in the range of 6.9-9.8℃. The lowest Sd-MT that showed the progress of grain development was 9.4-9.5℃ and the highest Sd-MT that showed no grain development was 9.1℃, both of which appeared in Odae and Haiami of the 2020 third transplants Therefore it is concluded that critical temperature for the grain development of temperate rice in natural conditions exists between 9.1℃ and 9.5℃.

• Nutrition Research and Practice
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• v.17 no.5
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• pp.899-916
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• 2023

BACKGROUND/OBJECTIVES: Oxidative stress is a fundamental neurodegenerative disease trigger that damages and decimates nerve cells. Neurodegenerative diseases are chronic central nervous system disorders that progress and result from neuronal degradation and loss. Recent studies have extensively focused on neurodegenerative disease treatment and prevention using dietary compounds. Heseperetin is an aglycone hesperidin form with various physiological activities, such as anti-inflammation, antioxidant, and antitumor. However, few studies have considered hesperetin's neuroprotective effects and mechanisms; thus, our study investigated this in hydrogen peroxide (H₂O₂)-treated SH-SY5Y cells. MATERIALS/METHODS: SH-SY5Y cells were treated with H₂O₂ (400 µM) in hesperetin absence or presence (10-40 µM) for 24 h. Three-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assays detected cell viability, and 4',6-diamidino-2-phenylindole staining allowed us to observe nuclear morphology changes such as chromatin condensation and apoptotic nuclei. Reactive oxygen species (ROS) detection assays measured intracellular ROS production; Griess reaction assays assessed nitric oxide (NO) production. Western blotting and quantitative polymerase chain reactions quantified corresponding mRNA and proteins. RESULTS: Subsequent experiments utilized various non-toxic hesperetin concentrations, establishing that hesperetin notably decreased intracellular ROS and NO production in H₂O₂-treated SH-SY5Y cells (P < 0.05). Furthermore, hesperetin inhibited H₂O₂-induced inflammation-related gene expression, including interluekin-6, tumor necrosis factor-α, and nuclear factor kappa B (NF-κB) p65 activation. In addition, hesperetin inhibited NF-κB translocation into H₂O₂-treated SH-SY5Y cell nuclei and suppressed mitogen-activated protein kinase protein expression, an essential apoptotic cell death regulator. Various apoptosis hallmarks, including shrinkage and nuclear condensation in H₂O₂-treated cells, were suppressed dose-dependently. Additionally, hesperetin treatment down-regulated Bax/Bcl-2 expression ratios and activated AMP-activated protein kinase-mammalian target of rapamycin autophagy pathways. CONCLUSION: These results substantiate that hesperetin activates autophagy and inhibits apoptosis and inflammation. Hesperetin is a potentially potent dietary agent that reduces neurodegenerative disease onset, progression, and prevention.

• Journal of fish pathology
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• v.37 no.1
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• pp.111-122
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• 2024

This study assessed the impact of the toltrazuril derivative N-(4-(4-Fluorophenoxy)-3-methylphenyl) acetamide on natural cytotoxic cell (NCC) activity of olive flounder, Paralichthys olivaceus spleen. Five groups of fifteen olive flounder, comprising non-treatment and vehicle control groups, were randomly assigned. N-(4-(4-Fluorophenoxy)-3-methylphenyl) acetamide was injected intramuscularly at doses of 120, 150 and 200 mg/kg body weight; a total of ten injections were given over the course of 30 days. The NK activity of flounder splenic cells was evaluated against YAC-1, mouse lymphoma cells or HINAE cells with a choice of co-cultivation times of 4 or 18 hrs. In case of YAC-1 co-culture we observed a significant increase in cytotoxicity at a dose of 200 mg/kg, up to 3.06 times more than that of the control group. Only the trial with the 4 hrs co-culture produced a significant difference in the HINAE cell experiment; the experimental group at the 200 mg/kg dose exhibited the maximum cytotoxicity, demonstrating 2.3 times more cytotoxicity than the control group. Furthermore, the expression level of IL-12b was markedly induced in the group with 200 mg/kg, which was 6.62 times greater than that of the control group. In terms of the altered NK cell activity, the repeated high doses of N-(4-(4-Fluorophenoxy)-3-methylphenyl) acetamide can cause changes in the normal performance of immune function.

• Journal of the Korea Society of Computer and Information
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• v.29 no.4
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• pp.145-153
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• 2024

Through the 106th session of the International Maritime Organization(IMO)'s Maritime Safety Committee(MSC), a mandatory safety training requirement for all personnel transferred or accommodated for offshore industrial activities was established and adopted under the name of SOLAS Chapter XV, IP(Industrial Personnel) Code. This regulation mandates pre-boarding safety training to enable individuals to anticipate and mitigate hazardous risks in navigation and operational environments. Consequently, the IP Code includes provisions regarding the training content for industrial personnel and regulations for the refusal of master who has a full responsibility for individuals who have not completed the required training(non-qualified industrial personnel). Referred to as the IP Code, this agreement is set to enter into force in July 2024, necessitating the establishment and operation of safety education for industrial personnel boarding ships before that date. Accordingly, this paper reviews the legal requirements related to training within IP code and analyzes the details of models including training objectives, target audience, duration, and course structure of safety trainings such as STCW, OPITO, GWO training, and other delegated training related to current ships. Additionally, it aims to propose a curriculum model for IP training courses which consists of a total of 16 hours over 2 days, offered by the Korea Institute of Maritime and Fisheries Technology, including teaching objectives, duration, and course structure.

• Animal Bioscience
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• v.37 no.7
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• pp.1156-1167
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• 2024

Objective: MicroRNAs (miRNAs) are endogenous non-coding RNAs that can play a role in the post-transcriptional regulation of mammalian preadipocyte differentiation. However, the precise functional mechanism of its regulation of fat metabolism is not fully understood. Methods: We identified bta-miR-365-3p, which specifically targets the 3' untranslated region (3'UTR) of the FK506-binding protein 5 (FKBP5), and verified its mechanisms for regulating expression and involvement in adipogenesis. Results: In this study, we found that the overexpression of bta-miR-365-3p significantly decreased the lipid accumulation and triglyceride content in the adipocytes. Compared to inhibiting bta-miR-36 5-3p group, overexpression of bta-miR-365-3p can inhibit the expression of adipocyte differentiation-related genes C/EBPα and PPARγ. The dual-luciferase reporter system further validated the targeting relationship between bta-miR-365-3p and FKBP5. FKBP5 mRNA and protein expression were detected by quantitative real-time polymerase chain reaction and Western blot. Overexpression of bta-miR-365-3p significantly down-regulated FKBP5 expression, while inhibition of bta-miR-365-3p showed the opposite, indicating that bta-miR-365-3p negatively regulates FKBP5. Adenosine 5'-monophosphate (AMP)-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) signaling pathway is closely related to the regulation of cell growth and is involved in the development of bovine adipocytes. In this study, overexpression of bta-miR-365-3p significantly inhibited mRNA and protein expression of AMPK, mTOR, and SREBP1 genes, while the inhibition of bta-miR-365-3p expression was contrary to these results. Overexpression of FKBP5 significantly upregulated AMPK, mTOR, and SREBP1 gene expression, while inhibition of FKBP5 expression was contrary to the above experimental results. Conclusion: In conclusion, these results indicate that bta-miR-365-3p may be involved in the AMPK/mTOR signaling pathway in regulating Yanbian yellow cattle preadipocytes differentiation by targeting the FKBP5 gene.

• Resources Recycling
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• v.33 no.3
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• pp.3-11
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• 2024

This study addressed the cost structure of metallurgical plants for vanadium recovery or production, which were previously planned or implemented. Vanadium metallurgy consists of several sub-processes such as such as pretreatment, roasting, leaching, precipitation, and filtration, in order to finally produce vanadium pentoxide. Here, lots of costs should be spent for such plants, in which these costs are largely divided into CAPEX (Capital Expenditure) and OPEX (Operational Expenditure). As a result, the capacities (feed input rates) and vanadium contents are various along the target projects for this study. However, final production rates and grades of vanadium pentoxide showed relatively small differences. In addition, a noticeable correlation is found between capacities and specific operating costs, in that a steadily decreasing trend is described with a non-linear curve with around -0.3 power. Therefore, for the plant capacity below 100,000 tons per year, the specific operating cost rapidly decreases as the capacity increases, whereas the cost remains relatively stable in the range of 0.6 to 1.2 million tons per year of the capacity. From a technical perspective, effective optimization of the metallurgical process plant can be achieved by improving vanadium recovery rate in the pre-treatment and/or roasting-leaching processes. Finally, the results of this study should be updated through future research with on-going field verification and further detailed cost analysis.

• Korea Journal of Hospital Management
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• v.29 no.2
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• pp.57-79
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• 2024

Purpose: The present study identified the determinants in the development of intrapreneurial intention in small and medium-sized local hospitals. A careful literature review led to the development of a conceptual model which identified two types of employee competence-individual competence and managerial competence-to influence intrapreneurial orientation positively. It was hypothesized that intrapreneurial orientation predicts intrapreneurial intention and is mediated by intrapreneurial commitment. Methodology/Approach: The target population was chosen from two medical institutions of 'D' Hospital and 'E' Geriatric Hospital in Changwon City, South Korea. Samples were collected from 299 respondents who completed a structured questionnaire. Findings: The results from a structural equation modeling statistical analysis indicated that (1) individual competence and managerial competence positively and significantly predict intrapreneurial orientation, (2) intrapreneurial orientation positively and significantly influences intrapreneurial intention, (3) intrapreneurial commitment partially mediates the relation of intrapreneurial orientation to intrapreneurial intention, and (4) the mediation effect of intrapreneurial commitment was significant in the medical-personnel group, but not in the non-medical group. Practical Implications: Overall findings from the present work provide vital insights into understanding the preconditions for developing employee intrapreneurship in small and medium-sized local hospitals.

• The Journal of Korean Society for Radiation Therapy
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• v.20 no.1
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• pp.11-15
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• 2008

Purpose: The goal of radiation treatment is to deliver a prescribed radiation dose to the target volume accurately while minimizing dose to normal tissues. In this paper, we comparing the dose distribution between three dimensional conformal radiation radiotherapy (3D-CRT) and helical tomotherapy (TOMO) plan for partial breast cancer. Materials and Methods: Twenty patients were included in the study, and plans for two techniques were developed for each patient (left breast:10 patients, right breast:10 patients). For each patient 3D-CRT planning was using pinnacle planning system, inverse plan was made using Tomotherapy Hi-Art system and using the same targets and optimization goals. We comparing the Homogeneity index (HI), Conformity index (CI) and sparing of the organs at risk for dose-volume histogram. Results: Whereas the HI, CI of TOMO was significantly better than the other, 3D-CRT was observed to have significantly poorer HI, CI. The percentage ipsilateral non-PTV breast volume that was delivered 50% of the prescribed dose was 3D-CRT (mean: 40.4%), TOMO (mean: 18.3%). The average ipsilateral lung volume percentage receiving 20% of the PD was 3D-CRT (mean: 4.8%), TOMO (mean: 14.2), concerning the average heart volume receiving 20% and 10% of the PD during treatment of left breast cancer 3D-CRT (mean: 1.6%, 3.0%), TOMO (mean: 9.7%, 26.3%) Conclusion: In summary, 3D-CRT and TOMO techniques were found to have acceptable PTV coverage in our study. However, in TOMO, high conformity to the PTV and effective breast tissue sparing was achieved at the expense of considerable dose exposure to the lung and heart.