• Toxicological Research
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• 제23권2호
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• pp.159-164
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• 2007

Toxicity screening of a newly developed oral heparin derivative were carried out in 6 male cynomolgus monkeys (Macaca fascicularis), composed of a treatment group and vehicle control group. A newly orally active heparin derivative, developed by Seoul National University, was once given to treatment group at dose of 500 mg/kg. A treatment group did not show any change in body weights, hematological parameters including platelet-related varivables (platelet, PDW, PCT, MPV) and serum biochemical parameters (e.g., AST, ALT, BUN, etc.) for 2 weeks compared with those of vehicle control group. We also confirmed the maximum plasma concentration (Cmax, 1.73 IU/ml) and the time (Tmax, 1 hr) to reach Cmax. The present study will be valuable in the proper interpretation for nonclinical study using cynomolgus monkeys in the development of new drug of heparin derivative.

• 한국콘텐츠학회논문지
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• 제13권3호
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• pp.240-250
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• 2013

자살 생각을 초기에 발견하는 것은 자살을 예방하는 데 중요하다. 본 연구는 의료 현장에서 사용될 수 있는 간단한 스크리닝 도구를 개발하는 것을 목적으로 하였다. 자살위험 스크리닝 도구는 의사들이 빠르고 쉽게 사용할 수 있도록 설계되었다. 미국 알래스카 Norton Sound region의 Screening for Depression and Thoughts of Suicide라는 도구로부터 2개의 항목으로 구성된 스크리닝 도구를 만들었다. 이 도구는 개인식별번호를 제외하는 등 한국의 실정에 맞게 양식이 수정되었으며 한국형 자살위험 스크리닝 도구로 이름붙였다. 이 도구의 신뢰성과 적용가능성은 7명의 의사들을 통해 검토되었다. 이 도구의 타당성은 4개의 의료기관에서 325명의 환자들을 조사하여 현재의 정신건강 상태를 외부 기준으로 하여 확인하였다. 이와 같은 2개 문항으로 구성된 자살위험 스크리닝 도구는 정신과 의사 및 기타 의사들에 의해 환자의 자살경향을 발견하는데 사용될 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.5989-5994
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• 2012

Background: There is little information on longitudinal patterns of participation in faecal occult blood test (FOBT) based colorectal cancer (CRC) screening or on demographic or behavioural factors associated with participation in re-screening. The lack of an agreed system for describing participatory behaviour over multiple rounds also hampers our ability to report, understand and make use of observed associations. Our aims were to develop a system for describing patterns of participatory behaviour in FOBT-based CRC screening programs and to identify factors associated with particular behavioural patterns. Methods: A descriptive framework was developed and applied to a data extract of screening invitation outcomes over two rounds of the NBCSP. The proportion of invitees in each behaviour category was determined and associations between behaviour patterns and demographic and program factors were identified using multivariate analyses. Results: We considered Re-Participants, Dropouts, Late Entrants and Never Participants to be the most appropriate labels for the four possible observed participatory categories after two invitation rounds. The screening participation rate of the South Australian cohort of the NBCSP remained stable over two rounds at 51%, with second round Dropouts (10.3%) being balanced by Late Entrants (10.5%). Non-Participants comprised 38.7% of invitees. Relative to Re-Participants, Dropouts were older, more likely to be female, of lower SES, had changed their place of residence between offers had a positive test result in the first round. Late Entrants tended to be in the youngest age band. Conclusions: Specific demographic characteristics are associated with behavioural sub-groups defined by responses to 2 offers of CRC screening. Targeted group-specific strategies could reduce dropout behaviour or encourage those who declined the first invitation to participate in the second round. It will be important to keep first round participants engaged in order to maximise the benefit of a CRC screening program.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4141-4149
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• 2013

Background: Mammography is considered the gold standard of breast cancer mass screening and many countries have implemented this as an established breast cancer screening strategy. However, although the incidence of breast cancer and racial characteristics are different between Western and Asian countries, many Asian countries adopted mammography for mass screening. Therefore, the objective of this research was to determine whether mammography mass screening is cost-effective for both Western and Asian countries. Materials and Methods: A systematic review was performed of 17 national mammography cost-effectiveness data sets. Per capita gross domestic product (GDP), breast cancer incidence rate, and the most optimal cost-effectiveness results [cost per life year saved (LYS)] of a mammography screening strategy for each data set were extracted. The CE/per capita GDP ratio is used to compare the cost-effectiveness of mammography by countries. Non-parametric regression was used to find a cut-off point which indicated the breast cancer incidence rate boundary line determining whether mammography screening is cost-effective or not. Results: We found that the cost-effective cut-off point of breast cancer incidence rate was 45.04; it exactly divided countries into Western and Asian countries (p<0.0014). Conclusions: Mammography screening is cost-effective in most of Western countries, but not in Asian countries. The reason for this result may be the issues of incidence rate or racial characteristics, such as dense breast tissue. The results indicate that mammography screening should be adopted prudently in Asian countries and other countries with low incidence rates.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5901-5908
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• 2014

Background: Data from BreastScreen Australia Screening and Assessment Services (SAS) for 2002-2010 were analysed to determine whether some SAS characteristics were more conducive that others to high screening performance, as indicated by high priority performance indicators and standards. Materials And Methods: Indicators investigated related to: numbers of benign open biopsies, screen-detected invasive cancers, and interval cancers, and wait times between screening and assessment. Multivariate Poisson regression was undertaken using as candidate predictors of performance, SAS size (screening volume), urban or rural location, year of screening, accreditation status, and percentages of clients from culturally and linguistically diverse backgrounds, rural and remote areas, and socio-economically disadvantaged areas. Results: Performance standards for benign biopsies and invasive cancer detection were uniformly met irrespective of SAS location and size. The interval cancer standard was also met, except in 2003 when the 95% confidence interval of the rate still incorporated the national standard. Performance indicators improved over time for: benign open biopsy for second or subsequent screening rounds; rates of invasive breast cancer detection for second or subsequent screening rounds; and rates of small cancer detection. No differences were found over time in interval cancer rates. Interval cancer rates did not differ between non-metropolitan and metropolitan SAS, although state-wide SAS had lower rates. The standard for wait time between screening and assessment (being assessed ${\leq}28$ days) was mostly unmet and this applied in particular to SAS with high percentages of culturally and linguistically diverse women in their screening populations. Conclusions: Gains in performance were observed, and all performance standards were met irrespective of SAS characteristics, except wait times to assessment. Additional descriptive data should be collected on SAS characteristics, and their associations with favourable screening performance, as these may be important when deciding on SAS design

• 한국융합학회논문지
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• 제11권5호
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• pp.289-297
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• 2020

본 연구는 학교를 기반으로 하는 학생 건강 검진 참여를 결정하는 요인들이 무엇인지를 밝히는 연구이다. 연구대상은 미국 웨스트버지니아주의 건강 관리사 6명이며, 자료 수집은 전화 인터뷰를 활용하였다. 연구 결과는 다음과 같다. 첫째, 자녀 건강에 대한 관심과 외부적인 압박, 그리고 무료 검진에 의해 동의하는 것으로 나타났다. 둘째, 건강 검진에 대한 지식 부족, 가정 통신문에 대한 무관심, 그리고 자녀의 정보 노출에 대한 불안감, 피를 뽑아야 하는 두려움이 동의를 하지 않는 것으로 나타났다. 셋째, 건강 검진의 장점으로 모든 절차가 무료로 진행된다는 점이었다. 넷째, 학부모가 동의를 결정하는 주된 결정권자이지만 때로는 자녀에게 그 결정권이 존재하고 있었다. 다섯째, 학생 주변에 존재하는 교사, 동료학생, 학교 모두 참여를 결정지을 수 있음을 확인하였다. 그러므로 가정 통신문 개선, 학부모 및 교사 교육, 무료 검사가 필요할 것이다.

• 대한인간공학회지
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• 제28권4호
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• pp.91-99
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• 2009

A visual stress may provoke migraine, cephalalgia, intervene a long term reading and learning capability and reduce the productivity of a laborer who uses computer for a good while. In this study, a web based screening tool for visual stress was developed, it applied to 72 visually normal young persons in parallel with traditional questionnaire about symptoms of visual stress. To estimate visual stress, It is proposed to measure difference of visual search time of Han Gul characters as targets between visual stressful pattern and non-visual stressful pattern as global background of characters. As a result of test, 5 subjects were screened whose mean visual search time in the stressful pattern with 6 CPD spatial frequency increase significantly more than in none stressful pattern(t-test, one-tailed, p=$1.0407\times10^{-11}$). 2 of them were diagnosed as mild visual stress syndrome in the clinic. None had visual distortion and 50% of subjects had visual discomfort in results of the questionnaire. Correlation between visual search time increase rate and normalized number of visual discomfort may be slight(C. coefficient=0.1355). This study may contribute as a basic research for screening person with migraine, visual reading disabilities and VDT syndrome. It is required to apply the test to visual reading disabilities, migraine with visual distortion and/or visual discomfort as well as normal person for higher reliability of the screening tool.

• 한국간호교육학회지
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• 제25권4호
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• pp.414-423
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• 2019

Purpose: This study evaluates the effect of behavioral relaxation training on distress and cancer screening intention of patients with upper gastrointestinal endoscopy. Methods: The research was conducted in a non-equivalent control group posttest design. Data were collected from endoscopy subjects in B city from October to November of 2018. Fifteen minutes of behavioral relaxation training were provided to the experimental group (n=40) and traditional relaxation therapy methods were provided to the control group (n=40). Outcome measures were distress and cancer screening intention of patients with upper gastrointestinal endoscopy. Data were analyzed with a ${\chi}^2$-test, independent t-test, Fisher's exact test with SPSS/PC version 23.0. Results: The objective discomfort (t=8.81, p<.001) of the experimental group was lower than that of the control group; there were no significant differences in the subjective discomfort (t=1.73, p=.088). The cancer screening intention (t=-5.85, p<.001) of the experimental group was significantly higher than that of the control group. Conclusion: Behavioral relaxation training was effective in heightening cancer screening intention. Therefore it can be usefully applied to increase cancer screening intention.

• Archives of Pharmacal Research
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• 제17권5호
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• pp.304-308
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• 1994

Among the new series of phenylacetamides, one of capsaicin derivatives, KR-25018 was found to have a very potent analgesic activity. Thus, the phamacological properties of KR-25018 were compared with those of morphine, capsaicin, and nonsteroidal antiinflammatory drugs (NSAIDs). The analgesic activities were evaluated in several animal models, using different stimuli, such as phenylbenzoquinone(PBQ)-induced weithing test, tail-filck test in mice and adjuvant arthritic flexion test in rat. The relationship of phamacological properties of KR-25018 to that of centrally acting opioids was assessed by the blocking test using naloxone. The analgesic potency of the KR-25018 $(MPED_{50}=0.89{\;}p.o.{\;}in{\;}PBQ-induced{\;}weithing{\;}test, {\;}MPED_{50}$=0.61$ s.c. in tail-flick test in mice0, with different action mechanism from morphine and NSAIDs, was comparable to that of morphine.

• Journal of Gastric Cancer
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• 제14권2호
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• pp.129-134
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• 2014

Purpose: This study aimed to analyze the effect of screening by using endoscopy on the diagnosis and treatment of gastric cancer. Materials and Methods: The clinicopathologic characteristics of gastric cancer were compared in individuals who underwent an endoscopy because of symptoms (non-screening group) or for screening purposes (screening group). The distributions of gastric cancer stages and treatment modalities in 2006 and 2011 were compared. Results: The proportion of patients in the screening group increased from 45.1% in 2006 to 65.4% in 2011 (P<0.001). The proportion of stage I cancers in the entire patient sample also increased (from 60.5% in 2006 to 70.6% in 2011; P=0.029). In 2011, the percentages of patients with cancer stages I, II, III, and IV were 79.9%, 8.2%, 10.9%, and 1.1%, respectively, in the screening group, and 47.9%, 10.8%, 29.8%, and 11.5%, respectively, in the non-screening group. The proportion of laparoscopic and robotic surgeries increased from 9.6% in 2006 to 48.3% in 2011 (P<0.001), and endoscopic submucosal dissection increased from 9.8% in 2006 to 19.1% 2011 (P<0.001). Conclusions: The proportion of patients diagnosed with gastric cancer by using the screening program increased between 2006 and 2011. This increase was associated with a high proportion of early-stage cancer diagnoses and increased use of minimally invasive treatments.