• Molecules and Cells
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• v.37 no.7
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• pp.540-546
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• 2014

Several types of genetic and epigenetic regulation have been implicated in the development of drug resistance, one significant challenge for cancer therapy. Although changes in the expression of non-coding RNA are also responsible for drug resistance, the specific identities and roles of them remain to be elucidated. Long non-coding RNAs (lncRNAs) are a type of ncRNA (> 200 nt) that influence the regulation of gene expression in various ways. In this study, we aimed to identify differentially expressed lncRNAs in 5-fluorouracil-resistant colon cancer cells. Using two pairs of 5-FU-resistant cells derived from the human colon cancer cell lines SNU-C4 and SNU-C5, we analyzed the expression of 90 lncRNAs by qPCR-based profiling and found that 19 and 23 lncRNAs were differentially expressed in SNU-C4R and SNU-C5R cells, respectively. We confirmed that snaR and BACE1AS were down-regulated in resistant cells. To further investigate the effects of snaR on cell growth, cell viability and cell cycle were analyzed after transfection of siRNAs targeting snaR. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. Our results provide an important insight into the involvement of lncRNAs in 5-FU resistance in colon cancer cells.

• Journal of Korean Society of Forest Science
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• v.96 no.6
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• pp.724-729
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• 2007

Due to the low productivity in timber harvesting, economic values of forest resources have been rarely validated in Korea. Since the Korea Forest Service provided a statistic of the timber assets for the survey of the 4th National Accounting (1998), no more statistics or measurements have been provided. Further, it becomes an issue that there is no clear standard to classify timber assets into produced or non-produced assets. In this research, we intended to provide a reasonable standard that enables one to classify timber assets either in produced or non-produced assets. For this purpose, articles in the '1993 System of National Accounts (SNA)', which presented definitions and scopes of biological assets, were scanned. The articles related to timber assets in the Korean version of SNA were compared with those in the original version of SNA that were proposed by UN. The results show that the Korean version of SNA seems to have much emphasis on natural occurrence or plantation for the classification standard, while its original version rather focus on the existence of direct control, responsibility, and management by institutional units. According to the original version of SNA, naturally occurring assets, which were basically classified into non-produced assets, were treated as being cultivated and classified into the produced asset when they (or their growth) were under the direct control, responsibility, and management of institutional units. Therefore, a guidance was presented to renew the Korean version of SNA and to innovate the classification standards for timber assets.

• Information Systems Review
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• v.24 no.4
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• pp.1-22
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• 2022

The transition to a non-face-to-face consumer society has rapidly occurred since Covid-19. The need for a subdivided urban logistics policy centered on courier delivery, a life-friendly last-mile logistics service, has been raised. This study proposes a SNS-based method that can analyze the demand relationship by region and product, respectively. We extend the market basket network (MBN) and co-purchased product network (CPN), find product category patterns, and confirm regional differences by using delivery order data. Our results imply that SNA analysis can be effectively applied to inventory distribution or product (SKU) selection strategies in urban logistics.

• Wind and Structures
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• v.36 no.3
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• pp.215-220
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• 2023

We study the progressive full-scale wind tunnel tests on a high solidity vertical axis wind turbine (VAWT) for various tip speeds and pitch angles to understand the VAWT shaft system's dynamics using 0-1 Test for chaos. We identify that while varying rotor speed (tip speed) of the turbine, the system's dynamics change from periodic to chaotic through quasiperiodic and strange non-chaotic (SNA) states. The present study is the first experimental evidence for the existence of these states in the VAWT shaft system to the best of our knowledge. Using the asymptotic growth value Kc in 0-1 test, when the turbine operates at the low tip speeds and high pitch angles for low incoming wind speeds, the system behaves periodic (Kc ≈ 0). However, when the incoming wind speed increases further the system's dynamics shift from periodic to chaotic vibrations through quasi-periodic and SNA. This phenomenon is due to the dynamic stalling of blades which induces chaotic vibration in the VAWT shaft system. Further, the singular continuous spectrum method validates the presence of SNA and differentiates the SNA from chaotic vibrations.

• Journal of the Korean Home Economics Association
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• v.42 no.7
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• pp.131-143
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• 2004

The purpose of this paper is to prepare a satellite account of the household sector that is reflected in the current national income account by approving the economic activities of unpaid household labor as production activity and estimating its value. The study produced three results. First, as different methods of evaluation can be useful according to different study goals or the contents of related policies, it is unreasonable to present a single result for estimating unpaid household labor. This study, therefore, presented the values of housework based on 5 methods, ranging from 124 to 150 trillion won. Second, to input the added value of household production from the fixed capital (household durable goods), this study adopted the declining balance method used in the Korea National Statistical Office. As a result, the total consumption of fixed capital was estimated at approximately 18.8 trillion won. Third, the total added value of unpaid household labor was estimated to range from 143 to 169 trillion wens. The amount is a production value excluded from the SNA which needs to be formed as a separate household satellite account. The ratio of this total value added was 30-35.4 percents to the 1999 GDP in Korea(477 trillion wens).

• Korean Journal of Cleft Lip And Palate
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• v.2 no.1_2
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• pp.15-22
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• 1999

It is well known that the postoperative skeletal instability after Le Fort I osteotomy for advancement of maxilla in the cleft patients is one of the major surgical problems. So we had tried to compare the amount of relapse after Le Fort I advancement surgery in the horizontal and vertical positional change, angular change of reference points between cleft patients and non-cleft patients. Longitudinal records of 10 consecutive cleft patients (test group) and 20 non-cleft patients (control group) were analyzed. Lateral cephalograms were taken preoperatively, immediately postoperatively, and 2, 6, 12 months postoperatively. We measured horizontal and vertical changes (ANS, PNS, AI) and angular change (SNA) of the reference points and lines. In the test group, horizontal relapse of ANS, PNS, AI point are 36.4%, 37.5%, 32.0% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 25.3%, 32.3%, 39.1% respectively at 12 months postoperatively. The angular change of SNA is 33.6% at 12 months postoperatively. In the control group, horizontal relapse of ANS, PNS, AI point are 23.8%, 30.2%, 21.7% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 22.7%, 27.3%, 25.1% respectively at 12 months postoperatively. The angular change of SNA is 22.2% at 12 months postoperatively. The cleft patients have a larger tendency of skeletal and dental relapse compared with non-cleft patients after Le Fort I surgery. So the oral and maxillofacial surgeons must keep in mind these facts in order to minimize the relapse phenomenon from the beginning of surgical planning to postoperative care.

• The korean journal of orthodontics
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• v.40 no.6
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• pp.432-443
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• 2010

Objective: The purpose of this prospective study was to evaluate the dentofacial effects of conventional and modified facemask therapies with rapid maxillary expansion, in a group of Class III patients; and compared with an untreated control group. Methods: The conventional facemask group (Group 1) comprised of 24 patients, 13 girls and 11 boys (mean age, $9.2{\pm}1.4$ years); the modified facemask treatment group (Group 2) comprised of 24 patients, 12 girls and 12 boys (mean age, $9.3{\pm}1.6$ years); and the control group (Group 3) comprised of 21 subjects, 11 girls and 10 boys (mean age, $9.8{\pm}1.9$ years). Treatment and control changes within the groups and the differences between the groups were analyzed statistically. Intra-group comparisons were evaluated using the non-parametric Wilcoxon's test and intergroup changes were analyzed using the Kruskal-Wallis test. The statistical significance of intergroup differences was further assessed with the Mann-Whitney test for independent samples and applying Bonferroni's correction (p < 0.016). Results: In group 1, SNB changes were less than the control. There were increases in SNA, ANB, SN-MP, A to N perp and Upper lip to E plane. In group 2, SNB, U1-NA (mm) U1-NA (${\circ}$) and Pog to N perp (mm) changes were less than the control. There were increases in SNA, ANB, SN-MP, A to N perp and Upper lip to E plane. Conclusions: Modified facemask appliance can be used effectively in Class III patients with a retrognathic maxilla. Facemask therapies with expansion resulted in an anterior advancement and translation of maxilla without rotation; and the mandible moved downward and backward ward in both treatment groups.

• Ocean and Polar Research
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• v.39 no.3
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• pp.233-244
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• 2017

This study seeks to analyze the needs of biotechnology companies in relation to their entry into the marine biotechnology industry and to discuss the policy implications associated with empirical tasks based on issues raised from empirical results gathered from a survey data of 200 biotechnology companies in Korea. This study made a comparison between marine and non-marine biotechnology companies and analyzed non-marine biotechnology companies' needs related to their entry into the marine biotechnology companies by using Social Network Analysis (SNA). Empirical results indicate that 23.5% of biotechnology companies produce goods using marine bio-resources. Once the utility of marine bio-resources is established, 58.8% of non-marine biotechnology companies intend to enter the marine biotechnology industry. This study also shows that non-marine biotechnology companies need technical support, information sharing, and the acquisition of raw materials to enter the marine biotechnology industry. The findings in this study provide important pointers for the direction of policies and future research in the area of marine biotechnology industry.

• Journal of the Korean Geographical Society
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• v.43 no.4
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• pp.526-543
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• 2008

Based on the social network analysis(SNA), this study examines the structural and spatial characteristics of the actor networks of the manufacturing industries for the elderly. In the field of economic geography, former researches on network have mainly focused on the network governance. However, this study focused on the social network analysis. Centrality indexes are used to analyze the topological structure of actor networks of firms and organizations. In order to investigate the spatial structure of actor networks, not only the regional distribution of actors but also the correlation between centrality index and distance are analyzed. Network matrixes among actors are transformed to network matrixes among regions using block modeling method to reveal the spatial characteristics of the actor networks. In spite of the importance of the Capital Region, networks in the non-Capital Region like Chungnam and Pusan were showed high network density. This suggested that some kinds of policy project operating in the non-Capital Region had the influence on this network in the initial stage of industry.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.34 no.6
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• pp.426-431
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• 2012

Purpose: The aim of this study was to evaluate the effect of temporary mandibular advancement devices (MAD) in obstructive sleep apnea (OSA) patients Methods: 28 patients (male 21, female 7) undergoing temporary mandibular advancement device treatment for OSA were selected from 2011.01. to 2012.02. in the department of Oral & Maxillofacial Surgery at SamsungMedicalCenter. Treatment efficacy was determined by polysomnography (PSG) at baseline & after MAD delivery. The response group was defined as >50% Apnea-Hypopnea Index (AHI) reduction plus post-MAD AHI <10, and the non-response group was defined as <50% AHI reduction. The lateral cephalogram was analysed including SNA, SNB, UL, MPH, PAS, PASU, and PAST using V-ceph$^{TM}$ (Cybermed, USA). Results: The responsers were 23 patients, and non-responsers were 5 patients. The AHI was significantly reduced with temporary MAD ($8.08{\pm}7.93$) compared with baseline ($28.51{\pm}20.56$) in the response group (n=23). No significant difference was observed between pre MAD and post MAD except SNB on cephalometric analysis. Among 11 patients successfully treated with the temporary device, 9 patients said that using permanent device brings better effect too. Conclusion: These results indicate that the Temporary MAD could not be the only effective tools on OSA but also be used to predict patient's reactivity about permanent appliance treatment. Further studies are warranted to evaluate the relations between temporary MAD and permanent MAD.