• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1413-1418
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• 2012

Background: Previous studies generally indicate that synchronous bilateral breast cancers (SBBC) have an equivalent or moderately poorer survival compared with unilateral cases. The prognostic characteristics of SBBC would be relevant when planning adjuvant therapies and follow-up medical surveillance. The frequency of SBBC among early breast cancers in clinical settings in Australia and New Zealand was investigated, plus their prognostic significance, using the Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand, which covered an estimated 60% of early invasive lesions in those countries. Design: Rate ratios (95% confidence limits) of SBBC were investigated among 35,370 female breast cancer cases by age of woman, histology type, grade, tumour diameter, nodal status, lymphatic/vascular invasion and oestrogen receptor status. Univariate and multivariable disease-specific survival analyses were undertaken. Results: 2.3% of cases were found to be SBBC (i.e., diagnoses occurring within 3 months). The figure increased from 1.4% in women less than 40 years to 4.1% in those aged 80 years or more. Disease-specific survivals did not vary by SBBC status (p=0.206). After adjusting for age, histology type, diameter, grade, nodal status, lymphatic/vascular invasion, and oestrogen receptor status, the relative risk of breast cancer death for SBBC was 1.17 (95% CL: 0.91, 1.51). After adjusting for favourable prognostic factors more common in SBBC cases (i.e., histology type, grade, lymphatic/vascular invasion, and oestrogen receptor status), the relative risk of breast cancer death for SBBC was 1.42 (95% CL: 1.10, 1.82). After adjusting for unfavourable prognostic factors more common in SBBC cases (i.e., older age and large tumour diameter), the relative risk of breast cancer death for SBBC was 0.98 (95% CL: 0.76, 1.26). Conclusions: Results confirm previous findings of an equivalent or moderately poorer survival for SBBC but indicate that SBBC status is likely to be an important prognostic indicator for some cases.

• Korean Journal of Radiology
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• v.25 no.8
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• pp.749-755
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• 2024

The recent surge in the incidence of small papillary thyroid cancers (PTCs) has been linked to the widespread use of ultrasonography, thereby prompting concerns regarding overdiagnosis. Active surveillance (AS) has emerged as a less invasive alternative management strategy for low-risk PTCs, especially for PTCs measuring ≤1 cm in maximal diameter. Recent studies report low disease progression rates of low-risk PTCs ≤1 cm under AS. Ongoing research is currently exploring the feasibility of AS for larger PTCs (<20 mm). AS protocols include meticulous ultrasound assessment, emphasis on standardized techniques, and a multidisciplinary approach; they involve monitoring the nodules for size, growth, potential extrathyroidal extension, proximity to the trachea and recurrent laryngeal nerve, and potential cervical nodal metastases. The criteria for progression, often defined as an increase in the maximum diameter of the PTC, warrant a review of precision and ongoing examinations. Challenges exist regarding the reliability of volume measurements for defining PTC disease progression. Although ultrasonography plays a pivotal role, challenges in assessing progression and minor extrathyroidal extension underscore the importance of a multidisciplinary approach in disease management. This comprehensive overview highlights the evolving landscape of AS for PTCs, emphasizing the need for standardized protocols, meticulous assessments, and ongoing research to inform decision-making.

• Journal of KSNVE
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• v.8 no.6
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• pp.1150-1157
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• 1998

In this Paper, we present an efficient method for finite element vibration analysis of constantly rotating structures with cyclic symmetry, which are deformed to some considerable extent by centrifugal force, Coriolis force and operating load, and vibrate due to several types of exciting forces. A structure with cyclic symmetry is composed of circumferentially repeated substructures with the same geometry. Being only one substructure modeled. the dynamic characteristics of the structure can be analyzed systematically. rapidly and exactly using discrete Fourier transform by means of a computer with small memory.

• International Journal of Fluid Machinery and Systems
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• v.1 no.1
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• pp.169-180
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• 2008

As a major component of a power plant, a turbine generator must have sufficient reliability. Longer blades have lower natural frequency, thereby requiring that the design of the shaft and blade takes into account the coupling of the blade vibration mode, nodal diameter k=0 and k=1 with vibration of the shaft. The present work analyzes the coupling of the translation motion of the shaft with in-plane vibration of the blades with k=1 modes. At a rotational speed ${\Omega}_1=|{\omega}_s-{\omega}_b|$, the resonance of the blades has a relatively large amplitude. A violent coupled resonance was observed at a rotational speed ${\Omega}_2=|{\omega}_s+{\omega}_b|$. Resonance in blade vibration at ${\Omega}_1=|{\omega}_s-{\omega}_b|$ was experimentally confirmed.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.10 s.181
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• pp.2513-2519
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• 2000

Free vibration characteristics of an initially stressed CD/DVD disk, which is designed for increasing critical speeds of current optical disks, are analyzed using the Rayleigh-Ritz technique based on variational formulations. Natural frequencies of the new disk depend on membrane stresses caused by disk rotation as well as residual stresses imposed during the cooling process of the injection molding. Critical speeds are calculated for the various initial patterns of radial and circumferential stresses. Initially imposed tensile stresses increase the natural frequencies of all the vibration modes except zero nodal diameter mode, whose natural frequency is independent of circumferential stress. A new disk with initial tensile stress of 0.5MPa is shown to have its critical speed about 30 % higher than the current optical disk.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.05a
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• pp.484-489
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• 2001

Recent trends in information storage devices disk are the transition from CD drives to high density DVD drives, the development of writable disk drives and the appearance of several high-density portable disk drives. In some flexible disk drives, self-excited disk vibrations become severe as rotation speed increases near or above critical speed. Critical speeds of CD/DVD, ASMO and floppy disks are experimentally measured and compared with analytical predictions. Flutter instability caused by aero-induced disk vibration at high speeds are experimentally observed. In ASMO, three nodal-diameter mode experiences its flutter at 8750 rpm with the frequency lock-on phenomenon. The CD/DVD disk does not have the aero-induce flutter up to 14,000 rpm.

• Journal of KSNVE
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• v.8 no.3
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• pp.477-484
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• 1998

An analytical procedure on the base of the substructure synthesis and assumed modes method is developed to investigate the flexibility effect of bladed disk assembly on vibrational modes of flexible rotor system. In modeling the system, Coriolis forces, gyroscopic moments, and centrifugal stiffening effects are taken into account. The coupled vibrations between the shaft and bladed disk are then extensively investigated through the numerical simulation of simplified models, with varying the shaft rotational speed and the prewist and stagger angles of the blade. It is found that the Coriolis and inertia forces and the inertia torque, which are induced by the one nodal diameter modes of the bladed disk and vary depending upon the stagger and prewist angles, lead to the coupled motions of the shaft and the bladed disk.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1997.10a
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• pp.101-109
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• 1997

An analytical procedure on the base of the substructure synthesis and assumed modes method is developed to investigate the flexibility effect of bladed disk assembly on vibrational modes of flexible rotor system. In modeling the system, Coriolis forces, gyroscopic moments, and centrifugal stiffening effects are taken into account. The coupled vibrations between the shaft and bladed disk are then extensively investigated through the numerical simulation of simplified models, with varying the shaft rotational speed and the pretwist and stagger angles of the blade. It is found that the Coriolis and inertia forces and the inertia torque, which are induced by the one nodal diameter modes of the bladed disk and vary depending upon the stagger and pretwist angles, lead to the coupled motions of the shaft and the bladed disk.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.11a
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• pp.777-783
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• 2000

As the disk rotation speed increases in information storage devices, aerodynamically excited disk vibration is induced by airflow around the disk. This paper investigates both experimental and theretical studies on the flutter instability. From the experimental results using an ASMO disk, it is found that the three nodal diameter mode of the optical disk experiences its flutter instability around 8750 rpm. At the flutter speed, the amplitude of the corresponding mode increases dramatically and the backward natural frequency does not increase with increasing rotational speeds. The experimental results on flutter instability are compared with analytical predictions.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2815-2819
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• 2014

Background: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervical carcinoma and to investigate a possible correlation of histology with prognosis. Materials and Methods: Two hundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO (International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the Radiation Oncology Clinic of GH Okmeydan Training and Research Hospital between January 1996 and December 2006 were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Disease-free survival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differences were compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results: There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.